Protein Information

Name peroxisome proliferator activated receptor gamma
Synonyms HUMPPARG; PAX8/PPARG fusion gene; NR1C3; PPAR gamma; PPAR gamma2; PPARG; PPARG 1; PPARG 2…

Compound Information

Name chloroform
CAS trichloromethane

Reference List

PubMed Abstract RScore(About this table)
19744549 Kumar R, Balaji S, Uma TS, Sehgal PK: Fruit extracts of Momordica charantia potentiate glucose uptake and up-regulate Glut-4, PPAR gamma and PI3K. J Ethnopharmacol. 2009 Dec 10;126(3):533-7. Epub 2009 Sep 8.

Effects of aqueous and chloroform extracts of Momordica charantia fruit on glucose uptake and up-regulation of glucose transporter (Glut-4), peroxisome proliferator activator receptor gamma (PPAR gamma) and phosphatidylinositol-3 kinase (PI3K), were investigated to show its efficacy as a hypoglycaemic agent.
65(0,2,2,5) Details
19242902 Dat NT, Lee K, Hong YS, Kim YH, Minh CV, Lee JJ: A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata. Planta Med. 2009 Jun;75(8):803-7. Epub 2009 Feb 25.

The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-gamma agonist, (9 S,13 R)-12-oxo-phytodienoic acid (1), together with 12 other compounds.
34(0,1,1,4) Details
19606518 Kubota H, Morii R, Kojima-Yuasa A, Huang X, Yano Y, Matsui-Yuasa I: Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. Am J Chin Med. 2009;37(3):597-608.

Further fractionation of the initial Z .jujuba extract with organic solvent revealed that the chloroform fraction (CHCl (3)-F) elicited the most inhibitory effect, which involved significant attenuation of the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor (PPAR) gamma and CCAAT enhancer binding proteins (C/EBPs) at the protein level.
32(0,1,1,2) Details