Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
10212237 Maechler P, Kennedy ED, Sebo E, Valeva A, Pozzan T, Wollheim CB: Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. J Biol Chem. 1999 Apr 30;274(18):12583-92.


Both the Ca2+-ATPase inhibitor cyclopiazonic acid and 4-chloro-m-cresol, an activator of ryanodine receptors, caused an almost complete emptying of ER Ca2+.
1(0,0,0,1) Details
16595676 Wang Y, Xu L, Duan H, Pasek DA, Eu JP, Meissner G: Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes. J Biol Chem. 2006 Jun 2;281(22):15572-81. Epub 2006 Apr 4.


To determine the basis of the reduced stored Ca2+ release in CSQ2 knockdown myotubes, we performed immunoblot analyses and found a significant reduction in both sarco/endoplasmic reticulum Ca2+-ATPase and skeletal muscle ryanodine receptor proteins in CSQ2 and CSQ1/CSQ2 knockdown myotubes.
1(0,0,0,1) Details
20038664 Jagadeshwaran U, Onken H, Hardy M, Moffett SB, Moffett DF: Cellular mechanisms of acid secretion in the posterior midgut of the larval mosquito (Aedes aegypti). J Exp Biol. 2010 Jan;213(Pt 2):295-300.


The V-type H (+)-ATPase inhibitor concanamycin A (10 mumol l (-1)) on the luminal side inhibited acidification and decreased V (te).
1(0,0,0,1) Details
19904006 Al-Mousa F, Michelangeli F: Commonly used ryanodine receptor activator, 4-chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps. Pharmacol Rep. 2009 Sep-Oct;61(5):838-42.


Here, we show that mM concentrations of 4CmC also inhibit the sarcoplasmic-endoplasmic reticulum Ca (2+)-ATPase (SERCA), (IC (50) 2-3mM) and cause Ca (2+) release. 4CmC also causes increased intracellular [Ca (2+)] levels in COS-7 cells, which lack functional RyRs.
1(0,0,0,1) Details
17316398 Rojas H, Colina C, Ramos M, Benaim G, Jaffe EH, Caputo C, DiPolo R: Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers Ca (i) 2+-induced Ca2+ release in rat cerebellar Type-1 astrocytes. J Neurochem. 2007 Mar;100(5):1188-202.


This was confirmed by pharmacological experiments using ryanodine receptors agonist (4-chloro-m-cresol) and the endoplasmic reticulum ATPase inhibitor (thapsigargin).
1(0,0,0,1) Details
6745265 Cotton NP, Clark AJ, Jackson JB: Changes in membrane ionic conductance, but not changes in slip, can account for the non-linear dependence of the electrochemical proton gradient upon the electron-transport rate in chromatophores. Eur J Biochem. 1984 Jul 2;142(1):193-8.

Simultaneous recordings of JDIS and the extravesicular pH from cresol-red absorbance changes, suggest that protons are the main current-carrying species across the chromatophore membrane at high values of delta psi in the presence and absence of Fo-ATPase inhibitor.
31(0,1,1,1) Details
2451665 Pikula S, Mullner N, Dux L, Martonosi A: Stabilization and crystallization of Ca2+-ATPase in detergent-solubilized sarcoplasmic reticulum. J Biol Chem. 1988 Apr 15;263(11):5277-86.

8(0,0,0,8) Details
2965700 Taylor KA, Mullner N, Pikula S, Dux L, Peracchia C, Varga S, Martonosi A: Electron microscope observations on Ca2+-ATPase microcrystals in detergent-solubilized sarcoplasmic reticulum. J Biol Chem. 1988 Apr 15;263(11):5287-94.

7(0,0,0,7) Details
17641978 Sarkozi S, Almassy J, Lukacs B, Dobrosi N, Nagy G, Jona I: Effect of natural phenol derivatives on skeletal type sarcoplasmic reticulum Ca2+ -ATPase and ryanodine receptor. J Muscle Res Cell Motil. 2007;28(2-3):167-74. Epub 2007 Jul 20.

4(0,0,0,4) Details
1325902 Mensink RE, Wassink H, Haaker H: A reinvestigation of the pre-steady-state ATPase activity of the nitrogenase from Azotobacter vinelandii. Eur J Biochem. 1992 Sep 1;208(2):289-94.

4(0,0,0,4) Details
15649823 Calderon-Guzman D, Hernandez-Islas JL, Espitia Vazquez IR, Barragan-Mejia G, Hernandez-Garcia E, Del Angel DS, Juarez-Olguin H: Effect of toluene and cresols on Na+,K+-ATPase, and serotonin in rat brain. Regul Toxicol Pharmacol. 2005 Feb;41(1):1-5. Epub 2004 Dec 13.

4(0,0,0,4) Details
1837235 Varga S, Taylor KA, Martonosi A: Effects of solutes on the formation of crystalline sheets of the Ca (2+)-ATPase in detergent-solubilized sarcoplasmic reticulum. Biochim Biophys Acta. 1991 Dec 9;1070(2):374-86.

3(0,0,0,3) Details
6092075 Van Walraven HS, Marvin HJ, Koppenaal E, Kraayenhof R: Proton movements and electric potential generation in reconstituted ATPase proteoliposomes from the thermophilic cyanobacterium Synechococcus 6716. Eur J Biochem. 1984 Nov 2;144(3):555-61.

The proton concentrations of extraliposomal and intraliposomal aqueous spaces were monitored by neutral red and cresol red; for internal measurements these pH indicators were trapped inside the vesicles during detergent dialysis.
3(0,0,0,3) Details
11896027 Tupling R, Green H: Silver ions induce Ca2+ release from the SR in vitro by acting on the Ca2+ release channel and the Ca2+ pump. J Appl Physiol. 2002 Apr;92(4):1603-10.


To further examine the effects of AgNO3 on the CRC and the Ca2+-ATPase, Ca2+ release was measured in muscle homogenates prepared from rat hindlimb muscle using indo 1.
3(0,0,0,3) Details
6197302 van Walraven HS, Lubberding HJ, Marvin HJ, Kraayenhof R: Characterization of reconstituted ATPase complex proteoliposomes prepared from the thermophilic cyanobacterium Synechococcus 6716. Eur J Biochem. 1983 Dec 1;137(1-2):101-6.

The probes used were a membrane-bound fluorescent aminoacridine, which monitors surface charge-density changes, the native carotenoids and added oxonol VI for monitoring electrical potential in the membrane and the pH indicators neutral red and cresol red.
2(0,0,0,2) Details
9688740 Williams JH, Ward CW, Spangenburg EE, Nelson RM: Functional aspects of skeletal muscle contractile apparatus and sarcoplasmic reticulum after fatigue. J Appl Physiol. 1998 Aug;85(2):619-26.


In fatigued fibers, maximal Ca2+-activated force of the contractile apparatus was unaltered, whereas maximal actomyosin-ATPase activity was depressed by 20%.
2(0,0,0,2) Details
15220318 Duhamel TA, Green HJ, Perco JG, Sandiford SD, Ouyang J: Human muscle sarcoplasmic reticulum function during submaximal exercise in normoxia and hypoxia. J Appl Physiol. 2004 Jul;97(1):180-7.


The reduction in maximal Ca (2+)-dependent ATPase activity at 30 min of exercise was accompanied by oxalate-dependent reductions (P < 0.05) in Ca (2+) uptake by approximately 20% (370 +/- 22 vs. 298 +/- 25 micromol x g protein (-1) x min (-1)).
1(0,0,0,1) Details