| PubMed |
Abstract |
RScore(About this table) |
| 11708902 |
Kappers WA, Edwards RJ, Murray S, Boobis AR: Diazinon is activated by CYP2C19 in human liver. . Toxicol Appl Pharmacol. 2001 Nov 15;177(1):68-76.
|
225(2,4,4,5) |
Details |
| 15764407 |
Sams C, Cocker J, Lennard MS: Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP). Xenobiotica. 2004 Oct;34(10):861-73.
In contrast, both desulphuration and dearylation of diazinon were catalysed at similar rates, in the rank order CYP2C19 > CYP1A2 > CYP2B6 > CYP3A4. |
82(1,1,1,2) |
Details |
| 16757081 |
Mutch E, Williams FM: Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32. Epub 2006 Apr 26.
There were significant correlations between diazoxon formation from diazinon (50 microM; 500 microM) with the three CYP3A4/5 marker reactions, while IHMP formation correlated significantly with the three CYP3A4/5 reactions, the CYP2C8 marker reaction (p <0.05) and the CYP2C19 marker (p <0.01). |
6(0,0,1,1) |
Details |