| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | diazinon |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7815357 | Jeong TC, Jordan SD, Matulka RA, Stanulis ED, Kaminski EJ, Holsapple MP: Role of metabolism by esterase and cytochrome P-450 in cocaine-induced suppression of the antibody response. J Pharmacol Exp Ther. 1995 Jan;272(1):407-16. To investigate the role of metabolism in cocaine-induced immunosuppression, diazinon and beta-ionone were administered as an esterase inhibitor and a cytochrome P-450 (P-450) inducer, respectively, to B6C3F1 female mice. |
82(1,1,1,2) | Details |
| 8896566 | Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE: The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat Genet. 1996 Nov;14(3):334-6. The insecticides parathion, chlorpyrifos and diazinon are bioactivated to potent cholinesterase inhibitors by cytochrome P-450 systems. |
81(1,1,1,1) | Details |
| 15764407 | Sams C, Cocker J, Lennard MS: Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP). Xenobiotica. 2004 Oct;34(10):861-73. The cytochrome P450 (CYP)-mediated biotransformation of the organophosphorothioate insecticides chlorpyrifos and diazinon was investigated. |
81(1,1,1,1) | Details |
| 9890448 | Fabrizi L, Gemma S, Testai E, Vittozzi L: Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver. J Biochem Mol Toxicol. 1999;13(1):53-61. |
81(1,1,1,1) | Details |
| 1596286 | Roberts SM, Roth L, Harbison RD, James RC: Cocaethylene hepatotoxicity in mice. Biochem Pharmacol. 1992 May 8;43(9):1989-95. Pretreatment of mice with the esterase inhibitor diazinon (10 mg/kg, i.p.) increased cocaethylene hepatotoxicity, as did pretreatment with the cytochrome P450 inducing agents phenobarbital (80 mg/kg/day, i.p., for 3 days) or beta-naphthoflavone (40 mg/kg/day, i.p., for 3 days). |
32(0,1,1,2) | Details |
| 11481665 | Abu-Qare AW, Abou-Donia MB: Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats. J Appl Toxicol. 2001 Jul-Aug;21(4):307-16. The lower inhibitory effect of the combination of methyl parathion and diazinon might be due to competition of diazinon with methyl parathion for cytochrome P-450 enzymes, resulting in formation of the potent cholinesterase inhibitor methyl paraoxon. |
31(0,1,1,1) | Details |
| 7871535 | Ronis MJ, Badger TM: Toxic interactions between fungicides that inhibit biosynthesis and phosphorothioate insecticides in the male rat and bobwhite quail (Colinus virginianus). Toxicol Appl Pharmacol. 1995 Feb;130(2):221-8. Induction of cytochrome P450 in rat and quail liver by EBIFs was accompanied by enhanced oxidative desulfuration of malathion, parathion, and diazinon to toxic oxon products. |
31(0,1,1,1) | Details |
| 16002382 | Searles Nielsen S, Mueller BA, De Roos AJ, Viernes HM, Farin FM, Checkoway H: Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1). Environ Health Perspect. 2005 Jul;113(7):909-13. Organophosphorus insecticides (OPs) target the developing nervous system, and until recently, the most common residential insecticides were chlorpyrifos and diazinon, two OPs metabolized in the body through the cytochrome P450/paraoxonase 1 (PON1) pathway. |
31(0,1,1,1) | Details |
| 10996483 | Sams C, Mason HJ, Rawbone R: Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes. Toxicol Lett. 2000 Aug 16;116(3):217-21. The role of specific cytochrome P450 isoforms in catalysing the oxidative biotransformation of the organophosphorothioate pesticides parathion, chlorpyrifos and diazinon into structures that inhibit cholinesterase has been investigated in human liver microsomes using chemical inhibitors. |
31(0,1,1,1) | Details |
| 8025560 | Carino FA, Koener JF, Plapp FW Jr, Feyereisen R: Constitutive overexpression of the cytochrome P450 gene CYP6A1 in a house fly strain with metabolic resistance to insecticides. Insect Biochem Mol Biol. 1994 Apr;24(4):411-8. Messenger RNA levels of the cytochrome P450 gene CYP6A1 were measured in the insecticide resistant Diazinon-R 'Rutgers' strain and in the susceptible strain sbo of the house fly with a cloned cDNA probe. |
7(0,0,1,2) | Details |
| 15557345 | Buratti FM, D'Aniello A, Volpe MT, Meneguz A, Testai E: Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab Dispos. 2005 Mar;33(3):295-302. Epub 2004 Nov 22. These results are in line with those found with chlorpyrifos, diazinon, azynphos-methyl, and parathion, characterized by the presence of an aromatic ring in the molecule. |
2(0,0,0,2) | Details |
| 18394709 | Timchalk C, Poet TS: Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat. Neurotoxicology. 2008 May;29(3):428-43. Epub 2008 Mar 10. It is anticipated that these OPs could interact at a number of important metabolic steps including: CYP450 mediated activation/detoxification, B-esterases [carboxylesterase (CaE), butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE)] or PON-1 (A-esterase) oxon detoxification. |
2(0,0,0,2) | Details |
| 4371680 | Capdevila J, Perry AS, Agosin M: Spectral and catalytic properties of cytochrome P-450 from a diazinon-resistant housefly strain. Chem Biol Interact. 1974 Aug;9(2):105-16. |
6(0,0,1,1) | Details |
| 9407006 | Dunkov BC, Guzov VM, Mocelin G, Shotkoski F, Brun A, Amichot M, Ffrench-Constant RH, Feyereisen R: The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbital. DNA Cell Biol. 1997 Nov;16(11):1345-56. The CYP6A2 protein produced in this system metabolized aldrin and heptachlor to their epoxides and metabolized the insecticide diazinon by desulfuration to diazoxon and by oxidative ester cleavage to 2-isopropyl-4-methyl-6-hydroxypyrimidine. |
2(0,0,0,2) | Details |
| 9461846 | Bride JM, Cuany A, Amichot M, Brun A, Babault M, Mouel TL, De Sousa G, Rahmani R, Berge JB: Cytochrome P-450 field insecticide tolerance and development of laboratory resistance in grape vine populations of Drosophila melanogaster (Diptera: Drosophilidae). J Econ Entomol. 1997 Dec;90(6):1514-20. Few significant variations of ECOD activity were detected among the natural populations despite many insecticide treatments, but activities were significantly correlated with toxicological tolerance to 5 of the 15 insecticides (deltamethrin, fipronil, chlorpyriphos ethyl, DDT, and diazinon). |
2(0,0,0,2) | Details |
| 14981232 | Li X, Baudry J, Berenbaum MR, Schuler MA: Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2939-44. Epub 2004 Feb 23. Baculovirus-mediated expression of the CYP6B8 and CYP6B1 proteins demonstrates that CYP6B8 metabolizes six biosynthetically diverse plant allelochemicals (xanthotoxin, and rutin) and three insecticides (diazinon, cypermethrin, and aldrin), whereas CYP6B1 metabolizes only two allelochemicals (xanthotoxin and and one insecticide (diazinon) of those tested. |
2(0,0,0,2) | Details |
| 10814887 | Cha SW, Gu HK, Lee KP, Lee MH, Han SS, Jeong TC: Immunotoxicity of ethyl in female BALB/c mice: role of esterase and cytochrome P450. Toxicol Lett. 2000 Jun 5;115(3):173-81. To investigate the role of esterase in ethyl -induced immunosuppression, mice were pretreated intraperitoneally with an esterase inhibitor, diazinon, at 20 mg/kg 30 min prior to the administration of ethyl intraperitoneally at 100 and 400 mg/kg for 7 consecutive days. |
2(0,0,0,2) | Details |
| 17933502 | Yehia MA, El-Banna SG, Okab AB: Diazinon toxicity affects histophysiological and biochemical parameters in rabbits. Exp Toxicol Pathol. 2007 Nov;59(3-4):215-25. Epub 2007 Oct 22. and microsomal protein were increased (P <0.01), while, liver/ body weight and cytochrome P-450 were decreased in both concentrations (P <0.01). |
1(0,0,0,1) | Details |
| 17442507 | Ueyama J, Wang D, Kondo T, Saito I, Takagi K, Takagi K, Kamijima M, Nakajima T, Miyamoto K, Wakusawa S, Hasegawa T: Toxicity of diazinon and its metabolites increases in diabetic rats. Toxicol Lett. 2007 May 15;170(3):229-37. Epub 2007 Mar 24. Hepatic drug-metabolizing enzyme activity was also estimated by measuring the systemic clearance of antipyrine, and the expression of hepatic cytochrome P450 (CYP) 3A2 and CYP1A2, which is closely related to the metabolism from DZN to DZN-oxon, a strong inhibitor of both ChE and AChE. |
1(0,0,0,1) | Details |
| 1868789 | Babich H, Rosenberg DW, Borenfreund E: In vitro cytotoxicity studies with the fish hepatoma cell line, PLHC-1 (Poeciliopsis lucida). Ecotoxicol Environ Saf. 1991 Jun;21(3):327-36. The organochlorine pesticides (alachlor and p,p'-methoxychlor) were more cytotoxic than the organophosphorus pesticides (EPN, diazinon, and malathion). Xenobiotic-metabolizing capacity was temperature dependent, with enzymatic activity increasing as the temperature was increased from 28 to 34 to 37 degrees C, was inducible by Aroclor 1254 (a chemical inducer of cytochrome P450-dependent monooxygenase activity), and was reduced by EPN (an inhibitor of P450 activity). |
1(0,0,0,1) | Details |
| 17098168 | Willoughby L, Chung H, Lumb C, Robin C, Batterham P, Daborn PJ: A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, and phenobarbital. Insect Biochem Mol Biol. 2006 Dec;36(12):934-42. Epub 2006 Sep 23. Mutations leading to changes in expression levels or substrate specificities of cytochrome P450 (P450), glutathione-S-transferase (GST) and esterase genes have been linked to many cases of resistance with the responsible enzyme shown to utilize the insecticide as a substrate. The insecticides spinosad, diazinon, nitenpyram, lufenuron and dicyclanil did not induce any P450, GST or esterase gene expression after a short exposure to high lethal concentrations of insecticide. |
1(0,0,0,1) | Details |
| 17936934 | Furlong CE: Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds. J Biochem Mol Toxicol. 2007;21(4):197-205. The detoxication of the oxon forms of diazinon and chlorpyrifos is achieved by hydrolysis to the respective aromatic and diethyl phosphates primarily by paraoxonase 1 (PON1), a plasma enzyme tightly associated with high-density lipoprotein particles and also found in liver. |
1(0,0,0,1) | Details |
| 8667213 | Kump DF, Matulka RA, Burton GF, Jordan SD, Holsapple MP: Alternations in splenocyte and thymocyte subpopulations in B6C3F1 mice exposed to cocaine plus diazinon. J Pharmacol Exp Ther. 1996 Jun;277(3):1477-85. Our laboratory has proposed a working model which asserts that cocaine's effects on immunity are mediated by reactive metabolites generated by the cytochrome P-450 system. |
1(0,0,0,1) | Details |
| 17456446 | Daborn PJ, Lumb C, Boey A, Wong W, Ffrench-Constant RH, Batterham P: Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression. Insect Biochem Mol Biol. 2007 May;37(5):512-9. Epub 2007 Mar 2. Drosophila over-expressing Cyp6g1, Cyp6g2, Cyp6t3, Cyp6a2, Cyp6a8, Cyp6a19, Cyp6a23 and Cyp12d1 were screened for resistance to four insecticides--DDT, nitenpyram, dicyclanil and diazinon. |
1(0,0,0,1) | Details |
| 15885262 | Timchalk C, Poet TS, Hinman MN, Busby AL, Kousba AA: Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat. Toxicol Appl Pharmacol. 2005 May 15;205(1):31-42. A high binary dose of 60/60 mg/kg increased the C (max) and AUC and decreased the clearance for both parent compounds, likely due to competition between CPF and DZN for CYP450 metabolism. |
1(0,0,0,1) | Details |
| 12620367 | Buratti FM, Volpe MT, Meneguz A, Vittozzi L, Testai E: CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol Appl Pharmacol. 2003 Feb 1;186(3):143-54. The bioactivation of azinphos-methyl (AZIN), chlorpyrifos (CPF), diazinon (DIA), and parathion (PAR), four widely used organophosphorothioate (OPT) pesticides has been investigated in human liver microsomes (HLM). In addition, the role of human cytochrome P450 (CYPs) in OPT desulfuration at pesticide levels representative of human exposure have been defined by means of correlation and immunoinhibition studies. |
1(0,0,0,1) | Details |