Protein Information

Name NA K ATPase
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name anthraquinone
CAS 9,10-anthracenedione

Reference List

PubMed Abstract RScore(About this table)
2840798 Zhou XM, Chen QH: [Biochemical study of Chinese rhubarb. Yao Xue Xue Bao. 1988 Jan;23(1):17-20.

Inhibitory effect of anthraquinone derivatives on Na+-K+-ATPase of the rabbit renal medulla and their diuretic action]
81(1,1,1,1) Details
2835785 Wanitschke R, Karbach U: Influence of rhein on rat colonic Na+,K+-ATPase and permeability in vitro. Pharmacology. 1988;36 Suppl 1:98-103.

Rhein, an aglucone of a laxative-acting anthraquinone, which induces net secretion in the human jejunum and colon, does not induce net secretion under open circuit current in in vitro conditions but reduces net absorption of electrolytes and water.
In the stripped rat descending colon at a concentration of 2.10 (-4) mol/l, the Na+, K+-ATPase is almost completely inhibited resulting in a decreased net absorption of electrolytes and water.
1(0,0,0,1) Details
9792515 Bohacova V, Docolomansky P, Breier A, Gemeiner P, Ziegelhoffer A: Interaction of lactate dehydrogenase with anthraquinone dyes: characterization of ligands for dye-ligand chromatography. J Chromatogr B Biomed Sci Appl. 1998 Sep 11;715(1):273-81.

Their specific feature is to mimic the adenine nucleotides ATP, ADP, NAD, NADH, which enables them to interact with the nucleotide-binding sites of enzymes such as dehydrogenases, kinases and ATPases.
1(0,0,0,1) Details
17356235 Breier A, Bohacova V, Docolomansky P: Inhibition of (Na (+)/K (+))-ATPase by Cibacron Blue 3G-A and its analogues. Gen Physiol Biophys. 2006 Dec;25(4):439-53.

A specific feature of anthraquinone dyes (AD) is to mimic the adenine nucleotides ATP, ADP, NAD and NADH, enabling them to act as ligands in interaction with nucleotide-binding sites of several enzymes and receptors.
Interaction affinity between the respective dye and (Na+/K+)-ATPase was characterized by means of enzyme kinetics.
1(0,0,0,1) Details