| Name | NADH dehydrogenase |
|---|---|
| Synonyms | B14.5b; NADH dehydrogenase; CI B14.5b; Complex I B14.5b; HLC 2; HLC2; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH ubiquinone oxidoreductase subunit B14.5b… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12688675 | Pawlowska J, Tarasiuk J, Wolf CR, Paine MJ, Borowski E: Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. In our previous studies we have shown that the NADH dehydrogenase catalyzed electron transfer phenomenon is correlated with the affinity of anthraquinone drugs to the enzyme. |
88(1,1,2,3) | Details |
| 10335267 | Tarasiuk J, Tkaczyk-Gobis K, Stefanska B, Dzieduszycka M, Priebe W, Martelli S, Borowski E: The role of structural factors of anthraquinone compounds and their -modified analogues in NADH dehydrogenase-catalysed radical formation. Anticancer Drug Des. 1998 Dec;13(8):923-39. |
84(1,1,1,4) | Details |
| 9296455 | Gille L, Nohl H: Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity. Free Radic Biol Med. 1997;23(5):775-82. The key and possibly initiating role of the exogenous NADH dehydrogenase of cardiac mitochondria in this reaction pathway provides a rationale to explain the selective cardiotoxic potency of the cytostatic anthraquinone glycosides. |
9(0,0,1,4) | Details |
| 2546562 | Tarasiuk J, Garnier-Suillerot A, Borowski E: Lack of competition between cytochrome c and anthraquinone type drugs for the reductive sites of NADH dehydrogenase. Biochem Pharmacol. 1989 Jul 15;38(14):2285-9. |
6(0,0,1,1) | Details |
| 7945727 | Jeziorek D, Dyl D, Liwo A, Ossowski T, Woznicki W: Enthalpy of addition to anthraquinone derivatives determines their ability to mediate oxidation. Anticancer Drug Des. 1994 Oct;9(5):435-48. Significant stabilization of hydroperoxides was estimated in weakly polar media (epsilon = 4) which can simulate the -reducing center of the mitochondrial NADH dehydrogenase. |
1(0,0,0,1) | Details |
| 18966468 | Das S, Saha A, Mandal PC: Studies on the formation of Cu (II) and Ni (II) complexes of l,2-dihydroxy-9,10-anthraquinone and lack of stimulated formation by the complexes. Talanta. 1996 Jan;43(1):95-102. |
0(0,0,0,0) | Details |
| 2983753 | Beraldo H, Garnier-Suillerot A, Tosi L, Lavelle F: (III)-adriamycin and (III)-daunorubicin complexes: physicochemical characteristics, interaction with DNA, and antitumor activity. Biochemistry. 1985 Jan 15;24(2):284-9. In these formulas, HAd and HDr stand for adriamycin and daunorubicin in which the 1,4-dihydroxy-anthraquinone moiety is half-deprotonated. |
0(0,0,0,0) | Details |