Protein Information

Name neurotoxic esterase
Synonyms NTE; SWS; Neuropathy target esterase; Neurotoxic esterase; PNPLA 6; patatin like phospholipase domain containing 6; Neuropathy target esterases…

Compound Information

Name diazinon
CAS

Reference List

PubMed Abstract RScore(About this table)
10896849 de Blaquiere GE, Waters L, Blain PG, Williams FM: Electrophysiological and biochemical effects of single and multiple doses of the organophosphate diazinon in the mouse. Toxicol Appl Pharmacol. 2000 Jul 15;166(2):81-91.

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10509429 Abdelsalam EB: Neurotoxic potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2.

The neurotoxic potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens.
81(1,1,1,1) Details
11350214 Quistad GB, Sparks SE, Casida JE: Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. Toxicol Appl Pharmacol. 2001 May 15;173(1):48-55.


Five OP pesticides inhibit 50% of the brain FAAH activity (ED50) at <30 mg/kg 4 h after ip administration to mice; while inhibition by chlorpyrifos, diazinon, and methamidophos occurs near acutely toxic levels, profenofos and tribufos are effective at asymptomatic doses.
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