Protein Information

Name H ras
Synonyms C H RAS; Transforming protein p21; N ras; HRAS1; HRASP; C H ras 1 protein N terminal fragment (37 AA); C has/bas p21 protein; C ras Ki 2 protein…

Compound Information

Name anthraquinone
CAS 9,10-anthracenedione

Reference List

PubMed Abstract RScore(About this table)
11697035 Ohkuma Y, Hiraku Y, Kawanishi S: Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu (II), cytochrome P450 reductase and NADPH. Free Radic Res. 2001 Jun;34(6):595-604.

The mechanism of metal-mediated DNA damage by carcinogenic danthron (1,8-dihydroxyanthraquinone) and anthraquinone was investigated by the DNA sequencing technique using 32P-labeled human DNA fragments obtained from the human c-Ha-ras-1 protooncogene and the p53 tumor suppressor gene.
31(0,1,1,1) Details
11560247 Hayashi S, Hong HH, Toyoda K, Ton TV, Devereux TR, Maronpot RR, Huff J, Sills RC: High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years. Toxicol Pathol. 2001 Jul-Aug;29(4):422-9.

1-Amino-2,4-dibromoanthraquinone (ADBAQ) is an anthraquinone-derived vat dye, and a potent carcinogen in laboratory animals.
The present study indentified genetic alterations in H-ras and K-ras proto-oncogenes in ADBAQ-induced tumors.
3(0,0,0,3) Details