| Name | complex is |
|---|---|
| Synonyms | 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9… |
| Name | anthraquinone |
|---|---|
| CAS | 9,10-anthracenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9467063 | Das S, Saha A, Mandal PC: Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu (II) complex. Environ Health Perspect. 1997 Dec;105 Suppl 6:1459-62. Our results show that the Cu (II)- complex is more efficient in modifying the base-pair region in double-stranded DNA compared to free |
1(0,0,0,1) | Details |
| 18754611 | Zagotto G, Sissi C, Lucatello L, Pivetta C, Cadamuro SA, Fox KR, Neidle S, Palumbo M: Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. J Med Chem. 2008 Sep 25;51(18):5566-74. The telomerase-telomere complex is a prospective anticancer target. |
1(0,0,0,1) | Details |
| 8431447 | van Houte LP, van Garderen CJ, Patel DJ: The antitumor drug nogalamycin forms two different intercalation complexes with d (GCGT).d (ACGC). Biochemistry. 1993 Feb 16;32(6):1667-74. In complex I, the aglycon ring of the drug stacks with the C6-G7 bases, and the sugars are directed to the G1.C8 end; while in the case of complex II the anthraquinone ring system is stacked with C2-G3 bases, and the sugars are pointed to the T4.A5 base pair end. |
32(0,1,1,2) | Details |
| 3165639 | Rizzo V, Penco S, Menozzi M, Geroni C, Vigevani A, Arcamone F: Studies of anthracycline--DNA complexes by circular dichroism. Anticancer Drug Des. 1988 Aug;3(2):103-15. Conformational correspondence with the known structure of the daunorubicin-oligonucleotide complex is inferred from the spectra of derivatives with modifications at position 6 or 11 in the anthraquinone chromophore. |
31(0,1,1,1) | Details |
| 7639535 | Malisza KL, Hasinoff BB: Production of by iron (III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/ system. Arch Biochem Biophys. 1995 Aug 1;321(1):51-60. The rate of self-reduction of the iron (III)-doxorubicin complex is consistent with a mechanism in which unbound doxorubicin binds to an iron (III)-doxorubicin complex of decreased coordination and after binding undergoes an intramolecular electron transfer. |
1(0,0,0,1) | Details |
| 15824924 | Kalayda GV, Jansen BA, Wielaard P, Tanke HJ, Reedijk J: Dinuclear platinum anticancer complexes with fluorescent N,N'-bis (aminoalkyl)-1,4-diaminoanthraquinones: cellular processing in two cisplatin-resistant cell lines reflects the differences in their resistance profiles. J Biol Inorg Chem. 2005 May;10(3):305-15. Epub 2005 Apr 12. The platinum complex is excreted from the cell via the Golgi apparatus, while the weakly basic anthraquinone ligand accumulates in the Golgi complex, where it is taken up by lysosomes and then transported to the cell surface. |
31(0,1,1,1) | Details |
| 19853921 | Guin PS, Das S, Mandal PC: Studies on the formation of a complex of Cu (II) with 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate - an analogue of the core unit of anthracycline anticancer drugs and its interaction with calf thymus DNA. J Inorg Biochem. 2009 Dec;103(12):1702-10. Epub 2009 Sep 29. The 1:2 metal-ligand complex is formed in aqueous solution at neutral and acidic pH while in alkaline pH both 1:1 and 1:2 species are formed. |
2(0,0,0,2) | Details |
| 9296455 | Gille L, Nohl H: Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity. Free Radic Biol Med. 1997;23(5):775-82. After one-electron transfer to the parent hydrophilic anthraquinone molecule destabilization of the radical formed causes cleavage of the sugar residue. This enzyme that is associated with complex I of the respiratory chain catalyzes the oxidation of cytosolic |
1(0,0,0,1) | Details |
| 18966468 | Das S, Saha A, Mandal PC: Studies on the formation of Cu (II) and Ni (II) complexes of l,2-dihydroxy-9,10-anthraquinone and lack of stimulated formation by the complexes. Talanta. 1996 Jan;43(1):95-102. The effective stability constant of the Cu (II) complex is 5.135 x 10 (29) while that of the Ni (II) complex is 3.446 x 10 (25). |
1(0,0,0,1) | Details |
| 3094197 | Wallace KB: Nonenzymatic activation and stimulation of lipid peroxidation by doxorubicin- Toxicol Appl Pharmacol. 1986 Oct;86(1):69-79. The data demonstrate that despite the implication of peroxide and in doxorubicin- stimulated lipid peroxidation, the immediate product of dioxygen reduction by the complex is -free radicals. The suggested occurrence of doxorubicin- complexes in vivo infers that nonenzymatic generation of -free radicals by the chelate may contribute to the mechanism of toxicity of doxorubicin and related anthraquinone anticancer agents observed clinically. |
1(0,0,0,1) | Details |
| 566070 | Bouhet JC, Pham van Chuong P: Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids. Ann Nutr Aliment. 1977;31(4-6):811-30. (-) Luteoskyrin and (+) Rugulosin are 2 hepatotoxic and carcinogenic anthraquinone-like pigments from Penicillia which contaminate rice and other foodstuffs. In the present work, characterization, specificity and structure of binary polychelates (pigment-metal) n and ternary complexes (pigment-metal-nucleic acids) are successively reported: whereas, unspecific complex II with double-stranded polynucleotides is shown to result from simple adsorption of polychelate onto the double helix, complex I is specific for single-stranded DNA (or polypurine nucleotides) and results from electrostatic association of separate pigment-metal units with the polyphosphate chain. |
1(0,0,0,1) | Details |
| 2400540 | Morier-Teissier E, Bernier JL, Lohez M, Catteau JP, Henichart JP: Free radical production and DNA cleavage by chelating peptide-anthraquinones. Anticancer Drug Des. 1990 Aug;5(3):291-305. Two pseudopeptides incorporating a peptide metal-chelating moiety (Gly-His- and a polyhydroxy anthraquinone ring related to the nuclei of anti-tumor drugs such as mitoxantrone and ametantrone, have been synthesized. This latter complex is able to induce DNA breakage at a high level. |
1(0,0,0,1) | Details |
| 8517915 | Jeziorek D, Dyl D, Liwo A, Woznicki W, Tempczyk A, Borowski E: A theoretical study of the mechanism of binding by model anthraquinones. Anticancer Drug Des. 1993 Jun;8(3):223-35. It was found that the -binding site is determined by three factors: the high electron density and high HOMO coefficients on the carbon atoms to which binds, the minimum loss of conjugation within the anthraquinone moiety on binding and the minimum number of bonds to other heavy atoms of the -binding carbons (the steric effect). For different molecules, the energy of the most stable complex is the greatest for compounds with the lowest ionization potential. |
1(0,0,0,1) | Details |