| 19534674 |
Tatyana K, Francesca E, Luca Z, Giovanni F, Cheng YC, Ginger ED, Enzo T: Inhibition of HIV-1 ribonuclease H activity by novel frangula-emodine derivatives. Med Chem. 2009 Sep;5(5):398-410. Epub 2009 Sep 1.
Given the structural similarities between integrase and RNase H proteins, we synthesized a series of frangula-emodine derivatives and showed that the introduction of a bromine atom in position 7 of the anthraquinone structure leads to derivatives which are able to inhibit both HIV-1 polymerase and RNase H functions at micromolar concentrations. |
113(1,2,2,3) |
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