Protein Information

Name casein
Synonyms Alpha; Alpha s1 casein; Alpha s1 casein precursor; CASA; CSN 1; CSN1; CSN1S1; Casein…

Compound Information

Name anthraquinone
CAS 9,10-anthracenedione

Reference List

PubMed Abstract RScore(About this table)
16449442 Slobodkin AI, Tourova TP, Kostrikina NA, Lysenko AM, German KE, Bonch-Osmolovskaya EA, Birkeland NK: Tepidimicrobium ferriphilum gen. nov., sp. nov., a novel moderately thermophilic, Fe (III)-reducing bacterium of the order Clostridiales. Int J Syst Evol Microbiol. 2006 Feb;56(Pt 2):369-72.

The substrates utilized by strain SB91T in the presence of 9,10-anthraquinone 2,6-disulfonate included peptone, tryptone, Casamino acids, yeast extract, beef extract, casein hydrolysate, alanine plus glycine, alanine plus proline, L-valine and n-propanol.
31(0,1,1,1) Details
12191608 Sarno S, Moro S, Meggio F, Zagotto G, Dal Ben D, Ghisellini P, Battistutta R, Zanotti G, Pinna LA: Toward the rational design of protein kinase casein kinase-2 inhibitors. . Pharmacol Ther. 2002 Feb-Mar;93(2-3):159-68.

A comparison with a series of anthraquinone and xanthenone derivatives highlights the crucial relevance of the hydroxyl group at position 3 for inhibition by emodin, and discloses the possibility of increasing the inhibitory potency by placing an electron withdrawing group at position 5.
2(0,0,0,2) Details
19625437 Niu L, Song L, Liu X, Dong X: Tepidimicrobium xylanilyticum sp. nov., an anaerobic xylanolytic bacterium, and emended description of the genus Tepidimicrobium. Int J Syst Evol Microbiol. 2009 Nov;59(Pt 11):2698-701. Epub 2009 Jul 22.

Strain PML14 (T) grew on a number of carbohydrates, including xylan, xylose, glucose and cellobiose, and a variety of proteinaceous compounds, including peptone, tryptone, Casamino acids, yeast extract, beef extract, casein hydrolysate, l-cysteine, l-serine, l-lysine, l-glycine, l-threonine, l-methionine and pyruvate.
Fe (III), 9,10-anthraquinone 2,6-disulfonate and thiosulfate were reduced with peptone as the electron donor.
1(0,0,0,1) Details
12419810 De Moliner E, Moro S, Sarno S, Zagotto G, Zanotti G, Pinna LA, Battistutta R: Inhibition of protein kinase CK2 by anthraquinone-related compounds. J Biol Chem. 2003 Jan 17;278(3):1831-6. Epub 2002 Nov 4.

Here we present and discuss three new crystal structures of ATP site-directed inhibitors in complex with "casein kinase-2" (CK2), a constitutively active protein kinase implicated in a variety of cellular functions and misfunctions.
1(0,0,0,1) Details
10083837 Yim H, Lee YH, Lee CH, Lee SK: Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 1999 Feb;65(1):9-13.

We measured IC50 values for emodin on the activities of several Ser/Thr protein kinases, including cAMP-dependent protein kinase (PKA), protein kinase C (PKC), cdc2, casein kinases I (CKI) and CKII.
1(0,0,0,1) Details
1295884 Takeuchi N, Nakamura T, Takeuchi F, Hashimoto E, Yamamura H: Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7.


Mitoxantrone, a new anthraquinone, showed inhibitory an effect on protein kinase C (PKC) activity.
0(0,0,0,0) Details