| 192248 |
Freundt KJ, Netz H: Behavior of blood acetaldehyde in alcohol-treated rats following administration of thiurams. Arzneimittelforschung. 1977;27(1):105-8.
At the same time, the blood acetaldehyde concentration showed a considerable increase which after thiram was much more significant than after disulfiram, Identical thiuram doses caused a significant reduction in the rate of elimination of acetaldehyde i.v., which suggests an inhibition of the aldehyde dehydrogenasel aldehyde oxidase and helps to explain the elevated blood acetaldehyde concentration which was observed in the presence of ethanol. |
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