| Name | choline acetyltransferase |
|---|---|
| Synonyms | CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase… |
| Name | diazinon |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16675431 | Slotkin TA, Levin ED, Seidler FJ: Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect. 2006 May;114(5):746-51. We contrasted neuritic outgrowth and cholinergic synaptic development in neonatal rats given different organophosphates (chlorpyrifos, diazinon, parathion) at doses spanning the threshold for impaired growth and viability. |
0(0,0,0,0) | Details |
| 16207942 | Paraoanu LE, Mocko JB, Becker-Roeck M, Smidek-Huhn J, Layer PG: Exposure to diazinon alters in vitro retinogenesis: retinospheroid morphology, development of chicken retinal cell types, and gene expression. Toxicol Sci. 2006 Jan;89(1):314-24. Epub 2005 Oct 5. The expression of transcripts for choline-acetyltransferase and muscarinic receptors was affected, revealing an effect of diazinon on the cholinergic system. |
81(1,1,1,1) | Details |
| 6451954 | Misawa M, Doull J, Kitos PA, Uyeki EM: Teratogenic effects of cholinergic insecticides in chick embryos. Toxicol Appl Pharmacol. 1981 Jan;57(1):20-9. Diazinon treatment on acetylcholinesterase and choline acetyltransferase activities. |
6(0,0,1,1) | Details |
| 18941570 | Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ: Exposure of neonatal rats to parathion elicits sex-selective impairment of systems in brain regions during adolescence and adulthood. Environ Health Perspect. 2008 Oct;116(10):1308-14. Epub 2008 May 19. METHODS: We assessed neurochemical indices related to the function of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in brain regions comprising all the major projections, with determinations carried out from adolescence to adulthood (PNDs 30, 60, and 100). Superimposed on this general pattern, the cerebrocortical effects showed a nonmonotonic dose-response relationship, with regression of the defects at the higher parathion dose; this relationship has been seen also after comparable treatments with chlorpyrifos and diazinon and likely represents the involvement of cholinesterase-related actions that mask or offset the effects of lower doses. |
1(0,0,0,1) | Details |
| 18335101 | Slotkin TA, Bodwell BE, Levin ED, Seidler FJ: Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and systems. Environ Health Perspect. 2008 Mar;116(3):340-8. METHODS: We then evaluated the lasting effects on indices of neural cell number and size, and on functional markers of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in a variety of brain regions. |
1(0,0,0,1) | Details |