Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
11829753 Baracca A, Barogi S, Paolini S, Lenaz G, Solaini G: Fluorescence resonance energy transfer between coumarin-derived mitochondrial F (1)-ATPase gamma subunit and pyrenylmaleimide-labelled fragments of IF (1) and c subunit. Biochem J. 2002 Feb 15;362(Pt 1):165-71.

Incubation of 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin (CPM) with bovine heart mitochondrial F (1)-ATPase pretreated with 1 nM sodium arsenite modified the only cysteine residue in the gamma subunit (gamma-Cys (78)), resulting in an enzyme-CPM fluorescent complex (CPM-F (1)) with an ATPase activity similar to that of the native enzyme.
84(1,1,1,4) Details
12680698 Shen J, Hsu CM, Kang BK, Rosen BP, Bhattacharjee H: The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance. Biometals. 2003 Sep;16(3):369-78.


Homologues of the bacterial ArsA ATPase are found in nearly every organism.
4(0,0,0,4) Details
16667014 Atkinson MM, Baker CJ: Role of the Plasmalemma H-ATPase in Pseudomonas syringae-Induced K/H Exchange in Suspension-Cultured Tobacco Cells. Plant Physiol. 1989 Sep;91(1):298-303.

Respiratory inhibitors such as oligomycin and sodium azide reduced the exchange by 50% to 75%, while glycolysis inhibitors such as sodium arsenite and sodium iodoacetate decreased exchange by approximately 90%.
4(0,0,0,4) Details
8419286 Kaur P, Rosen BP: Complementation between nucleotide binding domains in an anion-translocating ATPase. J Bacteriol. 1993 Jan;175(2):351-7.

3(0,0,0,3) Details
16467301 Ruan X, Bhattacharjee H, Rosen BP: Cys-113 and Cys-422 form a high affinity metalloid binding site in the ArsA ATPase. J Biol Chem. 2006 Apr 14;281(15):9925-34. Epub 2006 Feb 8.

2(0,0,0,2) Details
7744758 Bhattacharjee H, Li J, Ksenzenko MY, Rosen BP: Role of cysteinyl residues in metalloactivation of the oxyanion-translocating ArsA ATPase. J Biol Chem. 1995 May 12;270(19):11245-50.

2(0,0,0,2) Details
15637064 Jiang Y, Bhattacharjee H, Zhou T, Rosen BP, Ambudkar SV, Sauna ZE: Nonequivalence of the nucleotide binding domains of the ArsA ATPase. . J Biol Chem. 2005 Mar 18;280(11):9921-6. Epub 2005 Jan 6.

2(0,0,0,2) Details
11389146 Jia H, Kaur P: Role of the linker region of the anion-stimulated ATPase ArsA. J Biol Chem. 2001 Aug 3;276(31):29582-7. Epub 2001 Jun 1.

2(0,0,0,2) Details
7925850 Gargari ML, Bansal RC, Singh K, Mahmood A: Inhibition of glucose transport in human erythrocytes by 2,3-dioxoindole (isatin). Experientia. 1994 Sep 15;50(9):833-6.

The observed inhibition of sugar transport by isatin was not mediated through membrane -SH groups accessible to iodoacetate, iodoacetamide, DTNB, DNP or sodium arsenite.
Isatin inhibited sugar transport in the presence of 2 mM harmaline, an alkaloid inhibitor of Na+, K (+)-ATPase activity.
1(0,0,0,1) Details
18443843 Aggarwal M, Naraharisetti SB, Sarkar SN, Rao GS, Degen GH, Malik JK: Effects of subchronic coexposure to arsenic and endosulfan on the erythrocytes of broiler chickens: a biochemical study. Arch Environ Contam Toxicol. 2009 Jan;56(1):139-48. Epub 2008 Apr 29.


None of the treatments affected the activities of total ATPase and Mg2+-ATPase.
1(0,0,0,1) Details
1281474 Dou D, Owolabi JB, Dey S, Rosen BP: Construction of a chimeric ArsA-ArsB protein for overexpression of the oxyanion-translocating ATPase. J Biol Chem. 1992 Dec 25;267(36):25768-75.

1(0,0,0,1) Details
10220854 Ho IC, Lee TC: Sodium arsenite enhances copper accumulation in human lung adenocarcinoma cells. Toxicol Sci. 1999 Feb;47(2):176-80.

Our results suggest that Menkes protein is a potential target of arsenite.
1(0,0,0,1) Details
16469751 Hales DB, Allen JA, Shankara T, Janus P, Buck S, Diemer T, Hales KH: Mitochondrial function in Leydig cell steroidogenesis. Ann N Y Acad Sci. 2005 Dec;1061:120-34.


Sodium arsenite at low concentrations inhibited StAR protein but not mRNA expression and inhibited progesterone without disrupting delta psi (m).
0(0,0,0,0) Details
8229676 Yotis WW, Gopalsami C, Corrigan K, Hoerman K, Keene JJ Jr: Phosphorylated nutrient uptake by Treponema denticola and other potential periodontopathogens. J Basic Microbiol. 1993;33(5):357-68.


At concentrations usually employed (0.05-0.5 mM) the metabolic poisons 2,4-dinitrophenol, sodium azide, sodium arsenite and the ATPase inhibitor N,N1-dicyclohexylcarbodiimide did not alter significantly the uptake of ATP.
0(0,0,0,0) Details
8663271 Elia G, De Marco A, Rossi A, Santoro MG: Inhibition of HSP70 expression by calcium ionophore A23187 in human cells. J Biol Chem. 1996 Jul 5;271(27):16111-8.


In this study, we report that the calcium ionophore A23187, a glucose-regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or prostaglandin A1 treatment in human K562 cells.
0(0,0,0,0) Details
10379902 Odunuga OO, Okunade GW, Olorunsogo OO: Reversal of sodium arsenite inhibition of rat liver microsomal Ca2+ pumping ATPase by vitamin C. Biosci Rep. 1999 Feb;19(1):11-5.
163(2,2,2,3) Details