Protein Information

Name protein is
Synonyms ANX 2; p36; LIP 2; LIP2; ANX2; ANX2L4; ANX2P1; ANX2P2…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
1676954 Cochrane BJ, Irby RB, Snell TW: Effects of copper and tributyltin on stress protein abundance in the rotifer Brachionus plicatilis. Comp Biochem Physiol C. 1991;98(2-3):385-90.

This protein is immunologically crossreactive with the 65,000 Da heat shock protein of the moth Heliothis virescens, which is a member of a highly conserved family of mitochondrial proteins. 3.
No response was observed when rotifers were exposed to aluminum chloride, mercury chloride, pentachlorophenol, sodium arsenite, sodium azide, sodium dodecyl sulfate, or zinc chloride. 6.
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10896383 Pritts TA, Wang Q, Sun X, Moon MR, Fischer DR, Fischer JE, Wong HR, Hasselgren PO: Induction of the stress response in vivo decreases nuclear factor-kappa B activity in jejunal mucosa of endotoxemic mice. Arch Surg. 2000 Jul;135(7):860-6.

The transcription factor nuclear factor-kappa B (NF-kappa B), normally sequestered in the cytoplasm by its inhibitory protein, I kappa B, regulates many genes involved in inflammatory responses to critical illness.
METHODS: The stress response was induced in mice by hyperthermia (42 degrees C) or injection with sodium arsenite (10 mg/kg).
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17170114 Jiang HY, Jiang L, Wek RC: The eukaryotic initiation factor-2 kinase pathway facilitates differential GADD45a expression in response to environmental stress. J Biol Chem. 2007 Feb 9;282(6):3755-65. Epub 2006 Dec 14.


The basis for this difference between measurable GADD45a mRNA and protein lies in the observation that GADD45a protein is labile.
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8878445 Tsukamoto Y, Kuwabara K, Hirota S, Ikeda J, Stern D, Yanagi H, Matsumoto M, Ogawa S, Kitamura Y: 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein. J Clin Invest. 1996 Oct 15;98(8):1930-41.

We have found that exposure of cultured human aortic smooth muscle cells and mononuclear phagocytes (MPs) to hypoxia (pO2 approximately 12-14 torr) induces ORP150 transcripts and production of the antigen, whereas incubation with either hydrogen peroxide, sodium arsenite, heat shock, or 2-deoxyglucose was without effect.
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1520691 Deneke SM: Induction of cystine transport in bovine pulmonary artery endothelial cells by sodium arsenite. Biochim Biophys Acta. 1992 Aug 24;1109(2):127-31.

Others have reported that synthesis of the 30-34 kDa stress protein is maximal between 2-4 h and returns to baseline by 6-10 h.
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2113536 Nakai A, Hirayama C, Ohtsuka K, Hirayoshi K, Nagata K: Novel ATP-binding heat-inducible protein of Mr = 37,000 that is sensitive to transformation in BALB/3T3 cells. J Cell Physiol. 1990 Jun;143(3):577-89.

These studies established that a major ATP-binding protein of Mr = 37,000 is a heat-inducible protein and that the synthesis of this protein is regulated by malignant transformation.
This protein was drastically induced by treating the cells with alpha,alpha'-dipyridyl, an iron chelating reagent, but not with sodium arsenite, calcium ionophore, or tunicamycin.
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6893047 Johnston D, Oppermann H, Jackson J, Levinson W: Induction of four proteins in chick embryo cells by sodium arsenite. . J Biol Chem. 1980 Jul 25;255(14):6975-80.

Kinetically, all species appear 1 h after exposure to 50 microM arsenite, after 24 and 48 h of exposure, the 27,000 protein is still synthesized extensively, whereas normal cell proteins and the three other induced proteins are greatly reduced.
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8499460 Sato H, Ishii T, Sugita Y, Tateishi N, Bannai S: Induction of a 23 kDa stress protein by oxidative and sulfhydryl-reactive agents in mouse peritoneal macrophages. Biochim Biophys Acta. 1993 May 14;1148(1):127-32.

The synthesis of 23 kDa protein was enhanced when mouse peritoneal macrophages were exposed to oxidative agents such as hydrogen peroxide and menadione, or to sulfhydryl-reactive agents such as diethylmaleate, cadmium chloride and sodium arsenite.
This suggests that the 23 kDa protein is a stress protein predominantly expressed in macrophages.
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3667606 Keyse SM, Tyrrell RM: Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. J Biol Chem. 1987 Oct 25;262(30):14821-5.


Although sodium arsenite, diamide, and menadione all induced a 32-kDa protein, they also induced the major heat shock proteins.
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2266108 Sanchez ER: Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes. J Biol Chem. 1990 Dec 25;265(36):22067-70.


Induction of p56 also occurs in IM-9 cells subjected to chemical stress (sodium arsenite).
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7887613 Li D, Alic M, Brown JA, Gold MH: Regulation of manganese peroxidase gene transcription by hydrogen peroxide, chemical stress, and molecular oxygen. Appl Environ Microbiol. 1995 Jan;61(1):341-5.


The expression of manganese peroxidase (MnP) in nitrogen-limited cultures of the lignin-degrading fungus Phanerochaete chrysosporium is regulated at the level of gene transcription by H2O2 and various chemicals, including ethanol, sodium arsenite, and 2,4-dichlorophenol, as well as by Mn (II) and heat shock.
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3208630 Shuman J, Przybyla A: Expression of the 31-kD stress protein in rat myoblasts and hepatocytes. . DNA. 1988 Sep;7(7):475-82.

This protein is induced in myoblasts and hepatoma cells in response to a 43 degrees C heat shock, or exposure to sodium arsenite or cadmium chloride salts.
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1600951 Sanchez Y, Taulien J, Borkovich KA, Lindquist S: Hsp104 is required for tolerance to many forms of stress. EMBO J. 1992 Jun;11(6):2357-64.

The protein is of critical importance in tolerance to ethanol and of moderate importance in tolerance to sodium arsenite.
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9837857 Hartsfield CL, Alam J, Choi AM: Transcriptional regulation of the heme oxygenase 1 gene by pyrrolidine dithiocarbamate. FASEB J. 1998 Dec;12(15):1675-82.

Heme oxygenase 1 (HO-1), a stress response protein, is highly induced in response to various agents causing oxidative stress including ultraviolet irradiation, sodium arsenite, hyperoxia, and glutathione depletors.
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12650620 Agarwal M, Sahi C, Katiyar-Agarwal S, Agarwal S, Young T, Gallie DR, Sharma VM, Ganesan K, Grover A: Molecular characterization of rice hsp101: complementation of yeast hsp104 mutation by disaggregation of protein granules and differential expression in indica and japonica rice types. Plant Mol Biol. 2003 Mar;51(4):543-53.


HSP100 protein is an important component of the heat-shock response in diverse organisms.
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8228242 Tamura Y, Tsuboi N, Sato N, Kikuchi K: 70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity. J Immunol. 1993 Nov 15;151(10):5516-24.

The accumulated data indicated that the cell surface expression of Ag was clearly enhanced by several stressors, such as TNF, L-azetidine-2-carboxylic acid, and sodium arsenite.
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11931390 Prithivirajsingh S, Mishra SK, Mahadevan A: Functional analysis of a chromosomal arsenic resistance operon in Pseudomonas fluorescens strain MSP3. Mol Biol Rep. 2001;28(2):63-72.

ArsB protein is believed to use the cell membrane potential to drive the efflux of intracellular arsenite ions.
We reported earlier about the detection of a chromosomally located arsenic operon (arsRBC) in a gram-negative bacterium Pseudomonas fluorescens strain MSP3, which showed resistance to elevated levels of sodium arsenate and sodium arsenite.
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10802388 Somji S, Todd JH, Sens MA, Garrett SH, Sens DA: Expression of heat shock protein 60 in human proximal tubule cells exposed to heat, sodium arsenite and CdCl (2). Toxicol Lett. 2000 May 19;115(2):127-36.

A protective role through hsp 60 induction when the proximal tubule cell is acutely exposed to Cd (2+) and a deleterious role when hsp 60 protein is down-regulated during extended exposure to Cd (2+).
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18674524 Vahidnia A, Romijn F, van der Voet GB, de Wolff FA: Arsenic-induced neurotoxicity in relation to toxicokinetics: effects on sciatic nerve proteins. Chem Biol Interact. 2008 Nov 25;176(2-3):188-95. Epub 2008 Jul 12.


In conclusion, we show that expression of mu- and m-calpain protein is increased by exposure to As, possibly leading to increased NF-L degradation.
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8501139 Lai YK, Shen CH, Cheng TJ, Hou MC, Lee WC: Enhanced phosphorylation of a 65 kDa protein is associated with rapid induction of stress proteins in 9L rat brain tumor cells. J Cell Biochem. 1993 Mar;51(3):369-79.

Induction of heat-shock proteins and glucose-regulated proteins in 9L rat brain tumor cells can be differentially elicited by sodium arsenite, cadmium chloride, zinc chloride, copper sulfate, sodium fluoride, and L-azetidine-2-carboxylic acid.
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