| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1723229 | Junqueira VB, Simizu K, Pimentel R, Azzalis LA, Barros SB, Koch O, Videla LA: Effect of phenobarbital and 3-methylcholanthrene on the early oxidative stress component induced by lindane in rat liver. Xenobiotica. 1991 Aug;21(8):1053-65. PB pretreatment produced a 50% increase in lipid peroxidation (TBAR) by liver homogenates and microsomes, an effect accompanied by increases in cytochrome P-450, -cytochrome P-450 reductase, oxidase and microsomal production, MC pretreatment resulted in increases in liver cytochrome P-450 and oxidase only. 3. |
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| 18262267 | Jaksic Z, Hamer B, Landeka N, Batel R: Western mosquitofish as a bioindicator of exposure to organochlorine compounds. Ecotoxicol Environ Saf. 2008 Oct;71(2):426-35. Epub 2008 Feb 8. The evaluation of the alochthonous and cosmopolitan mosquitofish species Gambusia affinis suitability as a bioindicator species and the induction of its liver cytochrome P450-dependent mixed function oxygenase (MFO), measured as the 7-ethoxyresorfin-O-deethylase (EROD) activity, as well as changes in DNA integrity, measured by the Fast Micromethod, for the monitoring of organochlorine fresh water pesticide contamination, were the main aims of the study. The test mosquitofish were exposed under laboratory conditions to several doses (0.1, 10 and 100 microg l (-1)) of lindane in experimental basins for up to 7 days, and a subsequent field study was carried out at five natural ponds in the south-western Istrian peninsula, Croatia, where up to 10 fish were collected from each pond. |
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| 10817630 | Videla LA, Arisi AC, Fuzaro AP, Koch OR, Junqueira VB: Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication. Toxicol Lett. 2000 Apr 10;115(1):45-51. These changes were observed in the absence of changes in either microsomal functions (cytochrome P450 content, -dependent production, and NADPH-cytochrome P450 reductase or oxidase activities) or in oxidative stress-related enzymatic activities (superoxide dismutase, catalase, peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and glutathione-S-transferases), over control values. |
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| 19402758 | Weil M, Scholz S, Zimmer M, Sacher F, Duis K: Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test. Environ Toxicol Chem. 2009 Sep;28(9):1970-8. The effects of 14 substances on lethal and sublethal endpoints of the DarT and on expression of potential marker genes were investigated: the aryl hydrocarbon receptor 2, cytochrome P450 1A (cypla), heat shock protein 70, fizzy-related protein 1, the transcription factors v-maf musculoaponeurotic fibrosarcoma oncogene family protein g (avian) 1 and NF-E2-p45-related factor, and heme oxygenase 1 (hmox1). For pentachloroaniline and pentachlorobenzene, the Gene-DarT showed a 23- and 153-fold higher sensitivity, respectively, while for lindane, it showed a 13-fold lower sensitivity. |
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| 8584504 | Puri S, Kohli KK: Differences in hepatic drug metabolizing enzymes and their response to lindane in rat, rabbit and monkey. Pharmacol Toxicol. 1995 Aug;77(2):136-41. Untreated rabbit liver microsomes demonstrated the highest content of cytochrome P450 and activity of cytochrome c reductase compared to rat and monkey. |
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| 1712275 | Beurskens JE, Stams AJ, Zehnder AJ, Bachmann A: Relative biochemical reactivity of three hexachlorocyclohexane isomers. Ecotoxicol Environ Saf. 1991 Apr;21(2):128-36. The rate and mechanisms of degradation of three hexachlorocyclohexane (HCH) isomers were studied with rat liver cytochrome P450, which is known to react with chlorinated compounds in the presence and absence of molecular |
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| 1708174 | Barros SB, Simizu K, Junqueira VB: Liver lipid peroxidation-related parameters after short-term administration of hexachlorocyclohexane isomers to rats. Toxicol Lett. 1991 Apr;56(1-2):137-44. Rats treated with diets containing 20 ppm of alpha- or gamma-hexachlorocyclohexane (HCH) for 15 or 30 days showed increased levels of liver cytochrome P-450 followed by increased production of both thiobarbituric acid reactants by liver homogenates and microsomes and production by liver microsomes. |
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| 11165752 | Masuda C, Wanibuchi H, Otori K, Wei M, Yamamoto S, Hiroi T, Imaoka S, Funae Y, Fukushima S: Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats. Cancer Lett. 2001 Feb 26;163(2):179-85. Cytochrome P450 3A2 (CYP3A2) protein levels and activities showed a good correlation to the number and area of GST-P-positive foci. |
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| 10964798 | Walsh LP, McCormick C, Martin C, Stocco DM: Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ Health Perspect. 2000 Aug;108(8):769-76. We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein. StAR protein mediates the rate-limiting and acutely regulated step in steroidogenesis, the transfer of from the outer to the inner mitochondrial membrane where the cytochrome P450 side chain cleavage (P450scc) enzyme initiates the synthesis of all steroid hormones. |
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| 8671720 | Mattioli F, Robbiano L, Adamo D, Federa R, Martelli A, Brambilla G: Genotoxic effects of alpha-hexachlorocyclohexane in primary cultures of rodent and human hepatocytes. Mutagenesis. 1996 Jan;11(1):79-83. The reduction in the frequency of DNA breaks observed in rat hepatocytes simultaneously exposed to suggests that alpha-HCH is transformed into reactive species by a cytochrome P450-dependent reaction. |
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| 18174961 | Hewitt R, Forero A, Luncsford PJ, Martin FL: Enhanced micronucleus formation and modulation of BCL-2:BAX in MCF-7 cells after exposure to binary mixtures. Environ Health Perspect. 2007 Dec;115 Suppl 1:129-36. METHODS: In the presence or absence of lindane, chromosomal aberrations were detected in MCF-7 cells after 24-hr treatment with benzo [a] pyrene (B [a] P) or 2-amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) using the cytokinesis-block micronucleus assay. We investigated intracellular responses using quantitative gene expression analyses of cyclin-dependent kinase inhibitor 1A [CDKN1A (P21 (WAF1/CIP1))], B-cell leukemia/lymphoma 2 (BCL-2), BCL-2-associated X (BAX), and isoforms of cytochrome P450 (CYP), CYP1A1, CYP1A2, and CYP1B1. |
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| 1690460 | Klaunig JE, Ruch RJ, Weghorst CM: Comparative effects of phenobarbital, DDT, and lindane on mouse hepatocyte gap junctional intercellular communication. Toxicol Appl Pharmacol. 1990 Mar 1;102(3):553-63. Inhibition of intercellular communication by phenobarbital was prevented by addition of the cytochrome P450 enzyme inhibitor SKF-525A. |
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| 16246485 | Puatanachokchai R, Morimura K, Wanibuchi H, Oka M, Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y, Fukushima S: Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes. Cancer Lett. 2006 Aug 18;240(1):102-13. Epub 2005 Oct 24. The dose response curves of CYP450 content, -P450 reductase activity and formation revealed the same pattern as GST-P positive foci data. |
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| 18213484 | Auslander M, Yudkovski Y, Chalifa-Caspi V, Herut B, Ophir R, Reinhardt R, Neumann PM, Tom M: Pollution-affected fish hepatic transcriptome and its expression patterns on exposure to cadmium. Mar Biotechnol. 2008 May-Jun;10(3):250-61. Epub 2008 Jan 24. Individuals of the fish Lithognathus mormyrus were exposed to a series of pollutants including: benzo [a] pyrene, pp-DDE, Aroclor 1254, perfluorooctanoic acid, tributyl-tin lindane, 4-nonylphenol, methyl mercury and cadmium Prominently differentially expressed genes included elastase 4, carboxypeptidase B, trypsinogen, perforin, complement C31, cytochrome P450 2K5, ceruloplasmin, carboxyl ester lipase, and metallothionein. |
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| 10706031 | Corrigan FM, Wienburg CL, Shore RF, Daniel SE, Mann D: Organochlorine insecticides in substantia nigra in Parkinson's disease. J Toxicol Environ Health A. 2000 Feb 25;59(4):229-34. The levels of the gamma isomer of hexachlorocyclohexane (gammaHCH, lindane) were significantly higher in PD tissues (mean +/- SD: 0.56 +/- 0.434 microg/g lipid) than in the other three groups (CLBD 0.052 +/- 0.101 microg/g lipid; AD none detected; CON 0.125 +/- 0.195; all differences from PD significant at p < .05, Mann-Whitney U-test). |
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| 11684361 | Oropeza-Hernandez LF, Sierra-Santoyo A, Cebrian ME, Manno M, Albores A: Ovariectomy modulates the response of some cytochrome P450 isozymes to lindane in the rat. Toxicol Lett. 2001 Oct 15;124(1-3):91-9. |
87(1,1,2,2) | Details |
| 12849724 | Nativelle-Serpentini C, Richard S, Seralini GE, Sourdaine P: Aromatase activity modulation by lindane and bisphenol-A in human placental JEG-3 and transfected kidney E293 cells. Toxicol In Vitro. 2003 Aug;17(4):413-22. Therefore, lindane and BPA modulate aromatase activity suggesting an interaction with the cytochrome P-450 aromatase. |
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| 12516873 | Simon-Giavarotti KA, Giavarotti L, Gomes LF, Lima AF, Veridiano AM, Garcia EA, Mora OA, Fernandez V, Videla LA, Junqueira VB: Enhancement of lindane-induced liver oxidative stress and hepatotoxicity by thyroid hormone is reduced by gadolinium Free Radic Res. 2002 Oct;36(10):1033-9. Hyperthyroid animals treated with lindane exhibit enhanced liver microsomal (O2.-) production and cytochrome c reductase activity, with lower levels of cytochrome P450, superoxide dismutase (SOD) and catalase activity, and (GSH) content over control values. |
81(1,1,1,1) | Details |
| 15749814 | Ke FC, Fang SH, Lee MT, Sheu SY, Lai SY, Chen YJ, Huang FL, Wang PS, Stocco DM, Hwang JJ: Lindane, a gap junction blocker, suppresses FSH and transforming growth factor beta1-induced connexin43 gap junction formation and steroidogenesis in rat granulosa cells. J Endocrinol. 2005 Mar;184(3):555-66. The second aim was to determine the effect of lindane on FSH and TGF beta1-stimulated production and the levels of two critical players, cytochrome P450 side-chain cleavage (P450scc) enzyme and steroidogenic acute regulatory (StAR) protein. |
81(1,1,1,1) | Details |
| 1510613 | Popovic M, Dakovic-Svajcer K, Nerudova J: [Xenobiotic and biochemical parameters of isolated rat hepatocytes] . Arh Hig Rada Toksikol. 1992 Mar;43(1):21-7. The authors investigated the effects of the inductors (griseofulvin and fenitoin) and the inhibitors of the cytochrome P-450 (metronidazole, chloramphenicol and phenylbutazone), the effects of the drugs with the structure xanthinol- pentoxiphylline, azathioprine, thioguanine, 6-mercaptopurine), and the effects of several pesticides (lindane, binapicrile, parathion) on some biochemical parameters of the rat liver. |
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| 9057899 | Junqueira VB, Koch OR, Arisi AC, Fuzaro AP, Azzalis LA, Barros SB, Cravero A, Farre S, Videla LA: Regression of morphological alterations and oxidative stress-related parameters after acute lindane-induced hepatotoxicity in rats. Toxicology. 1997 Feb 28;117(2-3):199-205. One day after lindane treatment, a significant enhancement in the oxidative stress status of the liver was observed, characterized by an increase in thiobarbituric acid reactants production and in the microsomal generation of (O.-2) coupled to cytochrome P450 induction, and a decrement in the activity of superoxide dismutase (SOD) and catalase. |
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| 1699849 | Videla LA, Barros SB, Junqueira VB: Lindane-induced liver oxidative stress. Free Radic Biol Med. 1990;9(2):169-79. In addition, the interaction of lindane with the liver tissue results in the induction of the microsomal cytochrome P-450 system, together with enhanced rates of generation and a significant increase in indicators of lipid peroxidation. |
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| 15620088 | Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18. In addition, single and repeated-dose treatments of mice with lindane induced: (i) cytochrome P450 by 23 and 65%, respectively, (ii) cytochrome b5 by 49 and 131%, respectively, (iii) AHH activity by 64 and 50%, respectively. |
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| 17919674 | Johri A, Yadav S, Dhawan A, Parmar D: Overexpression of cerebral and hepatic cytochrome P450s alters behavioral activity of rat offspring following prenatal exposure to lindane. Toxicol Appl Pharmacol. 2007 Dec 15;225(3):278-92. Epub 2007 Aug 19. Oral administration of different doses (0.0625, 0.125 or 0.25 mg/kg corresponding to 1/1400th, 1/700th or 1/350th of LD (50)) of lindane to the pregnant Wistar rats from gestation days 5 to 21 were found to produce a dose-dependent increase in the activity of cytochrome P450 (CYP)-dependent 7-ethoxyresorufin-O-deethylase (EROD), 7-pentoxyresorufin-O-dealkylase (PROD) and N-nitrosodimethylamine demethylase (NDMA-d) in brain and liver of offspring postnatally at 3 weeks. |
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| 7509413 | Bainy AC, Arisi AC, Azzalis LA, Simizu K, Barros SB, Videla LA, Junqueira VB: Differential effects of short-term lindane administration on parameters related to oxidative stress in rat liver and erythrocytes. J Biochem Toxicol. 1993 Dec;8(4):187-94. Lindane induced an oxidative stress condition in the liver, which is related to an enhancement in microsomal -cytochrome c reductase and oxidase activities, formation and cytochrome P450 content, produced independently of the time of treatment. |
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| 7512143 | Junqueira VB, Bainy AC, Arisi AC, Azzalis LA, Simizu K, Pimentel R, Barros SB, Videla LA: Acute lindane intoxication: a study on lindane tissue concentration and oxidative stress-related parameters in liver and erythrocytes. J Biochem Toxicol. 1994 Feb;9(1):9-15. The liver from lindane-treated rats showed an enhanced microsomal pro-oxidant activity, evidenced by higher cytochrome P450 content and -cytochrome c reductase and oxidase activities. |
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| 14631868 | Fernandez V, Massa L, Quinones L, Simon-Giavarotti KA, Giavarotti L, D'Almeida V, Azzalis LA, Junqueira VB, Videla LA: Effects of gamma-hexachlorocyclohexane and L-3,3',5- on rat liver cytochrome P4502E1-dependent activity and content in relation to microsomal generation. Biol Res. 2003;36(3-4):359-65. HCCH treatment (a single dose of 40 mg/kg body wt) produced a 43% increase in the content of total cytochrome P450, whereas T3 (daily doses of 0.1 mg/kg body wt for two consecutive days) led to a 37% decrease. |
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| 1727005 | Piekoszewski W, Brandys J, Lipniak M: Studies on sex related differences in elimination of in the rat after pretreatment with phenobarbital, chrysene, Aroclor 1254 or lindane. Acta Pol Pharm. 1991;48(1-2):9-12. Cytochrome P-450 in liver microsomes plays a central role as a drug metabolizing enzyme. |
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| 16837770 | Ishii T, Nishimura K, Nishimura M: Administration of xenobiotics with anti-estrogenic effects results in mRNA induction of adult male-specific cytochrome P450 isozymes in the livers of adult female rats. J Pharmacol Sci. 2006 Jul;101(3):250-5. Epub 2006 Jul 13. On the other hand, ovariectomy, administration of ICI182780, a specific antagonist, or administration of lindane, which is a widely used pesticide with anti-estrogenic effects, induced these adult male-specific CYP mRNAs in adult female SD rats. |
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