| Name | homeodomain protein |
|---|---|
| Synonyms | Homeobox protein Meis3; Homeobox protein Meis3 variant; Homeodomain protein; MEIS 3; MEIS3; MRG2; Meis1 myeloid ecotropic viral integration site 1 homolog 3; Meis1 related protein 2… |
| Name | EXD |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7791786 | Lu Q, Knoepfler PS, Scheele J, Wright DD, Kamps MP: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol Cell Biol. 1995 Jul;15(7):3786-95. Recently, the Drosophila melanogaster protein Exd, which is highly related to Pbx1, was shown to bind DNA cooperatively with the Drosophila homeodomain proteins Ubx and Abd-A. |
82(1,1,1,2) | Details |
| 16778079 | Noro B, Culi J, McKay DJ, Zhang W, Mann RS: Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax. Genes Dev. 2006 Jun 15;20(12):1636-50. Both types of Hth isoforms include the evolutionarily conserved HM domain, which mediates a direct interaction with Extradenticle (Exd), another homeodomain protein. |
81(1,1,1,1) | Details |
| 17277370 | Stevens KE, Mann RS: A balance between two nuclear localization sequences and a nuclear export sequence governs extradenticle subcellular localization. Genetics. 2007 Apr;175(4):1625-36. Epub 2007 Feb 4. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax (Hth). |
81(1,1,1,1) | Details |
| 10983974 | Popperl H, Rikhof H, Chang H, Haffter P, Kimmel CB, Moens CB: lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish. Mol Cell. 2000 Aug;6(2):255-67. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. |
81(1,1,1,1) | Details |
| 7859741 | Sun B, Hursh DA, Jackson D, Beachy PA: Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. EMBO J. 1995 Feb 1;14(3):520-35. Other factors are also required, including one that appears to act through homeodomain protein binding sites and may be encoded by extradenticle (exd). |
81(1,1,1,1) | Details |
| 8104703 | Rauskolb C, Peifer M, Wieschaus E: extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell. 1993 Sep 24;74(6):1101-12. We have cloned and sequenced exd: it encodes a homeodomain protein with extensive identity (71%) to the human proto-oncoprotein Pbx1. exd is expressed during embryogenesis when the selector homeodomain proteins of the Antennapedia and bithorax complexes establish segmental identity. |
62(0,2,2,2) | Details |
| 8857540 | Mann RS, Abu-Shaar M: Nuclear import of the homeodomain protein extradenticle in response to Wg and Dpp signalling. Nature. 1996 Oct 17;383(6601):630-3. Thus one mechanism by which extracellular signals might control pattern is by directing the graded nuclear localization of homeodomain proteins such as Exd that directly control the expression of target genes. |
38(0,1,2,3) | Details |
| 8710498 | Knoepfler PS, Lu Q, Kamps MP: Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif. Nucleic Acids Res. 1996 Jun 15;24(12):2288-94. Heterodimers between the Pbx/Exd and Hox/HOM-C classes of homeodomain proteins bind regulatory elements in tissue-specific and developmentally regulated genes. |
31(0,1,1,1) | Details |
| 12399316 | Van Auken K, Weaver D, Robertson B, Sundaram M, Saldi T, Edgar L, Elling U, Lee M, Boese Q, Wood WB: Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Development. 2002 Nov;129(22):5255-68. Co-factor homeodomain proteins such as Drosophila Homothorax (Hth) and Extradenticle (Exd) and their respective vertebrate homologs, the Meis/Prep and Pbx proteins, can increase the DNA-binding specificity of Hox protein transcription factors and appear to be required for many of their developmental functions. |
31(0,1,1,1) | Details |
| 7914871 | Rauskolb C, Wieschaus E: Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J. 1994 Aug 1;13(15):3561-9. Mutations in the Drosophila gene extradenticle (exd), a homologue of the human proto-oncogene pbx1, cause homeotic transformations by altering the morphological consequences of homeotic selector gene activity. exd has been proposed to act by contributing to the specificity of selector homeodomain proteins for their downstream targets. |
31(0,1,1,1) | Details |
| 8972188 | Chang CP, de Vivo I, Cleary ML: The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis. Mol Cell Biol. 1997 Jan;17(1):81-8. The HCM is highly conserved throughout the Pbx/exd subfamily of divergent homeodomain proteins and functions in DNA-binding assays as a potential contact site for Hox dimerization. |
31(0,1,1,1) | Details |
| 8657138 | Lu Q, Kamps MP: Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. Mol Cell Biol. 1996 Apr;16(4):1632-40. Genetic studies have identified a family of divergent homeodomain proteins, including the human protooncoprotein Pbx1 and its drosophila homolog extradenticle (Exd), which function as cofactors with a subset of Hox and HOM-C proteins, and are essential for specific target gene expression. |
31(0,1,1,1) | Details |
| 11784113 | Williams TA, Nulsen C, Nagy LM: A complex role for distal-less in crustacean appendage development. Dev Biol. 2002 Jan 15;241(2):302-12. The developing leg of Drosophila is initially patterned by subdivision of the leg into proximal and distal domains by the activity of the homeodomain proteins Extradenticle (Exd) and Distal-less (Dll). |
6(0,0,1,1) | Details |
| 8763497 | Mann RS, Chan SK: Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins. Trends Genet. 1996 Jul;12(7):258-62. |
6(0,0,1,1) | Details |
| 10529430 | Ryoo HD, Marty T, Casares F, Affolter M, Mann RS: Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex. Development. 1999 Nov;126(22):5137-48. To regulate their target genes, the Hox proteins of Drosophila often bind to DNA as heterodimers with the homeodomain protein Extradenticle (EXD). Using a dominant negative form of HTH we provide evidence that similar complexes are important for several Hox- and exd-mediated functions in vivo. |
2(0,0,0,2) | Details |
| 9346235 | Rieckhof GE, Casares F, Ryoo HD, Abu-Shaar M, Mann RS: Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell. 1997 Oct 17;91(2):171-83. |
2(0,0,0,2) | Details |
| 10373562 | Jacobs Y, Schnabel CA, Cleary ML: Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol. 1999 Jul;19(7):5134-42. Pbx/exd proteins modulate the DNA binding affinities and specificities of Hox proteins and contribute to the execution of Hox-dependent developmental programs in arthropods and vertebrates. |
2(0,0,0,2) | Details |
| 10654609 | Ferretti E, Marshall H, Popperl H, Maconochie M, Krumlauf R, Blasi F: Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Development. 2000 Jan;127(1):155-66. The DNA-binding ability and selectivity of these proteins depend upon the formation of specific heterodimeric complexes with members of the PBC homeodomain protein family (Pbx genes). |
2(0,0,0,2) | Details |
| 9405369 | Grieder NC, Marty T, Ryoo HD, Mann RS, Affolter M: Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. EMBO J. 1997 Dec 15;16(24):7402-10. In vitro, HOM (HOX) specificity can be increased by the formation of heterodimers with Extradenticle (EXD) or PBX homeodomain proteins. We show that LAB and EXD bind cooperatively to the site in vitro, and that the expression of the enhancer in vivo requires exd and lab function. |
1(0,0,0,1) | Details |
| 16515781 | Moens CB, Selleri L: Hox cofactors in vertebrate development. Dev Biol. 2006 Mar 15;291(2):193-206. Epub 2006 Mar 3. These include the PBC and MEIS classes of TALE (Three Amino acid Loop Extension) homeodomain proteins. The PBC class comprises fly Extradenticle (Exd) and vertebrate Pbx homeoproteins, whereas the MEIS class includes fly Homothorax (Hth) and vertebrate Meis and Prep homeoproteins. |
1(0,0,0,1) | Details |
| 9482740 | Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F: The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J. 1998 Mar 2;17(5):1434-45. The products of the mammalian Pbx and Drosophila exd genes are able to interact with Hox proteins specifically and to increase their DNA binding affinity and selectivity. In the accompanying paper we show that Pbx proteins exist as stable heterodimers with a novel homeodomain protein, Prep1. |
1(0,0,0,1) | Details |
| 7915199 | Chan SK, Jaffe L, Capovilla M, Botas J, Mann RS: The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell. 1994 Aug 26;78(4):603-15. The Ultrabithorax (Ubx) and Antennapedia (Antp) genes of Drosophila encode homeodomain proteins that have very similar DNA binding specificities in vitro but specify the development of different segmental patterns in vivo. We describe cooperative interactions between Ubx protein and a divergent homeodomain protein, extradenticle (exd), that selectively increases the affinity of Ubx, but not Antp, for a particular DNA target. |
1(0,0,0,1) | Details |
| 11684652 | Waskiewicz AJ, Rikhof HA, Hernandez RE, Moens CB: Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning. Development. 2001 Nov;128(21):4139-51. Homeodomain-containing Hox proteins regulate segmental identity in Drosophila in concert with two partners known as Extradenticle (Exd) and Homothorax (Hth). These partners are themselves DNA-binding, homeodomain proteins, and probably function by revealing the intrinsic specificity of Hox proteins. |
1(0,0,0,1) | Details |