| Name | catalase |
|---|---|
| Synonyms | CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases… |
| Name | amitrole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2912161 | Guidet BR, Shah SV: In vivo generation of peroxide by rat kidney cortex and glomeruli. Am J Physiol. 1989 Jan;256(1 Pt 2):F158-64. Aminotriazole irreversibly inactivates catalase only in the presence of peroxide, and previous studies have shown that aminotriazole-mediated inhibition of catalase is a measure of in vivo changes in the peroxide generation. |
6(0,0,0,6) | Details |
| 16168691 | Bagnyukova TV, Storey KB, Lushchak VI: Adaptive response of antioxidant enzymes to catalase inhibition by aminotriazole in goldfish liver and kidney. Comp Biochem Physiol B Biochem Mol Biol. 2005 Nov;142(3):335-41. Epub 2005 Sep 15. |
6(0,0,0,6) | Details |
| 3271871 | Sichak SP, Mavis RD, Finkelstein JN, Clarkson TW: An examination of the oxidation of mercury vapor by rat brain homogenate. J Biochem Toxicol. 1986 Mar;1(1):53-68. The role of catalase compound I in mercury vapor oxidation by brain homogenate was examined by observing the effects of two inhibitors of catalase (catalase compound I) on homogenate mercury-oxidizing activity and catalase activity. |
4(0,0,0,4) | Details |
| 2611816 | Simmons TW, Jamall IS: Relative importance of intracellular peroxidase and catalase in vivo for prevention of peroxidation to the heart. Cardiovasc Res. 1989 Sep;23(9):774-9. |
4(0,0,0,4) | Details |
| 3985946 | Darr D, Fridovich I: Inhibition of catalase by 3,3'-diaminobenzidine. Biochem J. 1985 Mar 15;226(3):781-7. |
4(0,0,0,4) | Details |
| 16102377 | Manrique HM, Miquel M, Aragon CM: Brain catalase mediates potentiation of social recognition memory produced by in mice. Drug Alcohol Depend. 2005 Sep 1;79(3):343-50. Epub 2005 Apr 22. |
4(0,0,0,4) | Details |
| 2999539 | Aragon CM, Spivak K, Amit Z: Blockade of induced conditioned taste aversion by 3-amino-1,2,4-triazole: evidence for catalase mediated synthesis of in rat brain. Life Sci. 1985 Dec 2;37(22):2077-84. |
3(0,0,0,3) | Details |
| 3567333 | Panchenko LF, Pirozhkov SV, Popova SV, Antonenkov VD: [Effect of and the catalase inhibitor aminotriazole on lipid peroxidation in the rat myocardium]. Biull Eksp Biol Med. 1987 Apr;103(4):407-10. |
3(0,0,0,3) | Details |
| 2176263 | Duval DL, Howard D, McCalden TA, Billings RE: The determination of myeloperoxidase activity in liver. . Life Sci. 1990;47(24):PL145-50. The inhibitor was identified as catalase based upon its elution from the columns and removal with 3-amino- 1,2,4-triazole (AT), a catalase inhibitor. |
2(0,0,0,2) | Details |
| 8460719 | Kim KJ, Suh DJ: Asymmetric effects of H2O2 on alveolar epithelial barrier properties. Am J Physiol. 1993 Mar;264(3 Pt 1):L308-15. To determine the degree of cellular catalase participation in protection against H2O2 injury to the barrier, experiments were repeated in the presence of 20 mM aminotriazole (ATAZ; an inhibitor of catalase) in the same bathing fluid as the hydroperoxide. |
2(0,0,0,2) | Details |
| 2133088 | Koop DR: Inhibition of -inducible cytochrome P450IIE1 by 3-amino-1,2,4-triazole. Chem Res Toxicol. 1990 Jul-Aug;3(4):377-83. However, the autoinactivation was completely prevented by the addition of catalase. |
2(0,0,0,2) | Details |
| 11536262 | Thirunavukarasu PP, Wallace EM: Measurement of inhibin A: a modification to an enzyme-linked immunosorbent assay. Prenat Diagn. 2001 Aug;21(8):638-41. In the present study we have confirmed for one of those ELISAs that short-term sample storage as whole blood leads to a significant decline in detectable inhibin A and that this is most likely due to erythrocyte catalase interference with a critical oxidation step in the assay. |
2(0,0,0,2) | Details |
| 8299988 | Giulivi C, Hochstein P, Davies KJ: peroxide production by red blood cells. . Free Radic Biol Med. 1994 Jan;16(1):123-9. In our studies, aminotriazole was used as an H2O2 dependent (irreversible) catalase inhibitor, and catalase inhibition was used as an indirect measure of H2O2 production. |
1(0,0,0,1) | Details |
| 6833495 | Burger AG, Engler D, Buergi U, Weissel M, Steiger G, Ingbar SH, Rosin RE, Babior BM: Ether link cleavage is the major pathway of iodothyronine metabolism in the phagocytosing human leukocyte and also occurs in vivo in the rat. J Clin Invest. 1983 Apr;71(4):935-49. ELC was enhanced by the catalase inhibitor aminotriazole, and was inhibited by the peroxidase inhibitor propylthiouracil, suggesting that the enzyme is a peroxidase and that peroxide (H (2) O (2)) is a necessary cofactor in the reaction. |
1(0,0,0,1) | Details |
| 1275501 | Jones GL, Masters CJ: On the turnover and proteolysis of catalase in tissues of the guinea pig and acatalasemic mice. Arch Biochem Biophys. 1976 Apr;173(2):463-71. |
1(0,0,0,1) | Details |
| 4402915 | Thurman RG, Ley HG, Scholz R: Hepatic microsomal oxidation. Eur J Biochem. 1972 Feb;25(3):420-30. peroxide formation and the role of catalase. |
1(0,0,0,1) | Details |
| 7527573 | Van den Branden C, Vamecq J, Verbeelen D, Roels F: In vivo peroxide production in rat remnant kidney. . Ren Physiol Biochem. 1994 Sep-Oct;17(5):240-5. The peroxisomal L-alpha-hydroxyacid oxidase and L-lactate oxidase as well as the peroxisomal H2O2 scavenger catalase preserve their activity. |
1(0,0,0,1) | Details |
| 11577197 | Yuasa T, Ichimura K, Mizoguchi T, Shinozaki K: Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase. . Plant Cell Physiol. 2001 Sep;42(9):1012-6. In leaves, ATMPK6 was activated by paraquat and 3-amino-1,2,4-triazole (a catalase inhibitor). |
1(0,0,0,1) | Details |
| 3107850 | Krauss RS, Eling TE: Macromolecular binding of the thyroid carcinogen 3-amino-1,2,4-triazole (amitrole) catalyzed by prostaglandin H synthase, lactoperoxidase and thyroid peroxidase. Carcinogenesis. 1987 May;8(5):659-64. |
0(0,0,0,0) | Details |
| 3008887 | Dallegri F, Patrone F, Ballestrero A, Frumento G, Sacchetti C: Inhibition of neutrophil cytolysin production by target cells. Blood. 1986 May;67(5):1265-72. The lysis was inhibited by azide, catalase, -free medium and amino acids, suggesting the requirement for myeloperoxidase (MPO), peroxide (H2O2), ions (Cl-), and hypochlorous acid (HOC1), respectively. |
6(0,0,0,6) | Details |
| 2646962 | Aragon CM, Spivak K, Amit Z: Effects of 3-amino-1,2,4-triazole on -induced open-field activity: evidence for brain catalase mediation of ethanol's effects. Alcohol Clin Exp Res. 1989 Feb;13(1):104-8. |
6(0,0,0,6) | Details |
| 8451258 | Aragon CM, Amit Z: Differences in -induced behaviors in normal and acatalasemic mice: systematic examination using a biobehavioral approach. Pharmacol Biochem Behav. 1993 Mar;44(3):547-54. In studies designed to further examine the previously reported involvement of catalase in -induced effects, we attempted to confirm earlier observations by using normal (C3H-N) and acatalasemic (C3H-A) mice. |
6(0,0,0,6) | Details |
| 1757301 | Zhang J, Piantadosi CA: Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity. J Appl Physiol. 1991 Sep;71(3):1057-61. We investigated the relationship between regional generation of peroxide (H2O2) in the brain in the presence of an irreversible inhibitor of catalase, aminotriazole (ATZ), and protection from CNS O2 toxicity by a monoamine oxidase (MAO) inhibitor, pargyline. |
4(0,0,0,4) | Details |
| 9558485 | Masaki H, Okano Y, Sakurai H: Differential role of catalase and peroxidase in cultured human fibroblasts under exposure of H2O2 or ultraviolet B light. Arch Dermatol Res. 1998 Mar;290(3):113-8. |
4(0,0,0,4) | Details |
| 15223305 | Abilio VC, Silva RH, Carvalho RC, Grassl C, Calzavara MB, Registro S, D'Almeida V, Ribeiro Rde A, Frussa-Filho R: Important role of striatal catalase in aging- and reserpine-induced oral dyskinesia. Neuropharmacology. 2004 Aug;47(2):263-72. |
4(0,0,0,4) | Details |
| 1995347 | Middelkoop E, Strijland A, Tager JM: Does aminotriazole inhibit import of catalase into peroxisomes by retarding unfolding?. FEBS Lett. 1991 Feb 11;279(1):79-82. |
3(0,0,0,3) | Details |
| 19075818 | Mondal P, Ray M, Sahu S, Sabat SC: Co-expression of GroEL/ES enhances the expression of plant catalase in bacterial cytosol. Protein Pept Lett. 2008;15(10):1075-8. |
3(0,0,0,3) | Details |
| 15234257 | Canales JJ: Catalase-independent early-gene expression in rat brain following acute exposure. Brain Res. 2004 Jul 30;1016(1):96-101. |
2(0,0,0,2) | Details |
| 10600493 | Maccarrone M, Salucci ML, Melino G, Rosato N, Finazzi-Agro A: The early phase of apoptosis in human neuroblastoma CHP100 cells is characterized by lipoxygenase-dependent ultraweak light emission. Biochem Biophys Res Commun. 1999 Nov 30;265(3):758-62. The increase in luminescence was paralleled by increased 5-lipoxygenase (up to 250% of the control value) and decreased catalase (down to 50%) activity within the same time window. |
2(0,0,0,2) | Details |
| 9721600 | Rastogi L, Patnaik GK, Dikshit M: Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacol Res. 1998 Aug;38(2):125-32. MDA level, myeloperoxidase (a neutrophil maker) and catalase activity in the rat stomach homogenate were augmented 2, 4 and 19 h after pylorus ligation. |
2(0,0,0,2) | Details |
| 17854709 | O'Hara KA, Wu X, Patel D, Liang H, Yalowich JC, Chen N, Goodfellow V, Adedayo O, Dmitrienko GI, Hasinoff BB: Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F. Free Radic Biol Med. 2007 Oct 15;43(8):1132-44. Epub 2007 Jul 13. The GSH-promoted DNA nicking induced by kinamycin F in vitro was attenuated by deferoxamine, and catalase, which indicated that DNA damage initiated by this agent occurred in an iron-, -peroxide-, and -dependent manner. |
1(0,0,0,1) | Details |
| 8771766 | Nag AC, Sreepathi P, Lee ML, Reddan JR: Effect of oxidative insult on young and adult cardiac muscle cells in vitro. Cytobios. 1996;85(340):7-27. Microscopical studies suggested a more marked protection by catalase than by glutathione reductase in the neonatal cells. |
1(0,0,0,1) | Details |
| 4727356 | Teruya A, Higashi T: Differential effect of 3-amino-1,2,4-triazole on multiple forms of rat liver catalase. Chem Pharm Bull. 1973 Apr;21(4):840-5. |
1(0,0,0,1) | Details |
| 11673077 | Tayama S, Nakagawa Y: Cytogenetic effects of propyl in CHO-K1 cells. Mutat Res. 2001 Nov 15;498(1-2):117-27. Both catalase and AT suppressed the induction of SCEs by GA or inhibited cell proliferation, indicating that H (2) O (2) participated in the effects. |
1(0,0,0,1) | Details |
| 16407272 | Ishihara Y, Shimamoto N: Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress. J Biol Chem. 2006 Mar 10;281(10):6726-33. Epub 2006 Jan 4. We have previously shown that inhibition of catalase and peroxidase activities by 3-amino-1,2,4-triazole (ATZ) and mercaptosuccinic acid (MS), respectively, in rat primary hepatocytes caused sustained endogenous oxidative stress and apoptotic cell death without caspase-3 activation. |
1(0,0,0,1) | Details |
| 3768046 | Darr D, Fridovich I: Irreversible inactivation of catalase by 3-amino-1,2,4-triazole. Biochem Pharmacol. 1986 Oct 15;35(20):3642. |
1(0,0,0,1) | Details |
| 6406261 | Nickla H, Anderson J, Palzkill T: Enzymes involved in detoxification during development of Drosophila melanogaster. Experientia. 1983 Jun 15;39(6):610-2. Activities of superoxide dismutase (SOD), catalase (CAT), and peroxidases (PER) were examined at 24-h intervals during Drosophila development. |
1(0,0,0,1) | Details |
| 7649359 | Bjorkman U, Ekholm R: peroxide degradation and peroxidase activity in cultures of thyroid cells. Mol Cell Endocrinol. 1995 Apr 28;111(1):99-107. The involvement of enzymes in H2O2 degradation was studied by inhibiting catalase with aminotriazole (ATZ) and reducing GSH peroxidase by omitting in the incubation medium. |
1(0,0,0,1) | Details |
| 8967353 | Kingma JG Jr, Simard D, Rouleau JR, Tanguay RM, Currie RW: Effect of 3-aminotriazole on hyperthermia-mediated cardioprotection in rabbits. Am J Physiol. 1996 Apr;270(4 Pt 2):H1165-71. In this study we investigated the effects of 3-amino-1,2,4-triazole (3-AT), an irreversible catalase inhibitor, in heat-shocked (HS) rabbits subjected to ischemia-reperfusion injury. |
5(0,0,0,5) | Details |
| 10227131 | Ohwada T, Shirakawa Y, Kusumoto M, Masuda H, Sato T: Susceptibility to peroxide and catalase activity of root nodule bacteria. Biosci Biotechnol Biochem. 1999 Mar;63(3):457-62. |
5(0,0,0,5) | Details |
| 1727639 | Spitz DR, Adams DT, Sherman CM, Roberts RJ: Mechanisms of cellular resistance to peroxide, hyperoxia, and toxicity: the significance of increased catalase activity in H2O2-resistant fibroblasts. Arch Biochem Biophys. 1992 Jan;292(1):221-7. |
5(0,0,0,5) | Details |
| 9530823 | Kashiwagi A, Kashiwagi K, Takase M, Hanada H, Yamashita M, Naitoh T, Nakamura M: Inhibitor and temperature effect on catalase in the liver of adult diploid and haploid Rana rugosa. Comp Biochem Physiol B Biochem Mol Biol. 1998 Jan;119(1):235-9. |
5(0,0,0,5) | Details |
| 1397503 | van Eyk AD, Litthauer D, Oelofsen W: The isolation and partial characterization of catalase and a peroxidase active fraction from human white adipose tissue. Int J Biochem. 1992 Jul;24(7):1101-9. |
5(0,0,0,5) | Details |
| 208649 | Bhuyan KC, Bhuyan DK: Superoxide dismutase of the eye: relative functions of superoxide dismutase and catalase in protecting the ocular lens from oxidative damage. Biochim Biophys Acta. 1978 Aug 3;542(1):28-38. |
4(0,0,0,4) | Details |
| 3029209 | Turrens JF, Giulivi C, Boveris A: Increased spontaneous chemiluminescence from liver homogenates and isolated hepatocytes upon inhibition of O2- and H2O2 utilization. J Free Radic Biol Med. 1986;2(2):135-40. The intracellular steady-state concentrations of peroxide or were increased by inhibiting either catalase, peroxidase, or superoxide dismutase activities. |
4(0,0,0,4) | Details |
| 14550752 | Dorval J, Hontela A: Role of redox cycle and catalase in defense against oxidative stress induced by endosulfan in adrenocortical cells of rainbow trout (Oncorhynchus mykiss). Toxicol Appl Pharmacol. 2003 Oct 15;192(2):191-200. |
3(0,0,0,3) | Details |
| 2576777 | Barja de Quiroga G, Lopez-Torres M, Perez-Campo R: Catalase is needed to avoid tissue peroxidation in Rana perezi in normoxia. Comp Biochem Physiol C. 1989;94(2):391-8. |
3(0,0,0,3) | Details |
| 14980700 | Hashimoto T, Ibi M, Matsuno K, Nakashima S, Tanigawa T, Yoshikawa T, Yabe-Nishimura C: An endogenous metabolite of acts as a unique cytoprotective agent against oxidative stress-induced injury. Free Radic Biol Med. 2004 Mar 1;36(5):555-64. In these cells, augmented activity of catalase was demonstrated, while the levels of and peroxidase activity remained unchanged. |
2(0,0,0,2) | Details |
| 9612287 | Weissmann N, Grimminger F, Voswinckel R, Conzen J, Seeger W: Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs. Am J Physiol. 1998 May;274(5 Pt 1):L721-7. Both agents may stimulate guanylate cyclase, the latter via conversion to peroxide and formation of compound I with catalase. |
2(0,0,0,2) | Details |
| 3711540 | Tsiplenkova VG, Vikhert AM, Cherpachenko NM: Ultrastructural and histochemical observations in human and experimental alcoholic cardiomyopathy. J Am Coll Cardiol. 1986 Jul;8(1 Suppl A):22A-32A. The morphologic features of alcoholic cardiomyopathy in human sudden death compared with those of experimental alcoholic cardiomyopathy (6 weeks of administration and simultaneous inhibition of catalase activity) proved to be nearly identical. |
2(0,0,0,2) | Details |
| 11726392 | Lavrentiadou SN, Chan C, Kawcak T, Ravid T, Tsaba A, van der Vliet A, Rasooly R, Goldkorn T: -mediated apoptosis in lung epithelial cells is regulated by Am J Respir Cell Mol Biol. 2001 Dec;25(6):676-84. Moreover, increase of intracellular H (2) O (2), mediated by inhibition of catalase by aminotriazole, also induces generation and apoptosis. |
1(0,0,0,1) | Details |
| 15868480 | Lamarche F, Gonthier B, Signorini N, Eysseric H, Barret L: Impact of and on DNA and cell viability of cultured neurones. Cell Biol Toxicol. 2004 Nov;20(6):361-74. ROS also reduced viability, but this was observed only after both cytochrome P450 stimulation and catalase inhibition. |
1(0,0,0,1) | Details |
| 4342227 | Herzog V, Miller F: Endogenous peroxidase in the lacrimal gland of the rat and its differentiation against injected catalase and horseradish-peroxidase. Histochemie. 1972;30(3):235-46. |
1(0,0,0,1) | Details |
| 6521729 | Masters C, Crane D: On the role of peroxisomes in the metabolism of lipids--evidence from studies on mammalian tissues in vivo. Mol Cell Biochem. 1984 Nov;65(1):23-35. Clofibrate, for example, acts through induction of peroxisomal oxidases and catalase; and through activation of this pathway; and aminotriazole and allylisopropylacetamide through inhibition of the catalase step in the sequence. |
1(0,0,0,1) | Details |
| 10443915 | Karasu C: Increased activity of H2O2 in aorta isolated from chronically streptozotocin-diabetic rats: effects of antioxidant enzymes and enzymes inhibitors. Free Radic Biol Med. 1999 Jul;27(1-2):16-27. Our observations suggest that increased production of -derived free radicals (OFRs) in diabetic state leads to a decrease in SOD activity resulting an increase in endogenous anions (O2*-), that is limited cytotoxic actions, and an increase in catalase activity resulting a decrease in both H2O2 concentrations and the production of harmful (*OH) in diabetic aorta in long-term. |
1(0,0,0,1) | Details |
| 17597214 | Domico LM, Cooper KR, Bernard LP, Zeevalk GD: Reactive species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology. 2007 Nov;28(6):1079-91. Epub 2007 May 22. Inhibition of intracellular catalase with aminotriazole had little effect on H (2) O (2) generation, whereas exogenously added catalase significantly reduced H (2) O (2) production, demonstrating a large extracellular contribution to ROS generation. |
1(0,0,0,1) | Details |
| 1910297 | van der Zel A, Dadoo R, Geer BW, Heinstra PW: The involvement of catalase in metabolism in Drosophila melanogaster larvae. Arch Biochem Biophys. 1991 May 15;287(1):121-7. |
5(0,0,0,5) | Details |
| 7004234 | Cohen G, Sinet PM, Heikkila R: oxidation by rat brain in vivo. Alcohol Clin Exp Res. 1980 Oct;4(4):366-70. Can brain metabolize We present data demonstrating that brain catalase in conjunction with endogenous H2O2 will oxidize in vivo. |
5(0,0,0,5) | Details |
| 170980 | Williams-Smith DL, Patel K: Induced changes in the electron paramagnetic resonance spectra of mammalian catalases. Biochim Biophys Acta. 1975 Oct 20;405(2):243-52. |
5(0,0,0,5) | Details |
| 18587667 | Correa M, Manrique HM, Font L, Escrig MA, Aragon CM: Reduction in the anxiolytic effects of by centrally formed the role of catalase inhibitors and -sequestering agents. Psychopharmacology. 2008 Nov;200(4):455-64. Epub 2008 Jun 30. |
5(0,0,0,5) | Details |
| 7625566 | Reddy BV, Boyadjieva N, Sarkar DK: Effect of butanol, and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons: evidence for a mediatory role of in stimulation of beta-endorphin release. Alcohol Clin Exp Res. 1995 Apr;19(2):339-44. |
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| 10068450 | Lord-Fontaine S, Averill DA: Enhancement of cytotoxicity of peroxide by hyperthermia in chinese hamster ovary cells: role of antioxidant defenses. Arch Biochem Biophys. 1999 Mar 15;363(2):283-95. We determine the involvement of the two cellular antioxidant defenses against peroxides, catalase and the redox cycle, in cellular sensitivity to heat, to peroxide, and to heat combined with the oxidant. |
4(0,0,0,4) | Details |
| 1632841 | Aragon CM, Rogan F, Amit Z: metabolism in rat brain homogenates by a catalase-H2O2 system. Biochem Pharmacol. 1992 Jul 7;44(1):93-8. |
4(0,0,0,4) | Details |
| 2100169 | Green K, Costarides AP, Riley MV: Role of in the regulation of anterior chamber peroxide. Lens Eye Toxic Res. 1990;7(3-4):419-26. Catalase inhibition leads to an increase in the t 1/2 for peroxide loss from the anterior chamber and increased tissue damage. |
3(0,0,0,3) | Details |
| 7931250 | Barwell CJ, Ebrahimi SA: Some problems associated with measuring monoamine oxidase activity in the presence of azide. J Neural Transm Suppl. 1994;41:35-9. The colourimetric assay of monoamine oxidase activity, as peroxide production, normally requires the use of azide to inhibit breakdown of peroxide by catalase. |
3(0,0,0,3) | Details |
| 8216363 | Ou P, Wolff SP: Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates peroxide in vitro. Biochem Pharmacol. 1993 Oct 5;46(7):1139-44. |
2(0,0,0,2) | Details |
| 12711621 | Rabelo LA, Cortes SF, Alvarez-Leite JI, Lemos VS: Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2. Br J Pharmacol. 2003 Apr;138(7):1215-20. Aminotriazole (50 mM), which inhibits catalase, abolished its effect on control mice. |
2(0,0,0,2) | Details |
| 8569280 | Yuan H, Kaneko T, Matsuo M: Relevance of oxidative stress to the limited replicative capacity of cultured human diploid cells: the limit of cumulative population doublings increases under low concentrations of and decreases in response to aminotriazole. Mech Ageing Dev. 1995 Jul 14;81(2-3):159-68. When TIG-7 cells were serially cultivated in the presence of 10 mM or 20 mM 3-amino-1H-1,2,4-triazole, an inhibitor of catalase scavenging peroxide, the limit of their cumulative population doublings was shortened by 4.4% or 14.4%, respectively, as compared with untreated cells. |
1(0,0,0,1) | Details |
| 19578781 | Han YH, Park WH: The effects of N-acetyl buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive species and Oncol Rep. 2009 Aug;22(2):385-91. Here, we examined the effects of N-acetyl- (NAC, a well known antioxidant), L-buthionine sulfoximine (BSO, an inhibitor of GSH synthesis), diethyl-dithiocarbamate (DDC, an inhibitor of Cu, Zn-SOD) or 3-amino-1,2,4-triazole (AT, an inhibitor of catalase) on AMA-treated Calu-6 cells in relation to cell death, ROS and GSH levels. |
1(0,0,0,1) | Details |
| 9037247 | Renard P, Zachary MD, Bougelet C, Mirault ME, Haegeman G, Remacle J, Raes M: Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation. Biochem Pharmacol. 1997 Jan 24;53(2):149-60. In this study, we systematically evaluated the influence of peroxidase, glutathione reductase and catalase on IL-1-induced NF-kappa B activation by analysing the effect of specific inhibitors of these enzymes. |
1(0,0,0,1) | Details |
| 9635878 | Hwua YS, Yang JL: Effect of 3-aminotriazole on anchorage independence and mutagenicity in cadmium- and lead-treated diploid human fibroblasts. Carcinogenesis. 1998 May;19(5):881-8. Both cadmium and lead significantly induced anchorage-independent colonies in dose-dependent manners; the frequencies of anchorage-independent colonies induced by these metals were similar to those induced by N-methyl-N'-nitro-N-nitrosoguanidine at approximately equal cytotoxic dose ranges (30-10% survival). 3-Aminotriazole at non-cytotoxic dosages decreased catalase activity by > 80%, and markedly enhanced cadmium-induced cytotoxicity and anchorage-independent colonies. |
1(0,0,0,1) | Details |
| 2416291 | Premereur N, Van den Branden C, Roels F: Demonstration of H2O2 production in vivo during aminopyrine metabolism and phenobarbital induction. Arch Int Physiol Biochim. 1985 Sep;93(3):241-8. It has been shown previously that, by using and a catalase inhibitor, 3-amino-1, 2, 4,-triazole, changes in hepatic H2O2 production in vivo can be detected. |
1(0,0,0,1) | Details |
| 7562957 | Cai Y, Appelkvist EL, DePierre JW: Hepatic oxidative stress and related defenses during treatment of mice with and other peroxisome proliferators. J Biochem Toxicol. 1995 Apr;10(2):87-94. Cotreatment of mice with the peroxisome proliferator ASA (1%, w/w) and a catalase inhibitor, 3-amino-1,2,4-triazole (AT; 0.4%, w/w) for 7 days resulted in little inhibition of peroxisome proliferation, an elevated level of H2O2 in vivo, and total inhibition of the increased susceptibility to lipid peroxidation in vitro. |
1(0,0,0,1) | Details |
| 1924513 | Aragon CM, Spivak K, Amit Z: Effect of 3-amino-1,2,4-triazole on -induced narcosis, lethality and hypothermia in rats. Pharmacol Biochem Behav. 1991 May;39(1):55-9. It has been proposed that can be oxidized in brain via the peroxidatic activity of catalase and that centrally formed may mediate several of the psychopharmacological actions of |
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| 7586320 | Auyeung Y, Sievers RE, Weng D, Barbosa V, Wolfe CL: Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats. Circulation. 1995 Dec 1;92(11):3318-22. However, heat shock also induces myocardial catalase activity, potentially reducing free radical-mediated ischemic injury. |
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| 8926339 | Ou P, Wolff SP: A discontinuous method for catalase determination at 'near physiological' concentrations of H2O2 and its application to the study of H2O2 fluxes within cells. J Biochem Biophys Methods. 1996 Jan 11;31(1-2):59-67. |
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| 170981 | Williams-Smith DL, Morrison PJ: Electron paramagnetic resonance spectra of catalase in mammalian tissues. Biochim Biophys Acta. 1975 Oct 20;405(2):253-61. |
5(0,0,0,5) | Details |
| 18634817 | Koepke JI, Wood CS, Terlecky LJ, Walton PA, Terlecky SR: Progeric effects of catalase inactivation in human cells. Toxicol Appl Pharmacol. 2008 Oct 1;232(1):99-108. Epub 2008 Jun 24. |
4(0,0,0,4) | Details |
| 8865862 | Korybalska K, Breborowicz A, Martis L, Oreopoulos DG: In vitro detection of peroxide in mesothelial cells. Adv Perit Dial. 1996;12:7-10. peroxide can be indirectly detected in mesothelial cells by measuring the rate of inhibition of the intracellular catalase activity by 3-amino-1, 2,3-triazole (AT). |
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| 7546330 | Tampier L, Quintanilla ME, Mardones J: Effects of aminotriazole on water, and food intake and on brain catalase in UChA and UChB rats. Alcohol. 1995 Jul-Aug;12(4):341-4. |
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| 2764932 | Orii Y, Sakai Y, Ozawa K: Ubiquitous formation of catalase compound II in hemoglobin-free perfused rat liver and detection of novel spectral species. Biochem Biophys Res Commun. 1989 Aug 15;162(3):1272-8. |
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| 12681527 | Quertemont E, Escarabajal MD, De Witte P: Role of catalase in -induced conditioned taste aversion: a study with 3-amino-1,2,4-triazole. Drug Alcohol Depend. 2003 May 1;70(1):77-83. |
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| 12022476 | Gechev T, Gadjev I, Van Breusegem F, Inze D, Dukiandjiev S, Toneva V, Minkov I: peroxide protects tobacco from oxidative stress by inducing a set of antioxidant enzymes. Cell Mol Life Sci. 2002 Apr;59(4):708-14. Tolerance against oxidative stress generated by high light intensities or the catalase inhibitor aminotriazole (AT) was induced in intact tobacco plants by spraying them with peroxide (H2O2). |
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| 17660523 | Zimatkin SM, Buben AL: oxidation in the living brain. . Alcohol Alcohol. 2007 Nov-Dec;42(6):529-32. Epub 2007 Jul 28. AIM: The examination of the possibility of oxidation in the brain in vivo and the evaluation of the enzyme catalase in this process. |
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| 3445547 | Antonenkov VD, Gusev VA, Krasnova SN: [Effect of and the catalase inhibitor aminotriazole on the activity of antioxidative enzymes in the rat liver and heart]. Vopr Med Khim. 1987 Nov-Dec;33(6):59-64. |
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| 17961299 | Ishihara Y, Shimamoto N: Critical role of exposure time to endogenous oxidative stress in hepatocyte apoptosis. Redox Rep. 2007;12(6):275-81. We have previously shown that inhibition of catalase and peroxidase activities in rat primary hepatocytes by 3-amino-1,2,4-triazole (ATZ) and mercaptosuccinic acid (MS) results in sustained oxidative stress, followed by apoptosis. |
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| 11413233 | Ehrhart J, Zeevalk GD: peroxide removal and mixed disulfide formation during metabolic inhibition in mesencephalic cultures. J Neurochem. 2001 Jun;77(6):1496-507. Treatment of mesencephalic cultures with 10 microM buthionine sulfoximine for 24 h depleted total GSH by 60%, whereas 3 h exposure to 5 mM 3-amino-1,2,4-triazole irreversibly inactivated catalase activity by 90%. |
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| 2612724 | Antonenkov VD, Pirozhkov SV, Popova SV, Panchenko LF: Effect of chronic catalase inhibitor 3-amino-1,2,4-triazole and clofibrate treatment on lipid peroxidation in rat myocardium. Int J Biochem. 1989;21(12):1313-8. |
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| 2736964 | Brown JM, Grosso MA, Banerjee A, Whitman GJ, Repine JE, Harken AH: Erythrocyte catalase decreases cardiac reperfusion injury. Curr Surg. 1989 Mar-Apr;46(2):122-4. |
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| 1953728 | Metodiewa D, Dunford HB: 3-Aminotriazole is a substrate for lactoperoxidase but not for catalase. . Biochem Biophys Res Commun. 1991 Oct 31;180(2):585-90. Rapid scan spectrophotometry has been applied to investigate the reaction of 3-aminotriazole with mammalian heme enzymes, represented by lactoperoxidase and bovine liver catalase. |
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| 710686 | Crane D, Holmes RS, Masters CJ: On the relative rates of synthesis and degradation of catalase in vertebrate tissues. Int J Biochem. 1978;9(8):589-96. |
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| 166481 | Gotoh M, Griffin C, Hruban Z: Effect of and aminotriazole on matrical plates induced in hepatic microbodies. Virchows Arch B Cell Pathol. 1975;17(4):279-94. and aminotriazole and feeding decrease also the activity of hepatic catalase in rats fed ASA. |
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| 4696518 | Haining JL, Legan JS: Catalase turnover in rat liver and kidney as a function of age. Exp Gerontol. 1973 Apr;8(2):85-91. |
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| 2285988 | Hashimoto F, Sugimoto C, Hayashi H: Inhibition of synthesis from by aminotriazole treatment in vivo. Chem Pharm Bull. 1990 Sep;38(9):2532-6. 3-Amino-1,2,4-triazole (aminotriazole) is an irreversible inhibitor of catalase which is a marker enzyme of peroxisomes. |
1(0,0,0,1) | Details |
| 3034677 | Vince GS, Dean RT: Is enhanced free radical flux associated with increased intracellular proteolysis?. FEBS Lett. 1987 Jun 1;216(2):253-6. Depletion of the antioxidant and inhibition of catalase also increased proteolysis. |
1(0,0,0,1) | Details |
| 11966208 | Loshchagin OV, Kovalenko RI, Nozdrachev AD, Ianvareva IN, Krivoruchko BI: [Possible role of catalase in the adaptation to diving in semiaquatic rodents Ondatra zibethica] Zh Evol Biokhim Fiziol. 2002 Jan-Feb;38(1):71-5. |
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| 18457571 | Bayliak M, Gospodaryov D, Semchyshyn H, Lushchak V: Inhibition of catalase by aminotriazole in vivo results in reduction of glucose-6-phosphate dehydrogenase activity in Saccharomyces cerevisiae cells. Biochemistry. 2008 Apr;73(4):420-6. |
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| 889879 | Bhuyan KC, Bhuyan DK: Regulation of peroxide in eye humors. Biochim Biophys Acta. 1977 May 26;497(3):641-51. Effect of 3-amino-1H-1,2,4-triazole on catalase and peroxidase of rabbit eye.. |
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| 11730782 | Kotze AC, McClure SJ: Haemonchus contortus utilises catalase in defence against exogenous peroxide in vitro. Int J Parasitol. 2001 Dec;31(14):1563-71. |
5(0,0,0,5) | Details |
| 8031146 | Averill-Bates DA, Przybytkowski E: The role of in cellular defences against cytotoxicity of peroxide in Chinese hamster ovary cells. Arch Biochem Biophys. 1994 Jul;312(1):52-8. Clonogenic survival and activity of the cycle for cells depleted of total to about 8.6% of its initial value and/or with catalase activity reduced to about 10% of control levels were also determined. |
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| 8158665 | Steare SE, Yellon DM: The protective effect of heat stress against reperfusion arrhythmias in the rat. J Mol Cell Cardiol. 1993 Dec;25(12):1471-81. This protection against reperfusion arrhythmias was associated with a two-fold increase in endogenous catalase activity and expression of the inducible heat stress protein HSP 70. |
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| 11510883 | Kim CH, Choi H, Chun YS, Kim GT, Park JW, Kim MS: Hyperbaric oxygenation pretreatment induces catalase and reduces infarct size in ischemic rat myocardium. Pflugers Arch. 2001 Jul;442(4):519-25. |
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| 1962528 | Ohmori T, Ogata M: Methemoglobin formation by ferrocyanide in the hemolysate of acatalasemic mice. Acta Med Okayama. 1991 Aug;45(4):209-15. In the present study, effect of catalase (EC 1.11.1.6) on metHb formation by ferrocyanide was examined spectrophotometrically in the hemolysates of acatalasemic, homozygous hypocatalasemic and normal mice. |
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| 20032404 | Bechtel W, Bauer G: Modulation of intercellular ROS signaling of human tumor cells. . Anticancer Res. 2009 Nov;29(11):4559-70. Tumor cells are resistant against apoptosis-inducing intercellular reactive species (ROS) signaling but can be resensitized by the inhibition of catalase. |
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| 3169364 | Antonenkov VD, Panchenko LF: Effect of chronic treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart. Int J Biochem. 1988;20(8):823-8. |
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| 15907765 | Kashiwagi K, Shinkai T, Kajii E, Kashiwagi A: The effects of reactive species on amphibian aging. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Feb;140(2):197-205. Superoxide dismutase (SOD), catalase, and peroxidase (GPx) activity in 10-year-old liver decreased 40-80% from 3-year-old liver levels. |
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| 8285684 | Visscher PT, Taylor BF: A new mechanism for the aerobic catabolism of dimethyl sulfide. Appl Environ Microbiol. 1993 Nov;59(11):3784-9. H2O2 formed during oxidation is destroyed by catalase. |
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| 16798037 | Freitas DR, Rosa RM, Moraes J, Campos E, Logullo C, Da Silva Vaz I Jr, Masuda A: Relationship between glutathione S-transferase, catalase, consumption, lipid peroxidation and oxidative stress in eggs and larvae of Boophilus microplus (Acarina: Ixodidae). Comp Biochem Physiol A Mol Integr Physiol. 2007 Apr;146(4):688-94. Epub 2006 May 16. |
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| 19151196 | Zmijewski JW, Lorne E, Zhao X, Tsuruta Y, Sha Y, Liu G, Abraham E: Antiinflammatory effects of peroxide in neutrophil activation and acute lung injury. Am J Respir Crit Care Med. 2009 Apr 15;179(8):694-704. Epub 2009 Jan 16. OBJECTIVES: To address the role that increases in intracellular H (2) O (2) may play in acute inflammatory processes, we examined the effects of catalase inhibition or the absence of catalase on LPS-induced inflammatory responses. |
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| 7195942 | Kino M: Chronic effects of under partial inhibition of catalase activity in the rat heart: light and electron microscopic observations. J Mol Cell Cardiol. 1981 Jan;13(1):5-21. |
1(0,0,0,1) | Details |
| 12947053 | Navabpour S, Morris K, Allen R, Harrison E, A-H-Mackerness S, Buchanan-Wollaston V: Expression of senescence-enhanced genes in response to oxidative stress. J Exp Bot. 2003 Oct;54(391):2285-92. Epub 2003 Aug 28. Treatment of Arabidopsis cotyledon and leaf tissues with the catalase inhibitor, 3-amino-1,2,4-triazole, or with silver result in the enhanced expression of LSC54. |
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| 872941 | Deis FH, Lin GW, Lester D: In vitro inhibition of catalase by 4-hydroxypyrazole, a metabolite of pyrazole. FEBS Lett. 1977;78(1):81-2. |
1(0,0,0,1) | Details |
| 1847583 | Mugge A, Elwell JH, Peterson TE, Harrison DG: Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am J Physiol. 1991 Feb;260(2 Pt 1):C219-25. We impaired antioxidant defense in normal vascular tissue by inhibiting catalase activity with 3-amino-1,2,4-triazole (AT), superoxide dismutase with diethyldithiocarbamate (DETC), and by reducing content via inhibiting synthesis with L-buthionine-(S,R)-sulfoximine (BSO). |
1(0,0,0,1) | Details |
| 16136055 | Nie H, Xiong L, Lao N, Chen S, Xu N, Zhu Z: Hyperbaric preconditioning induces tolerance against spinal cord ischemia by upregulation of antioxidant enzymes in rabbits. J Cereb Blood Flow Metab. 2006 May;26(5):666-74. Activities of catalase (CAT) and superoxide dismutase were increased in spinal cord tissue in the HBO group 24 h after the last pretreatment and reached a higher level after spinal cord ischemia for 20 mins followed by reperfusion for 24 or 48 h, in comparison with those in control and HBA groups. |
1(0,0,0,1) | Details |
| 18669883 | Edwards DH, Li Y, Griffith TM: peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1774-81. Epub 2008 Jul 31. CPA-evoked relaxations were attenuated by exogenous catalase and potentiated by the catalase inhibitor 3-aminotriazole, and were abolished by the connexin-mimetic peptide (43) Gap26, which interrupts intercellular communication via gap junctions constructed from connexin 43. |
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| 17387509 | Yu Y, Zhong MK, Li J, Sun XL, Xie GQ, Wang W, Zhu GQ: Endogenous peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Arch. 2007 Jul;454(4):551-7. Epub 2007 Mar 27. Bilateral microinjection of polyethylene glycol-catalase (PEG-CAT, an analogue of endogenous catalase) or polyethylene glycol-superoxide dismutase (PEG-SOD, an analogue of endogenous superoxide dismutase) into the PVN abolished the CSAR, decreased baseline RSNA and mean arterial pressure (MAP). |
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| 10457996 | Oliiarnyk OD, Velykyi MM, Makhnevych TR: [Features of the inhibition of catalase activity by 3-amino-1,2,4-triazole in erythrocytes and liver of rats with streptozotocin diabetes]. Ukr Biokhim Zh. 1999 Jan-Feb;71(1):77-82. |
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| 10928718 | Escarabajal D, Miquel M, Aragon CM: A psychopharmacological study of the relationship between brain catalase activity and -induced locomotor activity in mice. J Stud Alcohol. 2000 Jul;61(4):493-8. |
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| 12538343 | Chuang SM, Wang IC, Hwua YS, Yang JL: Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases. Carcinogenesis. 2003 Jan;24(1):7-15. |
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| 3790167 | Handler JA, Bradford BU, Glassman E, Ladine JK, Thurman RG: Catalase-dependent metabolism in vivo in deermice lacking alcohol dehydrogenase. Biochem Pharmacol. 1986 Dec 15;35(24):4487-92. |
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| 3729967 | DeMaster EG, Redfern B, Shirota FN, Nagasawa HT: Differential inhibition of rat tissue catalase by cyanamide. Biochem Pharmacol. 1986 Jul 1;35(13):2081-5. |
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| 10333085 | Xu L, Badr MZ: Enhanced potential for oxidative stress in hyperinsulinemic rats: imbalance between hepatic peroxisomal peroxide production and decomposition due to hyperinsulinemia. Horm Metab Res. 1999 Apr;31(4):278-82. Consequently, this study was undertaken to evaluate the effect of sustained high serum insulin levels on the activity of hepatic catalase, a peroxisomal antioxidant enzyme involved in the decomposition of H2O2. |
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| 420858 | McMahon S, Stern A: The interrelationship of superoxide dismutase and peroxidatic enzymes in the red cell. Biochim Biophys Acta. 1979 Feb 9;566(2):253-8. Activities of superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) and catalase -peroxide:hydrogen-peroxide oxidoreductase, EC 1.11.1.6) were determined during the course of incubation of red cell suspensions with 1,4-naphthoquinone-2- |
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| 12775721 | Chovolou Y, Watjen W, Kampkotter A, Kahl R: Resistance to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis in rat hepatoma cells expressing TNF-alpha is linked to low antioxidant enzyme expression. J Biol Chem. 2003 Aug 8;278(32):29626-32. Epub 2003 May 29. Catalase expression and activity were lower in Yv2-12 and Yv13-44 cells than in H4IIE cells; furthermore, the transfectants were more susceptible to H2O2. |
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| 18818525 | Oh SH, Kim YS, Lim SC, Hou YF, Chang IY, You HJ: Dihydrocapsaicin (DHC), a saturated structural analog of induces autophagy in human cancer cells in a catalase-regulated manner. Autophagy. 2008 Nov 16;4(8):1009-19. Epub 2008 Nov 2. |
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| 7670505 | Bi YM, Kenton P, Mur L, Darby R, Draper J: peroxide does not function downstream of in the induction of PR protein expression. Plant J. 1995 Aug;8(2):235-45. H2O2 and the irreversible catalase inhibitor 3-amino-1,2,4-triazole (3-AT) were found to be weak inducers of PR-1a expression (relative to SA) in wild-type tobacco but were unable to induce PR-1a in SH-L plants, suggesting that the action of these compounds depends upon the accumulation of SA. |
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| 16910777 | Dasgupta J, Subbaram S, Connor KM, Rodriguez AM, Tirosh O, Beckman JS, Jourd'Heuil D, Melendez JA: Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1295-305. The rate of aminotriazole-inhibited catalase activity also was increased when SOD2 is overexpressed and reflects a 1.6-fold increase in the steady-state production of H (2) O (2). |
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| 1567224 | Royall JA, Gwin PD, Parks DA, Freeman BA: Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-alpha. Arch Biochem Biophys. 1992 May 1;294(2):686-94. We determined a basal intracellular H2O2 concentration of 32.8 +/- 10.7 pM in cultured bovine aortic endothelial cells by kinetic analysis of aminotriazole-mediated inactivation of endogenous catalase. |
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| 7930939 | Dannenberg AM Jr, Schofield BH, Rao JB, Dinh TT, Lee K, Boulay M, Abe Y, Tsuruta J, Steinbeck MJ: Histochemical demonstration of peroxide production by leukocytes in fixed-frozen tissue sections of inflammatory lesions. J Leukoc Biol. 1994 Oct;56(4):436-43. Catalase (150 micrograms/ml, about 1400 U/ml) inhibited the reaction, indicating that H2O2 was required to produce the chromogenic DAB product. |
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| 9208153 | Mian KB, Martin W: peroxide-induced impairment of reactivity in rat isolated aorta: potentiation by 3-amino-1,2,4-triazole. Br J Pharmacol. 1997 Jun;121(4):813-9. In this study the impairment induced by peroxide of vascular reactivity and the role of endogenous catalase in protection against this impairment was assessed in isolated rings of rat aorta. 2. |
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| 2162328 | Geffner JR, Minnucci F, Isturiz MA: Neutrophil-mediated cytotoxicity induced by secretory IgA. Immunol Lett. 1990 May;24(2):113-6. Catalase completely impaired this non-specific cytotoxicity (NSC), while superoxide dismutase (SOD) significantly enhanced it, suggesting a key role for peroxide (H2O2) in the lysis of target cells. |
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| 10569634 | Shiba D, Shimamoto N: Attenuation of endogenous oxidative stress-induced cell death by cytochrome P450 inhibitors in primary cultures of rat hepatocytes. Free Radic Biol Med. 1999 Nov;27(9-10):1019-26. To produce endogenous oxidative stress, 3-amino-1,2,4-triazole (ATZ) and mercaptosuccinic acid (MS), which are known to inhibit catalase and peroxidase activities, respectively, were used. |
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| 49150 | Breton-Gorius J, Guichard J: Fine structural and cytochemical identification of microperoxisomes in developing human erythrocytic cells. Am J Pathol. 1975 Jun;79(3):523-36. These findings suggest that small granules seen in maturing erythroblasts contain catalase and that they correspond to microperoxisomes described in other tissues. |
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| 2903826 | Michiels C, Remacle J: Use of the inhibition of enzymatic antioxidant systems in order to evaluate their physiological importance. Eur J Biochem. 1988 Nov 1;177(2):435-41. Inhibition values were obtained for catalase with aminotriazole, for superoxide dismutase with diethyldithiocarbamate, for peroxidase with mercaptosuccinate, for glutathione reductase with bischloroethylnitrosourea and for synthesis with buthionine sulfoximine. |
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| 10858500 | Calera JA, Sanchez-Weatherby J, Lopez-Medrano R, Leal F: Distinctive properties of the catalase B of Aspergillus nidulans. FEBS Lett. 2000 Jun 16;475(2):117-20. Aspergillus nidulans catalase B (CatB) was purified to homogeneity and characterized as a hydroperoxidase which resembles typical catalases in some physicochemical characteristics: (1) it has an apparent molecular weight of 360000 and is composed of four glycosylated subunits, (2) it has hydrophobic properties as revealed by extractability in /chloroform and binding to phenyl-Superose, and (3) it has an acidic isoelectric point at pH 3. 5. |
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| 14962975 | Carter AB, Tephly LA, Venkataraman S, Oberley LW, Zhang Y, Buettner GR, Spitz DR, Hunninghake GW: High levels of catalase and peroxidase activity dampen H2O2 signaling in human alveolar macrophages. Am J Respir Cell Mol Biol. 2004 Jul;31(1):43-53. Epub 2004 Feb 12. |
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| 12594029 | Ueda M, Kinoshita H, Yoshida T, Kamasawa N, Osumi M, Tanaka A: Effect of catalase-specific inhibitor 3-amino-1,2,4-triazole on yeast peroxisomal catalase in vivo. FEMS Microbiol Lett. 2003 Feb 14;219(1):93-8. |
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| 3427989 | Csukas S, Costarides A, Riley MV, Green K: peroxide in the rabbit anterior chamber: effects on and catalase effects on peroxide kinetics. Curr Eye Res. 1987 Dec;6(12):1395-402. |
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| 4040372 | Ribiere C, Sinaceur J, Nordmann J, Nordmann R: Discrepancy between the different subcellular activities of rat liver catalase and superoxide dismutases in response to acute administration. Alcohol Alcohol. 1985;20(1):13-8. |
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| 8098954 | Muriana FJ, Ruiz-Gutierrez V, Relimpio AM: Is peroxide involved in the benzyl viologen-mediated in-vivo inactivation of rat liver glutamine synthetase?. Int J Exp Pathol. 1993 Apr;74(2):219-24. An increase in the rat liver catalase activity was found concomitantly. |
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| 2782423 | Guidet B, Shah SV: Enhanced in vivo H2O2 generation by rat kidney in -induced renal failure. Am J Physiol. 1989 Sep;257(3 Pt 2):F440-5. Aminotriazole-mediated inhibition of catalase has been used in previous studies as a measure of in vivo changes in the peroxide generation. |
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| 9435555 | Spolarics Z, Wu JX: Role of and catalase in H2O2 detoxification in LPS-activated hepatic endothelial and Kupffer cells. Am J Physiol. 1997 Dec;273(6 Pt 1):G1304-11. |
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| 15042439 | Kashkin VA, De Witte P: but not induced changes in brain a microdialysis study. Amino Acids. 2004 Mar;26(2):117-24. Epub 2003 Dec 22. Research has suggested that catalase plays a role in mediating ethanol's psychopharmacological effects. |
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| 2058415 | Agardh CD, Zhang H, Smith ML, Siesjo BK: Free radical production and ischemic brain damage: influence of postischemic tension. Int J Dev Neurosci. 1991;9(2):127-38. At the end of this period, the animals were decapitated for assessment of H2O2 production with the aminotriazole/catalase method. |
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| 6367914 | Steiner B, Wong GH, Drummond L, Graves S: The role of respiratory protection on increased survival of Treponema pallidum (Nichols) when cocultivated with mammalian cells in vitro. Can J Microbiol. 1983 Nov;29(11):1595-600. Addition of catalase to the incubation medium enhanced T. pallidum survival when co-incubation was carried out under aerobic conditions. |
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| 17110013 | Orozco-Ibarra M, Medina-Campos ON, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Floriano-Sanchez E, Santamaria A, Ramirez V, Bobadilla NA, Pedraza-Chaverri J: Evaluation of oxidative stress in induced nephrotoxicity. Toxicology. 2007 Jan 5;229(1-2):123-35. Epub 2006 Oct 20. Additional experiments were performed using the following compounds with antioxidant or pro-oxidant effects before injection: (a) alpha-phenyl-tert-butyl-nitrone (PBN), a spin trapping agent; (b) 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron (III) (FeTPPS), a soluble complex able to metabolize (c) aminotriazole (ATZ), a catalase (CAT) inhibitor; (d) stannous (SnCl (2)), an HO-1 inductor; (e) tin (SnMP), an HO inhibitor. |
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| 10535764 | Coto-Montes A, Hardeland R: Antioxidative effects of in Drosophila melanogaster: antagonization of damage induced by the inhibition of catalase. J Pineal Res. 1999 Oct;27(3):154-8. |
2(0,0,0,2) | Details |
| 1958639 | Costarides AP, Nelson E, Green K: Morphological sequelae of intracameral peroxide after inhibition of synthesis. Lens Eye Toxic Res. 1991;8(4):441-7. In animals pretreated with either intravenous 3-aminotriazole (3AT) alone, to suppress catalase activity, or intravitreal buthionine sulfoximine alone (BSO), to inhibit gamma-glutamyl synthetase activity, the endothelium was normal. |
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| 9731227 | Ghanam K, Javellaud J, Ea-Kim L, Oudart N: The protective effect of 17 on vasomotor responses of aorta from -fed rabbit is reduced by inhibitors of superoxide dismutase and catalase. Biochem Biophys Res Commun. 1998 Aug 28;249(3):858-64. |
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| 6661212 | Allen RG, Farmer KJ, Sohal RS: Effect of catalase inactivation on levels of inorganic peroxides, superoxide dismutase, consumption and life span in adult houseflies (Musca domestica). Biochem J. 1983 Nov 15;216(2):503-6. |
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| 2928952 | Brown JM, Grosso MA, Whitman GJ, Banerjee A, Terada LS, Repine JE, Harken AH: The coincidence of myocardial reperfusion injury and peroxide production in the isolated rat heart. Surgery. 1989 Apr;105(4):496-501. To investigate the specific nature and timing of (O2) metabolite reperfusion injury, we used a rat-heart model (Langendorff's solution, 37 degrees C) and peroxide (H2O2)-dependent aminotriazole inactivation of catalase as a measure of myocardial H2O2 before, during, and after ischemia. |
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| 9705975 | Dantuma NP, Pijnenburg MA, Diederen JH, Van der Horst DJ: Electron microscopic visualization of receptor-mediated endocytosis of Dil-labeled lipoproteins by diaminobenzidine photoconversion. J Histochem Cytochem. 1998 Sep;46(9):1085-89. This background staining was completely abrogated by inhibition of peroxisomal catalase with aminotriazole. |
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| 9700086 | Peterson MW, Kirschbaum J: Asbestos-induced lung epithelial permeability: potential role of nonoxidant pathways. Am J Physiol. 1998 Aug;275(2 Pt 1):L262-8. We next depleted the cells of or catalase to determine whether depleting normal cellular antioxidants would increase the sensitivity to asbestos. |
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| 18439665 | Chandrashekar KN, Muralidhara: Oxidative alterations induced by in prepubertal rat testis in vitro: a mechanistic study. Theriogenology. 2008 Jul 1;70(1):97-104. Epub 2008 Apr 24. Further, DA-induced oxidative induction was potentiated (P <0.001) in the presence of iron (5 microM) and 3-amino triazole and mercaptosuccinate (P <0.001), known inhibitors of the peroxide metabolizing enzymes, catalase and peroxidase, respectively. |
1(0,0,0,1) | Details |
| 9035754 | Manoilov SE, Sedykh NV, Firsova VI, Vennikas OR, Cheliadina LD: [The effect of catalase inhibitor 3-amino-1,2,4-triazole on coupled oxidative phosphorylation and the state of adenyl system in liver mitochondria of albino rats] Biull Eksp Biol Med. 1996 Jun;121(6):638-40. |
1(0,0,0,1) | Details |
| 12611279 | Zheng QS, Zhang YT, Zheng RL: induces redifferentiation and growth inhibition in human hepatoma cells by increasing endogenous peroxide. Pharmazie. 2002 Nov;57(11):753-7. After treatment with AA, the content of peroxide (H2O2) and the activity of superoxide dismutase (SOD) increased in a concentration- and time-dependent manner, while the activity of catalase (CAT) decreased in a concentration- and time-dependent manner. |
1(0,0,0,1) | Details |
| 15763964 | Ishihara Y, Shiba D, Shimamoto N: Primary hepatocyte apoptosis is unlikely to relate to caspase-3 activity under sustained endogenous oxidative stress. Free Radic Res. 2005 Feb;39(2):163-73. We previously showed that inhibition of catalase and peroxidase activities in rat primary hepatocytes by 3-amino-1,2,4-triazole (ATZ) and mercaptosuccinic acid (MS) results in endogenous oxidative stress and apoptosis. |
1(0,0,0,1) | Details |
| 4623463 | Samis HV, Baird MB, Massie HR: Renewal of catalase activity in Drosophila following treatment with 3-amino-1,2,4-triazole. J Insect Physiol. 1972 May;18(5):991-1000. |
1(0,0,0,1) | Details |
| 2172174 | Mikalsen SO, Kaalhus O, Reith A, Sanner T: Role of catalase and oxidative stress in hepatic peroxisome proliferator-induced morphological transformation of Syrian hamster embryo cells. Int J Cancer. 1990 Nov 15;46(5):950-7. Thus, increased transformation frequencies by HPPs should be obtained when catalase was inhibited by 3-amino-1,2,4-triazole (amitrole). |
82(1,1,1,2) | Details |
| 8313532 | Mikalsen SO, Sanner T: Increased gap junctional intercellular communication in Syrian hamster embryo cells treated with oxidative agents. Carcinogenesis. 1994 Feb;15(2):381-7. The GJIC enhancement by H2O2 was slightly reduced by the addition of the scavenger dimethylsulphoxide or by the inhibition of catalase by amitrole. |
81(1,1,1,1) | Details |
| 9804838 | Bouvier F, Backhaus RA, Camara B: Induction and control of chromoplast-specific carotenoid genes by oxidative stress. J Biol Chem. 1998 Nov 13;273(46):30651-9. Similarly, down-regulation of catalase by amitrole induces expression of carotenogenic gene mRNAs leading to the synthesis of capsanthin in excised green pericarp discs. |
31(0,1,1,1) | Details |
| 10048749 | Hussain S, Hass BS, Slikker W Jr, Ali SF: Reduced levels of catalase activity potentiate MPP+-induced toxicity: comparison between MN9D cells and CHO cells. Toxicol Lett. 1999 Jan 11;104(1-2):49-56. |
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| 10656833 | Putnam CD, Arvai AS, Bourne Y, Tainer JA: Active and inhibited human catalase structures: ligand and binding and catalytic mechanism. J Mol Biol. 2000 Feb 11;296(1):295-309. |
5(0,0,0,5) | Details |
| 9433911 | Yano S, Yano N, Rodriguez N, Baek JH, Que X, Yamamura Y, Kim SJ: Suppression of intracellular peroxide generation and catalase levels in CD8+ T-lymphocytes from HIV+ individuals. Free Radic Biol Med. 1998 Jan 15;24(2):349-59. |
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| 8896899 | Masuoka N, Wakimoto M, Ubuka T, Nakano T: Spectrophotometric determination of peroxide: catalase activity and rates of peroxide removal by erythrocytes. Clin Chim Acta. 1996 Oct 29;254(2):101-12. |
4(0,0,0,4) | Details |
| 1407407 | Aragon CM, Amit Z: The effect of 3-amino-1,2,4-triazole on voluntary consumption: evidence for brain catalase involvement in the mechanism of action. Neuropharmacology. 1992 Jul;31(7):709-12. |
4(0,0,0,4) | Details |
| 2824562 | Winterbourn CC, Stern A: Human red cells scavenge extracellular peroxide and inhibit formation of hypochlorous acid and J Clin Invest. 1987 Nov;80(5):1486-91. Contribution by the GSH system was slight, and apparent only with low H2O2 concentrations when catalase was inhibited by aminotriazole. |
3(0,0,0,3) | Details |
| 10477740 | Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S: Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a peroxide-dependent pathway. Blood. 1999 Sep 15;94(6):2102-11. Thus, NB4 cells have relatively low levels of peroxidase (GPx) and catalase and have a constitutively higher H (2) O (2) content than U937 monocytic leukemia cells. |
3(0,0,0,3) | Details |
| 3720947 | Thayer WS: Role of catalase in metabolism of peroxide by the perfused rat heart. FEBS Lett. 1986 Jun 23;202(1):137-40. |
3(0,0,0,3) | Details |
| 2488015 | Costarides A, Recasens JF, Riley MV, Green K: The effects of 3-aminotriazole, and 1,3-bis-(2-chloroethyl)-1-nitrosourea on peroxide levels in the rabbit aqueous humor. Lens Eye Toxic Res. 1989;6(1-2):167-73. 3-aminotriazole (3-AT), a catalase inhibitor, given to pigmented rabbits in 0.2% drinking solution for 43 days, produced cataractous changes and over a 50% reduction in iris and ciliary process catalase activity. |
2(0,0,0,2) | Details |
| 8279580 | Maitre B, Jornot L, Junod AF: Effects of inhibition of catalase and superoxide dismutase activity on antioxidant enzyme mRNA levels. Am J Physiol. 1993 Dec;265(6 Pt 1):L636-43. |
2(0,0,0,2) | Details |
| 7989270 | Love DN, Redwin J: Characterization of the catalase of the genus Porphyromonas isolated from cats. J Appl Bacteriol. 1994 Oct;77(4):421-5. |
2(0,0,0,2) | Details |
| 2251784 | Antonenkov VD, Pirozhkov SV, Popova SV, Panchenko LF: [The effect of and the catalase inhibitor 3-amino-1,2,4-triazole on lipid peroxidation in rat liver homogenate and subcellular fractions]. Vopr Med Khim. 1990 Sep-Oct;36(5):15-8. |
2(0,0,0,2) | Details |
| 8469024 | Perez-Campo R, Lopez-Torres M, Rojas C, Cadenas S, Barja de Quiroga G: Lung glutathione reductase induction in aging catalase-depleted frogs correlates with early survival throughout the life span. Mech Ageing Dev. 1993 Feb;67(1-2):115-27. |
2(0,0,0,2) | Details |
| 15621054 | Lauer N, Suvorava T, Ruther U, Jacob R, Meyer W, Harrison DG, Kojda G: Critical involvement of peroxide in exercise-induced up-regulation of endothelial NO synthase. Cardiovasc Res. 2005 Jan 1;65(1):254-62. METHODS: To address this question, we generated mice overexpressing human catalase (hCat) driven by the murine Tie-2 promoter to specifically target this transgene to the endothelium (cat (++)). |
2(0,0,0,2) | Details |
| 7528112 | Kurose I, Wolf R, Grisham MB, Aw TY, Specian RD, Granger DN: Microvascular responses to inhibition of production. Circ Res. 1995 Jan;76(1):30-9. Treatment with either catalase or dimethylthiourea attenuated the L-NAME-induced oxidative stress, albumin leakage, and leukocyte-endothelial cell adhesion. |
2(0,0,0,2) | Details |
| 2168950 | Barja de Quiroga G, Perez-Campo R, Lopez-Torres M: Changes on cerebral antioxidant enzymes, peroxidation, and the system of frogs after aging and catalase inhibition. J Neurosci Res. 1990 Jul;26(3):370-6. |
1(0,0,0,1) | Details |
| 8021293 | Hiraishi H, Terano A, Razandi M, Pedram A, Sugimoto T, Harada T, Ivey KJ: Reactive metabolite-induced toxicity to cultured bovine endothelial cells: status of cellular iron in mediating injury. J Cell Physiol. 1994 Jul;160(1):132-4. Prevention of xanthine oxidase-induced damage by catalase was blocked by an inhibitor of catalase, aminotriazole. |
1(0,0,0,1) | Details |
| 9381482 | Kanthasamy AG, Ardelt B, Malave A, Mills EM, Powley TL, Borowitz JL, Isom GE: Reactive species generated by mediate toxicity in rat pheochromocytoma cells. Toxicol Lett. 1997 Sep 19;93(1):47-54. Also antioxidant defense enzymes (CuZn superoxide dismutase and especially catalase) in PC12 cells are inhibited by |
1(0,0,0,1) | Details |
| 9931285 | Shaikh ZA, Vu TT, Zaman K: Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol Appl Pharmacol. 1999 Feb 1;154(3):256-63. Depletion of following buthionine sulfoximine administration at the end of Week 5, or inhibition of catalase by aminotriazole at the end of Week 7, resulted in the development of acute nephrotoxicity within 6 h. |
1(0,0,0,1) | Details |
| 170803 | Thurman RG, Oshino N, Chance B: The role of peroxide production and catalase in hepatic metabolism. Adv Exp Med Biol. 1975;59:163-83. |
1(0,0,0,1) | Details |
| 7598537 | Takano JI, Koizumi H, Ohkawara A, Kamo N, Ueda T: Ultraviolet action spectra for peroxide generation in human and pig epidermal keratinocytes loaded with dihydrorhodamine 123. Arch Dermatol Res. 1995;287(3-4):321-5. Aminotriazole, an inhibitor of catalase, and low temperatures increased the stationary levels of peroxide generation in pig keratinocytes upon UV irradiation, indicating that the reaction used for measuring intracellular peroxides is competitive with the intrinsic reactions in scavenging peroxides. |
1(0,0,0,1) | Details |
| 3421709 | Miccadei S, Kyle ME, Gilfor D, Farber JL: Toxic consequence of the abrupt depletion of in cultured rat hepatocytes. Arch Biochem Biophys. 1988 Sep;265(2):311-20. Inhibition of glutathione reductase by 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) or inhibition of catalase by aminotriazole sensitized the hepatocytes to the cytotoxicity of DNFB. |
1(0,0,0,1) | Details |
| 856192 | Ishii H, Suga T, Ninobe S: Effect of 3-amino-1,2,4-triazole treatment on catalase activity and triglyceride level in fatty liver of the rat. Biochem Pharmacol. 1977 Apr 1;26(7):625-8. |
1(0,0,0,1) | Details |
| 11283936 | Kahlos K, Soini Y, Sormunen R, Kaarteenaho-Wiik R, Paakko P, Linnainmaa K, Kinnula VL: Expression and prognostic significance of catalase in malignant mesothelioma. Cancer. 2001 Apr 1;91(7):1349-57. |
9(0,0,0,9) | Details |
| 6378202 | DeMaster EG, Shirota FN, Nagasawa HT: The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase. Biochem Biophys Res Commun. 1984 Jul 18;122(1):358-65. |
9(0,0,0,9) | Details |
| 16728955 | Kang YS, Lee DH, Yoon BJ, Oh DC: Purification and characterization of a catalase from photosynthetic bacterium Rhodospirillum rubrum S1 grown under anaerobic conditions. J Microbiol. 2006 Apr;44(2):185-91. |
9(0,0,0,9) | Details |
| 15696052 | Grigoryants V, Hannawa KK, Pearce CG, Sinha I, Roelofs KJ, Ailawadi G, Deatrick KB, Woodrum DT, Cho BS, Henke PK, Stanley JC, Eagleton MJ, Upchurch GR: Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms. J Vasc Surg. 2005 Jan;41(1):108-14. |
8(0,0,0,8) | Details |
| 1646749 | Paller MS: peroxide and ischemic renal injury: effect of catalase inhibition. Free Radic Biol Med. 1991;10(1):29-34. |
8(0,0,0,8) | Details |
| 8400028 | Amrani M, Allen NJ, O'Shea J, Corbett J, Dunn MJ, Tadjkarimi S, Theodoropoulos S, Pepper J, Yacoub MH: Role of catalase and heat shock protein on recovery of cardiac endothelial and mechanical function after ischemia. Cardioscience. 1993 Sep;4(3):193-8. |
4(0,0,0,4) | Details |
| 3428124 | D'Alessandro N, Nicotra C, Crescimanno M, Rausa L: Effects of doxorubicin on mouse heart catalase. . Drugs Exp Clin Res. 1987;13(10):601-6. |
4(0,0,0,4) | Details |
| 8060524 | Koechling UM, Amit Z: Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of consumption in mice. Alcohol. 1994 May-Jun;11(3):235-9. |
4(0,0,0,4) | Details |
| 12439864 | Chen C, Hennig GE, Whiteley HE, Manautou JE: Protection against hepatotoxicity by clofibrate pretreatment: role of catalase induction. J Biochem Mol Toxicol. 2002;16(5):227-34. |
4(0,0,0,4) | Details |
| 10468195 | Pedraza-Chaverri J, Granados-Silvestre MD, Medina-Campos ON, Hernandez-Pando R: Effect of the in vivo catalase inhibition on aminonucleoside nephrosis. . Free Radic Biol Med. 1999 Aug;27(3-4):245-53. |
4(0,0,0,4) | Details |
| 7921163 | Cadenas S, Rojas C, Perez-Campo R, Lopez-Torres M, Barja G: Effect of dietary and catalase inhibition of antioxidants and molecular markers of oxidative damage in guinea pigs. Free Radic Res. 1994 Aug;21(2):109-18. |
3(0,0,0,3) | Details |
| 14553939 | Ro YT, Lee HI, Kim EJ, Koo JH, Kim E, Kim YM: Purification, characterization, and physiological response of a catalase-peroxidase in Mycobacterium sp. strain JC1 DSM 3803 grown on FEMS Microbiol Lett. 2003 Sep 26;226(2):397-403. |
3(0,0,0,3) | Details |
| 11673067 | Chao JI, Yang JL: Alteration of cadmium-induced mutational spectrum by catalase depletion in Chinese hamster ovary-K1 cells. Mutat Res. 2001 Nov 15;498(1-2):7-18. |
3(0,0,0,3) | Details |
| 18234233 | Yuan B, Ohyama K, Bessho T, Uchide N, Toyoda H: Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissues. Life Sci. 2008 Mar 12;82(11-12):623-30. Epub 2007 Dec 28. In this study, we examined the role of ROS elimination system (e.g., antioxidant enzymes, such as peroxidase (GPx) and catalase) in the apoptosis induction of the chorion cells, since the apoptosis induction by oxidative stress is a result of imbalance between production and elimination of ROS. |
3(0,0,0,3) | Details |
| 7682576 | Scott MD, van den Berg JJ, Repka T, Rouyer-Fessard P, Hebbel RP, Beuzard Y, Lubin BH: Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes. J Clin Invest. 1993 Apr;91(4):1706-12. In addition, alpha-hemoglobin chain loading resulted in a direct decrease (38.5%) in catalase activity. |
2(0,0,0,2) | Details |
| 6530393 | Hayashi H, Fukui K, Yamasaki F: Association of the liver peroxisomal fatty acyl- beta-oxidation system with the synthesis of bile acids. J Biochem. 1984 Dec;96(6):1713-9. It is known that fatty acyl- oxidase [EC 1.3.99.3] in peroxisomal FAOS conjugates with catalase [EC 1.11.1.6]. |
2(0,0,0,2) | Details |
| 8536535 | Batra SC, Haber PS, Mirmiran-Yazdy FS, Korsten MA, Gentry RT, Lieber CS: Gastric metabolism of in Syrian golden hamster. Dig Dis Sci. 1995 Dec;40(12):2712-6. In contrast to alcohol dehydrogenase, catalase activity in hamster gastric mucosa (870 +/- 93 units/g tissue) was eightfold higher than in rat gastric mucosa (111 +/- 9 units/g tissue; P < 0.0001). |
2(0,0,0,2) | Details |
| 16103719 | Dhaunsi GS, Al-Essa M, Muawad W, Srivastava BS, Rashwan N: Very-long-chain fatty acids activate lysosomal hydrolases in neonatal human skin tissue. Med Princ Pract. 2005;14 Suppl 1:92-7. ATZ (1-5 mM), an inhibitor of key peroxi somal enzyme catalase, also markedly increased the enzymic activities of acid phosphatase, alpha-glucosidase (23%) and alpha-galactosidase (18%) without any significant effect on NAGA or NAGTA. |
2(0,0,0,2) | Details |
| 2077003 | Engstrom PC, Easterling L, Baker RR, Matalon S: Mechanisms of extracellular peroxide clearance by alveolar type II pneumocytes. J Appl Physiol. 1990 Dec;69(6):2078-84. When coincubated with 300 microM H2O2, ATII cells cleared H2O2 at a higher rate than an equivalent amount of free catalase. |
2(0,0,0,2) | Details |
| 1520249 | Konno N, Kako KJ: Role of cellular defense against peroxide-induced inhibition of myocyte respiration. Basic Res Cardiol. 1992 May-Jun;87(3):239-49. Cellular defense was attenuated by i) inhibiting the catalase activity by 3-amino-1,2,4-triazole (AT), ii) reducing the concentration by diethyl (DEM) or ethacrinic acid (EA), and iii) permeabilizing the sarcolemmal membrane by saponin. |
1(0,0,0,1) | Details |
| 3954830 | Wickramasinghe SN: Observations on the biochemical basis of metabolism by human macrophages. Alcohol Alcohol. 1986;21(1):57-63. The metabolism of (0.1 and 1.0 mg/ml) to by blood-monocyte-derived macrophages was only slightly inhibited by pyrazole, 4-iodopyrazole and 3-amino-1,2,4-triazole indicating that it was largely independent of alcohol dehydrogenase and catalase. |
1(0,0,0,1) | Details |
| 666320 | Jones GL, Masters CJ: On the synthesis and degradation of the multiple forms of catalase in mouse liver: effects of aminotriazole and p-chlorophenoxyisobutric acid ethyl ester. Arch Biochem Biophys. 1978 Apr 30;187(2):431-40. |
1(0,0,0,1) | Details |
| 4038347 | Williams RN, Delamere NA, Paterson CA: Inactivation of catalase with 3-amino-1,2,4-triazole: an indirect irreversible mechanism. Biochem Pharmacol. 1985 Sep 15;34(18):3386-9. |
1(0,0,0,1) | Details |
| 17139608 | Alconada TM, Juarez MP: Acyl-CoA oxidase activity from Beauveria bassiana, an entomopathogenic fungus. J Basic Microbiol. 2006;46(6):435-43. In the presence of 3-amino-1,2,4-triazole (AT) to prevent H2O2 consumption by endogenous catalase, the lag phase became shorter and disappeared when AT concentrations were raised from 40 to 200 mM, thus enhancing acyl- oxidation. |
1(0,0,0,1) | Details |
| 7752581 | Zent R, Ailenberg M, Waddell TK, Downey GP, Silverman M: Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive species. Kidney Int. 1995 Mar;47(3):811-7. Aminotriazole, an inhibitor of endogenous catalase, inhibited mesangial cell-induced gel contraction in a dose dependent manner (5 mM to 40 mM), and this effect was completely reversed by addition of catalase. |
1(0,0,0,1) | Details |
| 15528010 | Lamarche F, Signorini-Allibe N, Gonthier B, Barret L: Influence of selenite, and astrocyte-conditioned medium on neuronal survival after chronic exposure to Alcohol. 2004 Jun;33(2):127-38. In the presence of 3-amino-1,2,4-triazole, a catalase inhibitor that created conditions that were favorable to reactive species accumulation, trolox was able to counteract the deleterious effect of the inhibitor. |
1(0,0,0,1) | Details |
| 12198405 | Sanchis-Segura C, Aragon CM: Brain catalase inhibition blocks -related decrease of blood luteinizing hormone levels in mice. Alcohol Clin Exp Res. 2002 Aug;26(8):1275-80. |
8(0,0,0,8) | Details |
| 9467862 | Kashiwagi A, Kashiwagi K, Takase M, Hanada H, Nakamura M: Comparison of catalase in diploid and haploid Rana rugosa using heat and chemical inactivation techniques. Comp Biochem Physiol B Biochem Mol Biol. 1997 Nov;118(3):499-503. |
8(0,0,0,8) | Details |
| 1859472 | Aragon CM, Rogan F, Amit Z: Dose- and time-dependent effect of an acute 3-amino-1,2,4-triazole injection on rat brain catalase activity. Biochem Pharmacol. 1991 Jul 15;42(3):699-702. |
8(0,0,0,8) | Details |
| 10976731 | Ball BA, Gravance CG, Medina V, Baumber J, Liu IK: Catalase activity in equine semen. Am J Vet Res. 2000 Sep;61(9):1026-30. |
8(0,0,0,8) | Details |
| 8821941 | Milano A, De Rossi E, Gusberti L, Heym B, Marone P, Riccardi G: The katE gene, which encodes the catalase HPII of Mycobacterium avium. Mol Microbiol. 1996 Jan;19(1):113-23. |
8(0,0,0,8) | Details |
| 6365291 | Jouve HM, Lasauniere C, Pelmont J: Properties of a catalase from a peroxide-resistant mutant of Proteus mirabilis. Can J Biochem Cell Biol. 1983 Nov;61(11):1219-27. |
8(0,0,0,8) | Details |
| 18207 | Isaacs JT, Binkley F: Cyclic AMP-dependent control of the rat hepatic -sulfhydryl ratio. Biochim Biophys Acta. 1977 Jun 23;498(1):29-38. Also, dibutyryl cyclic AMP caused hepatic catalase activity to decrease and to increase hepatic production of peroxide molecules. |
4(0,0,0,4) | Details |
| 7126616 | Jones GL, Neill AR: The effects of clofibrate and 3-amino-1,2,4-triazole on liver catalase and lipid metabolism in mice. Biochim Biophys Acta. 1982 Aug 18;712(2):420-6. |
4(0,0,0,4) | Details |
| 1560230 | Przedborski S, Jackson-Lewis V, Kostic V, Carlson E, Epstein CJ, Cadet JL: Superoxide dismutase, catalase, and peroxidase activities in /zinc-superoxide dismutase transgenic mice. J Neurochem. 1992 May;58(5):1760-7. |
4(0,0,0,4) | Details |
| 8288557 | Makino N, Mochizuki Y, Bannai S, Sugita Y: Kinetic studies on the removal of extracellular peroxide by cultured fibroblasts. J Biol Chem. 1994 Jan 14;269(2):1020-5. It was concluded that reactions 1 and 2 are principally due to GSH peroxidase and catalase, respectively. |
4(0,0,0,4) | Details |
| 11790383 | Shahidullah M, Duncan A, Strachan PD, Rafique KM, Ball SL, McPate MJ, Nelli S, Martin W: Role of catalase in the smooth muscle relaxant actions of azide and cyanamide. Eur J Pharmacol. 2002 Jan 18;435(1):93-101. |
3(0,0,0,3) | Details |
| 12621067 | Cicchetti R, Argentin G: The role of oxidative stress in the in vitro induction of micronuclei by pesticides in mouse lung fibroblasts. Mutagenesis. 2003 Mar;18(2):127-32. The involvement of the antioxidant enzymes catalase and peroxidase (both at 0.1 mg/ml) in defence against the genotoxicity of phosphamidon (80 microg/ml) and dieldrin (25 microM) was investigated in order to demonstrate that the two pesticides damage DNA through the generation of reactive species and therefore of oxidative stress. |
3(0,0,0,3) | Details |
| 11250878 | Asano T, Hattori T, Tada T, Kajikuri J, Kamiya T, Saitoh M, Yamada Y, Itoh M, Itoh T: Role of the epithelium in opposing H (2) O (2)-induced modulation of -induced contractions in rabbit intrapulmonary bronchiole. Br J Pharmacol. 2001 Mar;132(6):1271-80. Catalase (500 u ml (-1)) completely blocked both H (2) O (2)-induced effects on -contractions (enhancement and inhibition). |
3(0,0,0,3) | Details |
| 9140708 | Maenishi O, Ito H, Suzuki T: Acceleration of hypertensive cerebral injury by the inhibition of -xanthine oxidase system in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1997 May;19(4):461-77. It is well-known that, in ischemic cerebral injury, a free radical and its byproducts are generated by -xanthine oxidase system and eliminated by scavengers such as superoxide dismutase (SOD), catalase, and |
2(0,0,0,2) | Details |
| 1605888 | Aragon CM, Pesold CN, Amit Z: -induced motor activity in normal and acatalasemic mice. Alcohol. 1992 May-Jun;9(3):207-11. The role of brain catalase in modulating the psychopharmacological effects of was investigated by examining induced motor activity in normal, C3H-N, and a corresponding group of acatalasemic C3H-A, mice. |
2(0,0,0,2) | Details |
| 8168729 | Konorev EA, Struck AT, Baker JE, Ramanujam S, Thomas JP, Radi R, Kalyanaraman B: Intracellular catalase inhibition does not predispose rat heart to ischemia-reperfusion and peroxide-induced injuries. Free Radic Res Commun. 1993;19(6):397-407. The objective of this study was to determine whether inhibition of intracellular catalase would decrease the tolerance of the heart to ischemia-reperfusion and peroxide-induced injuries. |
2(0,0,0,2) | Details |
| 731180 | Feinstein RN, Fry RJ, Staffeldt EF: Comparative effects of aminotriazole on normal and acatalasemic mice. J Environ Pathol Toxicol. 1978 Jul-Aug;1(6):779-89. Some pharmacological and toxicological effects of dietary 3-amino-1,2,4-triazole (AT), a known catalase inhibitor, antithyroid agent, and carcinogen, have been examined, using acatalasemic (Csb) and normal catalase, "wild-type" (Csa) substrains of highly inbred C3H and C57BL mice. |
2(0,0,0,2) | Details |
| 1369090 | Okuda T, Matsuda Y, Sugawara M, Sagisaka S: Metabolic response to treatment with cold, paraquat, or 3-amino-1,2,4-triazole in leaves of winter wheat. Biosci Biotechnol Biochem. 1992 Dec;56(12):1911-5. We assayed the activities of glucose-6-phosphate dehydrogenase, catalase, reductase and free radical reductase and levels of peroxide, reduced and |
2(0,0,0,2) | Details |
| 9950959 | Zent R, Ailenberg M, Downey GP, Silverman M: ROS stimulate reorganization of mesangial cell-collagen gels by kinase signaling. Am J Physiol. 1999 Feb;276(2 Pt 2):F278-87. Exposure of mesangial cells grown in three-dimensional culture to H2O2, 3-amino-1,2,4-triazole (a catalase inhibitor), or puromycin is associated with gel reorganization accompanied by tyrosine phosphorylation of multiple proteins, including focal adhesion kinase (FAK). |
1(0,0,0,1) | Details |
| 6956216 | Hirschelmann R, Bekemeier H: Anti-inflammatory activity of catalase in carrageenin edema, edema and adjuvant arthritis of rats. Agents Actions Suppl. 1982;10:157-72. |
1(0,0,0,1) | Details |
| 2486936 | Green K, Greiff M, Cheeks L: Influence of peroxide on uptake by iris, ciliary epithelium and corneal endothelium. Lens Eye Toxic Res. 1989;6(3):405-14. This occurred even with suppression of catalase activity using 3-aminotriazole. |
1(0,0,0,1) | Details |
| 1450319 | Godwin JE, Heffner JE: Platelet prevention of oxidant lung oedema is not mediated through scavenging of peroxide. Blood Coagul Fibrinolysis. 1992 Oct;3(5):531-9. This hypothesis was tested by asking two questions: (1) do -supplemented platelets demonstrate augmented lung protection compared with control platelets, and (2) does conjugation of platelet with 1-chloro-2,4-dinitrobenzene or inactivation of catalase with 3-amino-1,2,4-triazole decrease in vitro platelet metabolism of peroxide? We incubated washed human platelets with or monoester and observed platelet contents of 181% and 189%, respectively, compared with control values. |
1(0,0,0,1) | Details |
| 1872989 | Tampier L, Quintanilla ME: Effect of 3-amino-1,2,4-triazole on the hypothermic effect of and on tolerance development. Alcohol. 1991 Jul-Aug;8(4):279-82. The effect of aminotriazole (AT), inhibitor of catalase activity, on hypothermia and narcosis induced by and on the acquisition of tolerance to the hypothermic and narcotic effect was studied. |
1(0,0,0,1) | Details |
| 11353799 | Hirsch-Ernst KI, Schlaefer K, Bauer D, Heder AF, Kahl GF: Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive species in primary rat hepatocyte cultures. Mol Pharmacol. 2001 Jun;59(6):1402-9. Addition of H (2) O (2) or of the catalase inhibitor 3-amino-1,2,4-triazole (AT) to the medium repressed induction to approximately 30% (at 1 mM H (2) O (2) and 2 mM AT, respectively). |
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| 8845916 | Burdon RH, Gill V, Alliangana D: peroxide in relation to proliferation and apoptosis in BHK-21 hamster fibroblasts. Free Radic Res. 1996 Feb;24(2):81-93. Other agents such as inhibitors of peroxidase and catalase, or mimics of superoxide dismutase, which also bring about elevated cellular levels of H2O2 in BHK-21 cells, similarly lead to decreased proliferation and an apparent increase in cells with apoptopic features. |
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| 16274876 | Johnson RM, Goyette G Jr, Ravindranath Y, Ho YS: Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes. Free Radic Biol Med. 2005 Dec 1;39(11):1407-17. Epub 2005 Aug 24. Methemoglobin and the rate of catalase inactivation by 3-amino-2,4,5-triazole (3-AT) were determined. |
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| 8947833 | Miyamoto T, Hayashi M, Takeuchi A, Okamoto T, Kawashima S, Takii T, Hayashi H, Onozaki K: Identification of a novel growth-promoting factor with a wide target cell spectrum from various tumor cells as catalase. J Biochem. 1996 Oct;120(4):725-30. |
8(0,0,0,8) | Details |
| 15319487 | Treichel JL, Henry MM, Skumatz CM, Eells JT, Burke JM: Antioxidants and ocular cell type differences in cytoprotection from toxicity in vitro. Toxicol Sci. 2004 Nov;82(1):183-92. Epub 2004 Aug 19. Here catalase and were analyzed in the two retinal cell lines to determine whether differences in these antioxidant systems contributed to cell-type-specific differences in cytotoxicity. |
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| 16938317 | Manrique HM, Miquel M, Aragon CM: Acute administration of 3-nitropropionic acid, a reactive species generator, boosts -induced locomotor stimulation. Neuropharmacology. 2006 Dec;51(7-8):1137-45. Epub 2006 Aug 28. New support for the role of brain catalase in the behavioural effects of |
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| 9231701 | Wang TS, Shu YF, Liu YC, Jan KY, Huang H: peroxidase and catalase modulate the genotoxicity of arsenite. . Toxicology. 1997 Sep 5;121(3):229-37. |
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| 10099326 | Lu X, Roe F, Jesaitis A, Lewandowski Z: Resistance of biofilms to the catalase inhibitor 3-amino-1,2, 4-triazole. Biotechnol Bioeng. 1998 Jul 20;59(2):156-62. |
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| 9013132 | Bouzyk E, Iwanenko T, Jarocewicz N, Kruszewski M, Sochanowicz B, Szumiel I: Antioxidant defense system in differentially peroxide sensitive L5178Y sublines. Free Radic Biol Med. 1997;22(4):697-704. The contribution of catalase, peroxidase (G-Px) and were evaluated. |
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| 7946385 | Kinnula VL, Yankaskas JR, Chang L, Virtanen I, Linnala A, Kang BH, Crapo JD: Primary and immortalized (BEAS 2B) human bronchial epithelial cells have significant antioxidative capacity in vitro. Am J Respir Cell Mol Biol. 1994 Nov;11(5):568-76. Immunocytochemical studies showed a similar pattern of intracellular localization with the moderate degrees of labeling for Mn superoxide dismutase (SOD), CuZn SOD, and catalase in freshly isolated bronchial epithelial cells, bronchial epithelial cells in primary culture, and BEAS 2B cells. |
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| 18797246 | Pastor R, Aragon CM: injected into the hypothalamic arcuate nucleus induces behavioral stimulation in rats: an effect prevented by catalase inhibition and naltrexone. Behav Pharmacol. 2008 Oct;19(7):698-705. |
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| 15451066 | Seo YJ, Lee JW, Lee EH, Lee HK, Kim HW, Kim YH: Role of in the adaptive tolerance to H2O2. Free Radic Biol Med. 2004 Oct 15;37(8):1272-81. We sought to evaluate the contributions of catalase and the system to the adaptive tolerance to H2O2. |
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| 1150002 | Nakamura A, Miyazaki K, Nagao Y, Horio T: Effect of injection of nuclear fraction from Rhodamine sarcoma on turnover of liver catalase. Gann. 1975 Feb;66(1):75-83. |
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| 6762127 | Katoch VM, Wayne LG, Diaz GA: Serological approaches for the characterization of catalase in tissue-derived mycobacteria. Ann Microbiol. 1982 Nov-Dec;133(3):407-14. |
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| 9241662 | He XX, Nebert DW, Vasiliou V, Zhu H, Shertzer HG: Genetic differences in drinking preference between inbred strains of mice. Pharmacogenetics. 1997 Jun;7(3):223-33. In B6 mice, we found that oral treatment with the aldehyde dehydrogenase (ALDH) inhibitor disulfiram decreased preference by 50%, whereas oral treatment of the catalase inhibitor 3-amino-1,2,4-triazole increased drinking preference by 15-20%. |
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| 3426685 | Kato S, Alderman J, Lieber CS: metabolism in alcohol dehydrogenase deficient deermice is mediated by the microsomal oxidizing system, not by catalase. Alcohol Alcohol Suppl. 1987;1:231-4. The participation of the microsomal oxidizing system (MEOS) and catalase in total metabolism is reviewed. |
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| 9199892 | Hanada H, Kashiwagi A, Takehara Y, Kanno T, Yabuki M, Sasaki J, Inoue M, Utsumi K: Do reactive species underlie the mechanism of apoptosis in the tadpole tail?. Free Radic Biol Med. 1997;23(2):294-301. During the apoptotic changes, the activity of Cu/Zn-type superoxide dismutase (SOD) in the tail markedly increased with a concomitant decrease in its catalase activity. |
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| 9196400 | Spector A, Ma W, Wang RR, Yang Y, Ho YS: The contribution of GSH peroxidase-1, catalase and GSH to the degradation of H2O2 by the mouse lens. Exp Eye Res. 1997 Mar;64(3):477-85. |
2(0,0,0,2) | Details |
| 6437142 | Khayat A, Dencker L: Organ and cellular distribution of inhaled metallic mercury in the rat and Marmoset monkey (Callithrix jacchus): influence of pretreatment. Acta Pharmacol Toxicol. 1984 Aug;55(2):145-52. Metallic mercury is oxidized by the catalase-H2O2 complex (Complex I) to the ionic form (Hg2+) and is known to be accumulated and retained in organs such as lungs, liver, myocardium, and brain, apparently after local oxidation in these organs. |
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| 18827562 | Kwee JK, Luque DG, Ferreira AC, Vasconcelos FC, Silva KL, Klumb CE, Maia RC: Modulation of reactive species by antioxidants in chronic myeloid leukemia cells enhances imatinib sensitivity through survivin downregulation. Anticancer Drugs. 2008 Nov;19(10):975-81. In this study, we demonstrated through fluorescein isothiocyanate-labeled annexin V for apoptotic cells detection and western blotting that by inhibiting catalase activity, imatinib apoptosis induction was significantly enhanced (P <0.05) through diminishing survivin expression in K562 cells. |
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| 3811274 | Antonenkov VD, Popova SV, Pirozhkov SV, Krasnova SN: [Characteristics of an experimental model of alcoholic cardiomyopathy by diagnostic enzyme tests]. Vopr Med Khim. 1986 Nov-Dec;32(6):115-8. Activity of catalase was assayed in liver and heart homogenates. |
1(0,0,0,1) | Details |
| 10501032 | Wang J, Zhang H, Allen RD: Overexpression of an Arabidopsis peroxisomal peroxidase gene in tobacco increases protection against oxidative stress. Plant Cell Physiol. 1999 Jul;40(7):725-32. The expression of APX3 in tobacco could protect leaves from oxidative stress damage caused by aminotriazole which inhibits catalase activity that is found mainly in glyoxysomes and peroxisomes and leads to accumulation of H2O2 in those organelles. |
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| 17933967 | Chen X, Patel K, Connors SG, Mendonca M, Welch WJ, Wilcox CS: Acute antihypertensive action of Tempol in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3246-53. Epub 2007 Oct 12. The antihypertensive response was unaffected by the infusion of a pegylated catalase or by the inhibition of catalase with 3-aminotriazole, inhibition of peroxidase with buthionine sulfoximine, inhibition of heme oxygenase with tin or inhibition of large-conductance Ca (2+)-activated channels with iberiotoxin. |
1(0,0,0,1) | Details |
| 6372785 | Van den Branden C, Kerckaert I, Roels F: Peroxisomal beta-oxidation from endogenous substrates. Biochem J. 1984 Mar 15;218(3):697-702. A system was developed in which it is possible to detect in vivo changes in hepatic H2O2 production, using a combination of the catalase inhibitor, 3-amino-1,2,4-triazole and |
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| 16002440 | Geracitano R, Tozzi A, Berretta N, Florenzano F, Guatteo E, Viscomi MT, Chiolo B, Molinari M, Bernardi G, Mercuri NB: Protective role of peroxide in -deprived dopaminergic neurones of the rat substantia nigra. J Physiol. 2005 Oct 1;568(Pt 1):97-110. Epub 2005 Jul 7. Taken together, our data suggest that H2O2 prevents the metabolic stress of DA neurones induced by hypoxia by serving as a supplementary source of molecular through its degradation by catalase. |
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| 3013154 | Kerckaert I, Roels F: Myocardial H2O2 production in the unanaesthetized rat. Basic Res Cardiol. 1986 Jan-Feb;81(1):83-91. Myocardial H2O2 production was studied by means of the in vivo administration of aminotriazole (AT), which inactivates the catalase-H2O2 complex compound I. |
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| 6094369 | Muller-Peddinghaus R: In vitro determination of phagocyte activity by luminol- and lucigenin-amplified chemiluminescence. Int J Immunopharmacol. 1984;6(5):455-66. The dependence of luminol-amplified CL upon the generation of the chain reaction intermediate H2O2 and its three main catalysts catalase, myeloperoxidase and makes this reaction prone to different artifacts if cell activity is to be determined. |
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| 2004600 | Riley JC, Behrman HR: In vivo generation of peroxide in the rat corpus luteum during luteolysis. Endocrinology. 1991 Apr;128(4):1749-53. The hypothesis that peroxide generation occurs in the corpora lutea of superovulated rats during luteolysis was tested using a peroxide-dependent inhibitor of catalase, 3-amino-1,2,4-triazole (AT). |
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| 17123644 | Citelli M, Lara FA, da Silva Vaz I Jr, Oliveira PL: Oxidative stress impairs heme detoxification in the midgut of the cattle tick, Rhipicephalus (Boophilus) microplus. Mol Biochem Parasitol. 2007 Jan;151(1):81-8. Epub 2006 Nov 13. Here, we investigated the role of catalase, an enzyme responsible for H (2) O (2) detoxification. |
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| 11139414 | Ward RJ, Kest W, Bruyeer P, Lallemand F, De Witte P: modulates catalase, aldehyde dehydrogenase, and elimination rates in rat brain. Alcohol Alcohol. 2001 Jan-Feb;36(1):39-43. |
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| 19302986 | Gaspar T, Domoki F, Lenti L, Institoris A, Snipes JA, Bari F, Busija DW: Neuroprotective effect of adenoviral catalase gene transfer in cortical neuronal cultures. Brain Res. 2009 May 13;1270:1-9. Epub 2009 Mar 17. |
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| 500584 | Ishii H, Suga T, Hayashi H, Niinobe S: Effect of Triton WR-1339 on the rates of synthesis and degradation of hepatic catalase of rat. J Biochem. 1979 Oct;86(4):1163-6. |
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| 10762670 | Karasu C: Time course of changes in endothelium-dependent and -independent relaxation of chronically diabetic aorta: role of reactive species. Eur J Pharmacol. 2000 Mar 31;392(3):163-73. Catalase, 160 U/ml, decreased the peak relaxant response to and accelerated fading of the relaxation in diabetic aorta. |
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| 2648406 | Brown JM, Grosso MA, Terada LS, Whitman GJ, Banerjee A, White CW, Harken AH, Repine JE: Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2516-20. |
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| 7121327 | Eremina SS: [Effect of 1,2,4-triaminotriazole on Candida mycoderma catalase in substrate oxidation]. Mikrobiologiia. 1982 May-Jun;51(3):416-9. |
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| 2386221 | Karmazyn M, Mailer K, Currie RW: Acquisition and decay of heat-shock-enhanced postischemic ventricular recovery. Am J Physiol. 1990 Aug;259(2 Pt 2):H424-31. The antioxidative enzyme catalase was increased 24, 48, and 96 h posthyperthermia. |
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| 12123625 | Srivastava P, Rajanikanth M, Raghavan SA, Dikshit M: Role of endogenous reactive derived species and cyclooxygenase mediators in -induced contractions in rat aorta: relationship to Pharmacol Res. 2002 May;45(5):375-82. Pretreatment of the rings with superoxide dismutase scavenger), catalase (H (2) O (2) inactivator), (extracellular OH. scavenger), or thiourea (intracellular OH. radical scavenger) significantly depressed the -induced contractions in the aortic rings. |
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| 3555347 | Kato S, Alderman J, Lieber CS: Respective roles of the microsomal oxidizing system and catalase in metabolism by deermice lacking alcohol dehydrogenase. Arch Biochem Biophys. 1987 May 1;254(2):586-91. |
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| 1733283 | Kinnula VL, Chang L, Everitt JI, Crapo JD: Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells. Am J Physiol. 1992 Jan;262(1 Pt 1):L69-77. Biochemical studies showed that cell culture resulted in a significant decrease in activities of catalase (49%), glutathione reductase (50%), peroxidase (74%), and in the capacity of the cells to scavenge extracellular H2O2. |
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| 3996592 | Del Principe D, Menichelli A, De Matteis W, Di Corpo ML, Di Giulio S, Finazzi-Agro A: peroxide has a role in the aggregation of human platelets. . FEBS Lett. 1985 Jun 3;185(1):142-6. Externally added catalase strongly inhibits the aggregation induced by particulate stimuli and by phorbol myristate acetate (PMA). |
2(0,0,0,2) | Details |
| 3427990 | Birnbaum D, Csukas S, Costarides A, Forbes E, Green K: 3-amino-triazole effects on the eye of young and adult rabbits in the presence and absence of peroxide. Curr Eye Res. 1987 Dec;6(12):1403-14. 3-aminotriazole (3AT) is known to reduce catalase levels in ocular tissues when given intravenously or orally. |
2(0,0,0,2) | Details |
| 16036580 | Gechev TS, Minkov IN, Hille J: peroxide-induced cell death in Arabidopsis: transcriptional and mutant analysis reveals a role of an -dependent dioxygenase gene in the cell death process. IUBMB Life. 2005 Mar;57(3):181-8. The catalase inhibitor aminotriazole (AT) reduced the catalase activity and caused endogenous accumulation of peroxide that eventually triggered cell death. |
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| 17206381 | Yang ES, Park JW: Antioxidant enzyme inhibitors enhance -induced cell death in U937 cells. Mol Cell Biochem. 2007 Jul;301(1-2):61-8. Epub 2007 Jan 6. The protective role of antioxidant enzymes against -induced oxidative damage in U937 cells was investigated in control and cells pre-treated with diethyldithiocarbamic acid, aminotriazole, and oxlalomalate, specific inhibitors of superoxide dismutase, catalase, and (+)-dependent isocitrate dehydrogenase, respectively. |
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| 9458725 | Kroll SL, Czyzyk-Krzeska MF: Role of H2O2 and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression. Am J Physiol. 1998 Jan;274(1 Pt 1):C167-74. Treatment with catalase or N-(2-mercaptopropionyl)- a reducing antioxidant agent that decreases H2O2 concentration, also induced TH mRNA. |
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| 8641435 | Banhegyi G, Csala M, Braun L, Garzo T, Mandl J: synthesis-dependent consumption in mouse liver. . FEBS Lett. 1996 Feb 26;381(1-2):39-41. This effect could be counteracted by the addition of catalase or mercaptosuccinate, indicating the role of peroxide formed during ascorbate synthesis in the depletion of GSH. |
1(0,0,0,1) | Details |
| 3415651 | Simmons TW, Jamall IS: Significance of alterations in hepatic antioxidant enzymes. Biochem J. 1988 May 1;251(3):913-7. The relative contributions of catalase and the selenoenzyme peroxidase (GSH-Px) were elucidated in the rat liver by selectively modulating the activities of these enzymes using dietary selenium (Se) and the catalase inhibitor 3-amino-1,2,4-triazole (3-AT). |
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| 2160967 | Heinecke JW, Shapiro BM: peroxidase activity of ovoperoxidase, the cross-linking enzyme of fertilization. J Biol Chem. 1990 Jun 5;265(16):9241-6. Ovoperoxidase catalyzed the breakdown of O2- in a reaction that was sensitive to inhibition by catalase, indicating a requirement for H2O2. |
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| 19933270 | Banerjee S, Zmijewski JW, Lorne E, Liu G, Sha Y, Abraham E: Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by peroxide. J Biol Chem. 2010 Jan 22;285(4):2665-75. Epub 2009 Nov 20. Lipopolysaccharide-induced SCF (beta-TrCP) ubiquitin ligase activity as well as binding of beta-TrCP to phosphorylated I kappaB alpha was decreased in the lungs of acatalasemic mice and mice treated with the catalase inhibitor aminotriazole, situations in which intracellular concentrations of H (2) O (2) are increased. |
1(0,0,0,1) | Details |
| 3624137 | Yusa T, Beckman JS, Crapo JD, Freeman BA: Hyperoxia increases H2O2 production by brain in vivo. J Appl Physiol. 1987 Jul;63(1):353-8. Hyperoxia and hyperbaric hyperoxia increased the rate of cerebral peroxide (H2O2) production in unanesthetized rats in vivo, as measured by the H2O2-mediated inactivation of endogenous catalase activity following injection of 3-amino-1,2,4-triazole. |
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| 16545695 | Scott MD: H2O2 injury in beta thalassemic erythrocytes: protective role of catalase and the prooxidant effects of GSH. Free Radic Biol Med. 2006 Apr 1;40(7):1264-72. Epub 2005 Dec 19. |
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| 14681974 | Lushchak OV, Bahniukova TV, Lushchak VI: [Effect of aminotriazole on the activity of catalase and glucose-6-phosphate dehydrogenase in tissues of two frog species--Rana ridibunda and Rana esculenta]. Ukr Biokhim Zh. 2003 Jul-Aug;75(4):45-50. |
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| 4040375 | DeMaster EG, Shirota FN, Nagasawa HT: Catalase mediated conversion of cyanamide to an inhibitor of aldehyde dehydrogenase. Alcohol. 1985 Jan-Feb;2(1):117-21. |
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| 8264727 | Atamna H, Ginsburg H: Origin of reactive species in erythrocytes infected with Plasmodium falciparum. Mol Biochem Parasitol. 1993 Oct;61(2):231-41. The rate of conversion is further increased in the presence of the catalase inhibitor 3-amino-1,2,4-triazole (3-AT) and the extent of inhibition of the lysate catalase increases upon acidification, implying that H2O2 is thus produced by the spontaneous dismutation of radicals generated during methemoglobin formation. |
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| 2272969 | Piantadosi CA, Tatro LG: Regional H2O2 concentration in rat brain after hyperoxic convulsions. . J Appl Physiol. 1990 Nov;69(5):1761-6. H2O2 concentration was determined ex vivo using a method based on the H2O2-dependent decline in catalase activity in the presence of the irreversible inhibitor of compound I, 3-amino-1,2,4-triazole. |
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| 17597213 | Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, Ijiri I: Catalase mediates formation in the striatum of free-moving rats. Neurotoxicology. 2007 Nov;28(6):1245-8. Epub 2007 May 13. |
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| 19659920 | Price M, Terlecky SR, Kessel D: A role for peroxide in the pro-apoptotic effects of photodynamic therapy. Photochem Photobiol. 2009 Nov-Dec;85(6):1491-6. A primary route for detoxification of cellular H2O2 involves the peroxisomal enzyme catalase. |
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| 9525474 | Hsieh HJ, Cheng CC, Wu ST, Chiu JJ, Wung BS, Wang DL: Increase of reactive species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression. J Cell Physiol. 1998 May;175(2):156-62. The shear-induced elevation of ROS was blocked by either antioxidant N-acetyl- (NAC) or catalase. |
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| 11110034 | Matutte B, Awe SO, Ameh FA, Leday AM, Rice JC, Opere CA, Ohia SE: Role of catalase in pre- and postjunctional responses of mammalian irides to peroxide. J Ocul Pharmacol Ther. 2000 Oct;16(5):429-38. |
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| 10812070 | Kowaltowski AJ, Vercesi AE, Rhee SG, Netto LE: Catalases and thioredoxin peroxidase protect Saccharomyces cerevisiae against Ca (2+)-induced mitochondrial membrane permeabilization and cell death. FEBS Lett. 2000 May 12;473(2):177-82. |
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| 2922765 | Boutin JA, Kass GE, Moldeus P: Drug-induced peroxide production in isolated rat hepatocytes. . Toxicology. 1989 Feb;54(2):129-37. A method for measuring drug-induced peroxide production in freshly isolated rat hepatocytes is described. 3-Amino-1,2,4-triazole, an irreversible inhibitor of the enzyme catalase markedly reduces the capacity of isolated hepatocytes to metabolize peroxide, with maximum inhibition (80%) being observed after 40 min of co-incubation. |
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| 2624761 | Simon RH, DeHart PD, Nadeau DM: Resistance of rat pulmonary alveolar epithelial cells to neutrophil- and oxidant-induced injury. Am J Respir Cell Mol Biol. 1989 Sep;1(3):221-9. In the present study, we investigated the roles of intracellular catalase and -dependent reactions in providing protection against cytotoxic concentrations of H2O2 and stimulated neutrophils. |
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| 1394830 | Inoue S, Ito K, Yamamoto K, Kawanishi S: causes metal-dependent damage to cellular and isolated DNA through H2O2 formation. Carcinogenesis. 1992 Sep;13(9):1497-502. The strand breakage was increased by the treatment of buthionine sulphoximine (a GSH synthesis inhibitor) and 3-aminotriazol (a catalase inhibitor) and decreased by catalase, indicating the involvement of H2O2. |
2(0,0,0,2) | Details |
| 7925949 | Willekens H, Villarroel R, Van Montagu M, Inze D, Van Camp W: Molecular identification of catalases from Nicotiana plumbaginifolia (L.). FEBS Lett. 1994 Sep 19;352(1):79-83. |
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| 3022971 | Dallegri F, Ballestrero A, Frumento G, Patrone F: Interference of target cell catalase with an early step of the neutrophil cytolytic pathway. Clin Exp Immunol. 1986 Sep;65(3):664-70. |
2(0,0,0,2) | Details |
| 3426683 | Shirota FN, DeMaster EG, Kwon CH, Nagasawa HT: Metabolism of cyanamide to and an inhibitor of aldehyde dehydrogenase (ALDH) by rat liver microsomes. Alcohol Alcohol Suppl. 1987;1:219-23. Rat liver microsomes, as well as purified catalase, convert the deterrent agent, cyanamide, to an active inhibitor of AlDH. |
2(0,0,0,2) | Details |
| 6404112 | Bond AN, Wickramasinghe SN: Investigations into the production of from by human blood and bone marrow cells in vitro. Acta Haematol. 1983;69(5):303-13. The metabolism of by nucleated marrow cells was only slightly inhibited by pyrazole and 3-amino-1,2,4-triazole indicating that it was largely independent of pyrazole-sensitive alcohol dehydrogenase and catalase. |
1(0,0,0,1) | Details |
| 1877684 | Banerjee A, Grosso MA, Brown JM, Rogers KB, Whitman GJ: metabolite effects on kinase and cardiac energetics after reperfusion. Am J Physiol. 1991 Aug;261(2 Pt 2):H590-7. There is also a burst of H2O2 during the first 10 min of reperfusion, as indicated by the in vivo inactivation of catalase that occurs only when H2O2, and the inactivator 3-aminotriazole (AMT), are simultaneously present. |
1(0,0,0,1) | Details |
| 11812238 | Bakeeva LE, Skulachev VP, Sudarikova YV, Tsyplenkova VG: Mitochondria enter the nucleus (one further problem in chronic alcoholism). Biochemistry. 2001 Dec;66(12):1335-41. The entrance of mitochondria into the nucleus was modeled in rats that were given and the catalase inhibitor aminotriazole for 12 weeks. |
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| 19515983 | Cardoso LM, Colombari DS, Menani JV, Toney GM, Chianca DA Jr, Colombari E: Cardiovascular responses to peroxide into the nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R462-9. Epub 2009 Jun 10. Injection of the catalase inhibitor 3-amino-1,2,4-triazole (100 nmol/40 nl) into the NTS also produced hypotension and bradycardia. |
1(0,0,0,1) | Details |
| 10712539 | Martinez C, Baccou JC, Bresson E, Baissac Y, Daniel JF, Jalloul A, Montillet JL, Geiger JP, Assigbetse K, Nicole M: mediated by the oxidative burst is a key molecule in local and systemic responses of cotton challenged by an avirulent race of Xanthomonas campestris pv malvacearum. Plant Physiol. 2000 Mar;122(3):757-66. The first peak of SA occurred 3 h after generation of (O (2)(.-)), and was inhibited by infiltration of catalase. |
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| 3148110 | Brown JM, Terada LS, Grosso MA, Whitman GJ, Velasco SE, Patt A, Harken AH, Repine JE: peroxide mediates reperfusion injury in the isolated rat heart. . Mol Cell Biochem. 1988 Dec;84(2):173-5. H2O2 was assessed using H2O2 dependent aminotriazole inactivation of myocardial catalase. |
1(0,0,0,1) | Details |
| 16054588 | Wagner BA, Evig CB, Reszka KJ, Buettner GR, Burns CP: Doxorubicin increases intracellular peroxide in PC3 prostate cancer cells. Arch Biochem Biophys. 2005 Aug 15;440(2):181-90. We studied the effect of doxorubicin on the production of peroxide by PC3 human prostate cancer cells, using a sensitive assay based on aminotriazole-mediated inhibition of catalase. |
1(0,0,0,1) | Details |
| 10190554 | Ziemann C, Burkle A, Kahl GF, Hirsch-Ernst KI: Reactive species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures. Carcinogenesis. 1999 Mar;20(3):407-14. Treatment of rat hepatocytes with the catalase inhibitor 3-amino-1,2,4-triazole (2-4 mM for 72 h or 10 mM for 1 h following the hepatocyte attachment period) also led to an up-regulation of mdrlb mRNA and P-glycoprotein expression. |
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| 19341793 | Onumah OE, Jules GE, Zhao Y, Zhou L, Yang H, Guo Z: Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells. Free Radic Biol Med. 2009 Jun 15;46(12):1658-67. Epub 2009 Mar 31. |
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| 18781324 | Shao N, Beck CF, Lemaire SD, Krieger-Liszkay A: Photosynthetic electron flow affects H2O2 signaling by inactivation of catalase in Chlamydomonas reinhardtii. Planta. 2008 Nov;228(6):1055-66. Epub 2008 Sep 10. |
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| 3965466 | Starke PE, Farber JL: Endogenous defenses against the cytotoxicity of peroxide in cultured rat hepatocytes. J Biol Chem. 1985 Jan 10;260(1):86-92. The catalase activity of cultured rat hepatocytes was inhibited by 90% pretreatment with 20 mM aminotriazole without effect on the activities of peroxidase or glutathione reductase, or on the viability of the cells over the subsequent 24 h. |
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| 11829410 | Milton NG: Inhibition of catalase activity with 3-amino-triazole enhances the cytotoxicity of the Alzheimer's amyloid-beta peptide. Neurotoxicology. 2001 Dec;22(6):767-74. |
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| 6846030 | Eide I, Syversen TL: Relationship between catalase activity and uptake of elemental mercury by rat brain. Acta Pharmacol Toxicol. 1983 Mar;52(3):217-23. |
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| 8719811 | Mian KB, Martin W: The inhibitory effect of 3-amino-1,2,4-triazole on relaxation induced by and azide but not peroxide or glyceryl trinitrate in rat aorta. Br J Pharmacol. 1995 Dec;116(8):3302-8. In this study we investigated the role of catalase in relaxation induced by azide, glyceryl trinitrate and peroxide in isolated rings of rat aorta. 2. |
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| 1784460 | Costarides AP, Riley MV, Green K: Roles of catalase and the redox cycle in the regulation of anterior-chamber peroxide. Ophthalmic Res. 1991;23(5):284-94. |
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| 1175685 | Vargaftig BB, Tranier Y, Chignard M: Blockade by metal complexing agents and by catalase of the effects of on platelets: relevance to the study of anti-inflammatory mechanisms. Eur J Pharmacol. 1975 Aug;33(1):19-29. |
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| 642030 | Feinstein RN, Fry RJ, Staffeldt EF: Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice. J Natl Cancer Inst. 1978 May;60(5):1113-6. |
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| 7980465 | Ou P, Wolff SP: Erythrocyte catalase inactivation (H2O2 production) by and in the presence of aminotriazole: role of transition metals and relevance to diabetes. Biochem J. 1994 Nov 1;303 ( Pt 3):935-9. |
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| 6703689 | Crane D, Masters C: On the role of catalase in the oxidation of tissue fatty acids. Arch Biochem Biophys. 1984 Feb 15;229(1):104-11. |
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| 12943922 | Sen P, Mukherjee S, Bhaumik G, Das P, Ganguly S, Choudhury N, Raha S: Enhancement of catalase activity by repetitive low-grade H2O2 exposures protects fibroblasts from subsequent stress-induced apoptosis. Mutat Res. 2003 Aug 28;529(1-2):87-94. |
3(0,0,0,3) | Details |
| 3828063 | Soffia F, Penna M: metabolism by rat heart homogenates. Alcohol. 1987 Jan-Feb;4(1):45-8. On the opposite, the presence of 3-amino-1,2,4-triazole (10 to 40 mM), a known catalase inhibitor, induced a concentration dependent reduction of the amount of AcH recovered during incubation even in presence of oxidase. |
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| 8417001 | Simonson SG, Zhang J, Canada AT Jr, Su YF, Benveniste H, Piantadosi CA: peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain. J Cereb Blood Flow Metab. 1993 Jan;13(1):125-34. Metabolism of H2O2 by catalase during ischemia and reperfusion was measured in forebrain homogenates using aminotriazole (ATZ), an irreversible H2O2-dependent inhibitor of catalase. |
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| 11216869 | Pedraza-Chaverri J, Granados-Silvestre MD, Medina-Campos ON, Maldonado PD, Olivares-Corichi IM, Ibarra-Rubio ME: Post-transcriptional control of catalase expression in garlic-treated rats. Mol Cell Biochem. 2001 Jan;216(1-2):9-19. |
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| 2249888 | Berger EM, Beehler CJ, Harada RN, Repine JE: Human phagocytic cells as metabolite scavengers. Inflammation. 1990 Oct;14(5):613-9. Treatment with aminotriazole or azide decreased both phagocyte and erythrocyte catalase activity and the ability of each cell to decrease H2O2 concentrations in vitro. |
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| 3355670 | Tampier L, Quintanilla ME, Letelier C, Mardones J: Effect of 3-amino-1,2,4-triazole on narcosis time and lethality of in UChA rats. Alcohol. 1988 Jan-Feb;5(1):5-8. The capacity of rat brain homogenates to oxidize by catalase peroxidative system, previously reported, was reevaluated in experiments using lower concentration, showing that the effect of this system can be observed even with a concentration of 50 mM, equivalent to non lethal blood level. |
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| 8399363 | Gulati S, Ainol L, Orak J, Singh AK, Singh I: Alterations of peroxisomal function in ischemia-reperfusion injury of rat kidney. Biochim Biophys Acta. 1993 Oct 20;1182(3):291-8. We have previously demonstrated that ischemic injury results in the loss of peroxisomal functions (e.g., inhibition of catalase activity and fatty-acid beta-oxidation activity). |
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| 1417978 | Marcocci L, Pietrangeli P, Mavelli I, Rotilio G: Plasma membrane as a site of redox activation of daunomycin in intact human erythrocytes. Biochem Pharmacol. 1992 Oct 20;44(8):1535-42. The method of H2O2-dependent irreversible inhibition of catalase (EC 1.11.1.6) activity by 3-amino-1,2,4-triazole was applied to intact erythrocytes, as well as to isolated membranes with added purified catalase. |
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| 4690233 | Nakamura A, Hara T, Minakami S: Intracellular distribution of hepatic catalase activity in rats treated with aminotriazole and allylisopropylacetamide. J Biochem. 1973 Jan;73(1):47-53. |
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| 2308904 | Lopez-Torres M, Perez-Campo R, Barja de Quiroga G: Aminotriazole effects on lung and heart H2O2 detoxifying enzymes and TBA-RS at two pO2. Pharmacol Toxicol. 1990 Jan;66(1):27-31. In order to clarify the physiological role in vivo of H2O2-detoxifying enzymes at low and high levels of O2 tension we studied catalase (CAT), peroxidases (GP), and in vivo peroxidation (TBA-RS) in the lung and heart of Rana perezi frogs chronically treated with hyperoxia, aminotriazole (AT) -a CAT inhibitor-, or both. |
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| 7143231 | Khayat AI, Shaikh ZA: Dose-effect relationship between pretreatment and retention and tissue distribution of mercury vapor in rats. J Pharmacol Exp Ther. 1982 Dec;223(3):649-53. Studies in rats treated with 3-aminotriazole indicated that probably also acted by inhibition of catalase-mediated oxidation of mercury vapor. |
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| 8250959 | Aniya Y, Shimoji M, Naito A: Increase in liver microsomal glutathione S-transferase activity by phenobarbital treatment of rats. Biochem Pharmacol. 1993 Nov 17;46(10):1741-7. When rats were given phenobarbital (PB) intraperitoneally for 3 days, liver microsomal GSH S-transferase activity was stimulated 1.3-1.4-fold and the effect of PB on the transferase was potentiated by combination with a catalase inhibitor, 3-amino-1,2,4-triazole. |
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| 1023562 | Lassman H: [Effect of on mouse modulla with simultaneous inhibition of catalase with aminotriazole] Verh Anat Ges. 1976;(70 Pt 1):127-32. |
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| 215336 | Miura T, Ogiso T: Effect of 3-amino-1,2,4-triazole on catalase and formation of methemoglobin from oxyhemoglobin in erythrocyte by radicals. Chem Pharm Bull. 1978 Nov;26(11):3540-5. |
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| 431040 | Davies P, Drath DB, Engel EE, Huber GL: The localization of catalase in the pulmonary alveolar macrophage. . Lab Invest. 1979 Feb;40(2):221-6. |
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| 12474118 | Pastor R, Sanchis-Segura C, Aragon CM: -stimulated behaviour in mice is modulated by brain catalase activity and H2O2 rate of production. Psychopharmacology. 2002 Dec;165(1):51-9. Epub 2002 Oct 25. |
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| 8489262 | Bradford BU, Seed CB, Handler JA, Forman DT, Thurman RG: Evidence that catalase is a major pathway of oxidation in vivo: dose-response studies in deer mice using as a selective substrate. Arch Biochem Biophys. 1993 May 15;303(1):172-6. |
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| 16023088 | Bagnyukova TV, Vasylkiv OY, Storey KB, Lushchak VI: Catalase inhibition by amino triazole induces oxidative stress in goldfish brain. Brain Res. 2005 Aug 9;1052(2):180-6. |
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| 1540380 | Kinnula VL, Whorton AR, Chang LY, Crapo JD: Regulation of peroxide generation in cultured endothelial cells. . Am J Respir Cell Mol Biol. 1992 Feb;6(2):175-82. Extracellular H2O2 generation was determined spectrofluorometrically using and intracellular H2O2 production (in or near peroxisomes) was measured indirectly using aminotriazole, which inactivates catalase in the presence of H2O2. |
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| 1755337 | Ohmori T, Takamoto K, Ogata M: The role of catalase in protecting erythrocytes against methemoglobin formation. Acta Med Okayama. 1991 Oct;45(5):321-4. |
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| 9203303 | Moreno-Sepulveda M, Vargas-Zapata R, Ballesteros-Elizondo R, Pineyro-Lopez A, Sepulveda-Saavedra J: Studies on the effect of peroxisomicine on catalase activity in albino mice. Toxicon. 1997 May;35(5):777-83. |
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| 9207193 | Obinger C, Regelsberger G, Strasser G, Burner U, Peschek GA: Purification and characterization of a homodimeric catalase-peroxidase from the cyanobacterium Anacystis nidulans. Biochem Biophys Res Commun. 1997 Jun 27;235(3):545-52. |
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| 9032791 | Ohta Y, Yamasaki T, Niwa T, Niimi K, Majima Y, Ishiguro I: Role of catalase in retinal antioxidant defence system: its comparative study among rabbits, guinea pigs, and rats. Ophthalmic Res. 1996;28(6):336-42. |
4(0,0,0,4) | Details |
| 6630509 | Balsam A, Sexton F, Borges M, Ingbar SH: Formation of diiodotyrosine from J Clin Invest. 1983 Oct;72(4):1234-45. Studies were performed to elucidate the nature of the pathway of hepatic (T4) metabolism that is activated by inhibitors of liver catalase. |
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| 15577745 | Piotrowski WJ, Marczak J, Kurmanowska Z, Gorski P: Concentration of TBA-reactive substances in type II pneumocytes exposed to oxidative stress. Arch Immunol Ther Exp. 2004 Nov-Dec;52(6):435-40. Aminotriazol (ATZ), an inhibitor of intracellular catalase, was used to estimate the protective role of catalase. |
3(0,0,0,3) | Details |
| 19607981 | Amantea D, Marrone MC, Nistico R, Federici M, Bagetta G, Bernardi G, Mercuri NB: Oxidative stress in stroke pathophysiology validation of peroxide metabolism as a pharmacological target to afford neuroprotection. Int Rev Neurobiol. 2009;85:363-74. is converted by superoxide dismutase into peroxide (H2O2), and the latter is then transformed into the toxic through the Haber-Weiss reaction, converted to water by peroxidase (GPx) or dismuted to water and through catalase. |
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| 3777154 | Suttorp N, Toepfer W, Roka L: Antioxidant defense mechanisms of endothelial cells: redox cycle versus catalase. Am J Physiol. 1986 Nov;251(5 Pt 1):C671-80. |
3(0,0,0,3) | Details |
| 8433009 | Karg E, Odh G, Wittbjer A, Rosengren E, Rorsman H: peroxide as an inducer of elevated tyrosinase level in melanoma cells. J Invest Dermatol. 1993 Feb;100(2 Suppl):209S-213S. Inhibition of intracellular catalase by 3-amino-1,2,4-triazole caused an increase in the tyrosinase level. |
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| 1911044 | Shau HY: Red cell regulation of tumor necrosis factor-induced human neutrophil cytostatic activity. Cancer Commun. 1991 Sep;3(9):283-6. RBC have two major pathways to detoxify H2O2, one by catalase and the other by the redox cycle. |
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| 2129307 | Karinje KU, Ogata M: metabolism in acatalasemic mice. Physiol Chem Phys Med NMR. 1990;22(4):193-8. metabolism was also studied in acatalasemic and normal mice treated with 3-amino-1,2,4-triazole (AT), which is known to be an inhibitor of catalase (EC 1.11.1.6). |
2(0,0,0,2) | Details |
| 7980410 | Fandrey J, Frede S, Jelkmann W: Role of peroxide in hypoxia-induced erythropoietin production. . Biochem J. 1994 Oct 15;303 ( Pt 2):507-10. Likewise, elevation of endogenous H2O2 levels by the addition of or the catalase inhibitor, aminotriazole, dose-dependently lowered Epo production. |
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| 9054188 | Cejkova J, Lojda Z: Histochemical study on xanthine oxidase activity in the normal rabbit cornea and lens and after repeated irradiation of the eye with UVB rays. Acta Histochem. 1996 Jan;98(1):47-52. Application of catalase, a scavenger of peroxide, to the eye surface during the irradiation diminished the increase of xanthine oxidase activity. |
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| 10086993 | Hiraishi H, Shimada T, Ivey KJ, Terano A: Role of antioxidant defenses against -induced damage in cultured rat gastric epithelial cells. J Pharmacol Exp Ther. 1999 Apr;289(1):103-9. The effects of impairment of the redox cycle and of inhibition of cellular catalase were examined. |
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| 1479014 | Nasr-Esfahani MH, Johnson MH: Quantitative analysis of cellular in early preimplantation mouse embryos developing in vivo and in vitro. Hum Reprod. 1992 Oct;7(9):1281-90. It is concluded that early embryos lack a mercaptosuccinate sensitive peroxidase activity for removing H2O2, which may be removed by catalase or the glutathione-S-transferase system. |
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| 1794560 | Unger WG, Boulton ME, Petal S, Goldsmith JP: Catalase activity in cultured human retinal pigment epithelial cells. Biochem Soc Trans. 1991 Nov;19(4):443S. |
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| 4763658 | Nakamura A, Minakami S: Turnover of hepatic catalase modified by aminotriazole. J Biochem. 1973 Oct;74(4):683-9. |
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| 4696515 | Nicolosi RJ, Baird MB, Massie HR, Samis HV: Senescence in Drosophila. Exp Gerontol. 1973 Apr;8(2):101-8. Renewal of catalase activity in flies of different ages. |
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| 9620307 | Peus D, Vasa RA, Meves A, Pott M, Beyerle A, Squillace K, Pittelkow MR: H2O2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes. J Invest Dermatol. 1998 Jun;110(6):966-71. Phosphorylation of EGFR was inhibited by the structurally unrelated antioxidants butylated hydroxyanisole, N-acetyl- and pyrrolidine dithiocarbamate, or by the H2O2-degrading enzyme catalase. |
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| 9385142 | De Lucas JR, Valenciano S, Dominguez AI, Turner G, Laborda F: Characterization of -nonutilizing mutants of Aspergillus nidulans isolated by the 3-amino-1,2,4-triazole positive selection method. Arch Microbiol. 1997 Dec;168(6):504-12. Conidia of Aspergillus nidulans were mutagenized with ultraviolet light and were incubated on a special selective medium containing the catalase inhibitor 3-amino-1,2,4-triazole. |
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| 19543301 | Guo HC, Zhang Z, Zhang LN, Xiong C, Feng C, Liu Q, Liu X, Shi XL, Wang YL: Chronic intermittent hypobaric hypoxia protects the heart against ischemia/reperfusion injury through upregulation of antioxidant enzymes in adult guinea pigs. Acta Pharmacol Sin. 2009 Jul;30(7):947-55. Epub 2009 Jun 22. The activity and protein expression of superoxide dismutase (SOD) and catalase (CAT) were significantly increased in the myocardium of CIHH guinea pigs. |
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| 6282638 | Geerts A, Roels F: In vivo cooperation between hepatic catalase and superoxide dismutase demonstrated by diethyldithiocarbamate. FEBS Lett. 1982 Apr 19;140(2):245-7. |
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