| Name | aspartate aminotransferase |
|---|---|
| Synonyms | Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16298865 | Jin YS, Heo SI, Lee MJ, Rhee HI, Wang MH: Free radical scavenging and hepatoprotective actions of Quercus aliena acorn extract against CCl4-induced liver. Free Radic Res. 2005 Dec;39(12):1351-8. Pretreatment with Quercus aliena acorn extracts reduced the increase in serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) levels. |
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| 15350811 | Kus I, Colakoglu N, Pekmez H, Seckin D, Ogeturk M, Sarsilmaz M: Protective effects of phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats. Anal Chim Acta. 2009 Jan 5;631(1):116-20. Epub 2008 Oct 22. Serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total and conjugated levels and hepatic malondialdehyde (MDA) contents were determined. |
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| 15818738 | Song SL, Gong ZJ, Zhang QR, Huang TX: Effects of Chinese traditional compound, JinSanE, on expression of TGF-beta1 and TGF-beta1 type II receptor mRNA, Smad3 and Smad7 on experimental hepatic fibrosis in vivo. J Viral Hepat. 2008 Jul;15(7):508-14. Epub 2008 Apr 4. The activities of several serum fibrosis-associated enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), the levels of serum (HA) were assayed. In this study, the therapeutic effects of Chinese traditional compound decoction, JinSanE, and the changes of TGF-beta/Smad signaling pathway system in carbon tetrachloride (CCl (4))-induced rat experimental liver fibrosis were examined. |
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| 19527736 | Cho YK, Yun JW, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Jin W, Kwon YH, Shin MK, Yoo TM, Kang JH, Park CS: Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers. Phytomedicine. 2004 Feb;11(2-3):152-6. Serum was assayed for hepatic enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities. |
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| 15194653 | Thirunavukkarasu C, Yang Y, Subbotin VM, Harvey SA, Fung J, Gandhi CR: Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats. J Med Food. 2007 Mar;10(1):110-7. TAK-044 treatment caused significant amelioration of portal hypertension, systemic hypotension, and liver injury (reduced activities of serum aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase), and improved hepatic synthetic capacity (increased serum albumin concentration) in both groups of rats relative to vehicle treated rats. |
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| 15902742 | Gui SY, Wei W, Wang H, Wu L, Sun WY, Wu CY: Protective effect of fufanghuangqiduogan against acute liver injury in mice. Gut. 2004 Jul;53(7):1010-9. METHODS: ALI was successfully induced by injecting carbon tetrachloride (CCl4) intraperitoneally and by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice, respectively. At the end of the experiment, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), content of malondialdehyde (MDA), activities of superoxide dismutase (SOD) and peroxidase (GSH-px) in liver homogenate were measured by biochemical methods. |
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| 18023088 | Li LJ, Yang YG, Zhang ZL, Nie SF, Li Z, Li F, Hua HY, Hu YJ, Zhang HS, Guo YB: Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs. Acta Pharmacol Sin. 2004 Jul;25(7):915-20. AIM: To investigate the protective effect of medical ozone (O (3)) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl (4))-induced hepatic injury in dogs. The biochemical and hematological indexes of alanine aminotransferase (ALT), aspartate aminotransferase/alanine aminotransferase (AST/ALT), serum total (TBIL), prothrombin time (PT), blood (AMMO), and blood urea (BUN) were measured after CCl (4) injection. |
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| 19220677 | Luo L, Zhou A: Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury. J Nutr Biochem. 2007 Dec;18(12):795-805. Epub 2007 May 3. RESULTS: The serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase and of liver fibrosis rats improved significantly by treatment with anisodamine. |
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| 19136384 | Ferre N, Martinez-Clemente M, Lopez-Parra M, Gonzalez-Periz A, Horrillo R, Planaguma A, Camps J, Joven J, Tres A, Guardiola F, Bataller R, Arroyo V, Claria J: Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Food Chem Toxicol. 2008 Oct;46(10):3311-7. Epub 2008 Aug 12. In this study, apolipoprotein E-deficient (ApoE-/-) mice were evaluated to define potential effects of hypercholesterolemia on the severity of carbon tetrachloride (CCl4)-induced liver injury. After CCl4 challenge, ApoE-/- mice exhibited exacerbated steatosis (Oil Red O staining), necroinflammation (hematoxylin-eosin staining), macrophage infiltration (F4/80 immunohistochemistry), and fibrosis (Sirius red staining and alpha-smooth muscle actin immunohistochemistry) and more severe liver injury [alanine aminotransferase (ALT) and aspartate aminotransferase] than wild-type controls. |
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| 18695788 | Martinez JA, Ramos SG, Meirelles MS, Verceze AV, Arantes MR, Vannucchi H: [Effects of on bleomycin-induced lung injury: a preliminary study]. Ross Fiziol Zh Im I M Sechenova. 2005 Mar;91(3):314-20. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). RESULTS: There were statistically significant differences between the BDL control and BDL experimental groups: aspartate aminotransferase (105.3 +/- 43 vs. 500.5 +/- 90.3 IU/L); alanine aminotransferase (78.75 +/- 37.7 vs. 162.75 +/- 35.4 IU/L); alkaline phosphatase (160 +/- 20.45 vs. 373.25 +/- 45.44 IU/L); arterial tension (85.25 +/- 8.1 vs. 49.9 +/- 22.5 mmHg); and saturation (95 +/- 0.7 vs. 73.3 +/- 12.07%). |
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| 19080687 | Sun C, Li DG, Chen YW, Chen YW, Wang BC: [Effects of gene-transfected bone marrow-derived liver stem cell transplantation on accumulation of extracellular matrix in rats with liver fibrosis]. J Bras Pneumol. 2008 Jul;34(7):445-52. Twenty-seven female rats were randomly divided into 3 equal groups to undergo subcutaneous injection of carbon tetrachloride to establish liver fibrosis models and then randomly divided into 3 equal groups: model group injected with normal saline via caudal vein, BDLSC group injected with 2 x 10 (6) BDLSCs via caudal vein, and BDLSC-uPA group injected with 2 x 10 (6) AduPA-transfected BDLSCs. Eight weeks later the serum levels of transaminase (ALT), aspartate aminotransferase (AST), total (TBIL), albumin (ALB), and ECM levels, i.e., laminin (LN), and procollagen III (PC III), were detected. |
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| 19703545 | Wu YH, Zhang XM, Hu MH, Wu XM, Zhao Y: Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo. Zhong Xi Yi Jie He Xue Bao. 2005 Nov;3(6):470-2. RESULTS: TPLA significantly reduced cellular leakage of hepatocyte aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and improved cell viability in vitro. |
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| 18404596 | Leal LK, Fonseca FN, Pereira FA, Canuto KM, Felipe CF, Fontenele JB, Pitombeira MV, Silveira ER, Viana GS: Protective effects of amburoside A, a glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats. Planta Med. 2008 Apr;74(5):497-502. Epub 2008 Apr 10. The aim of this study was to investigate the possible beneficial effects of amburoside A, AMB [4-(O-beta- D-glycopyranosyl) benzyl protocatechoate], against carbon tetrachloride (CCl (4)) toxicity in rats. O.) treatments of CCl (4)-intoxicated rats significantly inhibited the increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as compared to the group treated with CCl (4) only. |
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| 16629373 | Roy CK, Kamath JV, Asad M: Hepatoprotective activity of Psidium guajava Linn. leaf extract. J Appl Toxicol. 2007 Jan-Feb;27(1):25-31. The study was designed to evaluate the hepatoprotective activity of P. guajava in acute experimental liver injury induced by carbon tetrachloride, or thioacetamide and chronic liver damage induced by carbon tetrachloride. In the acute liver damage induced by different hepatotoxins, P. guajava leaf extracts (250 and 500mg/kg, po) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and |
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| 16050911 | Yonezawa LA, Kitamura SS, Mirandola RM, Antonelli AC, Ortolani EL: Preventive treatment with alleviates the poisoning effects of carbon tetrachloride in cattle. Food Chem Toxicol. 2008 Dec;46(12):3707-13. Epub 2008 Sep 26. Food intake was recorded and blood samples collected daily for 8 days after the CCl4 drenching to compare the activity of aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT) and the levels of erythrocyte (GSH) and serum malonyldialdehyde (MDA). |
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| 18007555 | Balderas-Renteria I, Camacho-Corona Mdel R, Carranza-Rosales P, Lozano-Garza HG, Castillo-Nava D, Alvarez-Mendoza FJ, Tamez-Cantu EM: Hepatoprotective effect of Leucophyllum frutescens on Wistar albino rats intoxicated with carbon tetrachloride. J Med Food. 2007 Jun;10(2):350-5. Levels of marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were increased significantly in CCl (4) treated rats (Group II). |
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| 18800905 | Adaramoye OA, Farombi EO, Nssien M, Idowu SO, Ademowo OG, Adeyemi EO: Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride. J Med Food. 2008 Sep;11(3):544-50. Pretreatment with KV, FI, and FII at a dose of 100 mg/kg of body weight for 2 weeks and then challenge with CCl (4) at a dose of 1.2 g/kg of body weight, three times a week for 2 consecutive weeks, decreased the CCl (4)-induced increase in activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) by 31%, 30%, and 31% and 41%, 55%, and 42%, respectively. |
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| 15968718 | Gao H, Zhou YW: Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II. Cell Biochem Funct. 2005 May-Jun;23(3):169-74. METHODS: Three animal models of liver damage induced by carbon tetrachloride (CCl (4): 0.1 mL/10 g, ip), D-galactosamine (D-GalN: 500 mg/kg, ip) and (AP: 0.15 g/kg, ip) were respectively treated with various concentrations of picroside II (5, 10, 20 mg/kg, ig). Then we chose the continuously monitoring method (recommended by International Clinical Chemistry League) to analyze serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values, Marland method to detect the activity of manganese-superoxide dismutase (SOD) in liver mitochondria, TBA colorimetry to determine the content of malonicdialdehyde (MDA) in liver tissue, DTNB method to evaluate the activity of glutathioneperoxidase (GSH-Px) and Lowry method to detect protein level in liver tissue. |
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| 15276869 | Campo GM, Avenoso A, Campo S, D'Ascola A, Ferlazzo AM, Calatroni A: The antioxidant and antifibrogenic effects of the glycosaminoglycans and -4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis. Zhong Xi Yi Jie He Xue Bao. 2008 Nov;6(11):1145-51. At the end of the 6-week treatment period (24 h after the last dose of GAGs), the following parameters were evaluated: (1) serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, as index of hepatic cell disruption; (2) hepatic conjugated dienes (CD), as index of lipid peroxidation; (3) hepatic TIMPs activity and expression; (4) hepatic superoxide dismutase (SOD) and peroxidase (GPx) activity, as index of endogenous defences; (5) hepatic as index of collagen deposition. |
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| 19812219 | Hosono-Fukao T, Hosono T, Seki T, Ariga T: Diallyl trisulfide protects rats from carbon tetrachloride-induced liver injury. J Nutr. 2009 Dec;139(12):2252-6. Epub 2009 Oct 7. DATS pretreatment significantly suppressed the CCl (4)-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase activities (P < 0.05). |
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| 19327382 | Tung YT, Wu JH, Huang CC, Peng HC, Chen YL, Yang SC, Chang ST: Protective effect of Acacia confusa bark extract and its active compound against carbon tetrachloride-induced chronic liver injury in rats. Food Chem Toxicol. 2009 Jun;47(6):1385-92. Epub 2009 Mar 25. CCl (4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), peroxidase (GPX) and catalase (CAT) in erythrocytes. |
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| 18418968 | Chen Y, Tao YY, Li FH, et al: [Effects of Danggui Buxue Decoction on liver fibrosis and hepatic lipid peroxidation in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jan;28(1):39-42. METHODS: Liver fibrosis model was established in 28 rats by the combination of injecting carbon tetrachloride (CCl4) subcutaneously and feeding high lipid and low protein diet. The inflammation and fatty degeneration in rat liver tissues were examined with HE staining; the collagen deposition observed with sirius red; the liver function including serum level of transaminase (ALT), aspartate aminotransferase (AST), albumin (Alb) and total (TBil) were determined using corresponding test kits; the hepatic lipid peroxidation indexes, including triglyceride (TG), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured by biochemical methods; the hepatic (Hyp) content was detected with Jamall's method and the expression of collagen type I was analyzed by Western blotting. |
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| 18695789 | Vercelino R, Tieppo J, Forgiarini Junior LA, Dias AS, Marroni CA, Marroni NP: [Experimental models for assessment of pulmonary alterations in hepatopulmonary syndrome]. Artif Cells Blood Substit Immobil Biotechnol. 2005;33(2):201-13. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). RESULTS: There were statistically significant differences between the BDL control and BDL experimental groups: aspartate aminotransferase (105.3 +/- 43 vs. 500.5 +/- 90.3 IU/L); alanine aminotransferase (78.75 +/- 37.7 vs. 162.75 +/- 35.4 IU/L); alkaline phosphatase (160 +/- 20.45 vs. 373.25 +/- 45.44 IU/L); arterial tension (85.25 +/- 8.1 vs. 49.9 +/- 22.5 mmHg); and saturation (95 +/- 0.7 vs. 73.3 +/- 12.07%). |
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| 15700767 | Ogeturk M, Kus I, Kavakli A, Zararsiz I, Ilhan N, Sarsilmaz M: Effects of on carbon tetrachloride-induced changes in rat serum. Differentiation. 2008 May;76(5):495-505. Epub 2007 Dec 17. Serum urea, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and conjugated alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total iron, and levels were determined. |
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| 15630193 | Fukao T, Hosono T, Misawa S, Seki T, Ariga T: Chemoprotective effect of diallyl trisulfide from garlic against carbon tetrachloride-induced acute liver injury of rats. J Gene Med. 2008 Jan;10(1):94-100. In the CCl4-induced acute liver injury model of rats, DATS (10 micromol/kg) significantly suppressed the increase in plasma lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) activities. |
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| 18664124 | Bezborodkina NN, Okovityi SV, Kudriavtseva MV, Kirik OV, Zarubina IV, Kudriavtsev BN: [Morphometry of hepatocyte mitochondrial apparatus in normal and cirrhotic rat liver]. Tsitologiia. 2008;50(3):228-36. Activities of and aspartate aminotransferases in blood of rats of experimental group exceeded normal ones 2.0 and 1.4 times, respectively. |
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| 17481882 | Zhen MC, Wang Q, Huang XH, Cao LQ, Chen XL, Sun K, Liu YJ, Li W, Zhang LJ: Green tea polyphenol inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis. Eur Surg Res. 2009;42(1):35-9. Epub 2008 Nov 6. caused significant amelioration of liver injury (reduced activities of serum alanine aminotransferase and aspartate aminotransferase). |
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| 15210065 | Yao HW, Li J, Chen JQ, Xu SY: Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats. World J Gastroenterol. 2005 May 21;11(19):2984-9. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), (NO) levels in plasma and (Hyp) contents in liver tissue were assayed by spectrophotometry. |
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| 20038332 | Wu XR, Wang Q, Wang L, Shi SS, Guo WD: [The effect of urokinase on hepatic fibrogenesis in rats] . Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):910-4. METHODS: Hepatic fibrosis was induced in rats by complex pathogenic factors including subcutaneous injections of carbon tetrachloride, and feeding. The serum levels of hyaluronicacid (HA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), (TBil) and the content of liver (Hyp) were detected using ELISA kits. |
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| 16381635 | Liu SQ, Yu JP, He L, Yu HG, Luo HS: [Effects of nuclear factor kappaB and transforming growth factor beta1 in the anti-liver fibrosis process using Ginkgo biloba extract]. Fitoterapia. 2010 Jan;81(1):1-7. Epub 2009 Jul 8. Malondialdehyde (MDA), superoxide dismutase (SOD) and peroxidase (GSH-Px) in liver tissues and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the sera were also examined. |
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| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. J Pharm Pharmacol. 2009 Nov;61(11):1511-20. Dicofol pretreatment at 25mg/kg increased CCl4-induced serum alanine aminotransferase activity by 4.3-fold and aspartate aminotransferase activity by 4.1-fold. |
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| 16173536 | Tang XH, Gao J, Fang F, Chen J, Xu LZ, Zhao XN, Xu Q: Hepatoprotection of oleanolic acid is related to its inhibition on mitochondrial permeability transition. Basic Clin Pharmacol Toxicol. 2009 Dec;105(6):380-6. Epub 2009 Sep 30. The protective effects of oleanolic acid (OA) on carbon tetrachloride (CCl4)-induced liver mitochondrial damage and the possible mechanisms were investigated. Pretreatment with OA prior to the administration of CCl4 significantly suppressed the increases of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (4.2- and 19.9-fold, respectively) in a dose-dependent manner in mice. |
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| 15635156 | Aniya Y, Koyama T, Miyagi C, Miyahira M, Inomata C, Kinoshita S, Ichiba T: Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Acta Histochem. 2004;106(4):289-97. Galactosamine (GalN, 400 mg/kg) and lipopolysaccharide (LPS, 0.5 microg/kg) induced hepatotoxicity of rats as seen by an elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and of lipid peroxidation in liver homogenates was significantly depressed when the herbal extract was given intraperitoneally 1 and 15 h before GalN and LPS treatment. Similarly, carbon tetrachloride (CCl4) induced liver injury as evidenced by an increase in AST and ALT activities in serum was also inhibited by the extract pretreatment. |
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| 17660703 | Qin LQ, Wang Y, Xu JY, Kaneko T, Sato A, Wang PY: One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats. Tohoku J Exp Med. 2007 Aug;212(4):379-87. After the challenge by CHCl (3) and CCl (4), the activities of aspartate aminotransferase and alanine aminotransferase, marker enzymes for liver damage, were elevated remarkably at all food groups. |
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| 18840618 | Young TH, Tang HS, Chao YC, Lee HS, Hsiong CH, Pao LH, Hu OY: Quantitative rat liver function test by single point method. World J Gastroenterol. 2005 Apr 21;11(15):2269-76. Rats were treated either with carbon tetrachloride (CCl (4)) alone (1 mL/kg, intraperitoneally [i.p.]) for one day or with isoniazid (INH) alone (150 mg/kg, i.p.) or (in order to ameliorate the effects of INH) with a combination of INH and bis-p-nitrophenyl (BNPP) (25 mg/kg, i.p.) for 21 days. Hepatotoxicity was assayed by plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and scores of histological activity index-necroinflammation (HAI-NI) of the respective liver specimens. |
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| 19066852 | Iida C, Fujii K, Koga E, Washino Y, Kitamura Y, Ichi I, Abe K, Matsura T, Kojo S: Effect of on carbon tetrachloride intoxication in the rat liver. Life Sci. 2009 Aug 12;85(7-8):281-90. Epub 2009 Jun 13. After 12 h, the activity of plasma ALT (alanine aminotransferase) was significantly higher than that of the control group, and plasma ALT and AST (aspartate aminotransferase) activities significantly increased 24 h after CCl (4) administration. |
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| 19848203 | Hong ZF, Li TJ, Zhao JY: [Effect of total alkaloids of Rubus alceaefolius poiron on gene expressions of CYP2E1 and CYP3A1 in rats with acute liver injury]. Eur J Pharmacol. 2010 Apr 10;631(1-3):53-60. Epub 2010 Jan 13. The model of acute hepatic injury was established with intra-peritoneal injection of carbon tetrachloride. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and severity of hepatic tissue injury were measured, and the mRNA expressions of CYP2E1 and CYP3A1 in liver tissue were detected by RT-PCR. |
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| 18761048 | Hsu YW, Tsai CF, Chang WH, Ho YC, Chen WK, Lu FJ: Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Zhonghua Yi Xue Za Zhi. 2007 Mar 27;87(12):859-62. CCl (4) induced liver damage and significantly (p <0.05) increased the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum and decreased the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), and GSH content in liver whereas increased hepatic malondialdehyde (MDA) content as compared with control group. |
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| 19054144 | Cui CP, Wei P, Liu Y, Zhang DJ, Wang LS, Wu CT: The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*. Zhonghua Gan Zang Bing Za Zhi. 2005 Dec;13(12):903-7. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity in rat serum were measured using biochemical assay. |
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| 16609998 | Cheung PY, Zhang Q, Zhang YO, Bai GR, Lin MC, Chan B, Fong CC, Shi L, Shi YF, Chun J, Kung HF, Yang M: Effect of WeiJia on carbon tetrachloride induced chronic liver injury. Regul Toxicol Pharmacol. 2007 Nov;49(2):101-6. Epub 2007 Feb 14. Degree of fibrosis were measured and serological markers for liver fibrosis and function including (HA), type IV collagen (CIV), gamma-glutamyl transferase (gamma-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. |
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| 18433134 | Seki T, Morimura S, Tabata S, Tang Y, Shigematsu T, Kida K: Antioxidant activity of produced from distilled residues of the Japanese liquor shochu. J Vet Med A Physiol Pathol Clin Med. 2005 Aug;52(6):292-7. Consequently, treatment with AFP at 200 mg/kg body weight or higher doses suppressed the elevation of alanine aminotransferase and aspartate aminotransferase levels in serum (P < 0.05). Its antioxidant activity was evaluated in vivo using carbon tetrachloride (CCl (4))-induced acute liver injury mouse models. |
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| 15299229 | Hewawasam RP, Jayatilaka KA, Pathirana C, Mudduwa LK: Hepatoprotective effect of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice. Toxicology. 2009 Jun 30;261(1-2):33-40. Epub 2009 Apr 24. Blood and liver tissue were collected for the assessment of serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and liver level. |
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| 19718641 | Liu F, Liu ZD, Wu N, Cong X, Fei R, Chen HS, Wei L: Transplanted endothelial progenitor cells ameliorate carbon tetrachloride-induced liver cirrhosis in rats. Pak J Pharm Sci. 2010 Jan;23(1):15-20. EPCs reduced the expression of alpha-smooth muscle actin, collagen III, and transforming growth factor beta (P < 0.05) as well as levels of aspartate aminotransferase, alanine aminotransferase, and total in the serum (P < 0.05), but at the same time they increased the levels of albumin and Ki67. |
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| 17973934 | Zhang BJ, Xu D, Guo Y, Ping J, Chen LB, Wang H: Protection by and anti-oxidant mechanism of against rat liver fibrosis induced by multiple hepatotoxic factors. Cell Biochem Funct. 2005 Sep-Oct;23(5):353-9. Serum levels of alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST), hepatic activity of superoxide dismutase (SOD) and hepatic malondialdehyde (MDA) and hepatic (Hyp) content were determined. |
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| 19938218 | Chao J, Lee MS, Amagaya S, Liao JW, Wu JB, Ho LK, Peng WH: Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride. J Ethnopharmacol. 2008 Feb 28;116(1):1-6. Epub 2007 Aug 19. Rats pretreated orally with SDGL (EtOH) (100 and 500 mg/kg) and silymarin (200 mg/kg) for 3 consecutive days prior to the administration of a single dose of 50% CCl (4) (0.10 ml/100 g of bw, ip) significantly prevented the increases in the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl (4)-treated rats. |
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| 18795620 | Zhao C, Dai CL, Xu F, Ju XH, Li XD, Wang CY: [Patterns of hepatic cells death during hepatic ischemia/reperfusion injury in cirrhotic rats]. Am J Chin Med. 2009;37(6):1085-97. METHODS: Cirrhotic rat model was established by carbon tetrachloride replication. Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels, Na+ - K+ ATPase, and Ca2+ ATPase were compared. the percentage of apoptotic/oncotic hepatic cells was measured with flow cytometry, and the changes in hepatic cellular structures were observed under transmission electron microscope. |
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| 20019074 | Xu L, Gao J, Wang Y, Yu W, Zhao X, Yang X, Zhong Z, Qian ZM: Myrica rubra Extracts Protect the Liver from CCl4-Induced Damage. Evid Based Complement Alternat Med. 2009 Dec 17. Et Zucc fruit extract (MCE) against carbon tetrachloride (CCl (4))-induced liver damage was investigated. Pretreatment with 50 mg kg (-1), 150 mg kg (-1) or 450 mg kg (-1) MCE significantly blocked the CCl (4)-induced increase in both serum aspartate aminotransferase (sAST) and serum alanine aminotransferase (sALT) levels in mice (P < 0.05 or 0.01 vs CCl (4) group). |
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| 15881884 | Il'nitskaia SI, Vasil'eva ED, Pakharukova MIu, Pivovarova EN, Kaledin VI: [Effect of estragole on glucocorticoid induction of tyrosine aminotransferase and tryprophan oxygenase in the rat and mouse liver]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Aug;29(8):711-5. In these mice, activities of the marker enzymes of liver damage: alanine aminotransferase (ALAT) and aspartate aminotransferase (AAT) increased in the blood 1.7-2.3-fold as compared with the untreated controls. By contrast, carbon tetrachloride (100 mg/kg) increased the blood AIAT and AsAT activities 135- and 30-fold as compared with the control, but inhibited the TAT and TO induction much less than Estragole did. |
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| 17097021 | Zhang ZT, Jiang P, Wang Y, Li JS, Xue JG, Zhou YZ, Yuan Z: Effects of hepatotrophic factors on the liver after portacaval shunt in rats with portal hypertension. World J Gastroenterol. 2006 Mar 28;12(12):1912-7. METHODS: Intrahepatic portal hypertension (IHPH) was induced by intragastric administration of carbon tetrachloride, and end-to-side PCS was performed. The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested biochemically and those of (HA) and laminin (LN) were measured by radioimmunoassay. |
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| 15646798 | Lee KJ, Kim JY, Jung KS, Choi CY, Chung YC, Kim DH, Jeong HG: Suppressive effects of Platycodon grandiflorum on the progress of carbon tetrachloride-induced hepatic fibrosis. Arch Pharm Res. 2004 Dec;27(12):1238-44. CK significantly suppressed CCl4-induced hepatic necrosis and inflammation, as determined by the serum enzymatic activities of and aspartate aminotransferase and serum tumor necrosis factor-alpha levels, in dose-dependent manners. |
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| 20082759 | Lai TY, Weng YJ, Kuo WW, Chen LM, Chung YT, Lin YM, Tsai FJ, Lee CH, Choong YM, Lai EY, Huang CY, Yeh YL: Taohe Chengqi Tang ameliorates acute liver injury induced by carbon tetrachloride in rats. Indian J Exp Biol. 2006 Apr;44(4):305-11. Twenty-four hours after CCl (4) injection, the rats were sacrificed to observe liver histopathological changes, and to evaluate activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and lipid peroxidation (LPO) and (GSH) levels in liver tissues. |
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| 16394527 | Yokogawa K, Ido A, Kurihara T, Mano Y, Nomura M, Ishizaki J, Miyamoto K: Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure. Indian J Med Res. 2004 Jul;120(1):30-4. The levels of serum aminotransferase activity, including aspartate aminotransferase (AST), in rats with acute hepatic failure at 24 h after an oral administration of CCl4 (0.01-0.5 ml/kg) were about 15-50 times higher (up to nearly 5000 IU/l) than those of vehicle control rats (about 85 IU/l). |
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| 15112349 | Liu QH, Li DG, Huang X, Zong CH, Xu QF, Lu HM: Suppressive effects of 17beta- on hepatic fibrosis in CCl4-induced rat model. Biol Pharm Bull. 2005 Jan;28(1):19-23. RESULTS: Beta-Est treatment reduced aspartate aminotransferase (AST), alanine aminotransferase (ALT), (HA) and type IV collagen (C IV) in sera, suppressed hepatic collagen content, decreased the areas of HSCs positive for alpha-SMA significantly in both intact and ovariectomized female hepatofibrotic rats. |
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| 15573529 | Venukumar MR, Latha MS: Effect of Coscinium fenestratum on hepatotoxicity in rats. Indian J Exp Biol. 2004 Aug;42(8):792-7. Anti-hepatotoxic activity of extract of Coscinium fenestratum stem (MEC) was investigated against carbon tetrachloride-induced hepatopathy in rats. Anti-hepatotoxic effect was studied by assaying the activities of serum marker enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, lactate dehydrogenase etc. and glucose (6) phosphate dehydrogenase in liver. |
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| 16696916 | Wang L, Ji G, Zheng PY, Long AH: [Establishment of a rat model of alcoholic liver fibrosis induced by complex factors]. Lab Anim. 2008 Oct;42(4):495-504. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (gamma-GT) in these three groups were all examined at the 12th week of the induction process. |
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| 18358653 | Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C: Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol. 2008 May 8;117(2):300-8. Epub 2008 Feb 14. RESULTS: Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total (TBIL). |
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| 17608861 | Desmyter L, Fan YD, Praet M, Jaworski T, Vervecken W, De Hemptinne B, Contreras R, Chen C: Rating of CCl (4)-induced rat liver fibrosis by blood serum glycomics. Indian J Exp Biol. 2008 Jan;46(1):52-9. Liver injury was assessed biochemically (alanine aminotransferase [ALT] activity, aspartate aminotransferase [AST] activity and total and histologically. |
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| 16676162 | Young SC, Wang CJ, Lin JJ, Peng PL, Hsu JL, Chou FP: Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. J Gastroenterol Hepatol. 2007 Jul;22(7):1148-54. Fibrosis and hepatic damage, as reveled by histology and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were induced in rats by an administration of CCl (4) (8%, 1 ml/kg body weight) thrice a week for 4 weeks. |
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| 19322917 | Hong RT, Xu JM, Mei Q: ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G553-62. Epub 2009 Jan 8. Serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and protein concentration were measured with routine laboratory methods using an autoanalyzer. |
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| 17879412 | Xue H, Guo H, Li YC, Hao ZM: Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. Metabolism. 2007 Sep;56(9):1265-9. improved serum manganese superoxide dismutase (MnSOD) (6 h: 131.3 +/- 17.6 vs 107.0 +/- 13.9, P < 0.01; 12 h: 141.4 +/- 12.5 vs 118.3 +/- 10.2, P < 0.01), lessened liver cell injury, decreased caspase-3 (6 h: 166.7 +/- 8.1 vs 145.5 +/- 14.6, P < 0.01; 12 h: 172.8 +/- 3.8 vs 148.0 +/- 6.5, P < 0.01) and NF-kappaB expression (6 h: 150.2 +/- 8.6 vs 139.7 +/- 6.0, P < 0.01; 12 h: 151.1 +/- 5.9 vs 148.1 +/- 5.3, P > 0.05) and serum alanine aminotransferase (ALT) (6 h: 413.3 +/- 104.1 vs 626.8 +/- 208.2, P < 0.01; 12 h: 322.2 +/- 98.8 vs 425.8 +/- 115.4, P < 0.05), aspartate aminotransferase (AST) (6 h: 665.2 +/- 70.1 vs 864.3 +/- 70.4, P < 0.01; 12 h: 531.1 +/- 98.6 vs 664.4 +/- 115.6, P < 0.01), malondialdehyde (MDA) levels (6 h: 11.1 +/- 2.17 vs 13.5 +/- 2.01, P < 0.01; 12 h: 9.36 +/- 1.10 vs 10.8 +/- 1.62, P < 0.05) in the I/R + hemin group when compared with the I/R group. |
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| 15514851 | Gao J, Dou H, Tang XH, Xu LZ, Fan YM, Zhao XN: Inhibitory effect of TCCE on CCl4-induced overexpression of IL-6 in acute liver injury. Acta Biochim Biophys Sin. 2004 Nov;36(11):767-72. This study was designed to characterize the protective effects of the chloroform fraction of the extract of T. catappa leaves (TCCE) against carbon tetrachloride (CCl4)-induced hepatotoxicity in mice, and analyze the changes in expression level of interleukin-6 (IL-6) in the process. It was found that TCCE pretreatment (10 or 30 mg/kg, ig) protected mice from CCl4 toxicity, as evidenced by the reversed alterations in serum alanine aminotransferase (sALT) and serum aspartate aminotransferase (sAST) activities. |
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| 17265550 | Liu J, Cho SN, Song KH, Kim DH, Kim MC, Cho SW: The effect of oculo-acupuncture on acute hepatic injury induced by carbon tetrachloride in dogs. Biochem Biophys Res Commun. 2006 Nov 10;350(1):157-61. Epub 2006 Sep 15. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transpeptidase (GGT) activities were measured in both control and experimental groups. |
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| 17637198 | Zhong MM, Chen FH, Yuan LP, Wang XH, Wu FR, Yuan FL, Cheng WM: Protective effect of total flavonoids from Bidens bipinnata L. against carbon tetrachloride-induced liver injury in mice. J Pharm Pharmacol. 2007 Jul;59(7):1017-25. Oral administration of TFB at doses of 50, 100 and 200 mg kg (-1) for 7 days significantly reduced the elevated relative values of liver weight, serum transaminases (alanine aminotransferase and aspartate aminotransferase) and the hepatic morphologic changes induced by CCl4 in mice. |
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| 18308943 | Carvalho AB, Quintanilha LF, Dias JV, Paredes BD, Mannheimer EG, Carvalho FG, Asensi KD, Gutfilen B, Fonseca LM, Resende CM, Rezende GF, Takiya CM, de Carvalho AC, Goldenberg RC: Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury. Am J Chin Med. 2005;33(4):627-37. Fourteen female Wistar rats were fed exclusively an alcoholic liquid diet and received intraperitoneal injections of carbon tetrachloride every other day during 15 weeks. Blood analysis was performed to evaluate alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin before cell therapy and 1 and 2 months after cell or placebo infusion. |
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| 15027814 | Chan WY, Chau FT, Lee KK, Kwong WH, Yew DT: Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. Previous studies showed that Pien Tze Huang, a Chinese folk medicine well known for its therapeutic activity in treating liver diseases, protected the liver against carbon tetrachloride (CCl4)-induced damage in mice. When used in treating mice with CCl4- or galactosamine-induced liver damage, both the original and new formulations of Pien Tze Huang were found to be able to suppress to a similar extent both the histopathological changes in the liver and the elevation of serum alanine aminotransferase and aspartate aminotransferase. |
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| 20067861 | Roy CK, Das AK: Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity. World J Gastroenterol. 2005 Oct 7;11(37):5795-800. In the acute liver damage induced by different hepatotoxins, P. guajava methanolic leaf extract (200 mg/kg, p.o.) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and in carbon tetrachloride and induced hepatotoxicity. |
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| 19083419 | Lee HS, Kim HH, Ku SK: Hepatoprotective effects of Artemisiae capillaris herba and Picrorrhiza rhizoma combinations on carbon tetrachloride-induced subacute liver damage in rats. Nutr Res. 2008 Apr;28(4):270-7. Ten weeks of carbon tetrachloride injections caused subacute hepatic damage, manifested as significantly less body weight gain and hepatic protein content, and a higher liver weight, serum aspartate aminotransferase and alanine aminotransferase levels, hepatic malondialdehyde (an index for lipid peroxidation), and (an index for collagen synthesis) concentrations. |
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| 19235544 | Yoshioka T, Yoshida S, Kurosaki T, Teshima M, Nishida K, Nakamura J, Nakashima M, To H, Kitahara T, Sasaki H: Cationic liposomes-mediated plasmid DNA delivery in murine hepatitis induced by carbon tetrachloride. J Liposome Res. 2009 Feb 23:1-7. Liver injury after injection of CCl (4) was confirmed by the determination of serum aspartate aminotransferase and alanine aminotransferase activities. |
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| 19824107 | Dong MX, Jia Y, Zhang YB, Li CC, Geng YT, Zhou L, Li XY, Liu JC, Niu YC: Emodin protects rat liver from CCl (4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. World J Gastroenterol. 2009 Oct 14;15(38):4753-62. AIM: To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl (4)) in rats and to further explore the underlying mechanisms. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and hepatic content were assayed by biochemical analyses. |
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| 15637473 | Ryeom HK, Kim SH, Kim JY, Kim HJ, Lee JM, Chang YM, Kim YS, Kang DS: Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Arch Toxicol. 2009 May;83(5):477-83. Epub 2008 Dec 10. Hepatic injury was induced to by the intragastric administration of carbon tetrachloride (CCl4) three times a week for three weeks. Liver enzyme (aspartate aminotransferase, AST; alanine aminotransferase, ALT) levels and the plasma indocyanine green (ICG) retention rate 15 minutes after an intravenous injection of ICG (ICG R15), was checked before and after the three-week administration of CCl4. |
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| 19615318 | Chen JM, Wang L, Liu T, Xing LJ, Zheng PY, Ji G: [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. Inflammopharmacology. 2010 Jan 14. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum were analyzed. METHODS: A total of 150 SD rats were divided into three groups: blank group, carbon tetrachloride (C (4)) group and ALF-inducing group. |
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| 17202657 | Wang CY, Ma FL, Liu JT, Tian JW, Fu FH: Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Arch Toxicol. 2007 Jan;81(1):45-55. Epub 2006 May 5. Spectrophotometrical method was used to measure activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (GPx) as well as malondialdehyde (MDA) level in hepatic tissue and the rate of (O2*-) generation in hepatic submitochondrial particles. |
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| 15525453 | Gao J, Tang X, Dou H, Fan Y, Zhao X, Xu Q: Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. Biol Pharm Bull. 2007 Jan;30(1):44-7. The aim of this study was to evaluate the effect of the chloroform extract of Terminalia catappa L. leaves (TCCE) on carbon tetrachloride (CCl (4))-induced acute liver damage and D-galactosamine (D-GalN)-induced hepatocyte injury. In the acute hepatic damage test, remarkable rises in the activity of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (5.7- and 2.0-fold) induced by CCl (4) were reversed and significant morphological changes were lessened with pre-treatment with 50 and 100 mg kg (-1) TCCE. |
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| 15354541 | Okovityi SV: [New derivatives of triazino- and imidazoindole with hepatoprotective activity]. Zhonghua Yi Xue Za Zhi. 2008 Oct 21;88(38):2685-9. Among indoles, 1,2,4-triazino [5,6-b]- and [6,5-b] as well as imidazo [4,5-b] series the compounds, decreasing concentration of alanine aminotransferase, aspartate aminotransferase and total in blood serum and reducing hexenal sleep duration were found. |
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| 18929613 | Shyu MH, Kao TC, Yen GC: Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl (4) via inhibition of hepatic stellate cells activation. Am J Chin Med. 2007;35(1):53-61. In this study, the protective effect of extract of Hsian-tsao (Mesona procumbens) (EHT) against liver fibrogenesis in carbon tetrachloride (CCl (4))-injured rats was evaluated. It also decreased the activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and the deposition of collagen in the liver. |
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| 17651073 | Salawu SO, Akindahunsi AA: Protective effect of some tropical vegetables against CCl4-induced hepatic damage. Glycobiology. 2008 Jan;18(1):97-103. Epub 2007 Oct 27. CCl4 at a dose of 0.5 mL/kg of body weight produced liver damage in rats as manifested by the rise in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total protein in serum (40.60 +/- 3.50 IU/L, 80.60 +/- 5.10 IU/L, and 73.20 +/- 1.87 g/L, respectively) and in liver homogenate (1,300.00 +/- 7.38 IU/L, 1,660.00 +/- 13.69 IU/L, and 250.00 +/- 7.51 g/L, respectively) compared to the control. |
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| 15730626 | Li Y, Li Y, Liu GT: [Protective effects of bicyclol on liver fibrosis induced by carbon tetrachloride]. Zhonghua Yi Xue Za Zhi. 2004 Dec 17;84(24):2096-101. The serum was isolated to measure the levels of transaminase (ALT), aspartate aminotransferase (AST), total (TB), albumin/globulin (A/G), total protein (TP), (HA), and pro-collagen peptide III (PIIIP). |
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| 17015280 | Jin YS, Lee MJ, Han W, Heo SI, Sohn SI, Wang MH: Antioxidant effects and hepatoprotective activity of 2,5-dihydroxy-4,3'-di (beta-d-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots on CCl4-induced liver damage. Chin Med J. 2006 Oct 20;119(20):1727-33. The increase in aspartate aminotransferase (AST) activities in serum associated with carbon tetrachloride (CCl4)-induced liver injury was inhibited by 2,5-dihydroxy-4,3'-di (beta-D-glucopyranosyloxy)-trans-stilbene and at a dose of 400 - 600 mg/kg samples had hepatoprotective activity comparable to the standard agent, silymarin. |
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| 19046688 | Futakawa S, Kitazume S, Oka R, Ogawa K, Hagiwara Y, Kinoshita A, Miyashita K, Hashimoto Y: Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta-galactoside alpha2,6-sialyltransferase, a possible hepatic disease biomarker. World J Gastroenterol. 2006 Apr 7;12(13):2047-52. Using the M2 ELISA, we observed that elevation of plasma ST6Gal I was much faster than elevation of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a carbon tetrachloride (CCl (4))-induced mouse liver injury model. |
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| 17721639 | Abdel-Salam OM, Sleem AA, Morsy FA: Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats. World J Gastroenterol. 2004 May 1;10(9):1315-20. The effect of biphenyldimethyldicarboxylate (DDB), a synthetic compound, in use for the treatment of chronic hepatitis was studied on hepatic injury caused in rats by administration of carbon tetrachloride (CCl4). The administration of DDB in CCl4-treated rats at 75 or 375 mg/kg resulted in 61.2-76.2% decrease in alanine aminotransferase (ALT) and 46.9-60.8% decrease in aspartate aminotransferase (AST), respectively compared with the CCl4 control group. |
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| 18093227 | Ikeda E, Yagi K, Kojima M, Yagyuu T, Ohshima A, Sobajima S, Tadokoro M, Katsube Y, Isoda K, Kondoh M, Kawase M, Go MJ, Adachi H, Yokota Y, Kirita T, Ohgushi H: Multipotent cells from the human third molar: feasibility of cell-based therapy for liver disease. Ann Hepatol. 2007 Oct-Dec;6(4):251-4. TGPCs were examined by the transplantation into a carbon tetrachloride (CCl4)-treated liver injured rat to determine whether this novel cell source might be useful for cell-based therapy to treat liver diseases. The TGPCs prevented the progression of liver fibrosis in the liver of CCl4-treated rats and contributed to the restoration of liver function, as assessed by the measurement of hepatic serum markers aspartate aminotransferase and alanine aminotransferase. |
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| 16117622 | Shahjahan M, Vani G, Devi CS: Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Aug;30(4):455-9. The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. The activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase were significantly (P < .001) increased in serum of CCl4-induced animals when compared with control animals. |
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| 19787836 | Peng XD, Dai LL, Huang CQ, He CM, Chen LJ: Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):642-50. Except for the normal control group, all rats in the other groups were administered with carbon tetrachloride to induce hepatic fibrosis. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), transforming growth factor (TGF)-beta1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-10 were measured. |
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| 17188414 | Lee CP, Shih PH, Hsu CL, Yen GC: Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. J Pharm Pharmacol. 2004 Nov;56(11):1449-55. The results showed that a tea seed oil diet significantly (p <0.05) lowered the serum levels of hepatic enzyme markers (alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase), inhibited fatty degeneration, reduced the content of the peroxidation product malondialdehyde, and elevated the content of GSH. |
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| 17590492 | Lee KJ, Choi JH, Jeong HG: Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Liver Int. 2005 Dec;25(6):1224-32. Pretreatment with kahweol and cafestol prior to the administration of CCl (4) significantly prevented the increase in the serum levels of hepatic enzyme markers (alanine aminotransferase and aspartate aminotransferase) and reduced oxidative stress, such as content and lipid peroxidation, in the liver in a dose-dependent manner. |
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| 16169207 | Tang X, Gao J, Wang Y, Fan YM, Xu LZ, Zhao XN, Xu Q, Qian ZM: Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria. Biomed Khim. 2004 May-Jun;50(3):293-303. We found that increases in the activity of serum aspartate aminotransferase and alanine aminotransferase and the level of liver lipid peroxidation (2.0-fold, 5.7-fold and 2.8-fold) induced by CCl4 were significantly inhibited by oral pretreatment with 20, 50 or 100 mg/kg of TCCE. |
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| 18624899 | Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kato T, Okochi H, Ochiya T: Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. Hepatol Res. 2009 Feb;39(2):200-6. Epub 2008 Nov 26. Markers of liver injury, alanine aminotransferase, aspartate aminotransferase, as well as were decreased after ASC-derived hepatocyte transplantation. |
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| 18313245 | Yuan LP, Chen FH, Ling L, Dou PF, Bo H, Zhong MM, Xia LJ: Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis. Biosci Biotechnol Biochem. 2008 May;72(5):1199-205. Epub 2008 May 7. The hepatoprotective effects of total flavonoids of Bidens pilosa L. (TFB), a traditional Chinese medicine were evaluated in carbon tetrachloride (CCl (4))-induced liver injury in mice and rats. Liver index (liver weight/body weight), serum levels of transaminases (alanine aminotransferase, ALT and aspartate aminotransferase, AST), hepatic malondialdehyde (MDA) content, superoxide dismutase (SOD) and peroxidase (GSH-Px) activities were evaluated following the 10 days treatment in mice. |
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| 18990340 | Wu T, Liu T, Zheng PY, Xing LJ, Ji G: [Effects of Qinggan Huoxue Recipe and its separated recipes on the expression of tumor necrosis factor-alpha in rats with alcoholic liver injury]. Stem Cells. 2008 May;26(5):1307-14. Epub 2008 Feb 28. METHODS: One hundred male Wistar rats were randomly divided into normal control group (n=10), carbon tetrachloride (CCl4) group (n=10) and ALI group (n=80). After 2-week suitable drugs treatment, the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed. |
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| 15960080 | Aneja R, Upadhyaya G, Prakash S, Dass SK, Chandra R: Ameliorating effect of phytoestrogens on CCl4-induced oxidative stress in the livers of male Wistar rats. Clin Exp Pharmacol Physiol. 2008 Mar;35(3):303-9. Epub 2007 Oct 30. In the present study, the protective effects, if any, of isoflavone phytoestrogens-- and daidzein on the carbon tetrachloride (CCl4) induced changes in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione S transferase (GSH) and levels of (GSH) and thiobarbituric acid reactive substances (TBARS)-were studied. |
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| 19239161 | Choi D, Kim SJ, Kwon do Y, Lee SY, Kim YC: depletion by inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. In Vivo. 2009 Sep-Oct;23(5):747-54. Hepatotoxicity caused by carbon tetrachloride (50 microl/kg, ip) in mice fed was decreased, as determined by changes in serum aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase activities. |
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| 19429327 | Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA: The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Bras Pneumol. 2008 Jul;34(7):453-60. MATERIALS AND METHODS: The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarker in blood of hepatic injury. |
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| 20354348 | Akachi T, Shiina Y, Ohishi Y, Kawaguchi T, Kawagishi H, Morita T, Mori M, Sugiyama K: Hepatoprotective Effects of Flavonoids from Shekwasha (Citrus depressa) against D-Galactosamine-Induced Liver Injury in Rats. J Ethnopharmacol. 2009 Apr 21;122(3):555-60. Epub 2009 Feb 7. Liver injury-suppressive activity, as assessed by plasma alanine aminotransferase and aspartate aminotransferase activities, was found only in the fraction that was extracted with n-hexane when three fractions were added to the diet and fed to rats. the most important compound in the n-hexane-soluble fraction, also had suppressive effects on liver injuries induced by carbon tetrachloride, and GalN/lipopolysaccharide (LPS) in addition to liver injury induced GalN. |
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| 18951966 | Zou YH, Yang Y, Li J, Wu Q, Li WP, Lu JT, Roberts MS: Potential therapeutic effects of a traditional Chinese formulation, BJ-JN, on liver fibrosis induced by carbon tetrachloride in rats. J Med Food. 2005 Summer;8(2):261-5. Evaluated with liver and spleen index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), (HA), (NO), hepatic malondialdehyde (MDA) content and superoxide dismutase (SOD) activity, as well as with histopathologic changes of liver. |
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| 15998439 | Liu GT, Li Y, Wei HL, Zhang H, Xu JY, Yu LH: Mechanism of protective action of bicyclol against CCl-induced liver injury in mice. Korean J Radiol. 2004 Oct-Dec;5(4):231-9. Oral administration of bicyclol markedly reduced the elevated serum transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and the hepatic morphologic changes induced by CCl (4) in mice. |
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| 17084009 | Avasarala S, Yang L, Sun Y, Leung AW, Chan WY, Cheung WT, Lee SS: A temporal study on the histopathological, biochemical and molecular responses of CCl (4)-induced hepatotoxicity in Cyp2e1-null mice. Food Chem Toxicol. 2007 Jun;45(6):888-95. Epub 2006 Nov 21. The levels of serum alanine aminotransferase and aspartate aminotransferase, markers for liver injury, were significantly higher at 12h, peaked at 24h and gradually decreased at 48 h after CCl (4) intoxication. |
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| 19966836 | Dai L, Ji H, Kong XW, Zhang YH: Antifibrotic effects of ZK14, a novel -donating biphenyldicarboxylate derivative, on rat HSC-T6 cells and CCl4-induced hepatic fibrosis. Acta Pharmacol Sin. 2010 Jan;31(1):27-34. Epub 2009 Dec 7. Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), (HA), type III collagen (PCIII), and (NO) were assessed, and liver samples were stained with hematoxylin-eosin. |
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| 15036476 | Rajesh MG, Latha MS: Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation. J Ethnopharmacol. 2009 Oct 29;126(1):50-6. Epub 2009 Aug 22. Hepatoprotective efficacy of Kamilari, a polyherbal preparation was studied in carbon tetrachloride (CCl4)-induced liver dysfunction in albino rats by determining different biochemical parameters in serum and tissues. In serum, the activities of enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and the concentrations of protein and were evaluated. |
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| 18654853 | Wang MY, Anderson G, Nowicki D, Jensen J: Hepatic protection by noni fruit juice against CCl (4)-induced chronic liver damage in female SD rats. Plant Foods Hum Nutr. 2008 Sep;63(3):141-5. Epub 2008 Jul 25. Serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), transaminase (ALT), total (TC), triglycerides (TG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels were increased in the placebo group compared with the TNJ group. |
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| 18436364 | Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG: Protective effect of phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. J Agric Food Chem. 2008 May 28;56(10):3785-90. Pretreatment with CAPE prior to administration of CCl (4) significantly prevented the increases in serum aspartate aminotransferase and alkaline phosphatase activities, hepatic lipid peroxidation formation, and depletion of content. |
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| 19298238 | Salam OM, Sleem AA, Omara EA, Hassan NS: Hepatoprotective effects of misoprostol and silymarin on carbon tetrachloride-induced hepatic damage in rats. Toxicology. 2008 Jun 3;248(1):18-24. Epub 2008 Mar 20. Misoprostol, given at 100 or 1000 microg/kg, decreased aspartate aminotransferase (AST) by 28 and 43.6% and alkaline phosphatase (ALP) by 19.3% and 53.4% respectively. |
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| 17963319 | Chang HY, Peng WH, Sheu MJ, Huang GJ, Tseng MC, Lai MT, Ho YL, Chang YS: Hepatoprotective and Antioxidant Effects of Extract from Phellinus merrillii on carbon tetrachloride-induced liver damage. Hum Exp Toxicol. 2008 Jul;27(7):559-66. Treatment with PM (0.5, 1 and 2 g/kg) prior to the administration of carbon tetrachloride (1.5 ml/kg in olive oil, 20%) significantly prevented the increased serum alanine aminotransferase (s-GOT) and serum aspartate aminotransferase (s-GPT) in a dose-dependent manner. |
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| 16624646 | Torres-Duran PV, Paredes-Carbajal MC, Mascher D, Zamora-Gonzalez J, Diaz-Zagoya JC, Juarez-Oropeza MA: Protective effect of Arthrospira maxima on fatty acid composition in fatty liver. Chem Biol Interact. 2004 Jul 20;148(3):125-38. A. maxima prevents fatty liver induced by either carbon tetrachloride (CCl4) or -rich diet; however, the liver lipid composition in these models is not clearly known yet. Additionally, triacylglycerols, total and aspartate aminotransferase were evaluated in blood. |
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| 16722379 | Min Q, Bai YT, Shu SJ, Ren P: [Protective effect of dl-tetrahydropalmatine on liver injury induced by carbon tetrachloride in mice]. Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):483-4 The mice were killed 17 h after injection ip of CCl4, serum and aspartate aminotransferase (ALT and AST) activity were measured, and maleic dialdehyde (MDA) and superoxide dismutase (SOD) activity in liver were detected. |
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| 15507327 | Ozbek H, Citoglu GS, Dulger H, Ugras S, Sever B: Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima. J Ethnopharmacol. 2004 Dec;95(2-3):143-9. extract of Ballota glandulosissima Hub.-Mor & Patzak (Lamiaceae) (BG) was investigated for anti-inflammatory activity using the carrageenan-induced rat paw oedema test and for hepatoprotective effect on carbon tetrachloride (CCl (4))-induced hepatotoxicity in rats. Biochemical parameters of hepatic damage such as serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and concentrations were determined. |
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| 15962327 | Taieb D, Malicet C, Garcia S, Rocchi P, Arnaud C, Dagorn JC, Iovanna JL, Vasseur S: Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity. Zhong Xi Yi Jie He Xue Bao. 2006 May;4(3):281-4. Serum and aspartate aminotransferase activities were higher and peaked earlier in p8 (-/-) mice than in wild-type mice, which is in agreement with the observation of significantly larger areas of necrosis in p8 (-/-) liver. |
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| 15816358 | Rincon-Sanchez AR, Covarrubias A, Rivas-Estilla AM, Pedraza-Chaverri J, Cruz C, Islas-Carbajal MC, Panduro A, Estanes A, Armendariz-Borunda J: alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage. J Ethnopharmacol. 2008 Dec 8;120(3):452-7. Epub 2008 Oct 1. Male Wistar rats treated with carbon tetrachloride (CCl4) for 8 weeks were used for the cirrhosis model. -treatment ameliorated the decrease in urinary excretion, and normalized serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and plasma renin observed in cirrhotic rats with ALD. |
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| 15793860 | Xu DH, Mei XT, Chen Y, Li YM, Lv JY, Xu SB: Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy- on experimental hepatic injury. World J Gastroenterol. 2009 Oct 7;15(37):4720-5. METHODS: Models of rat acute hepatic injury induced by carbon tetrachloride (CCl (4)) administration, rat hepatic fibrosis induced by thioacetamide, injury of primary cultured rat hepatocytes induced by CCl (4), respectively, were established. After treated with RF, content of serum transaminase (ALT), aspartate aminotransferase (AST) and albumin (Alb), (HA), the activity of peroxidase (GSH-Px), superoxide dismutase (SOD), and (Hyp) were measured and liver tissue was observed pathologically by hematoxylin-eosin (HE) staining. |
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| 16943688 | Paul SC, Lv P, Xiao YJ, An P, Liu SQ, Luo HS: Thalidomide in rat liver cirrhosis: blockade of tumor necrosis factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB. Exp Toxicol Pathol. 2005 Mar;56(4-5):291-303. METHODS: Liver cirrhosis was achieved by intraperitoneal injection of carbon tetrachloride thrice weekly, and thalidomide (10 or 100 mg/kg/day) was given daily by intragastric route for 8 weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), prealbumin (PA), (HA) and laminin (LN), and (HYP), NF-kappaBp65, alpha-smooth muscle actin (alpha-SMA) protein and TNF-alpha mRNA were studied in the liver, IkappaBalpha and TNF-alpha protein in the cytoplasm and NF-kappaBp65 protein in the nucleus. |
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| 17569349 | Cheng X, Xie CL, Wang J: [Changes of serum level after acute hepatic injury in mice and the effect of yugan capsule on it]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:58-60. METHODS: The mouse AHI model was induced by carbon tetrachloride ( CC14 ) at different time points. After treatment with or without YC, serum ( NO) , anlanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected, and liver histopathologic injury was observed at different time points after AHI, respectively. |
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| 18812033 | Yuan LP, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ: Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. J Ethnopharmacol. 2004 Mar;91(1):99-104. The results showed that TFB (80 and 160 mg kg (-1)) treatment for 10 weeks significantly reduced the elevated liver index (liver weight/body weight) and spleen index (spleen weight/body weight), elevated levels of serum transaminases (alanine aminotransferase and aspartate aminotransferase), type III procollagen and hepatic |
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| 16445600 | Yim HK, Jung YS, Kim SY, Kim YC: Contrasting changes in phase I and phase II metabolism of in male mice pretreated with carbon tetrachloride. World J Gastroenterol. 2007 Dec 7;13(45):5989-94. A 24 hr initial dose of CCl (4) (0.05 ml/kg, intraperitioneally) reduced the induction of hepatotoxicity resulting from treatment (350 mg/kg, intraperitoneally) as determined by changes in serum and aspartate aminotransferase, and sorbitol dehydrogenase activities. |
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| 18291569 | Lee KJ, Choi JH, Kim HG, Han EH, Hwang YP, Lee YC, Chung YC, Jeong HG: Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice. J Ethnopharmacol. 2008 Mar 28;116(3):539-46. Epub 2008 Jan 20. Pretreatment with CKS prior to the administration of CCl (4) significantly prevented the increase in serum alanine aminotransferase and aspartate aminotransferase activities and hepatic lipid peroxidation formation. |
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| 16804984 | He SX, Luo JY, Wang YP, Wang YL, Fu H, Xu JL, Zhao G, Liu EQ: Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats. Zhong Xi Yi Jie He Xue Bao. 2010 Jan;8(1):49-55. RESULTS: The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin (Alb) in EGb-protected group were notably improved as compared with the CCl (4)-treated group (P < 0.01). |
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| 16140330 | Ozdogan M, Ersoy E, Dundar K, Albayrak L, Devay S, Gundogdu H: Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis. J Surg Res. 2005 Dec;129(2):260-4. Epub 2005 Sep 2. MATERIALS AND METHODS: The effect of HBO on liver regeneration was studied in a mice model combining carbon tetrachloride induced cirrhosis and partial hepatectomy. Serum aspartate aminotransferase and alanine aminotransferase levels were measured to evaluate liver injury. |
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| 19736546 | Goo MJ, Ki MR, Lee HR, Yang HJ, Yuan DW, Hong IH, Park JK, Hong KS, Han JY, Hwang OK, Kim DH, Do SH, Cohn RD, Jeong KS: Helicobacter pylori promotes hepatic fibrosis in the animal model. Arch Med Res. 2006 May;37(4):479-83. To elucidate the pathological effect of H. pylori infection on the progression of hepatic fibrosis, C57BL/6 mice and Sprague-Dawley rats were orally inoculated with H. pylori, and hepatic fibrosis was induced with carbon tetrachloride (CCl (4)) administration. Significant increase in the fibrotic score as well as in serum alanine aminotransferase and aspartate aminotransferase levels was shown in the CCl (4)+H. pylori group compared with that in the CCl (4)-treated group. |
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| 15968720 | Zhang LM, Liu DW, Liu JB, Zhang XL, Wang XB, Tang LM, Wang LQ: Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats. Ann N Y Acad Sci. 2009 Apr;1160:348-9. The rats with acute hepatic injury induced by intraperitoneal injection of 2 mL/kg 50% carbon tetrachloride (CCl (4)) were randomly divided into saline control group and recombinant pcDNA3-ALR plasmid treatment groups. Hepatic histopathological alterations were observed after HE staining, the expression of proliferating cell nuclear antigen (PCNA) in liver tissue was detected by immunohistochemical staining, and the level of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) was determined by biochemical method. |
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| 19416217 | Bennett RG, Heimann DG, Tuma DJ: Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. 521. In the prevention study, relaxin reduced collagen and smooth muscle actin content and significantly reduced serum levels of the liver enzymes alanine aminotransferase and aspartate aminotransferase. |
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| 15239104 | Asamoto M, Hokaiwado N, Murasaki T, Shirai T: Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. World J Gastroenterol. 2005 Mar 28;11(12):1764-8. The present investigation concerned susceptibility to the liver-toxic substances D-galactosamine and carbon tetrachloride. These toxicants induced massive liver cell death and elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the wild-type rats; however, much fewer liver cells were damaged and serum enzyme elevation was much lower in the transgenic rats. |
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| 18277467 | Abdel Salam OM, Oraby FH, Hassan NS: Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats. Acta Biol Hung. 2007 Dec;58(4):411-9. The results showed that vinpocetine administered to CCl4-treated rats decreased the elevated alanine aminotransferase (ALT) by 49.3, 58.1 and 63.6%, aspartate aminotransferase (AST) by 10.5, 22.6 and 27.2% and alkaline phosphatase (ALP) by 52.5, 59.6 and 64.9%, respectively, and in a dose-dependent manner. |
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| 16831245 | Wen T, Ren F, Liu Y, Wu ZM, Zhao JY: [Expression of Fas antigen and Fas ligand in acute liver injury induced by carbon tetrachloride in rat]. Food Chem Toxicol. 2007 Nov;45(11):2118-25. Epub 2007 May 24. Serum aspartate aminotransferase (ALT) and alanine aminotransferase (AST) levels were also determined. |
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| 16227642 | Abdel Salam OM, Baiuomy AR, El-Shenawy SM, Hassan NS: Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or J Gastroenterol Hepatol. 2009 Jan;24(1):70-7. Epub 2008 Jun 25. The administration of PTX at 72 mg/kg, conferred significant protection against the hepatotoxic actions of CCl4, reducing serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels to 31%, 59.2% and 63%, respectively. |
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| 17965434 | Xu H, Guo T, Guo YF, Zhang J, Li Y, Feng W, Jiao B: Characterization and protection on acute liver injury of a polysaccharide MP-I from Mytilus coruscus. J Pharm Pharmacol. 2008 Oct;60(10):1393-402. MP-I was subjected to investigate the protective effect on carbon tetrachloride (CCl (4)) induced liver damage in male Kunming mice. Pharmacological studies revealed that MP-I could decrease serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), and hepatic malondialdehyde aldehydes (MDA) levels, increase the hepatic total superoxide dismutase (T-SOD) activity, and improve hepatic damage in the CCl (4) induced liver injury in mice in a dose-dependent manner. |
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| 16610055 | Ji G, Wang L, Zhang SH, Liu JW, Zheng PY, Liu T: Effect of Chinese medicine Qinggan Huoxuefang on inducing HSC apoptosis in alcoholic liver fibrosis rats. Hum Exp Toxicol. 2004 Jan;23(1):35-47. METHODS: Wistar rats were divided into three groups at random: normal control group (12),micro-amount carbon tetrachloride group (CCl (4))(12) and model group A (60). Blood samples were used for evaluation of transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (gamma-GT). |
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| 15573910 | Wei YH, Jun L, Qiang CJ: Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats. Fundam Clin Pharmacol. 2009 Apr;23(2):179-88. Epub 2009 Mar 9. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in plasma and (Hyp) contents in liver tissue were assayed by spectrophotometry. |
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| 17444574 | Hashimoto T, Goto M, Sakakibara H, Oi N, Okamoto M, Kanazawa K: Yellow tea is more potent than other types of tea in suppressing liver toxicity induced by carbon tetrachloride in rats. Phytother Res. 2007 Jul;21(7):668-70. The yellow tea significantly ameliorated the increase in the activity of the - and aspartate-aminotransferases in plasma. |
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| 18038910 | Hwang YP, Choi CY, Chung YC, Jeon SS, Jeong HG: Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. ScientificWorldJournal. 2007 Aug 24;7:1242-55. In mice, pretreatment with puerarin prior to the administration of CCl4 significantly prevented the increased serum enzymatic activity of aspartate aminotransferase and hepatic malondialdehyde formation in a dose-dependent manner. |
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| 20069380 | Abdel Salam OM, Sleem AA, Shafee N: Hepatoprotective effects of the donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats. Liver Transpl. 2009 Sep;15(9):1092-100. Serum aspartate aminotransferase (AST) levels decreased by 19.8, 22.7 and 59.4%, respectively, while alkaline phosphatase (ALP) decreased by 26.1 and 32.6% by the drug at 3.6 and 7.2 mg/kg, respectively. |
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| 19824117 | Pradeep HA, Khan S, Ravikumar K, Ahmed MF, Rao MS, Kiranmai M, Reddy DS, Ahamed SR, Ibrahim M: Hepatoprotective evaluation of Anogeissus latifolia: in vitro and in vivo studies. J Med Food. 2008 Jun;11(2):224-9. AIM: To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl (4)). Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. |
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| 16343076 | Ding J, Yu J, Wang C, Hu W, Li D, Luo Y, Luo H, Yu H: Ginkgo biloba extract alleviates liver fibrosis induced by CCl in rats. Dig Liver Dis. 2006 Jun;38(6):404-8. Epub 2006 Apr 3. AIMS: To investigate the protective effect of Ginkgo biloba extract (GbE) on liver fibrosis induced by carbon tetrachloride (CCl4) in rats and expressions of transforming growth factor beta1 (TGF-beta1) and collagen I during this period. Blood samples were collected for measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin. |
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| 18317933 | Wang MY, Nowicki D, Anderson G, Jensen J, West B: Liver protective effects of Morinda citrifolia (Noni). Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Jul;18(7):417-20. This study evaluated the protective effects of Noni fruit juice on acute liver injury induced by carbon tetrachloride (CCl (4)) in female Sprague-Dawley (SD) rats. Furthermore, serum alanine aminotransferase and aspartate aminotransferase levels were significantly lower in the Noni group than the placebo group. |
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| 17244260 | Wu ZM, Wen T, Tan YF, Liu Y, Ren F, Wu H: Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. World J Gastroenterol. 2007 Oct 28;13(40):5384-90. Administration of CCl (4) to rats caused severe hepatic damage, as demonstrated by the significant increase in the levels of serum alanine aminotransferase, aspartate aminotransferase and classic histological changes including hepatocyte necrosis or apoptosis, haemorrhage, fatty degeneration, etc. |
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| 18427963 | Bahcecioglu IH, Koca SS, Poyrazoglu OK, Yalniz M, Ozercan IH, Ustundag B, Sahin K, Dagli AF, Isik A: Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):225-30. Infliximab reduced the levels of aspartate aminotransferase and alanine aminotransferase (p <0.05 for both). |
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| 15515113 | Zavodnik LB, Zavodnik IB, Lapshina EA, Belonovskaya EB, Martinchik DI, Kravchuk RI, Bryszewska M, Reiter RJ: Protective effects of against carbon tetrachloride hepatotoxicity in rats. Phytother Res. 2006 Nov;20(11):997-1002. |
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| 16426832 | Zhang S, Ji G, Liu J: Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. World J Gastroenterol. 2005 Jun 28;11(24):3671-4. In the present study, we investigated the effects of puerarin on liver fibrosis in Wistar rats induced by plus carbon tetrachloride administration. |
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| 15070165 | Kim Y, DiSilvestro R, Clinton S: Effects of -beadlet or tomato-powder feeding on carbon tetrachloride-induced hepatotoxicty in rats. World J Gastroenterol. 2005 Jun 28;11(24):3680-5. |
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| 16619345 | Yilmaz BS, Ozbek H, Citoglu GS, Ugras S, Bayram I, Erdogan E: Analgesic and hepatotoxic effects of Ononis spinosa L. Phytother Res. 2006 Jun;20(6):500-3. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to at all time points.The hepatoprotective influence of OS on carbon tetrachloride (CCl (4))-induced acute liver toxicity was also studied. |
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| 16595196 | Di Stefano G, Fiume L, Domenicali M, Busi C, Chieco P, Kratz F, Lanza M, Mattioli A, Pariali M, Bernardi M: Doxorubicin coupled to lactosaminated albumin: Effects on rats with liver fibrosis and cirrhosis. Adv Exp Med Biol. 2009;643:305-11. Liver fibrosis/cirrhosis was produced by carbon tetrachloride (CCl4) poisoning. |
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| 19524009 | Hsu YW, Tsai CF, Chen WK, Lu FJ: Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009 Sep;47(9):2281-8. Epub 2009 Jun 11. Our results showed that oral administration of SBT seed oil at doses of 0.26, 1.30, and 2.60 mg/kg for 8 weeks significantly reduced the elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), and at least 13% in serum, and the level of malondialdehyde (MDA) in liver at least 22%, that was induced by CCl (4) (1 mL/kg) in mice. |
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| 17285312 | Iida C, Fujii K, Kishioka T, Nagae R, Onishi Y, Ichi I, Kojo S: Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver. Arch Toxicol. 2007 Jul;81(7):489-93. Epub 2007 Feb 7. After 12 h the activity of plasma AST (aspartate aminotransferase) and ALT (alanine aminotransferase) was significantly higher than that of the control group and plasma AST and ALT activities increased thereafter. |
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| 18724385 | Campo GM, Avenoso A, Campo S, Nastasi G, Traina P, D'Ascola A, Rugolo CA, Calatroni A: The antioxidant activity of -4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation. Br J Pharmacol. 2008 Nov;155(6):945-56. Epub 2008 Aug 25. KEY RESULTS: CCl4 injection produced: marked elevation of alanine aminotransferase and aspartate aminotransferase; hepatic membrane lipid peroxidation, assayed by levels; and depletion of and superoxide dismutase. |
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| 19761824 | Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y: The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. J Physiol Biochem. 2004 Sep;60(3):205-10. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver. |
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| 19072832 | Aram G, Potter JJ, Liu X, Wang L, Torbenson MS, Mezey E: Deficiency of reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. J Nutr Sci Vitaminol. 2010;56(1):60-7. Serum aspartate aminotransferase (AST) was higher after CCl (4) administration in gp91 (phox (-/-) ) than in WT mice, correlating with increased necrosis on liver histology. |
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| 16124045 | Shen XH, Cheng WF, Li XH, Sun JQ, Li F, Ma L, Xie LM: Effects of dietary supplementation with and on rat hepatic stellate cell apoptosis. Hepatology. 2004 Jul;40(1):205-10. Serum alanine aminotransferase and aspartate aminotransferase were also analyzed. METHODS: An acute liver damage model of rats was established by intraperitoneal injection of carbon tetrachloride (0.3 mL/100 g body weight) twice a week, then the rats were killed at 6, 24, 48, and 72 h after the first and third injection, respectively. |
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| 18829732 | Roomi M, Kalinovsky T, Roomi NW, Ivanov V, Rath M, Niedzwiecki A: A nutrient mixture suppresses carbon tetrachloride-induced acute hepatic toxicity in ICR mice. Hepatology. 2005 Jul;42(1):176-82. Mean serum aspartate aminotransferase and alanine aminotransferase were comparable in groups A and B, increased markedly in group C, and significantly lowered in group D compared with group C. |
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| 16996028 | Isoda K, Arita E, Kojima M, Ikkaku M, Tashiro F, Yamato E, Miyazaki J, Kawase M, Kondoh M, Yagi K: Protection against CCl4-induced injury in liver by adenovirally introduced thioredoxin gene. J Gastroenterol Hepatol. 2009 Jun;24(6):1070-6. Epub 2009 Feb 12. Serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were determined, and liver sections were stained with hematoxylin and eosin. |
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| 19496198 | Jin SZ, Meng XW, Han MZ, Sun X, Sun LY, Liu BR: Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure. Pathobiology. 2006;73(2):82-92. At the same time, the serum aspartate aminotransferase levels were measured in experimental and control groups at different time points (122.55 +/- 1.46 vs 120.70 +/- 4.22, P > 0.05; 54.26 +/- 6.50 vs 98.70 +/- 8.20, P < 0.05; 39.47 +/- 5.39 vs 78.34 +/- 4.50, P < 0.05; 28.94 +/- 2.70 vs 56.44 +/- 4.28, P < 0.05; 30.77 +/- 5.45 vs 42.50 +/- 6.28, P < 0.05). The labeled cells were subsequently infused into the caudal veins of BALB/c mice with hepatic injury induced by carbon tetrachloride and 2-acetylaminofluorene. |
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| 19793341 | Quan J, Piao L, Wang X, Li T, Yin X: Rossicaside B protects against carbon tetrachloride-induced hepatotoxicity in mice. Pharmacol Rep. 2005 Sep-Oct;57(5):596-603. The CCl (4) challenge caused a marked increase in the levels of serum aspartate aminotransferase, alanine aminotransferase and of tumour necrosis factor-alpha, and propagated lipid peroxidation with a concomitant reduction in (GSH) and antioxidative enzyme activities in the liver. |
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| 19056852 | Chen P, Li C, Pang W, Zhao Y, Dong W, Wang S, Zhang J: The protective role of Per2 against carbon tetrachloride-induced hepatotoxicity. Am J Pathol. 2009 Jan;174(1):63-70. Epub 2008 Dec 4. Serum and aspartate aminotransferase activities were elevated in Per2-null mice compared with wide-type mice at 24 hours after CCl (4) treatment, which was in agreement with the observation of significantly larger areas of centrilobular necrosis in the livers of Per2-null mice. |
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| 18460803 | Takahashi M, Kitamoto D, Imura T, Oku H, Takara K, Wada K: Characterization and bioavailability of liposomes containing a ukon extract. Phytother Res. 2007 Aug;21(8):793-5. Orally administrated LUE at a dose of 10 mg/kg as the extract had a much higher suppressive effect on the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, compared to the uncapsuled extract at a dose of 33 mg/kg. The bioactivity of LUE was further examined for its suppressive effect on carbon tetrachloride (CCl (4))-induced liver injury by using mice. |
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| 15581276 | Ozardali I, Bitiren M, Karakilcik AZ, Zerin M, Aksoy N, Musa D: Effects of on histopathological and enzymatic changes in experimental liver injury of rats. World J Gastroenterol. 2009 Jun 7;15(21):2657-64. Thus, GSHPx may prevent the harmful effects of free radicals and may reduce the formation of the reactive metabolites of carbon tetrachloride. |
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| 17177172 | Kim SJ, Jung YS, Yoon MY, Kim YC: Comparative effects of dimethylsulfoxide on metabolism and toxicity of carbon tetrachloride and dichloromethane. Free Radic Res. 2006 Sep;40(9):986-92. |
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| 19957847 | Yan L, Cai H, Chen Y, Tan W: [Effect of hepatocyte-like cells induced by CD34+ cells in vitro on the repair of injured hepatic tissues of mice in vivo]. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):115-20. Forty-eight 6-week-old female ICR mice were chosen to prepare liver injury model by injecting carbon tetrachloride and 2-acetylamionoflu-orene. |
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| 18078039 | Sapozhnikova TA, Zarudii FS, Baschenko NZh, Makara NS, Khisamutdinova RIu, Gabdrakhmanova SF, Ivanova NA, Nazarov VS: [Hepatoprotective effect of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol]. Eksp Klin Farmakol. 2007 Jul-Aug;70(4):30-1. 2-Demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol (11-DMP) produces antioxidant effect on the models of toxic hepatitis induced by and carbon tetrachloride. The drug normalizes the lipid peroxidation (LPO) prosess in rat liver of the rat and the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the rat blood, thus demonstrating hepatoprotective action. |
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| 18178045 | Wang N, Li P, Wang Y, Peng W, Wu Z, Tan S, Liang S, Shen X, Su W: Hepatoprotective effect of Hypericum japonicum extract and its fractions. Lab Invest. 2009 Nov;89(11):1291-303. Epub 2009 Sep 7. OBJECTIVE: To investigate the hepatoprotective activity of different parts of Hypericum japonicum against carbon tetrachloride (CCl (4))-induced hepatitis and alpha-naphthyl-isothiocyanate (ANIT)-induced cholestasis. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total (T-BIL) in serum were evaluated. |
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| 16097051 | Dai K, Qi JY, Tian DY: Leptin administration exacerbates thioacetamide-induced liver fibrosis in mice. Hepatology. 2009 Mar;49(3):911-9. The changes in biochemical markers, such as the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and superoxide dismutase (SOD), malondialdehyde (MDA) in liver were determined. |
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| 16698588 | Yuan GJ, Gong ZJ, Sun XM, Zheng SH, Li X: Tea polyphenols inhibit expressions of iNOS and TNF-alpha and prevent lipopolysaccharide-induced liver injury in rats. Biofactors. 2004;21(1-4):171-4. BACKGROUND: Tea polyphenols have been shown to protect against carbon tetrachloride (CCl4)-induced liver injury, liver fibrosis, hepatic ischemia-reperfusion injury. RESULTS: Administration of LPS resulted in liver injury in rats, evidenced by elevated activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocellular necrosis, and neutrophil infiltration in the liver. |
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| 18006644 | Fu Y, Zheng S, Lin J, Ryerse J, Chen A: protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. World J Gastroenterol. 2005 Aug 28;11(32):4957-61. The current study evaluates the in vivo role of in protecting the liver against injury and fibrogenesis caused by carbon tetrachloride (CCl (4)) in rats and further explores the underlying mechanisms. This report demonstrates that significantly protects the liver from injury by reducing the activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and by improving the histological architecture of the liver. |
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| 19827746 | El BK, Hashimoto Y, Muzandu K, Ikenaka Y, Ibrahim ZS, Kazusaka A, Fujita S, Ishizuka M: Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity. Liver Int. 2005 Aug;25(4):872-9. Pretreatment with PC mushroom extract significantly prevented the increased serum enzyme activities of and aspartate aminotransferases in a dose-dependent manner, and suppressed the expression of CYP2E1. |
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| 17877538 | Smyth R, Munday MR, York MJ, Clarke CJ, Dare T, Turton JA: Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. World J Gastroenterol. 2009 Mar 28;15(12):1452-8. Liver fibrosis was evident at 6 weeks in Experiments 1 and 2, and the activity of serum enzymes (including alanine aminotransferase, aspartate aminotransferase and dehydrogenase) was increased. |
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| 19646978 | Yasuda Y, Shimizu M, Sakai H, Iwasa J, Kubota M, Adachi S, Osawa Y, Tsurumi H, Hara Y, Moriwaki H: (-)- prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R. Plant Foods Hum Nutr. 2008 Jun;63(2):59-63. Epub 2008 Mar 4. Drinking water with 0.1% significantly decreased the serum levels of both aspartate aminotransferase and alanine aminotransferase raised by CCl4, thus indicating an improvement of liver injury. |
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| 17450508 | Moresco RN, Sperotto RL, Bernardi AS, Cardoso RF, Gomes P: Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride-induced hepatotoxicity in rats. J Nutr Biochem. 2006 Mar;17(3):177-82. Epub 2005 Aug 10. Blood samples obtained after treatments were measured for aspartate aminotransferase (AST) and alanine aminotransferase (ALT). |
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| 16303155 | Mohamed MA, Marzouk MS, Moharram FA, El-Sayed MM, Baiuomy AR: Phytochemical constituents and hepatoprotective activity of Viburnum tinus. Food Chem Toxicol. 2008 May;46(5):1778-85. Epub 2008 Jan 18. CCl4-induced hepatotoxicity has been evaluated in terms of the determination of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipid peroxide and levels in serum and compared using adult male rats weighing 150-180 g. |
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| 16278809 | Ohta Y, Imai Y, Matsura T, Kitagawa A, Yamada K: Preventive effect of neutropenia on carbon tetrachloride-induced hepatotoxicity in rats. J Appl Toxicol. 2006 Mar-Apr;26(2):178-86. In rats treated once with CCl4 (1 ml kg (-1), i.p.), the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indices of liver cell damage, and the hepatic activity of myeloperoxidase (MPO), an index of tissue neutrophil infiltration, increased at 6 h after the intoxication and further increased at 24 h. |
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| 19336974 | Mochizuki M, Shimizu S, Urasoko Y, Umeshita K, Kamata T, Kitazawa T, Nakamura D, Nishihata Y, Ohishi T, Edamoto H: Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats. Arch Pharm Res. 2007 Oct;30(10):1309-17. Hepatotoxicity in CCl4-treated pregnant rats evaluated by blood chemistry (alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities) and histopathological finding (area of damaged hepatocytes) was minimal on GD19, being weaker than that in non-pregnant rats. |
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| 17544377 | Okumura H, Katoh M, Minami K, Nakajima M, Yokoi T: Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. J Toxicol Sci. 2009 Apr;34(2):175-81. Depending on the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), urinary CMZ excretion was increased, whereas fecal CMZ excretion was decreased in rat with liver dysfunction. |
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| 19779110 | Peng HY, Chu YC, Chen SJ, Chou ST: Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats. J Nutr Biochem. 2006 Jul;17(7):485-91. Epub 2005 Oct 10. The GPE had a significant protective effect against liver injuries, as well as oxidative stress induced by CCl (4), resulting in reduced lipid peroxidation and improved serum biochemical parameters such as aspartate aminotransferase and alanine aminotransferase. |
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| 17472474 | Lee HS, Keum KY, Ku SK: Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride. Am J Chin Med. 2007;35(5):793-804. Animals were sacrificed 10 weeks after oral administration of PR extracts at 50, 100, or 200 mg/kg or silymarin at 100 mg/kg, which were administered simultaneously with CCl (4); changes in body weight, liver weight, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were observed along with differences in liver histopathology and histomorphometry. |
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| 16547767 | Wu Y, Wang F, Zheng Q, Lu L, Yao H, Zhou C, Wu X, Zhao Y: Hepatoprotective effect of total flavonoids from Laggera alata against carbon tetrachloride-induced injury in primary cultured neonatal rat hepatocytes and in rats with hepatic damage. Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. In vitro, TFLA at a concentration range of 1-100 microg/ml improved cell viability and inhibited cellular leakage of two enzymes, hepatocyte aspartate aminotransferase (AST) and alanine aminotransferase (ALT), caused by CCl (4). |
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| 17565875 | Chen ZZ, Yang RJ, Liu PC: [Safety and effect of two-step portal vein embolization in treatment of hepatic fibrosis: experiment with rabbits]. World J Gastroenterol. 2009 Oct 14;15(38):4816-22. METHODS: Twenty rabbit underwent intraperitoneal injection of carbon tetrachloride to establish models of hepatic fibrosis, and then were randomly divided into 2 equal groups: one-step group in which ileocolic vein was exposed, portal angiography was conducted, a catheter was inserted into the upper end of the main trunk of portal vein beyond the branches of right lower lobe of liver, a mixture of - lipiodol was infused into the portal vein branches supplying 70% - 90% of the liver via a catheter and then a coil was put at the proximal side of hepatic portal, and two-step group in which the portal vein branches were embolized by using a mixture of -lipiodol first at the first step and then by using polyvinyl particles 4 weeks later during the second operation. The serum levels of transaminase (ALT), aspartate aminotransferase (AST), total and albumin were examined before and 4, 7, and 14 days after the portal vein embolization. |
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| 20350579 | Hsu YW, Tsai CF, Chuang WC, Chen WK, Ho YC, Lu FJ: Protective effects of hydride against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2006 Dec 7;228(2-3):310-22. Epub 2006 Oct 6. The results showed that oral administration of hydride significantly reduced the elevated serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), and and the level of malondialdehyde (MDA) in the liver that were induced by CCl (4) in mice. |
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| 17697871 | Young TH, Tang HS, Lee HS, Hsiong CH, Hu OY: Effects of hyperglycemia on quantitative liver functions by the load test in diabetic rats. Chem Biol Interact. 2009 Dec 10;182(2-3):159-64. Epub 2009 Jul 30. Four groups of animal studies were carried out, as follows: (1) normal control (NC), (2) streptozotocin-induced diabetes (DM), (3) carbon tetrachloride-induced hepatotoxicity (CCl (4)), and (4) streptozotocin-induced diabetes with CCl (4)-induced hepatotoxicity (DM + CCl (4)). A significant increase in hepatic activities of aspartate aminotransferase and alanine aminotransferase was observed in the CCl (4)-treated groups (CCl (4) and DM + CCl (4)) compared with the NC and DM groups (P < .001). |
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| 18981533 | Ulicna O, Vancova O, Waczulikova I, Bozek P, Janega P, Babal P, Liskova S, Greksak M: Does rooibos tea (Aspalathus linearis) support regeneration of rat liver after intoxication by carbon tetrachloride?. Gen Physiol Biophys. 2008 Sep;27(3):179-86. Seven days later in the regeneration phase, the animals treated by RT during whole period of the experiment, and those which drunk RT only during the regeneration period, exhibited a trend for decrease in the activity of alanine aminotransferase and significant decrease in the activity of aspartate aminotransferase and in total content when compared with the water-drinking group. |
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| 19903377 | Badr AM, El-Demerdash E, Khalifa AE, Ghoneim AI, Ayoub NA, Abdel-Naim AB: Rubus sanctus protects against carbon tetrachloride-induced toxicity in rat isolated hepatocytes: isolation and characterization of its galloylated flavonoids. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Oct;23(10):1235-40. In addition, RE ameliorated CCl (4)-induced enzyme leakage by 40% for lactate dehydrogenase, 30% for alanine aminotransferase and 20% for aspartate aminotransferase as compared with CCl (4)-treated cells. |
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| 17318332 | Wang FR, Ai H, Chen XM, Lei CL: Hepatoprotective effect of a protein-enriched fraction from the maggots (Musca domestica) against CCl4-induced hepatic damage in rats. Biotechnol Lett. 2007 Jun;29(6):853-8. Epub 2007 Feb 22. The hepatoprotective potential of a protein-enriched fraction (PEF) isolated from the maggots of housefly (Musca domestica) was evaluated in rats against carbon tetrachloride (CCl4)-induced acute hepatic damage. Activities of serum aspartate aminotransferase and alanine aminotransferase increased by 4- and 13-fold induced by CCl4, were significantly inhibited by pretreatment with 50, 100 and 200 mg PEF/kg. |
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| 19913046 | Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY: Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Biochem Pharmacol. 2007 Aug 1;74(3):488-95. Epub 2007 May 3. Ginsan treatment markedly suppressed the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and hepatic histological necrosis increased by CCl (4) treatment. |
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| 18397225 | Tsai JH, Liu JY, Wu TT, Ho PC, Huang CY, Shyu JC, Hsieh YS, Tsai CC, Liu YC: Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 2009 Dec 10;126(3):487-91. Epub 2009 Sep 15. Moreover, silymarin significantly decreased the elevation of aspartate aminotransferase (AST), alanine aminotransferase, and alkaline phosphatase in serum, and also reversed the altered expressions of alpha-smooth muscle actin in liver tissue. |
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| 20079350 | Sun H, Che QM, Zhao X, Pu XP: Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats. J Biomed Sci. 2006 Jul;13(4):569-78. Epub 2006 Mar 18. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl (4)) in rats and investigate its possible protective mechanism. The antifibrotic effects of baicalein were assessed directly by hepatic histology and indirectly by measuring levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), hepatic laminin and procollagen type III (PCIII) in serum, as well as and matrix metalloproteinases (MMPs) in liver. |
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| 18987472 | Zhang JJ, Meng XK, Dong C, Qiao JL, Zhang RF, Yue GQ, Zhong HY: Development of a new animal model of liver cirrhosis in swine. Hepatobiliary Pancreat Dis Int. 2006 May;5(2):262-7. This study aimed to develop a new experimental model of liver cirrhosis in swine by using carbon tetrachloride (CCl (4)) and Alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, and portal venous pressure (PVP) levels were determined throughout CCl (4) treatment. |
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| 19596425 | Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY: Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. Int J Exp Pathol. 2007 Oct;88(5):361-76. A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. The activities of aspartate aminotransferase (AST) and alanine-aminotransferase (ALT) were more effectively suppressed by CC-700C than Silymarin. |
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| 17869397 | Guo TT, Xu HL, Zhang LX, Zhang JP, Guo YF, Gu JW, He PM: In vivo protective effect of Porphyra yezoensis polysaccharide against carbon tetrachloride induced hepatotoxicity in mice. Exp Toxicol Pathol. 2004 Oct;56(1-2):59-64. Levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver homogenate, content of malondialdehyde (MDA), activities of total superoxide dismutase (T-SOD) in liver were measured by biochemical methods. |
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| 15344427 | Lee SE, Song KH, Liu J, Kwon HJ, Youn SB, Lee YW, Cho SH, Kim DH: The effectiveness of auriculoacupoint treatment for artificially induced acute hepatic injury in dogs. Am J Chin Med. 2004;32(3):445-51. This study was to investigate effects of auriculoacupoint (AAP) treatment on carbon tetrachloride (CCl4)-induced acute hepatic injury in ten dogs (four females and six males). Compared to the control group, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in the experimental group were significantly decreased at the 4th day (p < 0.05) and at the 5th day (p < 0.05), respectively. |
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| 16941609 | Yemitan OK, Izegbu MC: Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and -induced hepatotoxicity in rats. Dig Dis Sci. 2004 Oct;49(10):1589-94. |
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| 15386534 | Kus I, Ogeturk M, Oner H, Sahin S, Yekeler H, Sarsilmaz M: Protective effects of against carbon tetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study. Phytochemistry. 2005 Dec;66(23):2780-6. Epub 2005 Nov 21. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and conjugated levels were determined. |
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| 16270387 | Chen L, Pan DD, Zhou J, Jiang YZ: Protective effect of -enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms. Biol Pharm Bull. 2006 Jan;29(1):141-5. AIM: To study the protective effects and mechanisms of Se-enriched lactobacillus on liver injury caused by carbon tetrachloride (CCl4) in mice. Then the activities of the following liver tissue injury-associated enzymes including peroxidase (GSH-Px), superoxide dismutase (SOD), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as malondialdehyde (MDA) content were assayed. |
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| 18044792 | Zhang C, Peng W, Jiang X, Chen B, Zhu J, Zang Y, Zhang J, Zhu T, Qin J: Transgene expression of human PON1 Q in mice protected the liver against CCl4-induced injury. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):318-25. Epub 2009 Nov 11. After CCl4 had been administrated to induce liver injury, mice were monitored for serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and malonyldialdehyde (MDA). |
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| 18598162 | Wu SJ, Lin YH, Chu CC, Tsai YH, Chao JC: or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats. World J Gastroenterol. 2005 Aug 21;11(31):4822-6. After 8 weeks, supplementation with and/or saikosaponin a significantly decreased plasma alanine aminotransferase and aspartate aminotransferase activities, as well as plasma and hepatic and triglyceride levels. |
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| 16829063 | Rivera-Huizar S, Rincon-Sanchez AR, Covarrubias-Pinedo A, Islas-Carbajal MC, Gabriel-Ortiz G, Pedraza-Chaverri J, Alvarez-Rodriguez A, Meza-Garcia E, Armendariz-Borunda J: Renal dysfunction as a consequence of acute liver damage by bile duct ligation in cirrhotic rats. Exp Toxicol Pathol. 2006 Nov;58(2-3):185-95. Epub 2006 Jul 7. RESULTS: Hyperbilirubinemia and increased alanine aminotransferase and aspartate aminotransferase (p <0.05) in rats with BDL were observed since the first day of bile obstruction in cirrhotic rats. |
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| 18697572 | Kuriakose GC, Kurup GM: Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats. Jpn J Vet Res. 2009 Aug;57(2):109-18. Carbon tetrachloride (CCl4) is used as a model for liver injury. Liver damage is detected by the measurement of the activities of serum enzymes like aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase and alkaline phosphatase which were released in to the blood from damaged cells. |
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| 20227265 | Coballase-Urrutia E, Pedraza-Chaverri J, Cardenas-Rodriguez N, Huerta-Gertrudis B, Edna Garcia-Cruz M, Ramirez-Morales A, Javier Sanchez-Gonzalez D, Maria Martinez-Martinez C, Camacho-Carranza R, Javier Espinosa-Aguirre J: Hepatoprotective effect of acetonic and methanolic extracts of Heterotheca inuloides against CCl (4)-induced toxicity in rats. Food Chem Toxicol. 2010 Mar 26. A model of hepatotoxicity by carbon tetrachloride (CCl (4)) in rats was used in order to evaluate the protective potential of the acetonic and methanolic extracts of Heterotheca inuloides. Pretreatment with the two H. inuloides extracts attenuated the increase in the activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) observed in CCl (4)-induced liver injury. |
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| 16282059 | You SF, Zheng PY, Ji G, Wei HF, Zhao J, Zhu PT: [Protective effects of yanggan lidan granules on carbon tetrachloride-induced liver damage in mice]. Exp Toxicol Pathol. 2010 Mar 11. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected. |
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| 16552805 | Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH: In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury. World J Gastroenterol. 2006 Mar 7;12(9):1379-85. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined with an automatic multifunction-biochemical analyzer and the levels of superoxide dismutase (SOD) and TNF-alpha were determined following the instructions of SOD kit and TNF radioimmunoassay kit. |
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| 19394401 | Ichi I, Kamikawa C, Nakagawa T, Kobayashi K, Kataoka R, Nagata E, Kitamura Y, Nakazaki C, Matsura T, Kojo S: Neutral sphingomyelinase-induced accumulation by oxidative stress during carbon tetrachloride intoxication. Inflammation. 2008 Aug;31(4):215-21. Epub 2008 Apr 22. After 12 h of oral administration of CCl4 (4 ml/kg body weight as a 1:1 mixture of CCl4 and mineral oil) to rats, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased. |
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