| Name | neurotoxic esterase |
|---|---|
| Synonyms | NTE; SWS; Neuropathy target esterase; Neurotoxic esterase; PNPLA 6; patatin like phospholipase domain containing 6; Neuropathy target esterases… |
| Name | mipafox |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7078105 | Soliman SA, Curley A, Novak R: A kinetic study on the inhibition of hen brain neurotoxic esterase by mipafox. J Anal Toxicol. 1982 Jan-Feb;6(1):4-9. |
82(1,1,1,2) | Details |
| 17184757 | Quesada E, Sabater E, Sogorb MA, Vilanova E, Carrera V: Recovery of neuropathy target esterase activity after inhibition with mipafox and O-hexyl O-2,5-dichlorophenyl phosphoramidate in bovine chromaffin cell cultures. Chem Biol Interact. 2007 Jan 30;165(2):99-105. Epub 2006 Nov 16. |
82(1,1,1,2) | Details |
| 15035642 | Kropp TJ, Glynn P, Richardson RJ: The mipafox-inhibited catalytic domain of human neuropathy target esterase ages by reversible loss. Biochemistry. 2004 Mar 30;43(12):3716-22. |
82(1,1,1,2) | Details |
| 9051410 | Williams FM, Charlton C, de Blaquiere GE, Mutch E, Kelly SS, Blain PG: The effects of multiple low doses of organophosphates on target enzymes in brain and diaphragm in the mouse. Hum Exp Toxicol. 1997 Feb;16(2):67-71. Mipafox also had a cumulative inhibitory effect on brain neuropathy target esterase. 4. |
81(1,1,1,1) | Details |
| 1446009 | Wu SY, Casida JE: Neuropathy target esterase inhibitors: 2-alkyl-, 2-alkoxy-, and 2-(aryloxy)-4H-1,3,2-benzodioxaphosphorin 2-oxides. Chem Res Toxicol. 1992 Sep-Oct;5(5):680-4. The standard probes used earlier to study neuropathy target esterase (NTE) are N,N'-diisopropyl phosphorofluorodiamidate (mipafox), diisopropyl phosphorofluoridate (DFP), 2-(2-methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide (2-CH3C6H4O-BDPO) (the metabolite of tri-o-cresyl and dipentyl 2,2-dichlorovinyl (DDP) with I50s for hen brain enzyme of 7000, 700, 29, and 3 nM, respectively. |
32(0,1,1,2) | Details |
| 10741477 | Moretto A, Jokanovic M, Lotti M: The relevance of inhibitor-substrate interactions when measuring neuropathy target esterase inhibition. Arch Toxicol. 2000 Feb;73(12):655-60. Neuropathy target esterase (NTE), thought to be the target for organophosphate polyneuropathy, is operationally defined as that neural phenyl esterase resistant to paraoxon (40 microM) and sensitive to mipafox (50 microM; 20 min, pH 8.0, 37 degrees C). |
32(0,1,1,2) | Details |
| 3753463 | Carrington CD, Abou-Donia MB: Kinetics of substrate hydrolysis and inhibition by mipafox of paraoxon-preinhibited hen brain esterase activity. Biochem J. 1986 Jun 1;236(2):503-7. For the purpose of assessing the potential of organophosphorus compounds, it has been determined that paraoxon-preinhibited hen brain has both neurotoxicant (mipafox)-sensitive (neurotoxic esterase; NTE) and -insensitive esterase components. |
6(0,0,1,1) | Details |
| 16766477 | Cho TM, Wild JR, Donnelly KC, Tiffany-Castiglioni E: Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH). J Toxicol Environ Health A. 2006 Aug;69(15):1413-29. Short-term effects of four OPH-treated OPs on acetylcholinesterase (AChE) and neuropathy target esterase (NTE) activities were measured in -differentiated or undifferentiated cells, and delayed effects of OPH-treated paraoxon or mipafox on levels of neuronal cytoskeletal proteins in nerve growth factor (NGF)-differentiated cells. |
6(0,0,1,1) | Details |
| 17913405 | Chang PA, Long DX, Wu YJ: Molecular cloning and expression of chicken neuropathy target esterase activity domain. Toxicol Lett. 2007 Nov 1;174(1-3):42-8. Epub 2007 Sep 1. After inhibition with different concentrations of mipafox for 60min, the calculated I (50) value was 4.95microM for COS7 cells over-expressing cNEST. |
2(0,0,0,2) | Details |
| 17615108 | Makhaeva GF, Malygin VV, Strakhova NN, Sigolaeva LV, Sokolovskaya LG, Eremenko AV, Kurochkin IN, Richardson RJ: Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: review of progress. Hum Exp Toxicol. 2007 Apr;26(4):273-82. |
2(0,0,0,2) | Details |
| 8525498 | Mutch E, Kelly SS, Blain PG, Williams FM: Comparative studies of two organophosphorus compounds in the mouse. Toxicol Lett. 1995 Nov;81(1):45-53. Mipafox (110 mumol/kg, s.c.) inhibited brain acetylcholinesterase (AChE), neuropathy target esterase (NTE) and phenylvalerate hydrolases by 58, 64 and 65%, while diaphragm AChE and phenylvalerate hydrolases were inhibited by 66 and 80%, respectively. |
81(1,1,1,1) | Details |
| 7365208 | Soliman SA, El-Sebae AE, Curely A, Ahmed NS: Subcellular distribution of neurotoxic esterase activity in lamb and mouse brain. J Environ Sci Health B. 1980;15(2):207-17. The specific inhibitor, N,N-diisopropylphosphorodiamidic (mipafox) was synthesized and purified. |
2(0,0,0,2) | Details |
| 3699331 | Novak R, Padilla S: An in vitro comparison of rat and chicken brain neurotoxic esterase. . Fundam Appl Toxicol. 1986 Apr;6(3):464-71. Mipafox titration of the paraoxon-resistant esterases at a fixed paraoxon concentration of 100 microM (mipafox concentration: 0-1000 microM) resulted in a mipafox I50 of 7.3 microM for chicken brain NTE and 11.6 microM for rat brain NTE. |
2(0,0,0,2) | Details |
| 2703698 | Koelle GB, Thampi NS, Han MS, Olajos EJ: Histochemical demonstration of neurotoxic esterase. . J Histochem Cytochem. 1989 May;37(5):589-96. We developed a histochemical method for localizing neurotoxic esterase (NTE), defined as the phenylvalerate (PV)-hydrolyzing esterase that is resistant to 40 microM paraoxon (A) but inactivated by paraoxon plus 50 microM mipafox (B). |
32(0,1,1,2) | Details |
| 8211998 | Lotti M, Moretto A, Capodicasa E, Bertolazzi M, Peraica M, Scapellato ML: Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy. Toxicol Appl Pharmacol. 1993 Oct;122(2):165-71. In fact, mipafox and methamidophos as well as certain classic protective inhibitors such as and sulfonyl form an inhibited NTE which apparently does not age and yet produces neuropathy. |
2(0,0,0,2) | Details |
| 8245968 | Tormo N, Gimeno JR, Sogorb MA, Diaz-Alejo N, Vilanova E: Soluble and particulate organophosphorus neuropathy target esterase in brain and sciatic nerve of the hen, cat, rat, and chick. J Neurochem. 1993 Dec;61(6):2164-8. In the present work, we have studied the particulate and soluble fractional distribution of paraoxon-resistant phenylvalerate esterase activity (B activity), paraoxon- and mipafox-resistant phenylvalerate esterase activity (C activity), and NTE activity (B-C) according to ultracentrifugation criteria (100,000 g for 1 h). |
2(0,0,0,2) | Details |
| 6623525 | Ishikawa Y, Chow E, McNamee MG, McChesney M, Wilson BW: Separation of paraoxon and mipafox sensitive esterases by density gradient sedimentation. Toxicol Lett. 1983 Jul;17(3-4):315-20. Enzyme activity from chick embryo brain with properties of neurotoxic esterase (NTE, insensitive to 40 microM paraoxon, sensitive to 50 microM mipafox) migrated in a 9S peak. |
6(0,0,1,1) | Details |
| 9586870 | Sarin S, Gill KD: Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure. Pharmacol Biochem Behav. 1998 Apr;59(4):1081-6. Dichlorvos administration significantly decreased the activities of neuropathy target esterase and other carboxylesterase viz., paraoxon resistant and mipafox and paraoxon resistant esterases. |
6(0,0,1,1) | Details |
| 9745921 | Makhaeva GF, Filonenko IV, Yankovskaya VL, Fomicheva SB, Malygin VV: Comparative studies of O,O-dialkyl-O-chloromethylchloroformimino phosphates: interaction with neuropathy target esterase and acetylcholinesterase. Neurotoxicology. 1998 Aug-Oct;19(4-5):623-8. |
2(0,0,0,2) | Details |
| 7314133 | Soliman SA, Curley A, El-Sebae AK: A direct method to assay neurotoxic esterase activity. Toxicol Lett. 1981 Nov;9(3):283-8. Paired samples of the microsomal preparation were preincubated for 20 min with paraoxon plus either (a) buffer or (b) mipafox before addition of substrate. |
2(0,0,0,2) | Details |
| 8343999 | Ehrich M, Jortner BS, Padilla S: Relationship of neuropathy target esterase inhibition to neuropathology and ataxia in hens given organophosphorus esters. Chem Biol Interact. 1993 Jun;87(1-3):431-7. Adult White Leghorn hens were acutely exposed to 3 dosages of the following organophosphorus compounds: mipafox, tri-ortho-tolyl (TOTP), phenyl saligenin and diisopropylphosphorofluoridate (DFP). |
2(0,0,0,2) | Details |
| 10505626 | Kamijima M, Casida JE: Localization of [3H] octylphosphonyl-labeled neuropathy target esterase by chicken nervous tissue autoradiography. Neurosci Lett. 1999 Oct 1;273(2):101-4. We use a more direct and quantitative autoradiographic approach of forming phosphorylated and aged [3H] octylphosphonyl-NTE on treatment with the highly potent [octyl-3H] octyl-4H-1,3,2-benzodioxaphosphorin 2-oxide to determine NTE as the labeling site resistant to the non-neuropathic paraoxon and sensitive to the neuropathic mipafox. |
2(0,0,0,2) | Details |
| 17184936 | Quesada E, Castell JV, Vilanova E, Carrera V: Over-expression of neuropathy target esterase activity in bovine chromaffin cell cultures by adenovirus-mediated gene transfer. Toxicol Lett. 2007 Feb 5;168(3):286-91. Epub 2006 Nov 16. After 60min of inhibition with mipafox increased concentrations, the calculated I (50) (60min) values were 5.5, 6.2 and 6.6microM for cells infected with 0, 2 and 10microl of vector preparation. |
2(0,0,0,2) | Details |
| 3579980 | Davis CS, Richardson RJ: Neurotoxic esterase: characterization of the solubilized enzyme and the conditions for its solubilization from chicken brain microsomal membranes with ionic, zwitterionic, or nonionic detergents. Biochem Pharmacol. 1987 May 1;36(9):1393-9. Mipafox pI50 values obtained from complete titration curves carried out on NTE solubilized in Triton X-100, or /asolectin were indistinguishable from the value for native enzyme from brain homogenate. |
2(0,0,0,2) | Details |
| 8568835 | Barril J, Tormo N, Diaz-Alejo N, Vilanova E: Organophosphorus inhibition and heat inactivation kinetics of particulate and soluble forms of peripheral nerve neuropathy target esterase. J Biochem Toxicol. 1995 Aug;10(4):211-8. NTE is operationally defined in this article as the phenylvalerate esterase activity which is resistant to inhibition by 40 microM paraoxon and sensitive to 250 microM mipafox. |
2(0,0,0,2) | Details |
| 9001593 | Escudero MA, Sogorb MA, Vilanova E: An automatable microassay for phenyl esterase activities sensitive to organophosphorus compounds. Toxicol Lett. 1996 Dec 31;89(3):241-7. An automatable microassay method developed for phenyl esterase (PVase) activity has been applied to determine the following activities in the soluble fraction of hen sciatic nerve: activity A (total PVase activity), activity B (paraoxon-resistant PVase activity), activity C (PVase activity resistant to 40 microM paraoxon and 250 microM mipafox) and neuropathy target esterase (NTE) activity (resistant to 40 microM paraoxon but sensitive to 250 microM mipafox), operationally defined as activity (B-C). |
6(0,0,1,1) | Details |
| 7881804 | Seifert J, Wilson BW: Solubilization of neuropathy target esterase and other phenyl carboxylesterases from chicken embryonic brain by phospholipase A2. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1994 Jul;108(3):337-41. NTE solubilization by phospholipase A2 did not affect its apparent Km and Vmax for the substrate phenyl or the susceptibility of phenyl carboxylesterases to inhibition by paraoxon and mipafox. |
2(0,0,0,2) | Details |
| 10421494 | Makhaeva GF, Malygin VV: A stable preparation of hen brain neuropathy target esterase for rapid biochemical assessment of potential of organophosphates. Chem Biol Interact. 1999 May 14;119-120:551-7. To obtain a stable NTE preparation the influence of intensive freezing and subsequent lyophilization of paraoxon-preinhibited (P2 + P3) hen brain membrane fraction on NTE properties has been studied using two neuropathic OP: mipafox and O,O-dipropyldichlorovinyl (PrDChVP). |
2(0,0,0,2) | Details |
| 7891095 | Yoshida M, Tomizawa M, Wu SY, Quistad GB, Casida JE: Neuropathy target esterase of hen brain: active site reactions with 2-[octyl-3H] octyl-4H-1,3,2-benzodioxaphosphorin 2-oxide and 2-octyl-4H-1,3,2-[aryl-3H] benzodioxaphosphorin 2-oxide. J Neurochem. 1995 Apr;64(4):1680-7. Two NTE-like proteins, i.e., resistant to paraoxon and sensitive to mipafox, of approximately 155 and approximately 119 kDa (designated NTE-155 and NTE-119, respectively) are labeled by [octyl-3H] octyl-BDPO and separated by -polyacrylamide gel electrophoresis. |
2(0,0,0,2) | Details |
| 9268605 | Ehrich M, Correll L, Veronesi B: Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fundam Appl Toxicol. 1997 Jul;38(1):55-63. For example, apparent IC50 values for NTE inhibition were less than 9.6-fold the apparent IC50 values for AChE inhibition when cells were exposed to the neuropathy-inducing OPs diisopropyl phosphorofluoridate, cyclic tolyl saligenin phenyl saligenin mipafox, dibutyl dichlorovinyl and di-octyl-dichlorovinyl |
2(0,0,0,2) | Details |
| 9305588 | Milatovic D, Moretto A, Osman KA, Lotti M: Phenyl esterases other than neuropathy target esterase and the promotion of organophosphate polyneuropathy. Chem Res Toxicol. 1997 Sep;10(9):1045-8. Brain and sciatic nerve PV esterases of hens were incubated with diisopropylphosphorofluoridate (DFP; 5 microM) or N,N-diisopropyl phosphorodiamidofluoridate (mipafox; 50 microM) to inhibit NTE and other esterases thought not to be relevant to promotion. |
2(0,0,0,2) | Details |
| 10421495 | Sigolaeva LV, Eremenko AV, Makower A, Makhaeva GF, Malygin VV, Kurochkin IN: A new approach for determination of neuropathy target esterase activity. Chem Biol Interact. 1999 May 14;119-120:559-65. The validity of this biosensor method is confirmed by the facts that the calibration curves for NTE obtained by colorimetric and flow-through electrochemical methods were nearly identical and the titration of NTE by test inhibitor mipafox was shown to yield the same pI50 values. |
2(0,0,0,2) | Details |
| 2051750 | Kayyali US, Moore TB, Randall JC, Richardson RJ: Neurotoxic esterase (NTE) assay: optimized conditions based on detergent-induced shifts in the /4-aminoantipyrine chromophore spectrum. J Anal Toxicol. 1991 Mar-Apr;15(2):86-9. NTE activity is calculated from the rate of phenyl hydrolysis resistant to paraoxon and sensitive to mipafox inhibition under specified conditions of inhibitor concentrations, pH, temperature, and incubation times with inhibitors and substrate. |
2(0,0,0,2) | Details |
| 3824383 | Padilla SS, Grizzle TB, Lyerly D: Triphenyl in vivo and in vitro inhibition of rat neurotoxic esterase. Toxicol Appl Pharmacol. 1987 Feb;87(2):249-56. By contrast, TPP was shown in vitro to be a potent (150 = 0.98 microM) inhibitor of rat brain NTE relative to Mipafox or diisopropyl phosphorofluoridate. |
2(0,0,0,2) | Details |
| 12746135 | Makhaeva GF, Sigolaeva LV, Zhuravleva LV, Eremenko AV, Kurochkin IN, Malygin VV, Richardson RJ: Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds. J Toxicol Environ Health A. 2003 Apr 11;66(7):599-610. The I50 (20 min at 37 degrees C) for N,N'-di-2-propylphosphorodiamidofluoridate (mipafox) against hen lymphocyte NTE was 6.94 +/- 0.28 microM amperometrically and 6.02 +/- 0.71 microM colorimetrically. |
2(0,0,0,2) | Details |
| 8343980 | Chemnitius JM, Dewald K, Kreuzer H, Zech R: Computerized analysis of covalent inhibition kinetics for identification of heart muscle cholinesterase and brain carboxylesterase isoenzymes. Chem Biol Interact. 1993 Jun;87(1-3):239-44. High sensitivity and specificity of the classic differential inhibition test for carboxylesterase activity of hen brain neuropathy target esterase (NTE) could be confirmed independently with both methods of inhibition curve analysis. |
1(0,0,0,1) | Details |
| 2260984 | Thomas TC, Szekacs A, Rojas S, Hammock BD, Wilson BW, McNamee MG: Characterization of neuropathy target esterase using trifluoromethyl ketones. Biochem Pharmacol. 1990 Dec 15;40(12):2587-96. This activity is identified as phenyl hydrolysis which is resistant to treatment with paraxon and sensitive to co-incubation with paraxon and mipafox. |
2(0,0,0,2) | Details |
| 2920006 | Thomas TC, Ishikawa Y, McNamee MG, Wilson BW: Correlation of neuropathy target esterase activity with specific tritiated di-isopropyl phosphorofluoridate-labelled proteins. Biochem J. 1989 Jan 1;257(1):109-16. This activity is identified by its resistance to treatment with Paraoxon and sensitivity to co-incubation with Paraoxon and Mipafox. |
2(0,0,0,2) | Details |
| 8343992 | Thomas TC, Szekacs A, Hammock BD, Wilson BW, McNamee MG: Affinity chromatography of neuropathy target esterase. . Chem Biol Interact. 1993 Jun;87(1-3):347-60. It proved difficult to elute active NTE under non-denaturing conditions, but SDS-PAGE analysis of MNTFP-Sepharose bound proteins eluted with 2% SDS identified a 155 kDa NTE-like protein that bound in a trifluoromethylketone- or mipafox-sensitive but paraoxon-insensitive manner. |
2(0,0,0,2) | Details |
| 11180931 | Sigolaeva LV, Makower A, Eremenko AV, Makhaeva GF, Malygin VV, Kurochkin IN, Scheller FW: Bioelectrochemical analysis of neuropathy target esterase activity in blood. Anal Biochem. 2001 Mar 1;290(1):1-9. |
2(0,0,0,2) | Details |
| 3966239 | Lotti M, Wei ET, Spear RC, Becker CE: Neurotoxic esterase in rooster testis. . Toxicol Appl Pharmacol. 1985 Jan;77(1):175-80. NTE activity after complete mipafox titration accounts for 30% of paraoxon-resistant phenyl esterases and corresponds to 7.93 +/- 0.39 nmol/min/mg of protein (mean +/- SD, n = 7). |
2(0,0,0,2) | Details |
| 9463518 | Barril J, Vilanova E: Reversible inhibition can profoundly mislead studies on progressive inhibition of enzymes: the interaction of paraoxon with soluble neuropathy target esterase. Chem Biol Interact. 1997 Dec 12;108(1-2):19-25. O,O'-diethyl p-nitrophenyl (paraoxon) was the non- OP of choice for the standard assay of NTE to block the non-relevant esterases (phenylvalerate hydrolases) because it was supposed not to inhibit the enzymic activity of the target protein while N,N'-diisopropyl phosphorodiamidofluoridate (mipafox) is the neuropathic OP used to inhibit (and so to detect) NTE activity. |
2(0,0,0,2) | Details |
| 2254952 | Pope CN, Padilla S: Potentiation of organophosphorus-induced delayed neurotoxicity by phenylmethylsulfonyl J Toxicol Environ Health. 1990 Dec;31(4):261-73. It is well known that pretreatment with the serine esterase inhibitor phenylmethylsulfonyl (PMSF) can protect experimental animals from organophosphorus-induced delayed neurotoxicity (OPIDN), presumably by blocking the active site of neurotoxic esterase (NTE) such that binding and "aging" of the neuropathic OP is thwarted. We report here that while PMSF (60 mg/kg, sc) given 4 h before the neuropathic organophosphate (OP) mipafox (50 mg/kg, im) completely prevented the clinical expression of OPIDN in hens, the identical PMSF treatment markedly amplified the delayed neurotoxicity (relative to hens treated with OP only) if administered 4 h after mipafox (5 or 50 mg/kg, im). |
1(0,0,0,1) | Details |
| 3715916 | Reveley JW, Sabourin TD, Moore MT, Goss LB: Distribution of neurotoxic esterase activity in the brain of control and diisopropyl phosphorofluoridate-treated hens: in vivo and in vitro exposure. Toxicol Lett. 1986 Apr;31(1):45-56. |
2(0,0,0,2) | Details |
| 7278155 | Soliman SA, Curley A: Assay of chicken brain neurotoxic esterase activity using leptophosoxon as the selective inhibitor. J Anal Toxicol. 1981 Jul-Aug;5(4):183-6. Part of that activity is due to paraoxon-insensitive esterases and a sub-part of this is sensitive to organophosphates, i.e., mipafox and leptophosoxon. |
2(0,0,0,2) | Details |
| 8685903 | Wu SY, Casida JE: Subacute neurotoxicity induced in mice by potent organophosphorus neuropathy target esterase inhibitors. Toxicol Appl Pharmacol. 1996 Jul;139(1):195-202. |
1(0,0,0,1) | Details |
| 16485911 | Kropp TJ, Richardson RJ: Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a adduct. Chem Res Toxicol. 2006 Feb;19(2):334-9. Aging of phosphylated serine esterases, e.g., acetylcholinesterase (AChE) and neuropathy target esterase (NTE), renders the inhibited enzymes refractory to reactivation. |
1(0,0,0,1) | Details |
| 17207828 | Moretto A, Nicolli A, Lotti M: The search of the target of promotion: Phenylbenzoate esterase activities in hen peripheral nerve. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):196-201. Epub 2006 Nov 29. Given the biochemical and toxicological characteristics of these compounds, the hypothesis was made that the target of promotion is a phenyl (PV) esterase similar to neuropathy target esterase (NTE), the target of organophosphate induced delayed polyneuropathy. The ideal substrate should be poorly hydrolysed by NTE but extensively by enzyme (s) that are insensitive to non-promoters, such as mipafox, and sensitive to promoters, such as phenyl sulfonyl (PMSF). |
1(0,0,0,1) | Details |
| 15177651 | Quesada E, Sogorb MA, Vilanova E, Carrera V: Bovine chromaffin cell cultures as model to study organophosporus neurotoxicity. Toxicol Lett. 2004 Jun 15;151(1):163-70. Based on the high level of phenyl esterase activities, and in particular of neuropathy target esterase (NTE) found in bovine adrenal medulla, chromaffin cells culture have been proposed as an alternative model for the study of organophosphorus neurotoxicity. Organophosphorus-induced polyneuropathy is a syndrome related to the inhibition and further modification by organophosphorus compounds of NTE (a protein that displays phenyl esterase activity resistant to mipafox and sensitive to paraoxon). |
1(0,0,0,1) | Details |
| 17323978 | Kropp TJ, Richardson RJ: Mechanism of aging of mipafox-inhibited butyrylcholinesterase. . Chem Res Toxicol. 2007 Mar;20(3):504-10. Epub 2007 Feb 27. However, recent evidence has shown that acetylcholinesterase (AChE) and the catalytic domain of human neuropathy target esterase (NEST) undergo aging by alternative mechanisms following their inhibition with N,N'-diisopropylphosphorodiamidofluoridate (mipafox, MIP). |
1(0,0,0,1) | Details |
| 7909676 | Husain K: Phenyl and ester hydrolases in the platelets of human, hen, rat and mouse. Hum Exp Toxicol. 1994 Mar;13(3):157-9. The activities of total phenyl hydrolase (PVase), paraoxon insensitive phenyl hydrolase (PI-PVase), paraoxon and mipafox resistant esterase (PMRE) and propionyl-cholinesterase (PChE) were maximal in hen followed by mouse, rat and human. 3. Neurotoxic esterase (NTE) and acetylcholinesterase (AChE) activities were concentrated in the platelets of hens followed by humans, rats and mice in order. 4. |
1(0,0,0,1) | Details |
| 1302299 | Carboni D, Ehrich M, Dyer K, Jortner BS: Comparative evolution of mipafox-induced delayed neuropathy in rats and hens. Neurotoxicology. 1992 Winter;13(4):723-33. Administration of this organophosphorus ester resulted in > or = 89% inhibition of brain and spinal cord neurotoxic esterase activity in both species 4 hr after dosing. |
1(0,0,0,1) | Details |
| 2018554 | Moretto A, Capodicasa E, Peraica M, Lotti M: Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochem Pharmacol. 1991 May 15;41(10):1497-504. The putative target protein in the nervous system for initiation of OPIDP in the adult hen is an enzyme called Neuropathy Target Esterase (NTE), which is dissected by selective inhibitors among nervous tissue esterases hydrolysing phenyl (PV). |
1(0,0,0,1) | Details |
| 10421491 | Lotti M, Moretto A: Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors. Chem Biol Interact. 1999 May 14;119-120:519-24. The target of promotion of axonopathies is thought to be similar or linked to NTE which is defined as the phenyl esterase activity (PVE) in nervous tissues resistant to paraoxon and sensitive to mipafox (40 and 50 microM, pH 8.0, 20 min, respectively). |
0(0,0,0,0) | Details |
| 12639502 | Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E: Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol Appl Pharmacol. 2003 Jan 15;186(2):110-8. Mipafox and paraoxon were used as OP models that respectively do and do not induce OPIDN. |
0(0,0,0,0) | Details |
| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. Neuropathy target esterase (NTE) is thought to be the target of OPIDP initiation. In this article, we mainly discuss OP pesticide poisoning, particularly when caused by chlorpyrifos, dichlorvos, isofenphos, methamidophos, mipafox, trichlorfon, trichlornat, phosphamidon/mevinphos and by certain carbamates. |
1(0,0,0,1) | Details |
| 7940598 | Yoshida M, Wu SY, Casida JE: Reactivity and stereospecificity of neuropathy target esterase and alpha-chymotrypsin with 2-substituted-4H-1,3,2-benzodioxaphosphorin 2-oxides. Toxicol Lett. 1994 Nov;74(2):167-76. These compounds react much faster with NTE than 2 standard inhibitors, O,O-diisopropyl fluorophosphonate (DFP) and mipafox. alpha-Chymotrypsin is similar to NTE in undergoing rapid inhibition by BDPOs which is known to involve phosphorylation followed by aging. |
1(0,0,0,1) | Details |
| 9051411 | Kelly SS, de Blaquiere GE, Williams FM, Blain PG: Effects of multiple doses of organophosphates on evoked potentials in mouse diaphragm. Hum Exp Toxicol. 1997 Feb;16(2):72-8. Male albino mice were injected s.c. with an organophosphate (mipafox, ecothiopate or paraoxon). At 3 h after injection the activity of brain and diaphragm acetylcholinesterase and of brain neuropathy target esterase (NTE) was measured. |
1(0,0,0,1) | Details |
| 20097189 | Gambalunga A, Pasqualato F, Lotti M: Soluble phenyl esterases of hen sciatic nerve and the potentiation of organophosphate induced delayed polyneuropathy. Chem Biol Interact. 2010 Jan 25. When these activities were inhibited in vitro by a mixture containing mipafox - an OP that causes OPIDP - paraoxon and p-toluene sulfonyl - two esterase inhibitors that do not cause either neuropathy or promotion-, then the remaining activity was sensitive to classical promoters such as phenylmethane sulfonyl (PMSF) and phenylmethyl benzyl |
0(0,0,0,0) | Details |
| 7705869 | Husain K, Pant SC, Raza SK, Singh R, Das Gupta S: A comparative study of delayed neurotoxicity in hens following repeated administration of organophosphorus compounds. Indian J Physiol Pharmacol. 1995 Jan;39(1):47-50. Hens treated with Mipafox (10 mg/kg, sc), sarin (50 micrograms/kg, sc) or parathion (1 mg/kg, sc) daily for 10 days exhibited severe, moderate and no ataxia respectively on 14th day after the start of exposure. |
0(0,0,0,0) | Details |
| 12765233 | Garcia-Perez AG, Barril J, Estevez J, Vilanova E: Properties of phenyl esterase activities from chicken serum are comparable with soluble esterases of peripheral nerves in relation with organophosphorus compounds inhibition. Toxicol Lett. 2003 Apr 30;142(1-2):1-10. Chicken serum, the usual in vivo animal for testing organophosphorus delayed neuropathy, has long been reported not to contain a homologous activity of the neuronal neuropathy target esterase (NTE) activity when it is assayed according to standard methods as the phenyl esterase (PVase) activity, which is resistant to paraoxon and sensitive to mipafox. |
0(0,0,0,0) | Details |
| 8511793 | Veronesi B, Ehrich M: Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6. Baseline activities of the major target esterases, i.e., cholinesterase, carboxylesterase, and neurotoxic esterase, were assayed in mouse and several human neural candidate cell lines. IC50 data indicated that the tested mouse cell line was consistently more sensitive than the human cell line to equimolar doses of various OP compounds (e.g., mipafox, parathion, paraoxon, DFP, leptophos oxon, fenthion, and fenitrothion). |
1(0,0,0,1) | Details |
| 4060153 | Veronesi B, Padilla S: Phenylmethylsulfonyl protects rats from Mipafox-induced delayed neuropathy. Toxicol Appl Pharmacol. 1985 Nov;81(2):258-64. Initiation of organophosphorus-induced delayed neuropathy (OPIDN) is thought to consist of two molecular events involving the phosphorylation of the target enzyme, neurotoxic esterase, or neuropathy target enzyme (NTE), and a subsequent "aging" reaction which transforms the inhibited NTE into a charged moiety critical to the neuropathic process. |
1(0,0,0,1) | Details |
| 16797889 | Romero D, Quesada E, Sogorb MA, Garcia-Fernandez AJ, Vilanova E, Carrera V: Comparison of chromaffin cells from several animal sources for their use as an in vitro model to study the mechanism of organophosphorous toxicity. Toxicol Lett. 2006 Sep 10;165(3):221-9. Epub 2006 Apr 28. It had been observed that the chromaffin cells of bovine adrenal medulla contain high levels of neuropathy target esterase (NTE), the esterase whose inhibition and aging is associated with induction of the organophosphorous induced delayed neuropathy. The mipafox I (50) calculated for 30-min inhibition of NTE at 37 degrees Celsius ranged between 7.4 and 12microM. |
1(0,0,0,1) | Details |
| 3376120 | Barril JB, Vilanova E, Pellin MC: Sciatic nerve neuropathy target esterase. Toxicology. 1988 Apr;49(1):107-14. |
1(0,0,0,1) | Details |
| 10421492 | Vilanova E, Escudero MA, Barril J: NTE soluble isoforms: new perspectives for targets of neuropathy inducers and promoters. Chem Biol Interact. 1999 May 14;119-120:525-40. Neural carboxylesterases can be discriminated by differential inhibition assays with organophosphorus compounds (OPs), paraoxon (O,O'-diethyl p-nitrophenyl and mipafox (N,N'-diisopropyl phosphorodiamidofluoridate) being the ones used to discriminate esterases that should be either irrelevant or candidates as targets of the mechanism of induction of the organophosphorus-induced delayed polyneuropathy (OPIDP). The brain membrane-bound phenyl esterase (PVase) defined by Dr Johnson in 1969 as neuropathy target esterase (NTE) and recently cloned by Dr Glynn and coworkers is termed here as particulate NTE due to its association to the membrane particulate fraction. |
1(0,0,0,1) | Details |
| 16122834 | Chang PA, Chen R, Wu YJ: Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SK-N-SH) cell line. Brain Res Mol Brain Res. 2005 Nov 18;141(1):30-8. Epub 2005 Aug 24. Neuropathy target esterase (NTE) is inhibited and aged by organophosphorus compounds that induce delayed neuropathy in human and some sensitive animals. Mipafox, a organophosphate, was shown to block process outgrowth and differentiation in cells that have lowered NTE activity due to RNA interference, suggesting that mipafox may interact with other molecules to exert its effect in this context. |
1(0,0,0,1) | Details |
| 8486913 | Husain K, Vijayaraghavan R, Pant SC, Raza SK, Pandey KS: Delayed effect of sarin in mice after repeated inhalation exposure. J Appl Toxicol. 1993 Mar-Apr;13(2):143-5. These changes were accompanied by significant inhibition of neurotoxic esterase (NTE) activity in the brain, spinal cord and platelets. These changes were comparatively less than in animals treated with the organophosphate, mipafox. |
1(0,0,0,1) | Details |
| 8043002 | Glynn P, Read DJ, Guo R, Wylie S, Johnson MK: Synthesis and characterization of a biotinylated organophosphorus ester for detection and affinity purification of a brain serine esterase: neuropathy target esterase. Biochem J. 1994 Jul 15;301 ( Pt 2):551-6. Specificity of S9B labelling was further demonstrated by inhibition with the neuropathic OP mipafox. |
1(0,0,0,1) | Details |
| 10720708 | Moretto A: Promoters and promotion of axonopathies. Toxicol Lett. 2000 Mar 15;112-113:17-21. The target of promotion is unknown but there are indications that it might be similar and/or linked to neuropathy target esterase (NTE), which is the molecular target of organophosphate-induced delayed polyneuropathy (OPIDP). NTE is defined as the activity resistant to paraoxon (40 microM) and sensitive to mipafox (50 microM). |
1(0,0,0,1) | Details |
| 9193923 | Harp P, Tanaka D Jr, Pope CN: Potentiation of organophosphorus-induced delayed neurotoxicity following phenyl saligenin exposures in 2-, 5-, and 8-week-old chickens. Fundam Appl Toxicol. 1997 May;37(1):64-70. Phenylmethylsulfonyl (PMSF), a nonneuropathic inhibitor of neurotoxic esterase (NTE), is a known potentiator of organophosphorus-induced delayed neurotoxicity (OPIDN). |
1(0,0,0,1) | Details |
| 16963094 | Read DJ, Langford L, Barbour HR, Forshaw PJ, Glynn P: Phospholipase B activity and organophosphorus compound toxicity in cultured neural cells. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):190-5. Epub 2006 Aug 8. Organophosphorus compounds (OP) such as phenyl saligenin (PSP) and mipafox (MPX) which cause delayed neuropathy, inhibit neuropathy target esterase (NTE), while OPs such as paraoxon (PXN) react more readily with acetylcholinesterase. |
81(1,1,1,1) | Details |
| 1302301 | Dyer KR, Jortner BS, Shell LG, Ehrich M: Comparative dose-response studies of organophosphorus ester-induced delayed neuropathy in rats and hens administered mipafox. Neurotoxicology. 1992 Winter;13(4):745-55. A single injection of mipafox was administered to both Long-Evans hooded rats and White Leghorn hens in dosages which inhibited the activity of brain neurotoxic esterase 30-50%, 60-80%, or greater than 80% four hr after intoxication. |
81(1,1,1,1) | Details |
| 8930121 | Sogorb MA, Vilanova E, Quintanar JL, Viniegra S: Bovine chromaffin cells in culture show carboxylesterase activities sensitive to organophosphorus compounds. Int J Biochem Cell Biol. 1996 Sep;28(9):983-9. From the phenyl esterase paraoxon and mipafox inhibition curves the following activities have been determined: B-activity (resistant to 40 microM paraoxon), 1.05 +/- 0.08 mU/10 (5) cells (n = 8); C-activity (resistant to 40 microM paraoxon plus 250 microM mipafox), 0.12 +/- 0.05 mU/10 (5) cells (n = 8); and neuropathy target esterase, calculated by the difference between B- and C-activities, 0.93 +/- 0.08 mU/10 (5) cells (n = 8). |
64(0,2,2,4) | Details |
| 8140588 | Carrera V, Diaz-Alejo N, Sogorb MA, Vicedo JL, Vilanova E: In vivo inhibition by mipafox of soluble and particulate forms of organophosphorus neuropathy target esterase (NTE) in hen sciatic nerve. Toxicol Lett. 1994 Mar;71(1):47-51. |
32(0,1,1,2) | Details |
| 3190748 | Johnson MK: Sensitivity and selectivity of compounds interacting with neuropathy target esterase. Biochem Pharmacol. 1988 Nov 1;37(21):4095-104. Assay of neuropathy target esterase (NTE) which accounts for about 70% of paraoxon-resistant phenyl (PV) esterase activity of hen brain depends on the fact that it is selectively inhibited by mipafox. |
32(0,1,1,2) | Details |
| 17663017 | Vose SC, Holland NT, Eskenazi B, Casida JE: Lysophosphatidylcholine hydrolases of human erythrocytes, lymphocytes, and brain: sensitive targets of conserved specificity for organophosphorus delayed neurotoxicants. Toxicol Appl Pharmacol. 2007 Oct 1;224(1):98-104. Epub 2007 Jun 27. Brain neuropathy target esterase (NTE), associated with organophosphorus (OP)-induced delayed neuropathy, has the same OP inhibitor sensitivity and specificity profiles assayed in the classical way (paraoxon-resistant, mipafox-sensitive hydrolysis of phenyl or with lysophosphatidylcholine (LysoPC) as the substrate. |
31(0,1,1,1) | Details |
| 19620706 | Hou WY, Long DX, Wu YJ: Effect of inhibition of neuropathy target esterase in mouse nervous tissues in vitro on and lysophosphatidylcholine homeostasis. Int J Toxicol. 2009 Sep-Oct;28(5):417-24. Epub 2009 Jul 20. The authors investigate the effect of neuropathy target esterase inhibition in mouse nervous tissues in vitro on the homeostasis of and lysophosphatidylcholine by treating the homogenates with tri-ortho-cresyl paraoxon, paraoxon plus mipafox, and phenylmethylsulfonyl |
34(0,1,1,4) | Details |
| 4026795 | Carrington CD, Abou-Donia MB: Characterization of [3H] di-isopropyl phosphorofluoridate-binding proteins in hen brain. Biochem J. 1985 Jun 15;228(3):537-44. The major Paraoxon-insensitive Mipafox-sensitive binding protein (Mr 160 000) was found to be identical with one previously identified as neurotoxic esterase, an enzyme that has been proposed to be the target site for organophosphorus-compound-induced delayed neurotoxicity. |
33(0,1,1,3) | Details |
| 15094302 | Quistad GB, Casida JE: Lysophospholipase inhibition by organophosphorus toxicants. Toxicol Appl Pharmacol. 2004 May 1;196(3):319-26. This study considers organophosphorus (OP) inhibitors with emphasis on mouse brain total LysoPLA activity relative to the mipafox-sensitive neuropathy target esterase (NTE)-LysoPLA recently established as 17% of the total activity and important in the action of OP delayed toxicants. |
31(0,1,1,1) | Details |
| 8343994 | Vilanova E, Barril J, Carrera V: Biochemical properties and possible toxicological significance of various forms of NTE. Chem Biol Interact. 1993 Jun;87(1-3):369-81. NTE (neuropathy target esterase) is considered to be the target for organophosphorus-induced delayed polyneuropathy and is operationally measured by radiolabelling or by determining its esteratic activity as the paraoxon-resistant mipafox-sensitive phosphorylable site (s). |
31(0,1,1,1) | Details |
| 3714122 | Veronesi B, Padilla S, Lyerly D: The correlation between neurotoxic esterase inhibition and mipafox-induced neuropathic damage in rats. Neurotoxicology. 1986 Spring;7(1):207-15. |
162(2,2,2,2) | Details |
| 12791540 | Kropp TJ, Richardson RJ: Relative inhibitory potencies of chlorpyrifos oxon, chlorpyrifos methyl oxon, and mipafox for acetylcholinesterase versus neuropathy target esterase. J Toxicol Environ Health A. 2003 Jun 27;66(12):1145-57. |
32(0,1,1,2) | Details |
| 8812209 | Mackay CE, Hammock BD, Wilson BW: Identification and isolation of a 155-kDa protein with neuropathy target esterase activity. Fundam Appl Toxicol. 1996 Mar;30(1):23-30. A method is presented for the isolation of a 155-kDa protein that possesses phenyl hydrolysis activity in the presence of paraoxon but is inhibited by mipafox; the functional definition of neuropathy target esterase (neurotoxic esterase; NTE). |
32(0,1,1,2) | Details |
| 8343998 | Milatovic D, Johnson MK: Reactivation of phosphorodiamidated acetylcholinesterase and neuropathy target esterase by treatment of inhibited enzyme with Chem Biol Interact. 1993 Jun;87(1-3):425-30. We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous (KF): the reaction proceeded with first-order kinetics. |
32(0,1,1,2) | Details |
| 9788582 | Li W, Casida JE: Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells. Toxicol Lett. 1998 Sep 15;98(3):139-46. This study compares two direct-acting neuropathy target esterase (NTE) inhibitors (mipafox and 2-octyl-4H-1,3,2-benzodioxophosphorin 2-oxide (OBDPO)), a metabolic precursor to an NTE inhibitor (tri-o-cresyl or TOCP) and a potent acetylcholinesterase inhibitor (chlorpyrifos oxon or CPO) for their effects on outgrowth of neurite-like and cell processes and on viability in differentiated cultured cells (rat adrenal pheochromocytoma (PC-12) and brain glial tumor (C6)). |
32(0,1,1,2) | Details |
| 7713347 | Ehrich M, Jortner BS, Padilla S: Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors. Fundam Appl Toxicol. 1995 Jan;24(1):94-101. Inhibition of neuropathy target esterase (NTE, neurotoxic esterase) and acetylcholinesterase (AChE) activities was compared in brain and spinal cords of adult While Leghorn hens and adult male Long Evan rats 4-48 hr after administration of triortho-tolyl (TOTP po, 50-500 mg/kg to hens; 300-1000 mg/kg to rats), phenyl saligenin (PSP im 0.1-2.5 mg/kg to hens; 5-24 mg/kg to rats), mipafox (3-30 mg/kg ip to hens and rats), diisopropyl phosphorofluoridate (DFP sc, 0.25-1.0 mg/kg to hens; 1-3 mg/kg to rats), dichlorvos (5-60 mg/kg ip to hens; 600-2000 mg/kg to rats), and carbaryl (300-560 mg/kg ip to hens; 30-170 mg/kg to rats). |
32(0,1,1,2) | Details |
| 2926399 | Meredith C, Johnson MK: Species distribution of paraoxon-resistant brain polypeptides radiolabelled with diisopropyl phosphorofluoridate ([3H] DiPF): electrophoretic assay for the aged polypeptide of [3H] DiPF-labelled neuropathy target esterase. J Neurochem. 1989 Apr;52(4):1248-52. Brain neuropathy target esterase is identified as a paraoxon-resistant, mipafox-sensitive esterase that can be labelled with [3H] diisopropyl phosphorofluoridate. |
8(0,0,1,3) | Details |
| 7671342 | Escudero MA, Barril J, Tormo N, Vilanova E: Separation of two forms of neuropathy target esterase in the soluble fraction of the hen sciatic nerve. Chem Biol Interact. 1995 Aug 18;97(3):247-55. Neuropathy target esterase (NTE) activity is operatively defined in this paper as the phenyl esterase activity resistant to 40 microM paraoxon but sensitive to 250 microM mipafox. |
7(0,0,1,2) | Details |
| 6870792 | Williams DG: Intramolecular group transfer is a characteristic of neurotoxic esterase and is independent of the tissue source of the enzyme. Biochem J. 1983 Mar 1;209(3):817-29. |
7(0,0,0,7) | Details |
| 7340807 | Williams DG, Johnson MK: Gel-electrophoretic identification of hen brain neurotoxic esterase, labelled with tritiated di-isopropyl phosphorofluoridate. Biochem J. 1981 Nov 1;199(2):323-33. Both were as sensitive to Mipafox as neurotoxic esterase and were also sensitive to phenyl benzylcarbamate. di-n-pentylphosphinate given in vivo inhibited neurotoxic esterase and the labelling of the band-1 polypeptide by 82% and 84% respectively, but inhibited the labelling of the band 2 polypeptide by 51%. |
90(1,1,2,5) | Details |
| 8337699 | Nostrandt AC, Ehrich M: Modification of mipafox-induced inhibition of neuropathy target esterase in neuroblastoma cells of human origin. Toxicol Appl Pharmacol. 1993 Jul;121(1):36-42. |
82(1,1,1,2) | Details |
| 6623496 | Reinders JH, Hansen LG, Metcalf RL: In vitro neurotoxic esterase assay using leptophos oxon analogs as inhibitors. Toxicol Lett. 1983 Jun;17(1-2):107-11. In comparing neurotoxic esterase (NTE) inhibition properties of a series of phenylphosphonates, it was discovered that certain compounds including leptophos inhibited mipafox-insensitive phenylvalerate hydrolases. |
32(0,1,1,2) | Details |
| 9349542 | Escudero MA, Vilanova E: Purification and characterization of naturally soluble neuropathy target esterase from chicken sciatic nerve by HPLC and western blot. J Neurochem. 1997 Nov;69(5):1975-82. Neuropathy target esterase (NTE) activity is defined operatively as the paraoxon-resistant mipafox-sensitive phenyl esterase activity. |
7(0,0,1,2) | Details |
| 9109545 | Escudero MA, Cespedes MV, Vilanova E: Chromatographic discrimination of soluble neuropathy target esterase isoenzymes and related phenyl esterases from chicken brain, spinal cord, and sciatic nerve. J Neurochem. 1997 May;68(5):2170-6. Neuropathy target esterase (NTE) activity is operatively defined in this work as the phenyl esterase (PVase) activity resistant to 40 microM paraoxon but sensitive to 250 microM mipafox. |
7(0,0,1,2) | Details |
| 1471154 | Carrera V, Barril J, Mauricio M, Pellin M, Vilanova E: Local application of neuropathic organophosphorus compounds to hen sciatic nerve: inhibition of neuropathy target esterase and peripheral neurological impairments. Toxicol Appl Pharmacol. 1992 Dec;117(2):218-25. At doses of 18-182 micrograms mipafox and 9-110 micrograms DFP, inhibition of neuropathy target esterase (NTE) for the treated segment was over 80%, whereas for the adjacent distal and proximal segments inhibition was under 40%, 15 min after application. |
82(1,1,1,2) | Details |
| 4049405 | Carrington CD, Abou-Donia MB: Paraoxon reversibly inhibits neurotoxic esterase. . Toxicol Appl Pharmacol. 1985 Jun 15;79(1):175-8. We report here that paraoxon is apparently able to reduce the rate of inhibition of both neurotoxic esterase isozymes by mipafox in a concentration-dependent manner. |
82(1,1,1,2) | Details |
| 7979963 | Kelly SS, Mutch E, Williams FM, Blain PG: Electrophysiological and biochemical effects following single doses of organophosphates in the mouse. Arch Toxicol. 1994;68(7):459-66. Mipafox inhibited brain and diaphragm acetylcholinesterase and brain neuropathy target esterase. |
82(1,1,1,2) | Details |
| 7983680 | Sogorb MA, Viniegra S, Reig JA, Vilanova E: Partial characterization of neuropathy target esterase and related phenyl esterases from bovine adrenal medulla. J Biochem Toxicol. 1994 Jun;9(3):145-52. The mechanism by which organophosphorus-induced delayed polyneuropathy is induced relates to the specific inhibition and subsequent modification ("aging") of a protein known as neuropathy target esterase (NTE), operatively defined as paraoxon-resistant and mipafox-sensitive phenyl (PV) esterase activity. |
32(0,1,1,2) | Details |
| 7082366 | Dudek BR, Richardson RJ: Evidence for the existence of neurotoxic esterase in neural and lymphatic tissue of the adult hen. Biochem Pharmacol. 1982 Mar 15;31(6):1117-21. Included among the paraoxon-resistant esterases is neurotoxic esterase (NTE), which is inhibited in vivo and in vitro by certain organophosphorus compounds, such as mipafox, which cause delayed neurotoxicity. |
32(0,1,1,2) | Details |