Protein Information

Name phospholipase A2
Synonyms 14 3 3 protein zeta/delta; Phospholipase A2; KCIP 1; Protein kinase C inhibitor protein 1; 14 3 3 protein/cytosolic phospholipase A2; 14 3 3 zeta; FAS; Factor activating exoenzyme S…

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
2299401 Saltarelli MD, Yamada K, Coyle JT: Phospholipase A2 and 3H-hemicholinium-3 binding sites in rat brain: a potential second-messenger role for fatty acids in the regulation of high-affinity choline uptake. J Neurosci. 1990 Jan;10(1):62-72.

The involvement of phospholipase A2 (PLA2) and fatty acid release in the regulation of sodium-dependent high-affinity choline uptake in rat brain was assessed in vitro through the use of the specific binding of 3H-hemicholinium-3 (3H-HCh-3).
63(0,2,2,3) Details
3196359 Yamada K, Saltarelli MD, Coyle JT: Involvement of phospholipase A2 in the regulation of [3H] hemicholinium-3 binding. Biochem Pharmacol. 1988 Nov 15;37(22):4367-73.

We have examined the effects of exogenous phospholipase A2 (PLA2) on the sodium-dependent high-affinity choline uptake mechanism as assessed by the specific binding of [3H] hemicholinium-3 ([3H] HCh-3).
32(0,1,1,2) Details
2732947 Yamada K, Saltarelli MD, Coyle JT: Specificity of the activation of [3H] hemicholinium-3 binding by phospholipase A2. J Pharmacol Exp Ther. 1989 Jun;249(3):836-42.

Phospholipase A2 (PLA2) treatment has been shown previously to stimulate the sodium-dependent high-affinity choline uptake system as assessed by both the specific binding of [3H] hemicholinium-3 ([ 3H] HCh-3) and the uptake of [3H] choline.
32(0,1,1,2) Details
1651249 Yamada K, Saltarelli MD, Coyle JT: [3H] hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. Eur J Pharmacol. 1991 Apr 3;195(3):395-7.

These results further implicate phospholipase A2 in the regulation of [3H] HCh-3 binding sites.
31(0,1,1,1) Details
10613396 Criswell KA, Loch-Caruso R: Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus. Reprod Toxicol. 1999 Nov-Dec;13(6):481-90.


Additionally, the phospholipase A2 inhibitor and antioxidant quinacrine increased the ED50 for contraction force inhibition to 84.5 microM lindane.
1(0,0,0,1) Details