| Name | cytochrome b5 |
|---|---|
| Synonyms | CYB 5; CYB5; CYB5A; Cytochrome b 5; Cytochrome b5; MCB 5; MCB5; Microsomal cytochrome b5… |
| Name | heptachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8900138 | Guzov VM, Houston HL, Murataliev MB, Walker FA, Feyereisen R: Molecular cloning, overexpression in Escherichia coli, structural and functional characterization of house fly cytochrome b5. J Biol Chem. 1996 Oct 25;271(43):26637-45. The cytochrome b5 is reduced by house fly cytochrome P450 reductase in a reconstituted system at a high rate (5.5 s-1), and it stimulates heptachlor epoxidation when reconstituted with house fly cytochrome P450 reductase, cytochrome P450 6A1, phospholipid, and detergent. |
92(1,1,2,7) | Details |
| 18930820 | Murataliev MB, Guzov VM, Walker FA, Feyereisen R: P450 reductase and cytochrome b5 interactions with cytochrome P450: effects on house fly CYP6A1 catalysis. Insect Biochem Mol Biol. 2008 Nov;38(11):1008-15. Epub 2008 Sep 27. Both holo- and apo-b5 stimulated CYP6A1 heptachlor epoxidase and steroid hydroxylase activities and influenced the regioselectivity of hydroxylation. |
4(0,0,0,4) | Details |
| 15620088 | Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18. The present study was under taken to demonstrate the effect of some commonly used insecticides on the activity of cytochrome P450 system including cytochrome b5, aryl hydrocarbon [benzo (a) pyrene] hydroxylase (AHH), N-nirosodimethylamine N-demethylase I [NDMA-dI] and -cytochrome c reductase as phase I of drug oxidation. In addition, the activity of glutathione S-transferase (GST), glutathione reductase (GR), and the level of (GSH) were determined in the liver of male mice after oral administration of sumithion, dursban, chlordane, methoxychlor, heptachlor epoxide, and lindane as single (24h) or as repeated doses for six consecutive days. |
2(0,0,0,2) | Details |
| 9407006 | Dunkov BC, Guzov VM, Mocelin G, Shotkoski F, Brun A, Amichot M, Ffrench-Constant RH, Feyereisen R: The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbital. DNA Cell Biol. 1997 Nov;16(11):1345-56. The CYP6A2 protein produced in this system metabolized aldrin and heptachlor to their epoxides and metabolized the insecticide diazinon by desulfuration to diazoxon and by oxidative ester cleavage to 2-isopropyl-4-methyl-6-hydroxypyrimidine. Metabolism in lysates of cells infected with recombinant baculovirus was greatly enhanced by the addition of purified housefly NADPH cytochrome P450 reductase and cytochrome b5. |
1(0,0,0,1) | Details |