| Name | anticholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18704829 | Nong A, Tan YM, Krolski ME, Wang J, Lunchick C, Conolly RB, Clewell HJ 3rd: Bayesian calibration of a physiologically based pharmacokinetic/pharmacodynamic model of carbaryl cholinesterase inhibition. J Toxicol Environ Health A. 2008;71(20):1363-81. A PBPK/PD model was developed to describe the tissue dosimetry of carbaryl and its metabolites (1-naphthol and "other hydroxylated metabolites") and subsequently to predict the carbaryl-induced inhibition of cholinesterase activity, in particular in the brain and blood. |
85(1,1,1,5) | Details |
| 105127 | Pipy B, Beraud M, Gaillard D: [Relationship between the phagocytic inhibition of the rat reticuloendothelial system and the anticholinesterasic effect of an insecticide, Carbaryl (author's transl)]. J Physiol. 1978;74(4):379-85. Phagocytic activity of the reticuloendothelial system (RES) and blood cholinesterase activity were determined in male rats after veinous administrations of carbaryl and 1-naphthol, a carbaryl metabolite. |
31(0,1,1,1) | Details |
| 1488778 | Casale GP, Bavari S, Gold RE, Vitzthum EF: Inhibition of interleukin-2-stimulated enhancement of human natural killer (NK) cell activity by carbaryl, an anticholinesterase insecticide. Toxicol Lett. 1992 Dec;63(3):299-311. |
2(0,0,0,2) | Details |
| 1916080 | Bavari S, Casale GP, Gold RE, Vitzthum EF: Modulation of interleukin-2-driven proliferation of human large granular lymphocytes by carbaryl, an anticholinesterase insecticide. Fundam Appl Toxicol. 1991 Jul;17(1):61-74. |
2(0,0,0,2) | Details |
| 8349949 | Casale GP, Vennerstrom JL, Bavari S, Wang TL: Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected and organophosphate insecticides and congeners of carbaryl. Immunopharmacol Immunotoxicol. 1993 Mar-Jun;15(2-3):199-215. The anticholinesterase (antiCHE) insecticides, a large family of pesticides used extensively throughout the world, inhibit serine hydrolases by carbamylating or phosphorylating a serine residue at the catalytic site. The data indicate a significant contribution of the 1-naphthol leaving group to inhibition of T cell proliferation by carbaryl, and are consistent with inhibition of a serine hydrolase (s) as a mechanism contributing to the observed inhibition of IL2-dependent proliferation. |
1(0,0,0,1) | Details |