| Name | cytochrome b5 |
|---|---|
| Synonyms | CYB 5; CYB5; CYB5A; Cytochrome b 5; Cytochrome b5; MCB 5; MCB5; Microsomal cytochrome b5… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11181502 | Nelson AC, Huang W, Moody DE: Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation. Drug Metab Dispos. 2001 Mar;29(3):319-25. Each microsomal fraction was also assayed for protein content, cytochrome P450, cytochrome b (5) reductase, cytochrome b (5), absorbance at 420, hydroxylation, hydroxylation, dextromethorphan N- and O-demethylation, glucuronidation of morphine and 1-naphthol, and ester cleavage of p-nitrophenolacetate. |
31(0,1,1,1) | Details |
| 2067545 | McMillan JM, Shaddock JG, Casciano DA, Arlotto MP, Leakey JE: Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone. Mutat Res. 1991 Jul;249(1):81-92. Cytochrome P450 and cytochrome b5 contents progressively decreased throughout the 72-h culture period to less than 25% of initial values, whereas cytochrome P450 reductase rapidly decreased by 50% during attachment, but then remained stable. Activated UDP-glucuronyltransferase activities towards 1-naphthol and declined more slowly over the 72 h than cytochrome P450 and remained at 50-60% of initial values at 72 h. |
1(0,0,0,1) | Details |
| 3240719 | Jagadeesan V, Oesch F: Effects of dietary zinc deficiency on the activity of enzymes associated with phase I and II of drug metabolism in Fischer-344 rats: activities of drug metabolising enzymes in zinc deficiency. Drug Nutr Interact. 1988;5(4):403-13. It was observed that the activities of microsomal epoxide hydrolase (with benz (a) pyrene 4-5 oxide as substrate), diphospho glucuronyl transferase (with 1-naphthol as substrate) and cytosolic glutathione-S-transferase (with chlorodinitrobenzene as substrate) were altered exclusively due to zinc deficiency. There was a change in the activities of the following enzymes, which could be due either to zinc deficiency and/or food restriction: 1) aryl hydrocarbon hydroxylase; 2) cytochrome b; 3) cytochrome c; and 4) cytochrome b5. |
1(0,0,0,1) | Details |
| 18447001 | Cho TM, Rose RL, Hodgson E: The effect of chlorpyrifos-oxon and other xenobiotics on the human cytochrome P450-dependent metabolism of naphthalene and deet. Drug Metabol Drug Interact. 2007;22(4):235-62. This metabolic activation is independent of cytochrome b5, suggesting that activation of CYP3A4 by CPO is associated with a conformational change of the isoform rather than facilitating electron transfer. CPO significantly activated the production of 1-naphthol (5-fold), 2-naphthol (10-fold), trans-1,2-dihydro-1,2-naphthalenediol (1.5-fold), and 1,4-naphthoquinone from naphthalene by human liver microsomes (HLM). |
1(0,0,0,1) | Details |
| 1957312 | De Sandro V, Chevrier M, Boddaert A, Melcion C, Cordier A, Richert L: Comparison of the effects of propylthiouracil, amiodarone, diphenylhydantoin, phenobarbital, and 3-methylcholanthrene on hepatic and renal T4 metabolism and thyroid gland function in rats. Toxicol Appl Pharmacol. 1991 Nov;111(2):263-78. PB increased the glucuronidation of morphine, whereas MC increased the glucuronidation of 1-naphthol. PB, a microsomal enzyme inducer, increased the cytochrome b5 and P450 content as well as the cytochrome P450-dependent O-depentylation of pentoxyresorufin. |
1(0,0,0,1) | Details |