| Name | 5 HT3 receptor |
|---|---|
| Synonyms | 5 HT 3; 5 hydroxytryptamine 3 receptor; serotonin receptor; HTR 3; HTR3; 5 HT3; 5 HT3A; 5 HT3R… |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7541281 | Downie DL, Hope AG, Belelli D, Lambert JJ, Peters JA, Bentley KR, Steward LJ, Chen CY, Barnes NM: The interaction of trichloroethanol with murine recombinant 5-HT3 receptors. Br J Pharmacol. 1995 Apr;114(8):1641-51. |
12(0,0,0,12) | Details |
| 9726627 | Bentley KR, Barnes NM: 5-hydroxytryptamine3 (5-HT3) receptor-mediated depolarisation of the rat isolated vagus nerve: modulation by trichloroethanol and related Eur J Pharmacol. 1998 Jul 31;354(1):25-31. |
6(0,0,0,6) | Details |
| 9518697 | Zhou Q, Verdoorn TA, Lovinger DM: potentiate the function of 5-HT3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel state. J Physiol. 1998 Mar 1;507 ( Pt 2):335-52. |
5(0,0,0,5) | Details |
| 10728877 | Lovinger DM, Sung KW, Zhou Q: and trichloroethanol alter gating of 5-HT3 receptor-channels in NCB-20 neuroblastoma cells. Neuropharmacology. 2000 Feb 14;39(4):561-70. |
4(0,0,0,4) | Details |
| 8496823 | Lovinger DM, Zhou Q: Trichloroethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in nodose ganglion neurons from the adult rat. J Pharmacol Exp Ther. 1993 May;265(2):771-6. Trichloroethanol (TCEt) potentiated ion current mediated by (5-HT) 3 receptors in isolated adult rat nodose ganglion neurons. |
2(0,0,0,2) | Details |
| 11834892 | Solt K, Johansson JS: Binding of the active metabolite of chloral hydrate, 2,2,2-trichloroethanol, to serum albumin demonstrated using fluorescence quenching. Pharmacology. 2002;64(3):152-9. There is evidence that TCE potentiates the action of ligand-gated ion channels such as the (A) and 5-HT (3) receptors, and the present results suggest that anesthetic may act by binding to these proteins and inducing structural changes that may in turn alter protein function. |
1(0,0,0,1) | Details |
| 16257471 | Hayrapetyan V, Jenschke M, Dillon GH, Machu TK: Co-expression of the (3B) subunit with the (3A) receptor reduces sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50. Epub 2005 Oct 28. Where -induced increases in peak amplitude were observed, the slope of the 20-80% rising phase of current onset was also enhanced, suggesting that increases in activation rate may be one mechanism through which enhance function of the 5-HT (3) receptors. |
1(0,0,0,1) | Details |
| 18094321 | Hu XQ, Peoples RW: 246 of the pretransmembrane domain 1 region alters 2,2,2-trichloroethanol action in the 5-hydroxytryptamine3A receptor. J Pharmacol Exp Ther. 2008 Mar;324(3):1011-8. Epub 2007 Dec 19. The current activated by trichloroethanol could be blocked by the competitive 5-HT (3) receptor antagonist tropanyl 3,5-dichlorobenzoate (MDL 72222), and it had a similar reversal potential to those of current activated by |
1(0,0,0,1) | Details |