Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
2904384 de Miguel C, Encio I, Lopez-Moratalla N, Santiago E: Interaction of F1-ATPase and its inhibitor peptide. Int J Biochem. 1988;20(9):983-7.

3(0,0,0,3) Details
9168052 Gruwel ML, Culic O, Schrader J: A 133Cs nuclear magnetic resonance study of endothelial Na (+)-K (+)-ATPase activity: can actin regulate its activity?. Biophys J. 1997 Jun;72(6):2775-82.

3(0,0,0,3) Details
16740258 Galkina SI, Sud'ina GF, Klein T: Metabolic regulation of neutrophil spreading, membrane tubulovesicular extensions (cytonemes) formation and intracellular pH upon adhesion to fibronectin. Exp Cell Res. 2006 Aug 1;312(13):2568-79. Epub 2006 May 3.


Inhibition of glucose metabolism or V-ATPase impaired neutrophil spreading, blocked the increase in the pHi and induced extrusion of membrane tubulovesicular extensions (cytonemes), anchoring cells to substrata.
3(0,0,0,3) Details
9740664 Hirohashi N, Lennarz WJ: Sperm-egg binding in the sea urchin: a high level of intracellular ATP stabilizes sperm attachment to the egg receptor. Dev Biol. 1998 Sep 15;201(2):270-9.


In contrast, the dynein ATPase inhibitor, erythro-9-[3-hydroxynonyl] adenine, which is known to inhibit flagellum motility by blocking ATP utilization, stabilized the binding of sperm to the receptor and allowed maintenance of a high internal ATP level.
2(0,0,0,2) Details
2157844 Blatt MR, Beilby MJ, Tester M: Voltage dependence of the Chara proton pump revealed by current-voltage measurement during rapid metabolic blockade with cyanide. J Membr Biol. 1990 Apr;114(3):205-23.


It is generally agreed that solute transport across the Chara plasma membrane is energized by a proton electrochemical gradient maintained by an H (+)-extruding ATPase.
2(0,0,0,2) Details
2304352 Peruche B, Ahlemeyer B, Brungs H, Krieglstein J: Cultured neurons for testing antihypoxic drug effects. J Pharmacol Methods. 1990 Mar;23(1):63-77.

Hypoxia was induced by addition of sodium cyanide to the nutrient medium, which led to a rapid depletion of energy stores.
However, only one (flunarizine) out of five calcium antagonists, two (naftidrofuryl, pyritinol) out of 13 nootropics, the kappa-agonist ketazocine, and the ATPase inhibitor ouabaine exerted neuroprotection.
1(0,0,0,1) Details
14659655 Hall IH, Schwab UE, Ward ES, Ives T: Disposition and intracellular levels of moxifloxacin in human THP-1 monocytes in unstimulated and stimulated conditions. Int J Antimicrob Agents. 2003 Dec;22(6):579-87.


The sodium-ATPase pump when blocked, also retarded moxifloxacin uptake at 2 and 4 h.
1(0,0,0,1) Details
10222047 Longo VD, Liou LL, Valentine JS, Gralla EB: Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys. 1999 May 1;365(1):131-42.


Succinate dehydrogenase activity also decreased in MnSOD mutants; cytochrome oxidase and ATPase activities did not.
1(0,0,0,1) Details
9639344 Lancaster MK, Harrison SM: Changes in contraction, cytosolic Ca2+ and pH during metabolic inhibition and upon restoration of mitochondrial respiration in rat ventricular myocytes. Exp Physiol. 1998 May;83(3):349-60.


This suggests that the rapid partial recovery of cytosolic acidosis could result from the rephosphorylation of ADP to ATP by the mitochondrial F1,F0-ATPase (a reaction that consumes protons).
1(0,0,0,1) Details
2306277 Wernke MJ, Cacini W: Concentrative uptake of digoxin by slices of chicken renal cortex. Biochem Pharmacol. 1990 Feb 15;39(4):655-9.


An inhibitory effect of ouabain and a stimulatory effect of reduced medium potassium concentration suggest a possible role for Na+,K (+)-ATPase in the uptake of digoxin by the renal cortex.
1(0,0,0,1) Details
12403008 Khodorov BI, Storozhevykh TP, Surin AM, Yuryavichyus AI, Sorokina EG, Borodin AV, Vinskaya NP, Khaspekov LG, Pinelis VG: The leading role of mitochondrial depolarization in the mechanism of glutamate-induced disruptions in Ca2+ homeostasis. Neurosci Behav Physiol. 2002 Sep-Oct;32(5):541-7.


Addition of oligomycin, a blocker of mitochondrial ATP synthase/ATPase, to the solution containing glutamate and CN- or DNP eliminated the post-glutamate plateau.
1(0,0,0,1) Details
8548485 Pierrot C, Pequeux A, Thuet P: Effects of ions substitutions and of inhibitors on transepithelial potential difference and sodium fluxes in perfused gills of the crab Pachygrapsus marmoratus. Arch Physiol Biochem. 1995 Aug;103(4):466-75.

The effect of ouabain supports the existence of a Na+/K+ exchange mechanism linked to the presence of Na (+)-K+ ATPase in the basolateral membrane of posterior gills.
Sodium cyanide (10 (-2) M) added to the perfusion and incubation media almost completely inhibited the transepithelial PD and considerably decreased the Na+ influx.
1(0,0,0,1) Details
9319415 Schwarzbaum P, Bernabeu R, Krumschnabel G, Wieser C: Effect of chemical anoxia on protein kinase C and Na+, K+-ATPase in hepatocytes of goldfish (Carassius auratus) and rainbow trout (Oncorhynchus mykiss). J Exp Biol. 1996;199(Pt 7):1515-21.

PKC and Na+/K+-ATPase activities were measured for up to 90 min in the absence (normoxia) and presence (chemical anoxia) of 2 mmol l-1 sodium cyanide.
ATPase activity was measured in hepatocytes exposed to 100 nmol l-1 phorbol-12,13-dibutyrate (PdBu), a treatment which enhanced PKC activity to its maximum level.
1(0,0,0,1) Details
11179041 Schafer M, Bahde D, Bosche B, Ladilov Y, Schafer C, Piper HM, Noll T: Modulation of early [Ca2+] i rise in metabolically inhibited endothelial cells by xestospongin C. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1002-10.


The inhibitor of ER-Ca (2+)-ATPase, thapsigargin (10 nM), augmented the 2-DG-induced rise of [Ca (2+)](i).
1(0,0,0,1) Details
6302084 Tsujibo H, Rosen BP: Energetics of calcium efflux from cells of Escherichia coli. J Bacteriol. 1983 May;154(2):854-8.


Intact cells of a H+-translocating ATPase-deficient strain of Escherichia coli were starved of endogenous energy reserves and passively loaded with 45CaCl2.
1(0,0,0,1) Details
16661065 Wyse R: Sucrose Uptake by Sugar Beet Tap Root Tissue. Plant Physiol. 1979 Nov;64(5):837-841.

Uptake was inhibited by dinitrophenol, sodium cyanide, low O (2), and penetrating sulfhydryl inhibitors.
ATPase inhibitors, sodium fluoride, and oligomycin reduced uptake by 20 and 40%, respectively.
1(0,0,0,1) Details
2547838 Teti A, Blair HC, Schlesinger P, Grano M, Zambonin-Zallone A, Kahn AJ, Teitelbaum SL, Hruska KA: Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. J Clin Invest. 1989 Sep;84(3):773-80.


These findings suggest that osteoclasts adherent to bone lack functional voltage-operated Ca2+ channels, and they reduced [Ca2+] i in response to protons via a membrane residing Ca-ATPase.
1(0,0,0,1) Details
9017669 Doolette DJ: Mechanism of adenosine accumulation in the hippocampal slice during energy deprivation. Neurochem Int. 1997 Feb;30(2):211-23.


Blocking of the mitochondrial electron transport chain with 200 microM sodium cyanide or mitochondrial uncoupling with 50 microM 2,4-dinitrophenol both produced a rapid depression of synaptic transmission that was antagonised by 1 microM 8-cyclopentyl-1, 3-dimethylxanthine, an adenosine A1 receptor antagonist.
0(0,0,0,0) Details
12232135 Wang MY, Glass A, Shaff JE, Kochian LV: Ammonium Uptake by Rice Roots (III. Plant Physiol. 1994 Mar;104(3):899-906.

Depolarization of [delta][psi] due to NH4+ uptake was eliminated by a protonophore (carboxylcyanide-m-chlorophenylhydrazone), inhibitors of ATP synthesis (sodium cyanide plus salicylhydroxamic acid), or an ATPase inhibitor (diethylstilbestrol).
31(0,1,1,1) Details
126980 Buchwalow IB, Unger E, Schulze W, Schon R, Raikhlin NT: [Inhibition and stimulation of ATPase activity and the nonenzymatic hydrolysis of ATP in electron histochemistry (author's transl)]. Histochemistry. 1975 Jul 16;44(1):1-11.

In rat liver, homogenized and fractionated, ATPase activity was studied both histochemically and biochemically in the presence of lead ions and with addition of cysteine, EDTA, 2,4-DNP, sodium cyanide, sodium fluoride and p-chloromercuribenzoate.
9(0,0,1,4) Details
6219742 Scully SP, Segel GB, Lichtman MA: Plasma membrane vesicles prepared from unadhered monocytes: characterization of calcium transport and the calcium ATPase. Cell Calcium. 1982 Dec;3(6):515-30.

The ionophore A23187 completely inhibited calcium accumulation while 5 mM sodium cyanide and 10 microM ouabain had no effect.
6(0,0,0,6) Details
3030328 Nagaya H, Satoh H, Maki Y: Actions of antisecretory agents on proton transport in hog gastric microsomes. Biochem Pharmacol. 1987 Feb 15;36(4):513-9.


The properties of K+-stimulated ATP hydrolysis (K+-ATPase) and vesicular accumulation of H+ (H+ accumulation) in hog gastric microsomes were investigated.
6(0,0,0,6) Details
6239843 Gollnick PD, Matoba H: Identification of fiber types in rat skeletal muscle based on the sensitivity of myofibrillar actomyosin ATPase to copper. Histochemistry. 1984;81(4):379-83.

The response to Cu2+ appears to result from a binding of Cu2+ onto the myofibrillar complex, probably on myosin itself, as it can be reversed by soaking of the pretreated muscle sections in sodium cyanide or the Cu2+ chelator diethyldithiocarbamate.
4(0,0,0,4) Details