| 11316513 |
Zucchi R, Ronca F, Ronca-Testoni S: Modulation of sarcoplasmic reticulum function: a new strategy in cardioprotection?. Pharmacol Ther. 2001 Jan;89(1):47-65.
This article reviews the experimental evidence suggesting that cytosolic Ca (2+) overload plays a major role in the development of myocardial injury during ischemia-reperfusion and that Ca (2+) release from the sarcoplasmic reticulum (SR) is of crucial importance in the early phase of ischemia. It is suggested that interventions able to deplete the SR Ca (2+) pool and/or to reduce the rate of SR Ca (2+) release should be cardioprotective. This thesis is supported by the review of experimental studies in which modulators of the SR Ca (2+)-ATPase or SR Ca (2+) release channel (ryanodine receptor) have been used. In addition, the role of the SR in ischemic preconditioning and in some instances of toxic myocardial injury (particularly, anthraquinone-induced injury) is discussed. |
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