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Harvey AM, Batt RD, Pritchard GG: Inhibition of RNA synthesis in Chlorella pyrenoidosa and Bacillus megaterium by the pine-blight toxin, dothistromin. J Gen Microbiol. 1976 Aug;96(2):268-76.
Dosthistromin, an anthraquinone derivative produced by the pine-blight fungus, Dothistroma pini, inhibits the growth of Chlorella pyrenoidosa and Bacillus megaterium. At growth inhibitory concentrations, dothistromin strongly inhibits incorporation of [3H] uridine into RNA of both species. With B. megaterium, marked inhibition of [3H] uridine incorporation is apparent within 5 min of addition of dothistromin, but only a slight inhibition of [3H] thymidine incorporation into the DNA-containing fraction or of [14C] leucine incorporation into protein is detectable after 10 min. |
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