| 6520339 |
Dalvi RR, Robbins TJ, Williams MK, Deoras DP, Donastorg F, Banks C: Thiram-induced toxic liver injury in male Sprague-Dawley rats. J Environ Sci Health B. 1984 Nov-Dec;19(8-9):703-12.
A single i.p. dose (120 mg/kg) of thiram given to male Sprague-Dawley rats caused a significant increase in the activity of SGOT and SGPT 24 hr post-treatment indicating liver damage. A considerable diminution in the serum cholinesterase activity was also noted in the treated rats as against the control animals. Additional evidence for thiram-induced liver toxicity is provided by the observation that there was approximately 50% inhibition of the activity of hepatic microsomal benzphetamine N-demethylase with a concomitant decrease in the concentration of cytochrome P-450, an important component of the mixed-function oxidase system. Although not significant, hepatic glutathione levels were also depleted by thiram, probably making the liver susceptible to toxic injury. |
81(1,1,1,1) |