| 12639559 |
Bharti SN, Naqvi F, Azam A: Synthesis, spectral studies and screening for amoebicidal activity of new palladium (II) complexes derived from thiophene-2-carboxaldehyde thiosemicarbazones. Bioorg Med Chem Lett. 2003 Feb 24;13(4):689-92.
In view of the antiamoebic properties observed for many thiophene-2-carboxaldehyde thiosemicarbazones, a series of N (4)-substituted thiosemicarbazones metal complexes derived from thiophene-2-carboxaldehyde was prepared for evaluation against Entamoeba histolytica. Reaction of thiophene-2-carboxaldehyde with cycloalkylaminothiocarbonylhydrazines having different amines gave the corresponding thiosemicarbazones. Reaction of latter with [Pd (DMSO)(2) Cl (2)] gave requisite palladium thiosemicarbazone complexes of the type [Pd (TSC) Cl (2)] (where TSC=thiosemicarbazones). Screening of antiamoebic activity of these compounds was assayed in vitro against (HM-1:1MSS) strain of E. histolytica. Enhancement of antiamoebic resulted from introducing palladium metal in the thiosemicarbazone moiety. Among the studied compounds, [Pd (2-TCA-1,2,3,4-THQTSC) Cl (2)] (2a) showed better activity. |
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