2012 - 2017, Ph.D., Pharmacy, East China University of Science and Technology
2008 - 2012, B.E., Pharmaceutical Engineering, East China University of Science and Technology.
Developed chemical biology tools to investigate cell signaling;
Discovery of selective FLT3 inhibitors against resistance mutation.;
Discovery of selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation.
1. Deheng Sun, Yu Yang, Jiankun Lyu, Wei Zhou, Wenlin Song, Zhenjiang Zhao, Zhuo Chen*, Yufang Xu*, Honglin li*. “Discovery and Rational Design of Pteridin-7(8H)-One-Based Inhibitors Targeting FMS-like Tyrosine Kinase 3 (FLT3) and Its Mutants.” Journal of Medicinal Chemistry, 2016, 59(13): 6187-6200.
2. Shaoying Tan, Deheng Sun, Jiankun Lyu, Xiao Sun, Fangshu Wu, Qiang Li, Yiqi Yang, Jianxu Liu, Xin Wang, Zhuo Chen*, Honglin Li*, Xuhong Qian, Yufang Xu*. “Antiproliferative and Apoptosis-inducing Activities of Novel Naphthalimide-cyclam Conjugates through Dual Topoisomerase (topo) I/II Inhibition.” Bioorganic & Medicinal Chemistry, 2015, 23(17): 5672-5680.
3. Yongjia Hao, Xia Wang, Tao Zhang, Deheng Sun, Yi Tong, Yuqiong Xu, Haiyang Chen, Linjiang Tong, Lili Zhu，Zhenjiang Zhao, Zhuo Chen, Jian Ding, Hua Xie*, Yufang Xu*, and Honglin Li*. “Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6, 7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.” Journal of Medicinal Chemistry, 2016, 59(15):7111-7124.
4. Yongjia Hao, Jiankun Lyu, Rong Qu, Deheng Sun, Zhenjiang Zhao, Zhuo Chen, Jian Ding , Hua Xie, Yufang Xu, Honglin Li*. “Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors.” Scientific Report,2017 (In press).
5. Qian Sun, Deheng Sun, Lun Song, Zhuo Chen, Zhaoyang Chen, Weibing Zhang*, and Junhong Qian*. “Highly Selective Fluorescent Turn-On Probe for Protein Thiols in Biotin Receptor-Positive Cancer Cells.” Analytical Chemistry, 2016, 88(6): 3400-3405.
6. Qian Sun, Haiyu Tian, Haoran Qu, Deheng Sun, Zhuo Chen, Liping Duan, Weibing Zhang* and Junhong Qian*. “Discrimination between Streptavidin and Avidin with Fluorescent Affinity-based Probes.” Analyst, 2015, 140(13): 4648-4653.
7. Weisi Wang, Xiao Sun, Deheng Sun, Shizhu Li, Yang Yu, Tingyuan Yang, Junmin Yao, Zhuo Chen* and Liping Duan*. “Carbazole Aminoalcohols Induce Antiproliferation and Apoptosis of Human Tumor Cells by Inhibiting Topoisomerase I.” ChemMedChem, 2016, 11 (24): 2675-2681.