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fipronil

Identification (Source:EPA,EU)

ID	262
Name	fipronil
CAS	120068-37-3
IUPAC
Inchi	InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2
CIPAC	581
EPA Code
Formula	C12H4Cl2F6N4OS
SMILES	FC(F)(F)S(=O)c2c(C#N)nn(c1c(Cl)cc(cc1Cl)C(F)(F)F)c2N
Status	Approved

Classification

Mode of Action	Broad-spectrum with contact and stomach action. GABA-gated chloride channel antagonist.
Pesticide Type	Insecticide, Veterinary treatment
Chemical Group	Phenylpyrazole
Classification	phenylpyrazole acaricides phenylpyrazole insecticides

Properties (Source:PubChem)

Molecular Weight	437.15
Physical State	White powder
AlogP	5.579
H-Bond Donor	1
H-Bond Acceptor	4
Surface Area	347.58
Polar Surface Area	103.91

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	0.068 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.00014 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.19 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.068 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	0.16 mg l-1
Birds	Acute		LD50	11.3 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	500 mg kg-1
Earthworms	Acute	14 day	LD50	> 500 mg kg-1
Fish	Chronic	21 day	NOEC	0.015 mg l-1
Fish	Acute	96 hour	LC50	0.248 mg l-1
Honeybees	Acute	48 hour	LD50	0.00417 μg bee-1
Mammals	Acute oral		LD50	92 mg kg-1
Mammals	Short term dietary		NOEL	0.35 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.0001 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.0002 mg kg-1
	Bio-concentration factor		CT50	3 days
	Bio-concentration factor		BCF	321

Related targets

Target Name	RScore (About this table)
GABA receptor (protein family or complex)	1862(15,32,42,102)	Details
chloride channel (protein family or complex)	762(8,10,13,47)	Details
CYP3A4	435(4,7,9,15)	Details
cytochrome P450 (protein family or complex)	208(2,3,5,8)	Details
CYP2B6	169(2,2,3,4)	Details
glycine receptor (protein family or complex)	83(1,1,1,3)	Details
demethylase	83(1,1,1,3)	Details
caspase 3	82(1,1,1,2)	Details
glutamate receptor	82(1,1,1,2)	Details
CYP2C19	81(1,1,1,1)	Details
microsomal monooxygenases	81(1,1,1,1)	Details
glutathione transferase	81(1,1,1,1)	Details
GABA at	81(1,1,1,1)	Details

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