| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | paclobutrazol |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2223832 | Ashman PJ, Mackenzie A, Bramley PM: Characterization of ent-kaurene oxidase activity from Gibberella fujikuroi. Biochim Biophys Acta. 1990 Nov 9;1036(2):151-7. Both the soluble and microsomal preparations showed characteristic cytochrome P-450 spectra, ligand binding spectra with the substrate and with the plant growth regulator, paclobutrazol, and inhibition of enzymic activity by |
81(1,1,1,1) | Details |
| 19581023 | Villa-Ruano N, Betancourt-Jimenez MG, Lozoya-Gloria E: Biosynthesis of uterotonic diterpenes from Montanoa tomentosa (zoapatle). J Plant Physiol. 2009 Dec 15;166(18):1961-7. Epub 2009 Jul 5. Partial characterization of the enzyme revealed that it requires and O2 but is inhibited by 50 microM paclobutrazol, suggesting a cytochrome P450 desaturase like enzyme (EC 1.14.14.-). |
32(0,1,1,2) | Details |
| 12231743 | Jennings JC, Coolbaugh RC, Nakata DA, West CA: Characterization and Solubilization of Kaurenoic Acid Hydroxylase from Gibberella fujikuroi. Plant Physiol. 1993 Mar;101(3):925-930. and the salts of several monovalent cations stimulated the conversion of ent-kaurenoic acid to these products, whereas CO and a number of known inhibitors of cytochrome P-450-dependent reactions, including paclobutrazol, tetcyclacis, BAS 111.W, flurprimidol, triarimol, and 1-phenylimida-zole, significantly reduced kaurenoic acid hydroxylase activity. |
32(0,1,1,2) | Details |
| 12651520 | Marshall JG, Rutledge RG, Blumwald E, Dumbroff EB: Reduction in turgid water volume in jack pine, white spruce and black spruce in response to drought and paclobutrazol. Tree Physiol. 2000 May;20(10):701-707. Repeated exposure to 7 days of drought or treatment with the cytochrome P (450) inhibitor, paclobutrazol ((2RS,3RS)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-pentan-3 -ol), reduced seedling height relative to that of untreated controls in all three species. |
31(0,1,1,1) | Details |
| 15012200 | Rademacher W: GROWTH RETARDANTS: Effects on Biosynthesis and Other Metabolic Pathways. Annu Rev Plant Physiol Plant Mol Biol. 2000 Jun;51:501-531. To date, four different types of such inhibitors are known: (a) Onium compounds, such as chlormequat mepiquat chlorphonium, and AMO-1618, which block the cyclases copalyl- synthase and ent-kaurene synthase involved in the early steps of GA metabolism. (b) Compounds with an N-containing heterocycle, e.g. ancymidol, flurprimidol, tetcyclacis, paclobutrazol, uniconazole-P, and inabenfide. These retardants block cytochrome P450-dependent monooxygenases, thereby inhibiting oxidation of ent-kaurene into ent-kaurenoic acid. (c) Structural mimics of which is the co-substrate of dioxygenases that catalyze late steps of GA formation. |
1(0,0,0,1) | Details |
| 14988475 | Davidson SE, Smith JJ, Helliwell CA, Poole AT, Reid JB: The pea gene LH encodes ent-kaurene oxidase. Plant Physiol. 2004 Mar;134(3):1123-34. Epub 2004 Feb 26. It codes for a cytochrome P450 from the CYP701A subfamily and has ent-kaurene oxidase (KO) activity, catalyzing the three step oxidation of ent-kaurene to ent-kaurenoic acid in the (GA) biosynthetic pathway when expressed in yeast (Saccharomyces cerevisiae). Differences in sensitivity to the GA synthesis inhibitor, paclobutrazol, between the mutants appear to result from the distinct nature of the genetic lesions. |
1(0,0,0,1) | Details |
| 16666477 | Hallahan DL, Heasman AP, Grossel MC, Quigley R, Hedden P, Bowyer JR: Synthesis and Biological Activity of an Azido Derivative of Paclobutrazol, an Inhibitor of Biosynthesis. Plant Physiol. 1988 Dec;88(4):1425-1429. The azido compound bound to Cytochrome P-450 in microsomes from Cucurbita maxima, and induced a Type II spectral change, with an apparent binding constant of 0.24+/-0.04 micromolar. |
1(0,0,0,1) | Details |