Protein Information

Name butyrylcholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name ethylene
CAS ethene

Reference List

PubMed Abstract RScore(About this table)
19827033 Chiou SY, Huang CF, Hwang MT, Lin G: Comparison of active sites of butyrylcholinesterase and acetylcholinesterase based on inhibition by geometric isomers of benzene-di-N-substituted carbamates. J Biochem Mol Toxicol. 2009 Sep;23(5):303-8.

These two para compounds, with the angle of 180 degrees between two C (benzene)--O bonds, mimic the preferable anti C--O/C--N conformers for the choline ethylene backbone of butyrylcholine during the butyrylcholinesterase catalysis.
12(0,0,1,7) Details
20060815 Gaydess A, Duysen E, Li Y, Gilman V, Kabanov A, Lockridge O, Bronich T: Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system. Chem Biol Interact. 2010 Jan 11.

In this study, we evaluated the feasibility of delivering BChE to the CNS by packing it into a block ionomer complex of nanoscale size with a cationic poly (l-lysine)-graft-poly (ethylene oxide) (PLL-g-PEO) copolymer.
2(0,0,0,2) Details