| Name | VKORC1 |
|---|---|
| Synonyms | Vitamin K epoxide reductase; IMAGE3455200; MST134; MST576; MSTP134; MSTP576; Phylloquinone epoxide reductase; UNQ308… |
| Name | bromadiolone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17994578 | Markussen MD, Heiberg AC, Fredholm M, Kristensen M: Characterization of bromadiolone resistance in a danish strain of Norway rats, Rattus norvegicus, by hepatic gene expression profiling of genes involved in -dependent gamma-carboxylation. J Biochem Mol Toxicol. 2007;21(6):373-81. We compared liver expression of the VKORC1 gene, which encodes a protein of the vitamin K 2,3-epoxide reductase complex, the NQO1 gene, which encodes a NAD (P) H dehydrogenase and the Calumenin gene between bromadiolone-resistant and anticoagulant-susceptible rats upon saline and bromadiolone administration. |
113(1,2,2,3) | Details |
| 8129744 | Misenheimer TM, Lund M, Baker EM, Suttie JW: Biochemical basis of and bromadiolone resistance in the house mouse, Mus musculus domesticus. Biochem Pharmacol. 1994 Feb 11;47(4):673-8. The hepatic vitamin K epoxide reductase in the bromadiolone-resistant mice and in one phenotype of -resistant mice was highly insensitive to in vitro inhibition by and bromadiolone. |
31(0,1,1,1) | Details |
| 16933704 | Kupper J, Grobosch T, Kistler R, Sydler T, Naegeli H: [Bromadiolone poisoning in foxes] . Schweiz Arch Tierheilkd. 2006 Aug;148(8):405-8. Bromadiolone is an anticoagulant rodenticide that inhibits the reactivation of vitamin K1 by the enzyme vitamin K1-epoxide reductase. |
81(1,1,1,1) | Details |
| 18080289 | Markussen MD, Heiberg AC, Fredholm M, Kristensen M: Differential expression of cytochrome P450 genes between bromadiolone-resistant and anticoagulant-susceptible Norway rats: a possible role for pharmacokinetics in bromadiolone resistance. Pest Manag Sci. 2008 Mar;64(3):239-48. To examine the involvement of pharmacokinetics in bromadiolone resistance in male and female rats, liver expression profiles of seven cytochrome P450 genes from a Danish bromadiolone-resistant rat strain (with an Y139C-VKORC1 mutation) were compared with profiles from an anticoagulant-susceptible strain. |
7(0,0,1,2) | Details |
| 19752778 | Grandemange A, Kohn MH, Lasseur R, Longin-Sauvageon C, Berny P, Benoit E: Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats. Pharmacogenet Genomics. 2009 Oct;19(10):742-50. RESULTS AND CONCLUSION: In this manuscript we report the prothrombin times measured in the F7 generation after exposure to chlorophacinone, bromadiolone, difenacoum and difethialone. |
6(0,0,0,6) | Details |
| 15879509 | Pelz HJ, Rost S, Hunerberg M, Fregin A, Heiberg AC, Baert K, MacNicoll AD, Prescott CV, Walker AS, Oldenburg J, Muller CR: The genetic basis of resistance to anticoagulants in rodents. Genetics. 2005 Aug;170(4):1839-47. Epub 2005 May 6. Anticoagulant compounds, i.e., derivatives of either (e.g., bromadiolone) or indane-1,3-dione (e.g., diphacinone, chlorophacinone), have been in worldwide use as rodenticides for > 50 years. These compounds inhibit blood coagulation by repression of the vitamin K reductase reaction (VKOR). |
4(0,0,0,4) | Details |