Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name dichlorvos
CAS 2,2-dichloroethenyl dimethyl phosphate

Reference List

PubMed Abstract RScore(About this table)
16023296 Gupta SC, Siddique HR, Saxena DK, Chowdhuri DK: Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinesterase. Biochim Biophys Acta. 2005 Aug 30;1725(1):81-92.

Third instar larvae of Drosophila melanogaster transgenic for hsp70 were exposed to 0.1 to 100.0 ppb dichlorvos and 5.0 mM CuSO (4) (an inducer of oxidative stress and stress genes) and hsp70, and activities of acetylcholinesterase (AchE), superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (LPO) product were measured.
31(0,1,1,1) Details
17640809 Gupta SC, Siddique HR, Mathur N, Vishwakarma AL, Mishra RK, Saxena DK, Chowdhuri DK: Induction of hsp70, alterations in oxidative stress markers and apoptosis against dichlorvos exposure in transgenic Drosophila melanogaster: modulation by reactive oxygen species. Biochim Biophys Acta. 2007 Sep;1770(9):1382-94. Epub 2007 Jun 16.

Dichlorvos (0.015-15.0 ppb) without or with inhibitors of Hsp70, superoxide dismutase (SOD) and catalase (CAT) were fed to the third instar larvae of Drosophila melanogaster transgenic for hsp70 (hsp70-lacZ) Bg (9) to examine Hsp70 expression, oxidative stress and apoptotic markers.
31(0,1,1,1) Details
18539328 Celik I, Suzek H: Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Ecotoxicol Environ Saf. 2009 Mar;72(3):905-8. Epub 2008 Jun 9.

In this study, the effects of dichlorvos (DIC) at sublethal concentration on malondialdehyde (MDA) content and antioxidant defense system (ADS) such as reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in various tissues of rats exposed to 0.0225 and 0.0450 millimole (mmol) DIC in drinking water were administered orally to rats ad libitum for 28 days continuously.
6(0,0,1,1) Details
8291132 Syrovatskaia LP, Sereda PI, Gromov LA, Filonenko MA, Ovinova: [Activity of antioxidant defense enzymes and the state of lipid peroxidation in the rat brain in decis and dichlofos poisoning]. Ukr Biokhim Zh. 1993 May-Jun;65(3):113-7.

The activity of the antioxidant system enzymes--superoxide dismutase (SOD) and catalase and lipids peroxidation in the rat brain under deltametrin and dichlorvos intoxication has been studied in vivo.
6(0,0,1,1) Details
16020401 Cankayali I, Demirag K, Eris O, Ersoz B, Moral AR: The effects of N-acetylcysteine on oxidative stress in organophosphate poisoning model. Adv Ther. 2005 Mar-Apr;22(2):107-16.

In addition to their muscarinic, nicotinic, and central nervous system effects, some organophosphate insecticides cause oxidative stress by increasing lipid peroxidation in erythrocytes and by increasing levels of the enzymes superoxide dismutase and catalase.
Invasive hemodynamic monitoring was begun and all rats were injected with 70 mg/kg of dichlorvos (DDVP) intraperitoneally.
2(0,0,0,2) Details
8714762 Hai DQ, Varga IS, Matkovics B: Effects of an organophosphate on the antioxidant systems of fish tissues. Acta Biol Hung. 1995;46(1):39-50.

The effect of a Hungarian made and applied insecticide, organophosphate (Dichlorvos) on antioxidant enzymes and other oxidative and redox parameters of two different fish species, carp (Cyprinus carpio L.) and catfish (Ictalurus nebulosus) was studied.
From antioxidant enzymes, changes in superoxide dismutase, catalase, glutathione peroxidase and, in the case of carp, acetylcholinesterase activities were studied in tissue homogenates.
1(0,0,0,1) Details
1587340 Julka D, Pal R, Gill KD: Neurotoxicity of dichlorvos: effect on antioxidant defense system in the rat central nervous system. Exp Mol Pathol. 1992 Apr;56(2):144-52.

We observed significant increases in the activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase which were accompanied by a decrease in the values of lipid peroxidation.
1(0,0,0,1) Details
1475794 Yamano T, Morita S: Hepatotoxicity of trichlorfon and dichlorvos in isolated rat hepatocytes. . Toxicology. 1992 Nov 22;76(1):69-77.

0(0,0,0,0) Details
9206589 Hai DQ, Varga SI, Matkovics B: Organophosphate effects on antioxidant system of carp (Cyprinus carpio) and catfish (Ictalurus nebulosus). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 May;117(1):83-8.

The effect of the organophosphate insecticide Dichlorvos on antioxidant enzymes and other oxidative and redox parameters of carp (Cyprinus carpio L.) and catfish (Ictalurus nebulosus) were studied.
Changes in superoxide dismutase, catalase, glutathione peroxidase, and in the case of carp acetylcholinesterase activities were studied in tissue homogenates.
1(0,0,0,1) Details