Protein Information

Name alanine aminotransferase
Synonyms AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
15183996 David M, Mushigeri SB, Shivakumar R, Philip GH: Response of Cyprinus carpio (Linn) to sublethal concentration of cypermethrin: alterations in protein metabolic profiles. Chemosphere. 2004 Jul;56(4):347-52.

Total, structural and soluble proteins showed decrement; where as free amino acids and the activities of protease, aspartate aminotransferase and alanine aminotransferase significantly increased in cypermethrin exposed fish.
6(0,0,1,1) Details
1872879 Reddy AT, Yellamma K: Cypermethrin induced changes in nitrogen metabolism of fish, Tilapia mossambica. Biochem Int. 1991 Mar;23(4):649-54.

At sublethal concentrations, cypermethrin caused a decrease in total proteins and an increase in free amino acids, protease, alanine aminotransferase and aspartate aminotransferase in liver, brain and gill tissues of Tilapia mossambica.
6(0,0,1,1) Details
18946182 Eraslan G, Kanbur M, Silici S, Altinordulu S, Karabacak M: Effecs of cypermethrin on some biochemical changes in rats: the protective role of propolis. Exp Anim. 2008 Oct;57(5):453-60.

Serum glucose, triglyceride, uric acid, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities/levels, plasma and tissue malondialdehyde (MDA) levels, and erythrocyte and tissue superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were determined.
1(0,0,0,1) Details
12716053 el-Demerdash FM, Yousef MI, Al-Salhen KS: Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits. J Environ Sci Health B. 2003 May;38(3):365-78.

The activities of glutathione S-transferase (GST) (liver, brain and testes), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (liver and testes), and alkaline phosphatase (AlP) (liver) were significantly (P < 0.05) decreased due to cypermethrin administration.
6(0,0,1,1) Details
1292170 Dudrikova E, Lenhardt L, Poracova J: [Biochemical aspects of the toxic effects of Supermethrin and the histochemical activity of alkaline phosphatase, acid phosphatase and non-specific esterase in subchronic poisoning in sheep]. Vet Med. 1992 Nov;37(11):613-22.


During the experiment changes of aspartate aminotransferase (EC 2.6.1.1), alanine aminotransferase (EC 2.6.1.2), acetylcholine esterase (EC 3.1.1.7), urea und creatinine levels in blood serum were observed.
2(0,0,0,2) Details
8812184 Philip GH, Rajasree BH: Action of cypermethrin on tissue transamination during nitrogen metabolism in Cyprinus carpio. Ecotoxicol Environ Saf. 1996 Jul;34(2):174-9.

Activity levels of both the transaminases, aspartate aminotransferase and alanine aminotransferase, and glutamate dehydrogenase were elevated, indicating active transamination and oxidative deamination.
1(0,0,0,1) Details
14630057 Grajeda-Cota P, Ramirez-Mares MV, Gonzalez de Mejia E: Vitamin C protects against in vitro cytotoxicity of cypermethrin in rat hepatocytes. Toxicol In Vitro. 2004 Feb;18(1):13-9.

In vitro cell viability, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) leakage were measured, as indicators of hepatic damage, at 1, 15 and 30 min of exposure to CM.
1(0,0,0,1) Details
19669582 Khan DA, Hashmi I, Mahjabeen W, Naqvi TA: Monitoring health implications of pesticide exposure in factory workers in Pakistan. Environ Monit Assess. 2009 Aug 8.

Plasma cypermethrin, endosulfan, imidacloprid, thiodicarb, carbofuran, and methamidophos levels were found to be higher than allowable daily intake.
Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea, and gamma glutamyltransferase (GGT) were measured on Selectra E auto analyzer.
1(0,0,0,1) Details
17640710 Borges A, Scotti LV, Siqueira DR, Zanini R, Amaral F, Jurinitz DF, Wassermann GF: Changes in hematological and serum biochemical values in jundia Rhamdia quelen due to sub-lethal toxicity of cypermethrin. Chemosphere. 2007 Oct;69(6):920-6. Epub 2007 Jul 20.

The 45% LC (50), 0.12 ppm, produced significant increase in Na (+), Mg (2+), P, K (+), creatinine, urea, glucose, cholesterol, and alkaline phosphatase, and reduction in triglycerides and alanine aminotransferase levels in serum.
1(0,0,0,1) Details
18778926 Khan A, Faridi HA, Ali M, Khan MZ, Siddique M, Hussain I, Ahmad M: Effects of cypermethrin on some clinico-hemato-biochemical and pathological parameters in male dwarf goats (Capra hircus). Exp Toxicol Pathol. 2009 Mar;61(2):151-60. Epub 2008 Sep 7.

Erythrocyte counts, hemoglobin, hematocrit, total protein, globulin and fibrinogen decreased significantly while total leukocyte counts, alanine aminotransferase and aspartate aminotransferase concentration increased significantly in all the treated groups.
1(0,0,0,1) Details