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cypermethrin

Identification (Source:EPA,EU)

ID	268
Name	cypermethrin
CAS	52315-07-8
IUPAC
Inchi	InChI=1S/C22H19Cl2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3
CIPAC	332
EPA Code	109702/129064
Formula	C22H19Cl2NO3
SMILES	Cl/C(Cl)=C/C3C(C(=O)OC(C#N)c2cccc(Oc1ccccc1)c2)C3(C)C
Status	Approved

Classification

Mode of Action	Non-systemic with contact and stomach action. Sodium channel modulator.
Pesticide Type	Insecticide, Veterinary Treatment
Chemical Group	Pyrethroid
Classification	pyrethroid ester insecticides pyrethroid ester acaricides

Properties (Source:PubChem)

Molecular Weight	416.3
Physical State	Liquid
AlogP	5.304
H-Bond Donor	0
H-Bond Acceptor	4
Surface Area	391.36
Polar Surface Area	59.32

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	> 0.1 mg l-1
Algae	Chronic	96 hour	NOEC, growth	1.3 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.0128 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.0003 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.00004 mg l-1
Birds	Short term dietary		LC50/LD50	> 5620 mg/kg feed
Birds	Acute		LD50	> 10000 mg kg-1
Earthworms	Acute	14 day	LD50	> 100 mg kg-1
Fish	Acute	96 hour	LC50	0.0028 mg l-1
Fish	Chronic	21 day	NOEC	0.00003 mg l-1
Honeybees	Acute	48 hour	LD50	0.02 μg bee-1
Mammals	Acute oral		LD50	287 mg kg-1
Mammals	Short term dietary		NOEL	7.5 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	1204

Related targets

Target Name	RScore (About this table)
calcineurin (protein family or complex)	536(4,9,9,66)	Details
Acetylcholinesterase	488(4,7,13,48)	Details
ATPase	414(3,6,15,39)	Details
cytochrome P450 (protein family or complex)	363(3,5,9,43)	Details
sodium channel (protein family or complex)	221(2,2,4,51)	Details
cholinesterase	181(2,2,3,16)	Details
gamma aminobutyric acid receptor (protein family or complex)	175(2,2,2,15)	Details
estrogen receptor alpha	148(1,3,3,8)	Details
cis 3	126(1,2,3,11)	Details
chloride channel (protein family or complex)	120(1,2,2,10)	Details
ATPases	96(1,1,3,6)	Details
lipase	94(1,1,3,4)	Details
cytochrome P450 monooxygenases	90(1,1,1,10)	Details
glucose 6 phosphate dehydrogenase	88(1,1,2,3)	Details
monoamine oxidase A	85(1,1,1,5)	Details
androgen receptor	84(1,1,1,4)	Details
P450scc	81(1,1,1,1)	Details
calcineurin inhibitors	125(0,4,4,5)	Details
glycogen phosphorylase	82(0,2,5,7)	Details
calmodulin	61(0,1,3,21)	Details
c fos	55(0,1,2,20)	Details
protein phosphatases	50(0,1,1,20)	Details
PP1	43(0,1,1,13)	Details
cytochrome b5	42(0,1,2,7)	Details
FKBP12	41(0,1,1,11)	Details
brains	40(0,1,2,5)	Details
c jun	40(0,1,2,5)	Details
N methyl D aspartate receptor (protein family or complex)	40(0,1,1,10)	Details
p70	39(0,1,2,4)	Details
IL 12 (protein family or complex)	39(0,1,2,4)	Details
PP2A	38(0,1,1,8)	Details
immunophilin	34(0,1,1,4)	Details
protein phosphatase 1 (protein family or complex)	34(0,1,1,4)	Details
lysozyme	33(0,1,1,3)	Details
olfactory receptor	31(0,1,1,1)	Details
rOC 1	31(0,1,1,1)	Details
glutathione S transferase	44(0,0,4,24)	Details
aspartate aminotransferase	26(0,0,3,11)	Details
alkaline phosphatase	26(0,0,2,16)	Details
alanine aminotransferase	26(0,0,3,11)	Details
hemoglobin (protein family or complex)	24(0,0,3,9)	Details
superoxide dismutase	23(0,0,2,13)	Details
catalase	22(0,0,1,17)	Details
P glycoprotein	20(0,0,1,15)	Details
CA3	18(0,0,3,3)	Details
lactate dehydrogenase (protein family or complex)	15(0,0,1,10)	Details
C18	15(0,0,2,5)	Details
Hsp70	14(0,0,2,4)	Details

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