Protein Information

Name lipase
Synonyms HGL; HPL; HGL; Human giant larvae homolog; LGL 2; LGL2; LLGL 2; LLGL2…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
10466103 Simon LM, Laszlo K, Kotorman M, Vertesi A, Bagi K, Nemcsok J: Effects of synthetic pyrethroids and methidation on activities of some digestive enzymes in carp (Cyprinus carpio L.). J Environ Sci Health B. 1999 Sep;34(5):819-28.

These pesticides modified the lipase activity to a lesser extent; the highest inhibition was measured with cypermethrin.
87(1,1,2,2) Details
1883403 Reddy AT, Ayyanna K, Yellamma K: Cypermethrin induced modulations in lipid metabolism of freshwater teleost, Tilapia mossambica. Biochem Int. 1991 Mar;23(5):963-7.

Increase in total lipid, lipase and free fatty acids with decrease in glycerol content suggests simultaneous operation of lipogenesis and lipolysis during cypermethrin stress.
6(0,0,1,1) Details
17442360 Crow JA, Borazjani A, Potter PM, Ross MK: Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol Appl Pharmacol. 2007 May 15;221(1):1-12. Epub 2007 Mar 12.

Both trans-permethrin and bioresmethrin were effectively cleaved by this serum CE, but deltamethrin, esfenvalerate, alpha-cypermethrin and cis-permethrin were slowly hydrolyzed.
Lastly, two model lipase enzymes were examined for their ability to hydrolyze pyrethroids.
1(0,0,0,1) Details