| Name | FKBP12 |
|---|---|
| Synonyms | 12 kDa FKBP; PPIase; Rotamase; Peptidyl prolyl cis trans isomerase; FK506 binding protein 1; FK506 binding protein 12; FK506 binding protein 1A; FK506 binding protein 1A (12kD)… |
| Name | cypermethrin |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17950843 | MacMillan D, Currie S, McCarron JG: FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle. Cell Calcium. 2008 Jun;43(6):539-49. Epub 2007 Oct 24. In aorta, although RyR3 (the main isoform), FKBP12 and calcineurin were each present, RyR-mediated Ca (2+) release was unaffected by either FK506, rapamycin or the calcineurin inhibitors cypermethrin and okadaic acid in single voltage clamped aortic myocytes. |
37(0,1,1,7) | Details |
| 16278292 | MacMillan D, Currie S, Bradley KN, Muir TC, McCarron JG: In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. J Cell Sci. 2005 Dec 1;118(Pt 23):5443-51. Epub 2005 Nov 8. Release from the IP3R may be modulated by endogenous proteins associated with the receptor, such as the 12 kDa FK506-binding protein (FKBP12), either directly or indirectly by inhibition of the phosphatase calcineurin. This potentiation was due to the inhibition of calcineurin; it was mimicked by the phosphatase inhibitors cypermethrin and okadaic acid. |
4(0,0,0,4) | Details |