Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
20147568 Sushma N, Devasena T: Aqueous extract of Trigonella foenum graecum (fenugreek) prevents cypermethrin-induced hepatotoxicity and nephrotoxicity. Hum Exp Toxicol. 2010 Apr;29(4):311-9. Epub 2010 Feb 10.

CM treatment caused increased thiobarbituric acid reactive substances (TBARS), depletion in glutathione (GSH) and reduction in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in liver and kidneys.
1(0,0,0,1) Details
12965126 Nasuti C, Cantalamessa F, Falcioni G, Gabbianelli R: Different effects of Type I and Type II pyrethroids on erythrocyte plasma membrane properties and enzymatic activity in rats. Toxicology. 2003 Sep 30;191(2-3):233-44.

Pyrethroids are divided into two groups according to their chemical structures: type I pyrethroids are devoid of a cyano moiety at the alpha-position (i.e. permethrin, PERM), while type II pyrethroids have an alpha-cyano moiety (i.e. cypermethrin, CY).
The different modifications induced by pyrethroids on lipid peroxidation, osmotic fragility and the antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)) were measured.
1(0,0,0,1) Details
19500828 Wang XZ, Liu SS, Sun Y, Wu JY, Zhou YL, Zhang JH: Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress. Theriogenology. 2009 Sep 15;72(5):599-611. Epub 2009 Jun 4.

These toxic effects of beta-CYP may be mediated by increasing oxidative stress, as the moderate and high doses of this compound increased malondialdehyde and nitric oxide in testes (P <0.05); reduced the activity of catalase, glutathione peroxidase (GSH-Px), and superoxide dismutase (P <0.05); and activated ERK1/2 (P <0.05).
1(0,0,0,1) Details
17140720 Nasuti C, Gabbianelli R, Falcioni ML, Di Stefano A, Sozio P, Cantalamessa F: Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids. Toxicology. 2007 Jan 18;229(3):194-205. Epub 2006 Oct 29.


The aim of the present study was to evaluate the effect of neonatal exposition to permethrin and cypermethrin (1/10 of DL (50)) in rats from the eighth to the fifteenth day of life.
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15546634 Li X, Ping X, Xiumei S, Zhenbin W, Liqiang X: Toxicity of cypermethrin on growth, pigments, and superoxide dismutase of Scenedesmus obliquus. Ecotoxicol Environ Saf. 2005 Feb;60(2):188-92.
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2393682 Karnaukhova TB, Korobova LN, Reikh EM: [Superoxide dismutase activity as an index of the toxic action of pesticides]. Nauchnye Doki Vyss Shkoly Biol Nauki. 1990;(5):146-9.

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19687627 Raina R, Verma PK, Pankaj NK, Prawez S: Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application. J Vet Sci. 2009 Sep;10(3):257-9.

However, the superoxide dismutase activity declined significantly after 60 days of exposure.
1(0,0,0,1) Details
20027135 Slaninova A, Smutna M, Modra H, Svobodova Z: A review: oxidative stress in fish induced by pesticides. Neuro Endocrinol Lett. 2009;30 Suppl 1:2-12.

The antioxidant enzymes changes have been observed after actuation of pesticides deltamethrin and cypermethrin.
Butachlor causes increased activity of superoxide dismutase -catalase system in the kidney.
1(0,0,0,1) Details
18214882 Kanbur M, Liman BC, Eraslan G, Altinordulu S: Effects of cypermethrin, propetamphos, and combination involving cypermethrin and propetamphos on lipid peroxidation in mice. Environ Toxicol. 2008 Aug;23(4):473-9.

Serum nitric oxide (NO) and plasma malondialdehyde (MDA) levels and erythrocyte superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were measured.
1(0,0,0,1) Details
15365239 Manna S, Bhattacharyya D, Mandal TK, Das S: Repeated dose toxicity of alfa-cypermethrin in rats. J Vet Sci. 2004 Sep;5(3):241-5.

It increased malondialdehyde (MDA) level, while decreased the activities of catalase (CAT), superoxide dismutase (SOD) and glycogen level in liver significantly.
1(0,0,0,1) Details
18946182 Eraslan G, Kanbur M, Silici S, Altinordulu S, Karabacak M: Effecs of cypermethrin on some biochemical changes in rats: the protective role of propolis. Exp Anim. 2008 Oct;57(5):453-60.

Serum glucose, triglyceride, uric acid, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities/levels, plasma and tissue malondialdehyde (MDA) levels, and erythrocyte and tissue superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were determined.
1(0,0,0,1) Details
15991261 Khan SM: Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticide-induced liver injury. Cell Biochem Funct. 2006 Jul-Aug;24(4):327-32.

Administering a combination dose of chlorpyriphos and cypermethrin (20 mg kg (-1) each) on alternate days over a 15-day period to male mice resulted in induction of sub-acute toxicity as reflected by elevated levels of liver damage marker enzymes alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT).
Decreased activities of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), total thiol, glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were also observed in pesticide-treated as compared to control mice.
1(0,0,0,1) Details