| Name | calcineurin inhibitors |
|---|---|
| Synonyms | CABIN 1; CAIN; CABIN1; Calcineurin binding protein 1; Calcineurin binding protein cabin 1; Calcineurin inhibitor; Calcineurin binding protein 1s; Calcineurin binding protein cabin 1s… |
| Name | cypermethrin |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10463953 | Alexanian AR, Bamburg JR: Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB. FASEB J. 1999 Sep;13(12):1611-20. Cypermethrin, a direct and highly specific calcineurin inhibitor, mimicked the immunophilin ligands in its neurotrophic effect. |
32(0,1,1,2) | Details |
| 7531976 | Richter A, Davies DE, Alexander P: Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. Biochem Pharmacol. 1995 Jan 31;49(3):367-73. The role of calcineurin in CyA- or FK506-induced growth inhibition was investigated using the synthetic pyrethroid insecticides: cypermethrin, deltamethrin and fenvalerate, which are known calcineurin inhibitors. |
31(0,1,1,1) | Details |
| 17950843 | MacMillan D, Currie S, McCarron JG: FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle. Cell Calcium. 2008 Jun;43(6):539-49. Epub 2007 Oct 24. In aorta, although RyR3 (the main isoform), FKBP12 and calcineurin were each present, RyR-mediated Ca (2+) release was unaffected by either FK506, rapamycin or the calcineurin inhibitors cypermethrin and okadaic acid in single voltage clamped aortic myocytes. |
31(0,1,1,1) | Details |
| 10898953 | Mukerjee N, McGinnis KM, Park YH, Gnegy ME, Wang KK: Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells. Arch Biochem Biophys. 2000 Jul 15;379(2):337-43. Last, calcineurin inhibitors FK506 and cypermethrin provided partial protection against thapsigargin-mediated apoptosis, suggesting that calcineurin overactivation contributes to thapsigargin-induced apoptosis. |
31(0,1,1,1) | Details |
| 20139366 | Rosado JA, Pariente JA, Salido GM, Redondo PC: SERCA2b activity is regulated by cyclophilins in human platelets. . Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):419-25. Epub 2010 Feb 5. Cypermethrin, a non-CsA-related calcineurin inhibitor, did not alter SERCA2b activity. |
0(0,0,0,0) | Details |
| 19243469 | Hui KK, Liadis N, Robertson J, Kanungo A, Henderson JT: Calcineurin inhibition enhances motor neuron survival following injury. J Cell Mol Med. 2009 Feb 20. To examine the mechanism responsible for neuroprotection by these agents, pharmacologic inhibitors of several potential alternate signaling pathways (17-(allylamino)-17-demethoxygeldanamycin, rapamycin, cypermethrin) were evaluated with respect to neuroprotection. |
0(0,0,0,0) | Details |
| 17166943 | Ahn HS, Kim SE, Choi BH, Choi JS, Kim MJ, Rhie DJ, Yoon SH, Jo YH, Kim MS, Sung KW, Kwon OJ, Hahn SJ: Calcineurin-independent inhibition of KV1.3 by FK-506 (tacrolimus): a novel pharmacological property. Am J Physiol Cell Physiol. 2007 May;292(5):C1714-22. Epub 2006 Dec 13. Other calcineurin inhibitors (cypermethrin or calcineurin autoinhibitory peptide) alone had no effect on the amplitude or kinetics of K (V) 1.3. |
0(0,0,0,0) | Details |
| 18093324 | Johnson AS, Garcia DM: Carbachol-mediated pigment granule dispersion in retinal pigment epithelium requires Ca2+ and calcineurin. BMC Cell Biol. 2007 Dec 19;8:53. The calcineurin inhibitor cypermethrin blocked carbachol-induced dispersion; whereas, two protein kinase C inhibitors (staurosporine and bisindolylmaleimide II) failed to block carbachol-induced dispersion, and the protein kinase C activator phorbol 12- 13- failed to elicit dispersion. |
0(0,0,0,0) | Details |