Protein Information

Name cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
11748873 Latuszynska J, Luty S, Raszewski G, Tokarska-Rodak M, Przebirowska D, Przylepa E, Haratym-Maj A: Neurotoxic effect of dermally-applied chlorpyrifos and cypermethrin in Wistar rats. 1-96.

The aim of the study was to evaluate the neurotoxic effect of a dermally-applied mixture of chlorpyrifos and cypermethrin in rats based on cognitive function, activity of the blood cholinesterase and brain acetylcholinesterase, as well as histologic brain examination.
162(2,2,2,2) Details
15929901 Roldan-Tapi L, Leyva A, Laynez F, Santed FS: Chronic neuropsychological sequelae of cholinesterase inhibitors in the absence of structural brain damage: two cases of acute poisoning. Environ Health Perspect. 2005 Jun;113(6):762-6.

6(0,0,0,6) Details
1883402 Reddy AT, Ayyanna K, Yellamma K: Sensitivity of brain cholinesterase to cypermethrin toxicity in freshwater teleost Tilapia mossambica. Biochem Int. 1991 Mar;23(5):959-62.
6(0,0,1,1) Details
14677911 Latuszynska J, Luty S, Raszewski G, Przebirowska D, Tokarska-Rodak M: Neurotoxic effect of dermally applied chlorpyrifos and cypermethrin. Ann Agric Environ Med. 2003;10(2):197-201.

Blood was taken from the heart after 1 day, 1 week, 2 and 3 weeks after the administration of the preparation in order to determine cholinesterase activity in serum, and the brain was taken to evaluate brain cholinesterase activity.
2(0,0,0,2) Details
15895843 Kimura K, Yokoyama K, Sato H, Nordin RB, Naing L, Kimura S, Okabe S, Maeno T, Kobayashi Y, Kitamura F, Araki S: Effects of pesticides on the peripheral and central nervous system in tobacco farmers in Malaysia: studies on peripheral nerve conduction, brain-evoked potentials and computerized posturography. Ann Agric Environ Med. 2001;8(2):163-70.

Median SCV (finger-wrist) in farmers using Delsen (mancozeb, dithiocarbamate fungicide), who showed significant decrease of serum cholinesterase activities, were significantly lower compared with the controls.
Sural SCV in farmers using Fastac (alpha-cypermethrin, pyrethroid insecticide) and median MCV (elbow-wrist) in farmers using Tamex (butralin, dinitroaniline herbicide) were significantly slowed compared with their respective controls.
1(0,0,0,1) Details
11402526 : Evaluation of certain veterinary drug residues in food. World Health Organ Tech Rep Ser. 2001;900:i-vi

The first part of the report considers the interpretation of data on inhibition of cholinesterase activity and recommendations arising from an informal meeting on harmonization with the Joint FAO/WHO Meeting on Pesticide Residues.
A summary follows of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: one anthelminthic agent (ivermectin); four antimicrobial agents (flumequine, lincomycin, oxytetracycline and tilmicosin); six insecticides (cyhalothrin, cypermethrin, alpha-cypermethrin, dicyclanil, permethrin and metrifonate (trichlorfon)); and one production aid (melengestrol acetate).
1(0,0,0,1) Details
17239417 Flaskos J, Harris W, Sachana M, Munoz D, Tack J, Hargreaves AJ: The effects of diazinon and cypermethrin on the differentiation of neuronal and glial cell lines. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):172-80. Epub 2006 Dec 15.

Diazinon is a known anti-cholinesterase, but there is limited information regarding its molecular mechanism of action.
1(0,0,0,1) Details
19079663 Khan DA, Bhatti MM, Khan FA, Naqvi ST, Karam A: Adverse effects of pesticides residues on biochemical markers in pakistani tobacco farmers. Int J Clin Exp Med. 2008;1(3):274-82. Epub 2008 Jul 15.

Plasma butyrylcholinesterase (BChE) was analyzed by Ellman's method.
The tobacco farmers had multiple pesticides residues above ADI in their blood consisting of 35 (63%) methomyl; 31 (56%) thiodicarb; 34 (62%) cypermethrin; 27 (49%) Imidacloprid; 18 (32%) Methamidophos and 15 (27%) endosulfan.
1(0,0,0,1) Details
10794385 Sheets LP: A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides. Neurotoxicology. 2000 Feb-Apr;21(1-2):57-63.

The first involves multi-generation reproduction studies with rats that were treated with OP insecticides (coumaphos, fenamiphos, tribufos, trichlorfon, or oxydemeton-methyl) through the diet and examined for effects, including cholinesterase (ChE) inhibition.
The second involves rats that were treated by gavage with an acute dose of a pyrethroid (cismethrin, permethrin, deltamethrin or cypermethrin) to establish relative sensitivity to either a lethal dose or to a low, behaviorally-active dose.
1(0,0,0,1) Details