| Name | PP2A |
|---|---|
| Synonyms | PP2A; PP2A subunit B prime; PR53; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine protein phosphatase 2A regulatory subunit B'; PP2A subunit B primes… |
| Name | cypermethrin |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17981404 | Moreno-Delgado D, Blanco I, Ortiz J: Phosphatases regulate synthesis in rat brain. . Neuroscience. 2007 Dec 12;150(3):616-24. Epub 2007 Sep 21. Other phosphatase inhibitors like endothall (PP2A), cypermethrin and cyclosporin A (protein phosphatase 2B, PP2B) had much lower effects. |
33(0,1,1,3) | Details |
| 15136564 | Coronella-Wood J, Terrand J, Sun H, Chen QM: c-Fos phosphorylation induced by H2O2 prevents proteasomal degradation of c-Fos in cardiomyocytes. J Biol Chem. 2004 Aug 6;279(32):33567-74. Epub 2004 May 10. The phosphatase inhibitor okadaic acid, but not PP2B inhibiter cypermethrin, extended the time course of c-Fos protein elevation after H2O2 exposure. Treatment of immunoprecipitated c-Fos protein with the type 2 serine/ phosphatase A (PP2A) and immunoblotting of c-Fos protein with antibodies against phosphorylated serine or demonstrated that c-Fos was phosphorylated at serine residues. |
1(0,0,0,1) | Details |
| 8869588 | Abayasekara DR, Ford SL, Persaud SJ, Jones PM: Role of phosphoprotein phosphatases in the corpus luteum: II control of secretion by isolated rat luteal cells. J Endocrinol. 1996 Aug;150(2):213-21. We have recently demonstrated the presence and activity of PP1 and PP2A in rat luteal cells and the present study was undertaken to determine the consequences of inhibiting PP activity in terms of secretion. In contrast to the inhibitory effects of PP1/2A inhibitors on biosynthesis, a PP2B inhibitor, cypermethrin, had no effect on LH-stimulated steroidogenesis. |
1(0,0,0,1) | Details |
| 16139540 | Shin DS, Wilkie MP, Pamenter ME, Buck LT: and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. Comp Biochem Physiol A Mol Integr Physiol. 2005 Sep;142(1):50-7. Okadaic acid and calyculin A, inhibitors of serine/ PP1 and PP2A, potentiated NMDAR currents during normoxia and prevented anoxia-mediated attenuation of NMDAR currents. However, cypermethrin, an inhibitor of the Ca (2+)/calmodulin-dependent PP2B (calcineurin), abolished the anoxic decrease in NMDAR activity at 20, but not 40 min suggesting that this phosphatase might play an early role in attenuating NMDAR activity during anoxia. |
1(0,0,0,1) | Details |
| 17200551 | Swingle M, Ni L, Honkanen RE: Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods Mol Biol. 2007;365:23-38. Common mistakes in the employment of these compounds will also be addressed briefly, notably the widespread misconception that they only inhibit the activity of PP1 and PP2A. Inhibitors of PP2B (calcineurin) will only be mentioned in passing, except to state that, in our hands, cypermethrin, deltamethrin, and fenvalerate, which are sold as potent inhibitors of PP2B, do not inhibit the catalytic activity of PP2B. |
1(0,0,0,1) | Details |
| 18429239 | Weiser DC, Shenolikar S: Use of protein phosphatase inhibitors. . Curr Protoc Protein Sci. 2003 May;Chapter 13:Unit 13.10. This unit describes protocols for inhibiting the cellular PP1/PP2A activity with okadaic acid, microcystin-LR, and PP2B/calcineurin and a widely utilized strategy for inhibiting protein tyrosine phosphatases. |
1(0,0,0,1) | Details |
| 18322273 | Zhong M, Murtazina DA, Phillips J, Ku CY, Sanborn BM: Multiple signals regulate phospholipase CBeta3 in human myometrial cells. Biol Reprod. 2008 Jun;78(6):1007-17. Epub 2008 Mar 5. Cypermethrin, a PP2B phosphatase inhibitor, but not okadaic acid, a PP1/PP2A inhibitor, prolonged the effect of CALCA on P-S (1105), whereas the reverse was the case for the -stimulated increase in P-S (1105). |
0(0,0,0,0) | Details |