Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
17159788 Dobsikova R, Velisek J, Wlasow T, Gomulka P, Svobodova Z, Novotny L: Effects of cypermethrin on some haematological, biochemical and histopathological parameters of common carp (Cyprinus carpio L.). Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:91-5.

As far as biochemical indices are concerned, the exposure caused a significant (P <0.01) increase in glucose and lactate concentration and creatine kinase activity, and a significant (P <0.01) decrease in total proteins, albumins, total globulins, ammonia, lactate dehydrogenase and alkaline phosphatase in blood plasma of exposed carp compared to the control group.
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19581076 Aslam F, Khan A, Khan MZ, Sharaf S, Gul ST, Saleemi MK: Toxico-pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium. Exp Toxicol Pathol. 2009 Jul 4.

Total plasma proteins, fibrinogen and creatinine were significantly (P <0.05) increased while alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and urea decreased significantly (P <0.05) in CY-treated group when compared with the control group.
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19084261 Saha S, Kaviraj A: Effects of cypermethrin on some biochemical parameters and its amelioration through dietary supplementation of ascorbic acid in freshwater catfish Heteropneustes fossilis. Chemosphere. 2009 Mar;74(9):1254-9. Epub 2008 Dec 11.

Acid and alkaline phosphatase activities of liver and ascorbic acid level of blood, liver and kidney also decreased significantly in H. fossilis exposed to cypermethrin as compared with control.
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12716053 el-Demerdash FM, Yousef MI, Al-Salhen KS: Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits. J Environ Sci Health B. 2003 May;38(3):365-78.

The activities of glutathione S-transferase (GST) (liver, brain and testes), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (liver and testes), and alkaline phosphatase (AlP) (liver) were significantly (P < 0.05) decreased due to cypermethrin administration.
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1292170 Dudrikova E, Lenhardt L, Poracova J: [Biochemical aspects of the toxic effects of Supermethrin and the histochemical activity of alkaline phosphatase, acid phosphatase and non-specific esterase in subchronic poisoning in sheep]. Vet Med. 1992 Nov;37(11):613-22.

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17640710 Borges A, Scotti LV, Siqueira DR, Zanini R, Amaral F, Jurinitz DF, Wassermann GF: Changes in hematological and serum biochemical values in jundia Rhamdia quelen due to sub-lethal toxicity of cypermethrin. Chemosphere. 2007 Oct;69(6):920-6. Epub 2007 Jul 20.

The 30% LC (50), 0.08 ppm, produced significant increases in Mg (2+), P, K (+), creatinine, urea, glucose, cholesterol, aspartate aminotransferase and alkaline phosphatase levels, and reduction in total proteins and triglycerides in serum.
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16459564 Singh VK, Dixit P, Saxena PN: Cybil induced hepatobiochemical changes in wistar rats. J Environ Biol. 2005 Oct;26(4):725-7.

Cybil, 25%EC formulation of Cypermethrin, induces biochemical changes in the liver of wistar rats after oral intubation of the same at acute (one day) and subacute (7, 14 and 21 days) levels.
When compared with the control values, both the doses enhanced the level of glycogen, cholesterol, total lipid and acid phosphatase activities, while decreased activity of alkaline phosphatase.
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20218522 Dahamna S, Harzallah D, Guemache A, Sekfali N: Biochemical investigation of cypermethrin toxicity in rabbits. Commun Agric Appl Biol Sci. 2009;74(1):149-53.

An increase, in the plasma enzyme activity in Alkaline phosphatase, related to their role in the cell permeability.
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12524023 Das BK, Mukherjee SC: Toxicity of cypermethrin in Labeo rohita fingerlings: biochemical, enzymatic and haematological consequences. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):109-21.

Acid phosphatase was unchanged while alkaline phosphatase was depleted.
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15365239 Manna S, Bhattacharyya D, Mandal TK, Das S: Repeated dose toxicity of alfa-cypermethrin in rats. J Vet Sci. 2004 Sep;5(3):241-5.

It increased the serum aminotransaminases (AST, ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities and blood glucose level significantly. alpha-CP decreased RBC count, PCV and Hb level significantly.
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18946182 Eraslan G, Kanbur M, Silici S, Altinordulu S, Karabacak M: Effecs of cypermethrin on some biochemical changes in rats: the protective role of propolis. Exp Anim. 2008 Oct;57(5):453-60.

Serum glucose, triglyceride, uric acid, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities/levels, plasma and tissue malondialdehyde (MDA) levels, and erythrocyte and tissue superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were determined.
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14502587 Mosleh YY, Ismail SM, Ahmed MT, Ahmed YM: Comparative toxicity and biochemical responses of certain pesticides to the mature earthworm Aporrectodea caliginosa under laboratory conditions. Environ Toxicol. 2003 Oct;18(5):338-46.

This study was conducted to investigate the toxicity of aldicarb, cypermethrin, profenofos, chlorfluazuron, atrazine, and metalaxyl toward mature Aporrectodea caliginosa earthworms.
The effects of the LC (25) values of these pesticides on the growth rate in relation to glucose, soluble protein, and activities of glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), acid phosphatase (AcP), and alkaline phosphatase (AIP) were also studied.
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18922205 Singh V, Singh DK: The effect of abiotic factors on the toxicity of cypermethrin against the snail Lymnaea acuminata in the control of fascioliasis. J Helminthol. 2009 Mar;83(1):39-45. Epub 2008 Oct 16.

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