| Name | protein phosphatases |
|---|---|
| Synonyms | DUSP17; DUSP19; Dual specificity phosphatase 19; Dual specificity protein phosphatase 19; Dual specificity phosphatase TS DSP1; LMW DSP3; Protein phosphatase; Protein phosphatase SKRP1… |
| Name | cypermethrin |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10683197 | Alcantara-Hernandez R, Vazquez-Prado J, Garcia-Sainz JA: Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid. Br J Pharmacol. 2000 Feb;129(4):724-30. Other inhibitors of protein phosphatases (calyculin A, tautomycin and cypermethrin) mimicked this effect. |
34(0,1,1,4) | Details |
| 17200551 | Swingle M, Ni L, Honkanen RE: Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods Mol Biol. 2007;365:23-38. Inhibitors of PP2B (calcineurin) will only be mentioned in passing, except to state that, in our hands, cypermethrin, deltamethrin, and fenvalerate, which are sold as potent inhibitors of PP2B, do not inhibit the catalytic activity of PP2B. |
2(0,0,0,2) | Details |
| 11341974 | Siddiqui RA, Jenski LJ, Neff K, Harvey K, Kovacs RJ, Stillwell W: induces apoptosis in Jurkat cells by a protein phosphatase-mediated process. Biochim Biophys Acta. 2001 Jan 15;1499(3):265-75. DHA-induced apoptosis was effectively inhibited by tautomycin and cypermethrin at concentrations that affect protein phosphatase 1 (PP1) and protein phosphatase 2B (PP2B) activities, respectively, implying a role for these phosphatases in the apoptotic pathway. |
2(0,0,0,2) | Details |
| 7723735 | Garver TD, Oyler GA, Harris KA, Polavarapu R, Damuni Z, Lehman RA, Billingsley ML: Tau phosphorylation in brain slices: pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase. Mol Pharmacol. 1995 Apr;47(4):745-56. However, combinations of FK-520 (5 microM) and okadaic acid (100 nM) caused tau mobility shifts similar to those seen after 10 microM okadaic acid treatment; similar results were seen using the calcineurin-selective inhibitor cypermethrin. |
2(0,0,0,2) | Details |
| 1315545 | Enan E, Matsumura F: Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Biochem Pharmacol. 1992 Apr 15;43(8):1777-84. The inhibitory action of synthetic pyrethroids and some chlorinated hydrocarbon insecticides on the neural -calmodulin-dependent protein phosphatase, calcineurin, was studied using one radiotracer and two colorimetric methods. It was found that all insecticidal Type II pyrethroids (cypermethrin, deltamethrin and fenvalerate) are potent inhibitors of isolated calcineurin from bovine brain. |
1(0,0,0,1) | Details |
| 11442772 | Spessert R, Rapp M, Vollrath L: Serine/threonine phosphatase inhibitors decrease adrenergic arylalkylamine n-acetyltransferase induction in the rat pineal gland. J Neuroendocrinol. 2001 Jul;13(7):581-7. In the present study, the role of protein phosphatases in the adrenergic regulation of rat pineal AA-NAT was investigated using specific inhibitors. In cultured pineals, the serine/ phosphatase type 1 and type 2A inhibitors okadaic acid and calyculin A significantly decreased adrenergically or cAMP-induced AA-NAT activity, whereas the serine/ phosphatase type 2B inhibitor cypermethrin and phosphatase inhibitor dephostatin were ineffective. |
1(0,0,0,1) | Details |
| 10197980 | Stathopoulos-Gerontides A, Guo JJ, Cyert MS: Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation. Genes Dev. 1999 Apr 1;13(7):798-803. Calcineurin, a Ca2+/calmodulin dependent protein phosphatase, regulates Ca2+-dependent processes in a wide variety of cells. |
1(0,0,0,1) | Details |
| 14666168 | Ciereszko R, Opalka M, Kaminska B, Wojtczak M, Okrasa S, Dusza L: Luteotrophic action of prolactin during the early luteal phase in pigs: the involvement of protein kinases and phosphatases. Reprod Biol. 2001 Nov;1(2):62-83. The involvement of protein phosphatases in transmission of the PRL signal in early luteal cells in pigs is also suggested. In addition, treatments included: PKC inhibitors--staurosporine and chelerythrine kinase inhibitors-- and tyrphostin; serine-threonine phosphatase inhibitors--okadaic acid, cantharidin (inhibitors of PP1/2A) and cypermethrin (inhibitor of PP2B); and phosphatase inhibitor-- orthovanadate. |
1(0,0,0,1) | Details |
| 12717004 | Quignard JF, Rakotoarisoa L, Mironneau J, Mironneau C: Stimulation of L-type Ca2+ channels by inositol pentakis- and hexakisphosphates in rat vascular smooth muscle cells. J Physiol. 2003 Jun 15;549(Pt 3):729-37. Epub 2003 Apr 25. Neither the PKA inhibitor H89 (1 micro M) nor the protein phosphatase inhibitors okadaic acid (500 nM) or cypermethrin (1 micro M) prevented or mimicked the InsP5,6-induced stimulation of Ba2+ current. However, InsP5 or InsP6 could mimic some effects of protein phosphatase inhibitor so as to extend after washing-out forskolin the stimulatory effects of the adenylyl cyclase activator on Ba2+ current. |
1(0,0,0,1) | Details |
| 18265323 | Weiser DC, Shenolikar S: Use of protein phosphatase inhibitors. . Curr Protoc Mol Biol. 2003 May;Chapter 18:Unit 18.10. |
1(0,0,0,1) | Details |
| 18429239 | Weiser DC, Shenolikar S: Use of protein phosphatase inhibitors. . Curr Protoc Protein Sci. 2003 May;Chapter 13:Unit 13.10. |
1(0,0,0,1) | Details |
| 12065290 | Webster CR, Blanch C, Anwer MS: Role of PP2B in cAMP-induced dephosphorylation and translocation of NTCP. . Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G44-50. The ability of cAMP to translocate and dephosphorylate NTCP is, in part, dependent on cAMP-mediated increases in cytosolic Ca2+ concentration ([Ca2+]), indicating that a Ca2+/calmodulin-dependent protein phosphatase (PP2B) may be involved. Thus we studied the role of PP2B using the inhibitor cypermethrin (CM). |
1(0,0,0,1) | Details |
| 16139540 | Shin DS, Wilkie MP, Pamenter ME, Buck LT: and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. Comp Biochem Physiol A Mol Integr Physiol. 2005 Sep;142(1):50-7. The goal of this study was to determine if protein phosphatases (PPs) and intracellular mediate reductions in turtle cortical neuron whole-cell NMDAR currents during anoxia, thereby preventing ECD. However, cypermethrin, an inhibitor of the Ca (2+)/calmodulin-dependent PP2B (calcineurin), abolished the anoxic decrease in NMDAR activity at 20, but not 40 min suggesting that this phosphatase might play an early role in attenuating NMDAR activity during anoxia. |
1(0,0,0,1) | Details |
| 10936494 | Thompson TL, Moore CC, Smith B: priming modulates autoreceptor-mediated potentiation of uptake. Eur J Pharmacol. 2000 Aug 11;401(3):357-63. The ability of selective protein phosphatase inhibitors to modulate autoreceptor-mediated potentiation of uptake was also examined. Pretreatment with protein phosphatase 2B (deltamethrin, cypermethrin) or protein phosphatase 1 (tautomycin) inhibitors attenuated basal and quinpirole-potentiated uptake in ovariectomized but not -primed tissue. |
1(0,0,0,1) | Details |
| 18322273 | Zhong M, Murtazina DA, Phillips J, Ku CY, Sanborn BM: Multiple signals regulate phospholipase CBeta3 in human myometrial cells. Biol Reprod. 2008 Jun;78(6):1007-17. Epub 2008 Mar 5. Cypermethrin, a PP2B phosphatase inhibitor, but not okadaic acid, a PP1/PP2A inhibitor, prolonged the effect of CALCA on P-S (1105), whereas the reverse was the case for the -stimulated increase in P-S (1105). |
0(0,0,0,0) | Details |
| 17008368 | Yang CH, Huang CC, Hsu KS: Novelty exploration elicits a reversal of acute stress-induced modulation of hippocampal synaptic plasticity in the rat. J Physiol. 2006 Dec 1;577(Pt 2):601-15. Epub 2006 Sep 28. Novelty exploration-induced reversal of stress effects was prevented when the animals were given the NMDA receptor antagonist D-(-)-2-amino-5-phosphonopentanoic acid, the cholinergic antagonist atropine and the protein phosphatase (PP) 2B inhibitors cyclosporin A and cypermethrin, but not the alpha1-adrenergic antagonist prazosin, the beta-adrenergic antagonist or the PP1/2A inhibitor okadaic acid, respectively before being subjected to the novel environment. |
0(0,0,0,0) | Details |