Protein Information

Name brains
Synonyms BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
6090849 Cole LM, Lawrence LJ, Casida JE: Similar properties of [35S] t-butylbicyclophosphorothionate receptor and coupled components of the GABA receptor-ionophore complex in brains of human, cow, rat, chicken and fish. Life Sci. 1984 Oct 22;35(17):1755-62.

This species similarity includes dissociation constants of 61-77 nM at 37 degrees C, maximum receptor densities of 3-7 pmol/mg protein, and sensitivity to inhibition or displacement by gamma-aminobutyric acid (GABA), two cage convulsants (picrotoxinin and t-butylbicycloorthobenzoate) and the insecticide [1R,cis, alpha S]-cypermethrin, indicating a constancy during vertebrate evolution of the [35S] TBPS binding site and its coupling with other components of the GABA receptor-ionophore complex.
1(0,0,0,1) Details
3487848 Edwards R, Millburn P, Hutson DH: Comparative toxicity of cis-cypermethrin in rainbow trout, frog, mouse, and quail. Toxicol Appl Pharmacol. 1986 Jul;84(3):512-22.

Concentrations of [14C] cis-cypermethrin in the brains of representative members of each of these classes of chordates were measured at toxic signs (an onset of hyperactivity followed by seizures and loss of balance/equilibrium) as an indicator of target organ sensitivity.
31(0,1,1,1) Details
11003126 Salawu OA, Iyaniwura TT, Adaudi AO: Effects of anticonvulsants on acute cypermethrin poisoning in mice and rats. Vet Hum Toxicol. 2000 Oct;42(5):303-5.

Rat brains implanted with electroencephalographic (EEG) and electromyograhic electrodes were given 58 mg cypermethrin/ kg followed by 5 mg diazepam/kg, 20 mg phenobarbitone/kg, or 50 mg diphenylhydantoin/kg.
6(0,0,1,1) Details
10867365 Gupta A, Agarwal AK, Shukla1 GS: Effect of quinalphos and cypermethrin exposure on developing blood-brain barrier: role of nitric oxide. Environ Toxicol Pharmacol. 2000 Jan 1;8(2):73-78.

Functional integrity of the BBB was assessed by measuring the brain uptake index (BUI) of HRP and by visually grading the brains of control and treated rat pups for the staining of EB.
2(0,0,0,2) Details