| Name | GABA receptor (protein family or complex) |
|---|---|
| Synonyms | GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors |
| Name | dieldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8625394 | Harrison JB, Chen HH, Sattelle E, Barker PJ, Huskisson NS, Rauh JJ, Bai D, Sattelle DB: Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system in Drosophila melanogaster. Cell Tissue Res. 1996 May;284(2):269-78. An antibody raised against a peptide based on the C-terminal derived amino acid sequence from a cloned Drosophila melanogaster (fruit fly) gene, Rdl (resistant to dieldrin), was used to investigate localization of a GABA receptor subunit in adult male D. melanogaster. |
8(0,0,1,3) | Details |
| 9862468 | Anthony N, Unruh T, Ganser D, ffrench-Constant R: Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae. Mol Gen Genet. 1998 Nov;260(2-3):165-75. Resistance to cyclodiene insecticides is associated with replacements of a single amino acid 302) in a (GABA) receptor subunit encoded by the single-copy gene Resistance to dieldrin (Rdl). |
8(0,0,1,3) | Details |
| 9372130 | Aronstein K, Ffrench-Constant R: Immunocytochemistry of a novel GABA receptor subunit Rdl in Drosophila melanogaster. Invert Neurosci. 1995;1(1):25-31. Following our recent cloning of a novel (GABA) receptor subunit gene Resistance to dieldrin or Rdl form cyclodiene resistance locus in Drosophila melanogaster, we were interested in defining its pattern of expression during development. |
8(0,0,1,3) | Details |
| 8389005 | Ffrench-Constant RH, Rocheleau TA, Steichen JC, Chalmers AE: A point mutation in a Drosophila GABA receptor confers insecticide resistance. Nature. 1993 Jun 3;363(6428):449-51. Previously, we used a field-isolated Drosophila mutant Rdl (Resistant to dieldrin) insensitive to PTX and cyclodienes to clone a putative GABA receptor. |
8(0,0,1,3) | Details |
| 7527461 | Zhang HG, ffrench-Constant RH, Jackson MB: A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms. J Physiol. 1994 Aug 15;479 ( Pt 1):65-75. The Drosophila gene Rdl (resistance to dieldrin) encodes a GABA receptor. |
8(0,0,1,3) | Details |
| 8601436 | Shotkoski F, Zhang HG, Jackson MB, ffrench-Constant RH: Stable expression of insect GABA receptors in insect cell lines. FEBS Lett. 1996 Feb 19;380(3):257-62. We are interested in establishing stably transformed insect cell lines efficiently expressing the insect (GABA) receptor subunit gene Resistance to dieldrin or Rdl. |
8(0,0,1,3) | Details |
| 7704314 | Shotkoski F, Lee HJ, Zhang HG, Jackson MB, ffrench-Constant RH: Functional expression of insecticide-resistant GABA receptors from the mosquito Aedes aegypti. Insect Mol Biol. 1994 Nov;3(4):283-7. As a first step towards this goal, we here report the functional homomultimeric expression of a (GABA) receptor subunit gene, Resistance to dieldrin (Rdl), from the yellow fever mosquito Aedes aegypti in baculovirus-infected insect cell lines. |
7(0,0,1,2) | Details |
| 7563084 | Stilwell GE, Rocheleau T, ffrench-Constant RH: GABA receptor minigene rescues insecticide resistance phenotypes in Drosophila. J Mol Biol. 1995 Oct 20;253(2):223-7. A single point mutation within the GABA receptor gene Resistance to dieldrin (Rdl) confers a high level of resistance to cyclodiene insecticides in a wide range of insects. |
7(0,0,1,2) | Details |
| 9257933 | Rauh JJ, Benner E, Schnee ME, Cordova D, Holyoke CW, Howard MH, Bai D, Buckingham SD, Hutton ML, Hamon A, Roush RT, Sattelle DB: Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for -gated channels of insects and vertebrates. Br J Pharmacol. 1997 Aug;121(7):1496-505. A variety of (GABA) receptor convulsants, including the insecticides heptachlor (IC50, 35 +/- 3 nM) and dieldrin (IC50, 93 +/- 7 nM), displaced [3H]-BIDN from rootworm membranes. |
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| 17044880 | Brooke BD, Hunt RH, Matambo TS, Koekemoer LL, Van Wyk P, Coetzee M: Dieldrin resistance in the malaria vector Anopheles gambiae in Ghana. Med Vet Entomol. 2006 Sep;20(3):294-9. We conclude that dieldrin resistance in the An. gambiae population of the Obuasi region occurs at a high level - most likely in the absence of selection - and that control of the resistance phenotype is polyfactorial and must include components other than mutations in the GABA receptor locus. |
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| 10761585 | Ffrench-Constant RH, Anthony N, Aronstein K, Rocheleau T, Stilwell G: Cyclodiene insecticide resistance: from molecular to population genetics. Annu Rev Entomol. 2000;45:449-66. Emphasis is given to the use of a resistant Drosophila mutant as an entry point to cloning the associated (GABA) receptor subunit gene, Resistance to dieldrin. |
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| 9740020 | Stilwell GE, ffrench-Constant RH: Transcriptional analysis of the Drosophila GABA receptor gene resistance to dieldrin. J Neurobiol. 1998 Sep 15;36(4):468-84. |
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| 20188834 | Tantely ML, Tortosa P, Alout H, Berticat C, Berthomieu A, Rutee A, Dehecq JS, Makoundou P, Labbe P, Pasteur N, Weill M: Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Reunion Island. Insect Biochem Mol Biol. 2010 Feb 25. A simple molecular test was developed to detect Rdl (R) allele, encoding a (GABA) receptor resistant to dieldrin. |
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| 15796751 | Du W, Awolola TS, Howell P, Koekemoer LL, Brooke BD, Benedict MQ, Coetzee M, Zheng L: Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis. Insect Mol Biol. 2005 Apr;14(2):179-83. Substitutions of a conserved residue in the Rdl locus coding for a (GABA) receptor subunit with serine or confer resistance to dieldrin in various insect species. |
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| 9419893 | Severson DW, Anthony NM, Andreev O, ffrench-Constant RH: Molecular mapping of insecticide resistance genes in the yellow fever mosquito (Aedes aegypti). J Hered. 1997 Nov-Dec;88(6):520-4. The para sodium channel gene homologue and the GABA receptor gene Resistance to dieldrin map to the same genome regions as the DDT/pyrethroid and cyclodiene resistance loci, respectively. |
6(0,0,1,1) | Details |
| 18093001 | Narusuye K, Nakao T, Abe R, Nagatomi Y, Hirase K, Ozoe Y: Molecular cloning of a GABA receptor subunit from Laodelphax striatella (Fallen) and patch clamp analysis of the homo-oligomeric receptors expressed in a Drosophila cell line. Insect Mol Biol. 2007 Dec;16(6):723-33. Antagonists such as fipronil (100 nM), 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) (100 nM), dieldrin (100 nM) and SR95531 (gabazine) (1 microM) suppressed -induced currents. |
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| 15578595 | Bass C, Schroeder I, Turberg A, Field LM, Williamson MS: Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). Pest Manag Sci. 2004 Dec;60(12):1157-62. In many insect species, resistance to cyclodiene insecticides is caused by amino acid substitutions at a single residue (A302) within the M2 transmembrane region of the (GABA) receptor sub-unit termed Rdl (resistance to dieldrin). |
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| 8597060 | Narahashi T, Carter DB, Frey J, Ginsburg K, Hamilton BJ, Nagata K, Roy ML, Song JH, Tatebayashi H: channels and GABAA receptor-channel complex as targets of environmental toxicants. Toxicol Lett. 1995 Dec;82-83:239-45. Dieldrin-induced potentiation of current was observed only when the gamma 2 subunit was present in embryonic kidney cells (HEK-293) transfected with GABA receptor subunits. |
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| 12642390 | Bamber BA, Twyman RE, Jorgensen EM: Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans. Br J Pharmacol. 2003 Mar;138(5):883-93. Picrotoxin sensitivity strongly correlates with dieldrin sensitivity, yet UNC-49B homomers were highly dieldrin resistant. |
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| 7476913 | Zhang HG, Lee HJ, Rocheleau T, ffrench-Constant RH, Jackson MB: Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors. Mol Pharmacol. 1995 Nov;48(5):835-40. These include Resistance to dieldrin, or Rdl, and a homologue of the vertebrate GABAA receptor beta subunit. |
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| 2556203 | Holden-Dye L, Krogsgaard-Larsen P, Nielsen L, Walker RJ: GABA receptors on the somatic muscle cells of the parasitic nematode, Ascaris suum: stereoselectivity indicates similarity to a GABAA-type agonist recognition site. Br J Pharmacol. 1989 Nov;98(3):841-50. The Ascaris GABA receptor does not recognise agents that are known to block the gated chloride channel in mammalian preparations such as t-butylbicyclophosphorothionate (TBPS, 10 microM, n = 2) or the insecticide dieldrin (100 microM, n = 3). 7. |
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| 12770091 | Le Corronc H, Alix P, Hue B: Differential sensitivity of two insect -gated channels to dieldrin, fipronil and picrotoxinin. J Insect Physiol. 2002 Apr;48(4):419-431. In the central nervous system of both vertebrates and invertebrates inhibitory neurotransmission is mainly achieved through activation of (GABA) receptors. |
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| 1653332 | Bermudez I, Hawkins CA, Taylor AM, Beadle DJ: Actions of insecticides on the insect GABA receptor complex. . J Recept Res. 1991;11(1-4):221-32. In contrast dieldrin, ivermectin, lindane, picrotoxin and TBPS are inhibitors of [35S] TBPS binding at the nanomolar range. |
2(0,0,0,2) | Details |
| 12766256 | Zhao X, Salgado VL, Yeh JZ, Narahashi T: Differential actions of fipronil and dieldrin insecticides on -gated channels in cockroach neurons. J Pharmacol Exp Ther. 2003 Sep;306(3):914-24. Epub 2003 May 23. Fipronil and dieldrin are known to inhibit GABA receptors in both mammals and insects. |
196(2,3,3,6) | Details |
| 10952672 | Grolleau F, Sattelle DB: Single channel analysis of the blocking actions of BIDN and fipronil on a Drosophila melanogaster GABA receptor (RDL) stably expressed in a Drosophila cell line. Br J Pharmacol. 2000 Aug;130(8):1833-42. Single channel recordings were obtained from a DROSOPHILA: S2 cell line stably expressing the wild-type RDL (ac) Drosophila melanogaster homomer-forming ionotropic GABA receptor subunit, a product of the resistance to dieldrin gene, RDL: (50 microM) was applied by pressure ejection to outside-out patches from S2-RDL cells at a holding potential of -60 mV. |
83(1,1,1,3) | Details |
| 9014156 | Buckingham SD, Matsuda K, Hosie AM, Baylis HA, Squire MD, Lansdell SJ, Millar NS, Sattelle B: Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line. Neuropharmacology. 1996;35(9-10):1393-401. Here, we report the generation of a Drosophila melanogaster cell line (S2-RDLA302S) stably expressing a mutated, dieldrin-resistant (A302S) form of RDL. |
2(0,0,0,2) | Details |
| 16758255 | Hosie AM, Buckingham SD, Hamon A, Sattelle DB: Replacement of with at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G. Invert Neurosci. 2006 Jun;6(2):75-9. Epub 2006 Apr 29. The A301S mutation that confers resistance to dieldrin did not significantly affect the antagonism by PCG. |
2(0,0,0,2) | Details |
| 1722072 | Narahashi T: Transmitter-activated ion channels as the target of chemical agents. Adv Exp Med Biol. 1991;287:61-73. Lindane and the cyclodienes dieldrin, endrin, heptachlor-epoxide, and isobenzan suppressed the -activated current. It seems that general anesthetics have a specific affinity for the GABA receptor-channel complex. |
2(0,0,0,2) | Details |
| 3000377 | Bloomquist JR, Soderlund DM: insecticides inhibit -dependent uptake by mouse brain vesicles. Biochem Biophys Res Commun. 1985 Nov 27;133(1):37-43. The insecticides endrin, dieldrin, aldrin, lindane (gamma-1,2,3,4,5,6-hexachlorocyclohexane) and deltamethrin inhibited -dependent 36Cl- uptake by mouse brain vesicles. These results demonstrate the disruption of gamma-aminobutyric acid receptor- ionophore function in mammalian brain by insecticides and provide evidence that this complex is the principal site of cyclodiene action. |
1(0,0,0,1) | Details |
| 12370061 | Narahashi T: Nerve membrane ion channels as the target site of insecticides. Mini Rev Med Chem. 2002 Aug;2(4):419-32. Dieldrin, lindane and fipronil block GABA receptors. |
82(1,1,1,2) | Details |
| 1593011 | Smyth KA, Parker AG, Yen JL, McKenzie JA: Selection of dieldrin-resistant strains of Lucilia cuprina (Diptera: Calliphoridae) after ethyl methanesulfonate mutagenesis of a susceptible strain. J Econ Entomol. 1992 Apr;85(2):352-8. Dieldrin resistance may be caused by less effective blocking of insect neuronal GABA receptors by the chemical in resistant strains. |
81(1,1,1,1) | Details |
| 9087552 | Thompson M, Steichen JC, ffrench-Constant RH: Conservation of cyclodiene insecticide resistance-associated mutations in insects. Insect Mol Biol. 1993;2(3):149-54. In Drosophila melanogaster resistance is associated with a single base pair substitution in the GABA receptor/ ion channel gene Rdl. |
1(0,0,0,1) | Details |
| 10333576 | Rufingier C, Pasteur N, Lagnel J, Martin C, Navajas M: Mechanisms of insecticide resistance in the aphid Nasonovia ribisnigri (Mosley) (Homoptera: Aphididae) from France. Insect Biochem Mol Biol. 1999 Apr;29(4):385-91. Endosulfan resistance was associated with a moderate level of resistance to dieldrin, and resistance to both insecticides was due, in part, to increased detoxification by glutathione S-transferases (GST). The endosulfan resistant strain displayed the same amino acid at position 302 of the Rdl gene (GABA receptor) as susceptible aphids (e.g. |
1(0,0,0,1) | Details |
| 7885191 | Cole LM, Roush RT, Casida JE: Drosophila -gated chloride channel: modified [3H] EBOB binding site associated with --> Ser or Gly mutants of Rdl subunit. Life Sci. 1995;56(10):757-65. This specific binding of [3H] EBOB is strongly inhibited by: a large number and variety of insecticidal channel blockers at 20 nM (lindane, alpha-endosulfan, dieldrin, 12-ketoendrin, fipronil, and a representative bicycloorthobenzoate and dithiane) or 200 nM (picrotoxinin); the insecticidal channel activators avermectin and moxidectin at 20 nM; muscimol at 30 microM and GABA at 300 microM. Cyclodiene resistance in D. melanogaster has been attributed to a mutation resulting in an Ala302--> Ser replacement in the Rdl GABA receptor subunit and in D. simulans to an homologous --> Ser or Gly replacement. |
1(0,0,0,1) | Details |
| 8054658 | Bloomquist JR: Cyclodiene resistance at the insect GABA receptor/chloride channel complex confers broad cross resistance to convulsants and experimental phenylpyrazole insecticides. Arch Insect Biochem Physiol. 1994;26(1):69-79. The Maryland strain of D. melanogaster was resistant to dieldrin, lindane, picrotoxinin, TBPS, p-CN-TBOB, and JKU 0422. |
1(0,0,0,1) | Details |
| 1311215 | Bloomquist JR, Roush RT, ffrench-Constant RH: Reduced neuronal sensitivity to dieldrin and picrotoxinin in a cyclodiene-resistant strain of Drosophila melanogaster (Meigen). Arch Insect Biochem Physiol. 1992;19(1):17-25. The possible role of an altered GABA receptor in this resistance is discussed. |
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| 9831449 | Ikeda T, Nagata K, Shono T, Narahashi T: Dieldrin and picrotoxinin modulation of (A) receptor single channels. Neuroreport. 1998 Oct 5;9(14):3189-95. Previous studies have demonstrated that dieldrin and picrotoxin share the common binding site on the GABA receptor. |
81(1,1,1,1) | Details |
| 10212398 | Wolff MA, Wingate VP: Characterization and comparative pharmacological studies of a functional (GABA) receptor cloned from the tobacco budworm, Heliothis virescens (Noctuidae:Lepidoptera). Invert Neurosci. 1998 Mar;3(4):305-15. The HVRDL GABA receptor was insensitive to blockage by dieldrin and the GABAA antagonist, bicuculline. |
39(0,1,2,4) | Details |
| 7582519 | Hosie AM, Baylis HA, Buckingham SD, Sattelle DB: Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster. Br J Pharmacol. 1995 Jul;115(6):909-12. Mutant RDL GABA-receptors, which have a naturally occurring amino acid substitution (A302--> S) in the putative ion-channel lining region, conferring resistance to dieldrin and picrotoxinin, were markedly less sensitive to fipronil than the wild-type receptors. 4. |
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| 18651916 | Hirata K, Ishida C, Eguchi Y, Sakai K, Ozoe F, Ozoe Y, Matsuda K: Role of a serine residue (S278) in the pore-facing region of the housefly -gated chloride channel in determining sensitivity to noncompetitive antagonists. Insect Mol Biol. 2008 Aug;17(4):341-50. Gamma-hexachlorocyclohexane (gamma-HCH), fipronil and picrotoxinin are noncompetitive antagonists (NCAs) of -gated channels (GluCls), yet their potencies are weaker than those on gamma-aminobutyric acid receptors (GABARs). The A302S mutation of Drosophila RDL (resistant to dieldrin) GABAR confers NCA resistance, and housefly GluCls (MdGluCls) possess S278 as the residue corresponding to the A302. |
1(0,0,0,1) | Details |
| 3009836 | Abalis IM, Eldefrawi ME, Eldefrawi AT: Effects of insecticides on -induced influx into rat brain microsacs. J Toxicol Environ Health. 1986;18(1):13-23. The actions of different insecticides known to affect binding of ligands to (GABA) receptors were studied on the function of GABAA receptors in rat brain as assayed by -induced 36Cl- influx into membrane microsacs. The -induced 36Cl- flux was inhibited by several cyclodienes and gamma-hexachlorocyclohexane (gamma-BHC) with the following order of decreasing potency: endosulfan I greater than endrin greater than endosulfan II greater than dieldrin greater than heptachlor epoxide greater than gamma-BHC greater than heptachlor. |
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| 16813330 | Li A, Yang Y, Wu S, Li C, Wu Y: Investigation of resistance mechanisms to fipronil in diamondback moth (Lepidoptera: Plutellidae). J Econ Entomol. 2006 Jun;99(3):914-9. The selection resulted in 300-fold increase in resistance to fipronil, and 3.5- and 6.5-fold cross-resistance to dieldrin and endosulfan, respectively, in the SZ-F strain compared with the unselected SZ strain. The genomic DNA fragments flanking the second membrane-spanning region of Rdl (GABA) receptor gene from P. xylostella, PxRdl, were cloned and sequenced. |
1(0,0,0,1) | Details |
| 19133471 | Zhou XM, Wu QJ, Zhang YJ, Bai LY, Huang XY: Cloning and characterization of a GABA receptor from Plutella xylostella (Lepidoptera: Plutellidae). J Econ Entomol. 2008 Dec;101(6):1888-96. The subunit gene encoded a 483-amino acid polypeptide that showed 84% sequence identity with DmRdl subunit (U02042) (Drosophila melanogaster resistant to dieldrin). |
1(0,0,0,1) | Details |
| 19906878 | Dupuis JP, Bazelot M, Barbara GS, Paute S, Gauthier M, Raymond-Delpech V: Homomeric RDL and heteromeric RDL/LCCH3 GABA receptors in the honeybee antennal lobes: two candidates for inhibitory transmission in olfactory processing. J Neurophysiol. 2010 Jan;103(1):458-68. Epub 2009 Nov 11. Molecular analysis of the -responding cells revealed that both subunits RDL and LCCH3 were expressed out of the three orthologs of Drosophila melanogaster GABA-receptor subunits encoded within the honeybee genome (RDL, resistant to dieldrin; GRD, /-like receptor of Drosophila; LCCH3, ligand-gated chloride channel homologue 3), opening the door to possible homo- and/or heteromeric associations. |
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| 8982503 | Hosie AM, Ozoe Y, Koike K, Ohmoto T, Nikaido T, Sattelle DB: Actions of picrodendrin antagonists on dieldrin-sensitive and -resistant Drosophila GABA receptors. Br J Pharmacol. 1996 Dec;119(8):1569-76. |
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| 18520997 | Es-Salah Z, Lapied B, Le Goff G, Hamon A: RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity. Neuroreport. 2008 Jun 11;19(9):939-43. In Drosophila, the resistance to dieldrin (RDL) (GABA) receptor subunit displays an editing site (R122) that is close to the putative -binding site. |
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| 12510900 | Andreasen MH, Ffrench-Constant RH: In situ hybridization to the Rdl locus on polytene chromosome 3L of Anopheles stephensi. Med Vet Entomol. 2002 Dec;16(4):452-5. We are interested in generating a Y-autosome translocation of the Resistance to dieldrin (Rdl) locus in the malaria vector mosquito Anopheles stephensi Liston (Diptera: Culicidae), for use in sterile insect release. These fragments encode the second membrane-spanning region of the gamma-aminobutyric acid receptor and show high levels of both nucleotide and predicted amino acid identity to other Rdl-like receptors. |
1(0,0,0,1) | Details |
| 8653417 | Hosie AM, Shirai Y, Buckingham SD, Rauh JJ, Roush RT, Baylis HA, Sattelle DB: Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes. Brain Res. 1995 Sep 25;693(1-2):257-60. |
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| 10198127 | Andreev D, Kreitman M, Phillips TW, Beeman RW, ffrench-Constant RH: Multiple origins of cyclodiene insecticide resistance in Tribolium castaneum (Coleoptera: Tenebrionidae). J Mol Evol. 1999 May;48(5):615-24. Target-site insensitivity to cyclodienes is conferred by single point mutations in the gene Resistance to dieldrin (Rdl), which codes for a subunit of a (GABA) receptor. |
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| 10455279 | Matsuda K, Hosie AM, Holyoke CW Jr, Rauh JJ, Sattelle DB: Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist. Br J Pharmacol. 1999 Jul;127(6):1305-7. |
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| 1651498 | Ffrench-Constant RH, Mortlock DP, Shaffer CD, MacIntyre RJ, Roush RT: Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate subtype A receptor locus. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7209-13. To our knowledge, this represents the first cloning of an invertebrate GABA receptor and also allows us to manipulate the resistance status of an insect via germ-line transformation. |
1(0,0,0,1) | Details |
| 9745915 | Narahashi T, Ginsburg KS, Nagata K, Song JH, Tatebayashi H: Ion channels as targets for insecticides. Neurotoxicology. 1998 Aug-Oct;19(4-5):581-90. Dieldrin stimulation requires the gamma2s subunit in the GABA receptor, whereas dieldrin suppression occurs in the presence or absence of the gamma2s subunit. |
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| 8169820 | Nagata K, Narahashi T: Dual action of the cyclodiene insecticide dieldrin on the gamma-aminobutyric acid receptor-chloride channel complex of rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 1994 Apr;269(1):164-71. |
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| 16027231 | Buckingham SD, Biggin PC, Sattelle BM, Brown LA, Sattelle DB: Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides. Mol Pharmacol. 2005 Oct;68(4):942-51. Epub 2005 Jul 18. A -gated chloride channel subunit from Drosophila melanogaster [Resistant to Dieldrin (RDL)] has been cloned, functionally expressed, and found to exhibit many aspects of the pharmacology of native, bicuculline-insensitive insect GABA receptors. |
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| 7603613 | Shirai Y, Hosie AM, Buckingham SD, Holyoke CW Jr, Baylis HA, Sattelle DB: Actions of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster. Neurosci Lett. 1995 Apr 7;189(1):1-4. The actions of picrotoxinin and four of its analogues were tested on a Drosophila melanogaster homo-oligomeric (gamma-aminobutyric acid) receptor formed when RDL (resistance to dieldrin) subunits were expressed in Xenopus oocytes. |
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| 2409983 | Abalis IM, Eldefrawi ME, Eldefrawi AT: Binding of GABA receptor channel drugs to a putative voltage-dependent chloride channel in Torpedo electric organ. Biochem Pharmacol. 1985 Jul 15;34(14):2579-82. |
1(0,0,0,1) | Details |
| 15148245 | Gisselmann G, Plonka J, Pusch H, Hatt H: Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric -gated cation channels. Br J Pharmacol. 2004 Jun;142(3):409-13. Epub 2004 May 17. Picrotoxin effectively blocked the -gated channel (IC50=0.25 microm), but bicuculline, TPMTA, dieldrin and lindane did not. |
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| 14637375 | Ikeda T, Zhao X, Kono Y, Yeh JZ, Narahashi T: Fipronil modulation of -induced currents in cockroach thoracic ganglion neurons. Neurotoxicology. 2003 Dec;24(6):807-15. Although fipronil is known to block GABA receptors, the mechanisms of its selective toxicity and efficacy against insects with dieldrin-resistant GABA receptors are not fully understood. |
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| 20180551 | McGonigle I, Lummis SC: Molecular characterization of agonists that bind to an insect GABA receptor. Biochemistry. 2010 Apr 6;49(13):2897-902. One of the most widely studied insect GABA receptors is constructed from RDL (resistance to dieldrin) subunits from Drosophila melanogaster. |
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| 10679793 | Hollins B, McClintock TS: Lobster GABA receptor subunit expressed in neural tissues. J Neurosci Res. 2000 Feb 15;59(4):534-41. The sequences were most similar to the Drosophila RDL (resistance to dieldrin) subunit with 54% identity, and 30-35% identity with vertebrate ionotropic GABA receptor subunits. |
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| 2458634 | Matsumoto K, Eldefrawi ME, Eldefrawi AT: Action of polychlorocycloalkane insecticides on binding of [35S] t-butylbicyclophosphorothionate to Torpedo electric organ membranes and stereospecificity of the binding site. Toxicol Appl Pharmacol. 1988 Sep 15;95(2):220-9. Endrin was more potent than dieldrin, but endosulfan I and II had similar effects. |
0(0,0,0,0) | Details |