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Cheng S, Chen J, Qiu Y, Hong X, Xia Y, Feng T, Liu J, Song L, Zhang Z, Wang X: Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. Toxicology. 2006 Mar 1;220(1):37-45. Epub 2006 Jan 18.
Furthermore, our results demonstrated that the 22R-HC could remove the carbaryl-induced restraint of progesterone biosynthesis, suggesting that carbaryl caused a disruption of cholesterol transport across mitochondrial membranes, which was further confirmed by the observation that carbaryl inhibited the gene expression of steroidogenic acute regulatory protein (StAR). |
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