Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name carbaryl
CAS

Reference List

PubMed Abstract RScore(About this table)
6443788 Chan HH, Buhler DR: Comparison of nitrosocarbaryl and carbaryl: in vitro effects on hepatic microsomal aryl hydrocarbon hydroxylase, aminopyrine N-demethylase, epoxide hydrolase and cytosolic glutathione-S-transferase. Proc Natl Sci Counc Repub China B. 1984 Oct;8(4):302-7.

Nitrosocarbaryl was more potent and had much higher inhibitory effect than carbaryl on microsomal aryl hydrocarbon hydroxylase, aminopyrine N-demethylase, epoxide hydrolase and cytosolic glutathione-S-transferase.
44(0,1,3,4) Details
19476409 Vioque-Fernandez A, de Almeida EA, Lopez-Barea J: Biochemical and proteomic effects in Procambarus clarkii after chlorpyrifos or carbaryl exposure under sublethal conditions. Biomarkers. 2009 Aug;14(5):299-310.

Chlorpyrifos lowered ethoxyresorufin-O-deethylase (EROD), catalase and oxidized glutathione (GSSG) levels but raised glutathione-S-transferase activity, while carbaryl raised EROD, catalase and glutathione-S-transferase, but lowered glutathione peroxidase and reduced glutathione (GSH) levels.
6(0,0,1,1) Details
19715699 Deng H, Huang Y, Feng Q, Zheng S: Two epsilon glutathione S-transferase cDNAs from the common cutworm, Spodoptera litura: characterization and developmental and induced expression by insecticides. J Insect Physiol. 2009 Dec;55(12):1174-83. Epub 2009 Sep 2.

Slgste2 expression was up-regulated by 1-naphthyl methylcarbamate (carbaryl), 1,1,1-trichloro-2,2-bis-(p-chlorophenyl) ethane (DDT), deltamethrin, tebufenozide (RH5992) and Bacillus thuringiensis (Bt), but not affected by malathion, while Slgste3 expression was slightly up-regulated by carbaryl, Bt and DDT, but not affected by RH5992, malathion and deltamethrin.
2(0,0,0,2) Details
17166588 Forcella M, Berra E, Giacchini R, Rossaro B, Parenti P: Increased alanine concentration is associated with exposure to fenitrothion but not carbamates in Chironomus riparius larvae. Ecotoxicol Environ Saf. 2007 Mar;66(3):326-34. Epub 2006 Dec 12.

Chironomus riparius Meigen were exposed to three different insecticides, the organophosphorous fenitrothion and the carbamates carbaryl and carbofuran (0, 1, 10, and 100 microg/L) for 24h as fourth-instar larvae.
Acetylcholinesterase (AChE), naphtylacetate esterase (NAE), p-nitrophenylacetate esterase (PNPAE), glutathione-S-transferase (GST), and a number of metabolites (alanine, pyruvate, lactate, trehalose, aspartate, oxalacetate) were measured to determine which was the most valuable biochemical biomarker of exposure.
1(0,0,0,1) Details
12602852 Bhavan PS, Geraldine P: Carbaryl-induced alterations in biochemical metabolism of the prawn, Macrobrachium malcolmsonii. J Environ Biol. 2002 Apr;23(2):157-62.

The concentration of glutathione S-transferase (GST) was found to be higher in test prawns when compared with controls.
1(0,0,0,1) Details
16188102 Qiu Y, Chen JF, Song L, He J, Liu R, Zhang CW, Wang XR: [Effects of carbaryl on serum steroid hormone and the function of antioxidant system in female rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Aug;23(4):290-3.

The activities of superoxide dismutase (SOD) and glutathione-s-transferase (GST), and the levels of malondialdehyde (MDA) and glutathione (GSH) were measured by spectrophotometry.
1(0,0,0,1) Details
19362380 Ferrari A, Lascano CI, Anguiano OL, D'Angelo AM, Venturino A: Antioxidant responses to azinphos methyl and carbaryl during the embryonic development of the toad Rhinella (Bufo) arenarum Hensel. Aquat Toxicol. 2009 Jun 4;93(1):37-44. Epub 2009 Mar 24.

Glutathione-S-transferases, which may participate in the conjugation of lipid peroxide products in addition to pesticide detoxification, showed an increase of activity at the beginning and at the end of development.
1(0,0,0,1) Details
2109706 Gay L, Ehrich M: A comparative study of drug metabolizing enzymes in adrenal glands and livers of rats and chickens. Int J Biochem. 1990;22(1):15-8.


Drug metabolizing enzymes (cytochrome P450, glutathione-S-transferase, carboxylesterase) were compared in livers and adrenal glands from rats and chickens. 2.
1(0,0,0,1) Details
17089332 Yu SJ, McCord E Jr: Lack of cross-resistance to indoxacarb in insecticide-resistant Spodoptera frugiperda (Lepidoptera: Noctuidae) and Plutella xylostella (Lepidoptera: Yponomeutidae). Pest Manag Sci. 2007 Jan;63(1):63-7.


Two field strains of the fall armyworm, Spodoptera frugiperda (JE Smith), collected from corn in north Florida showed high resistance to carbaryl (626- and 1159-fold) and moderate resistance to parathion-methyl (30- and 39-fold) as compared with a laboratory susceptible strain.
0(0,0,0,0) Details
15378568 Reuveny H, Cohen E: Evaluation of mechanisms of azinphos-methyl resistance in the codling moth Cydia pomonella (L.). Arch Insect Biochem Physiol. 2004 Oct;57(2):92-100.


Of the three carbamates examined, only carbaryl was inhibitory at the mM range while pirimicarb and aldicarb were inactive.
0(0,0,0,0) Details